L N Sutton
Affiliation: The Children's Hospital of Philadelphia
- In utero surgery for hydrocephalusCornelia S von Koch
Department of Neurological Surgery, University of California San Francisco, Room M 779, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143 0112, USA
Childs Nerv Syst 19:574-86. 2003..Neonatal hydrocephalus is one of the most common congenital anomalies affecting the nervous system...
- Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningoceleL N Sutton
Department of Neurosurgery, Children s Hospital of Phildelphia, 10194, USA
JAMA 282:1826-31. 1999..Hindbrain herniation occurs in a large percentage of children with myelomeningocele and is the leading cause of death in this population. The effect of early fetal closure of myelomeningocele on hindbrain herniation is unknown...
- Fetal neurosurgeryL N Sutton
Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, USA
Neurosurgery 48:124-42; discussion 142-4. 2001..The challenge is to define which patients might benefit from such radical procedures before these techniques are accepted as standard care...
- Fetal surgery for neural tube defectsLeslie N Sutton
Department of Neurosurgery, Children s Hospital of Philadelphia, 6th Floor Wood Bldg, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
Best Pract Res Clin Obstet Gynaecol 22:175-88. 2008..A randomized prospective trial (the MOMS trial) is currently being conducted by three centers in the United States, and is estimated to be completed in 2009...
- Fetal surgery for myelomeningoceleLeslie N Sutton
Division of Neurosurgery, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19087, USA
Childs Nerv Syst 19:587-91. 2003..Although in utero treatment of myelomeningocele shows promise in decreasing the morbidity of this disease, the risks to the fetus are significant, and the benefits are unproven...
- The effect of intrauterine myelomeningocele repair on the incidence of shunt-dependent hydrocephalusNoel Tulipan
Department of Neurosurgery, Vanderbilt University Medical Center, A 2219 Medical Center North, Nashville, TN 37232 2380, USA
Pediatr Neurosurg 38:27-33. 2003..However, the existing cohort of IUMR patients has not yet been systematically compared to a comparable group of conventionally treated controls...
- The Rationale for in utero repair of myelomeningoceleD S Walsh
Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, PA 19104, USA
Fetal Diagn Ther 16:312-22. 2001..CONCLUSIONS: In utero repair of myelomeningocele may improve neurologic outcomes and reduce hindbrain herniation in selected patients...
- Fetal head biometry following in-utero repair of myelomeningoceleE Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Ultrasound Obstet Gynecol 24:606-11. 2004..To evaluate the impact of prenatal myelomeningocele repair on fetal head biometry...
- Fetal myelomeningocele repair: short-term clinical outcomesMark P Johnson
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadephia, PA 19104, USA
Am J Obstet Gynecol 189:482-7. 2003..The study was undertaken to evaluate short-term clinical outcomes with antenatal myelomeningocele (MMC) repair...
- A randomized trial of prenatal versus postnatal repair of myelomeningoceleN Scott Adzick
Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
N Engl J Med 364:993-1004. 2011..Prenatal repair of myelomeningocele, the most common form of spina bifida, may result in better neurologic function than repair deferred until after delivery. We compared outcomes of in utero repair with standard postnatal repair...
- Anticancer effects of the novel 1alpha, 25-dihydroxyvitamin D3 hybrid analog QW1624F2-2 in human neuroblastomaC Damodar Reddy
Division of Neurosurgery, The Children s Hospital of Philadelphia and The Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
J Cell Biochem 97:198-206. 2006..In summary, the low-calcemic hybrid analog QW showed significant anti-tumor activity in vivo and thus exhibits potential as a novel cancer therapeutic...
- Anticancer effects of fenretinide in human medulloblastomaC Damodar Reddy
Division of Neuro Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Cancer Lett 231:262-9. 2006..These results suggest that pharmacologically achievable concentrations of fenretinide are effective in killing MB cells and thus show its therapeutic potential to treat human MB...
- Maternal-fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of ageMark Paul Johnson
The Center for Fetal Diagnosis and Treatment, Philadelphia, PA 19104, USA
Am J Obstet Gynecol 194:1145-50; discussion 1150-2. 2006..This study was undertaken to examine short-term neurodevelopmental outcomes in children with myelomeningocele (MMC) who underwent in utero neurosurgical closure...
- Cervical chordoma in a patient with tuberous sclerosis presenting with shoulder painPhillip B Storm
Department of Neurosurgery, University of Pennsylvania and Children s Hospital of Philadelphia, PA 19104 4399, USA
Pediatr Neurosurg 43:167-9. 2007
- Does a myelomeningocele sac compared to no sac result in decreased postnatal leg function following maternal fetal surgery for spina bifida aperta?R Douglas Wilson
Department of Surgery and Obstetrics and Gynecology, Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
Fetal Diagn Ther 22:348-51. 2007..A fetus with large sac S1 myelomeningocele (MMC) but bilateral talipes prompted the question, 'Does the presence or size of an MMC sac affect postnatal leg function?'..
- Energy expenditure in obesity associated with craniopharyngiomaRoy J Kim
Division of Endocrinology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Childs Nerv Syst 26:913-7. 2010..Obesity is a common yet incompletely understood complication of childhood craniopharyngioma. We hypothesized that craniopharyngioma is associated with specific defects in energy balance compared to obese control children...
- All-trans-retinoic acid-induced apoptosis in human medulloblastoma: activation of caspase-3/poly(ADP-ribose) polymerase 1 pathwayKiranmai Gumireddy
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
Clin Cancer Res 9:4052-9. 2003....
- Dermoid inclusion cysts and early spinal cord tethering after fetal surgery for myelomeningoceleCatherine A Mazzola
Department of Neurosurgery, University of Pittsburgh and Children s Hospital of Pittsburgh, Pittsburgh 15213, USA
N Engl J Med 347:256-9. 2002
- Development of the Spitz-Holter valve in PhiladelphiaJ A Boockvar
Division of Neurosurgery, Children s Hospital of Philadelphia, Pennsylvania, USA
J Neurosurg 95:145-7. 2001..Sc. (Hon) and Eugene Spitz. M.D., and on a review of the available literature, the authors narrate the exciting story of the development of the Spitz-Holter valve, which took place in Philadelphia during the early 1950s...
- Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgeryEnrico Danzer
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 25:47-53. 2009..To evaluate lower extremity neuromotor function (LENF) and short-term ambulatory potential following fetal myelomeningocele (fMMC) closure...
- Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxibRatnakar Patti
Division of Neuro Oncology, Joseph Stokes Research Institute 515G, 3516 Civic Center Blvd, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Cancer Lett 180:13-21. 2002..Growth inhibition by celecoxib and rofecoxib was independent of Bcl-2 expression. Celecoxib suppressed the expression of Akt and activated the caspase-3 in DAOY and PFSK, whereas rofecoxib did not have such an effect...
- Fetal head biometry assessed by fetal magnetic resonance imaging following in utero myelomeningocele repairEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 22:1-6. 2007..To examine the impact of fetal myelomeningocele (MMC) repair on fetal head biometry and cerebrospinal fluid (CSF) spaces assessed by magnetic resonance imaging (MR) studies...
- Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findingsEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Neurosurg Pediatr 2:406-13. 2008..The goal in this study was to evaluate the incidence and clinical implications of the development of cutaneously derived intradural inclusion cysts (ICs) following fetal myelomeningocele (fMMC) closure...
- Fetal surgery for myelomeningoceleLeslie N Sutton
University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, USA
Clin Neurosurg 51:155-62. 2004
- A new look at myelomeningoceles: functional level, vertebral level, shunting, and the implications for fetal interventionNatalie E Rintoul
Divisions of Neonatology, Philadelphia, Pennsylvania 10194, USA
Pediatrics 109:409-13. 2002..We sought to determine the distribution of postnatally repaired MMC lesions as characterized by both functional and radiologic assessment, as well as the incidence of shunting when patients were categorized according to these 2 methods...
- Prenatal diagnosis of terminal myelocystocele in the fetal surgery era: case reportPaola Midrio
Department of Surgery, The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
Neurosurgery 50:1152-4; discussion 1154-5. 2002..This case exemplifies the importance of performing a multidisciplinary evaluation and magnetic resonance imaging in the patient with suspected meningomyelocele when fetal surgery is being considered...
- Efficacy of spinal instrumentation and fusion in the prevention of postlaminectomy spinal deformity in children with intramedullary spinal cord tumorsScott L Simon
Department of Neurosurgery, The University of Pennsylvania, Philadelphia, PA, USA
J Pediatr Orthop 28:244-9. 2008..05). Removal of greater than 4 laminae (P = 0.03) was found to be associated with the development of postresection spinal deformity...
- Fetal posterior fossa volume: assessment with MR imagingSara C Chen
Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, USA
Radiology 238:997-1003. 2006..To retrospectively determine the relationship between posterior fossa volume (PFV) and estimated gestational age (EGA) and/or femur length (FL) during pregnancy for the purpose of developing a normal growth curve...
- Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adultsDiana C H Stripp
Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Int J Radiat Oncol Biol Phys 58:714-20. 2004..The optimal management of craniopharyngiomas remains controversial, especially in children and young adults. This study reports a single institution's experience with such patients...
- Ventriculosagittal sinus shunt placement: technical case reportUzma Samadani
Division of Neurosurgery, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Neurosurgery 53:778-9; discussion 780. 2003..Determining an appropriate site for distal catheter placement for ventricular shunting for some hydrocephalic patients can be difficult. We describe a simplification of the technique for sagittal sinus shunt placement using a guidewire...
- Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion geneAngela J Sievert
Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Brain Pathol 19:449-58. 2009..Further studies are required to determine the role of this fusion gene in downstream MAPK signaling and its role in development of pediatric low-grade astrocytomas...
- Endovascular and surgical treatment of ruptured cerebral aneurysms in pediatric patientsMichael F Stiefel
Department of Neurosurgery and Division of Interventional Neuroradiology, University of Pennsylvania Medical Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Neurosurgery 63:859-65; discussion 865-6. 2008..Pediatric cerebral aneurysms are rare. There are very few recent studies that focus on the multidisciplinary treatment of ruptured aneurysms. We reviewed our pediatric endovascular and surgical experience with ruptured cerebral aneurysms...
- Intramedullary cervical spine germinoma: case reportJason H Huang
Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Neurosurgery 55:1432. 2004..We report an extremely rare case of primary intramedullary germinoma in the cervical spinal cord arising in an 18-year-old man who had not undergone previous surgery or irradiation...
- Childhood intracranial ependymoma: twenty-year experience from a single institutionHui Kuo G Shu
Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 30322, USA
Cancer 110:432-41. 2007..In this article, they report their 20-year institutional experience with this disease...
- Chiari I malformation presenting with hearing loss: surgical treatment and literature reviewGregory G Heuer
Division of Neurosurgery, Children s Hospital of Philadelphia, Wood Center, 6th Floor, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
Childs Nerv Syst 24:1063-6. 2008..Chiari I malformations can present with a number of clinical signs and symptoms...
- Conus medulla-cauda compression from nerve root hypertrophy in a child with Dejerine-Sottas syndrome: improvement with laminectomy and duraplasty. Case reportKleopas A Kleopa
Division of Neurology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
J Neurosurg 97:244-7. 2002..Magnetic resonance imaging of the spine revealed nerve root hypertrophy resulting in compression of the conus medullaris and cauda equina. Decompressive surgery was successful in reversing some of his deficits...
- Anti-proliferative effects of 20-epi-vitamin-D3 analogue, KH1060 in human neuroblastoma: induction of RAR-beta and p21(Cip1)Kiranmai Gumireddy
Department of Pediatrics, Brown University School of Medicine, Providence, RI 02905, USA
Cancer Lett 190:51-60. 2003..Taken together, all the six NB cells were more susceptible to growth inhibition by KH1060 than 1,25-D(3), suggesting its possible use in NB to potentiate the action of retinoids, which are in clinical use for this disease...
- Effect of 20-epi-1alpha,25-dihydroxyvitamin D3 on the proliferation of human neuroblastoma: role of cell cycle regulators and the Myc-Id2 pathwayKiranmai Gumireddy
Department of Pediatrics, Brown University School of Medicine, Providence, RI 02905, USA
Biochem Pharmacol 65:1943-55. 2003..In sum, we show that 20-epi-1,25(OH)(2)D(3) exerts strong antiproliferative effects by regulating key growth control networks (Myc-Id2-pRB) in NB cells...
- Delayed cranial vault reconstruction for sagittal synostosis in older children: an algorithm for tailoring the reconstructive approach to the craniofacial deformityJeffrey Weinzweig
Department of Surgery, Brown University School of Medicine, Rhode Island Hospital, Providence, USA
Plast Reconstr Surg 110:397-408. 2002..However, it is essential that the extent of the deformity be carefully evaluated preoperatively to permit selection of the appropriate technique for reconstruction...
- Spina bifidaLaura E Mitchell
Institute of BioScience and Technology, The Texas A and M University System Health Science Center, TX 77030 3303, USA
Lancet 364:1885-95. 2004..Medical management is a lifelong necessity for individuals with spina bifida, and should be provided by a multidisciplinary team...