Derry C Roopenian

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. ncbi FcRn: the neonatal Fc receptor comes of age
    Derry C Roopenian
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:715-25. 2007
  2. ncbi The immunogenomics of minor histocompatibility antigens
    Derry Roopenian
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Immunol Rev 190:86-94. 2002
  3. pmc Clinical ramifications of the MHC family Fc receptor FcRn
    Derry C Roopenian
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Clin Immunol 30:790-7. 2010
  4. ncbi The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs
    Derry C Roopenian
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 170:3528-33. 2003
  5. pmc IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice
    Caroline G McPhee
    The Jackson Laboratory, Bar Harbor, ME 04609
    J Immunol 191:4581-8. 2013
  6. ncbi Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease
    Stefka B Petkova
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Int Immunol 18:1759-69. 2006
  7. ncbi Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide
    Eun Young Choi
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Immunity 17:593-603. 2002
  8. doi Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies
    Derry C Roopenian
    The Jackson Laboratory, Bar Harbor, ME, USA
    Methods Mol Biol 602:93-104. 2010
  9. pmc MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis
    Caroline G McPhee
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 187:4695-704. 2011
  10. pmc Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice
    Thomas J Sproule
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Genet 10:e1004068. 2014

Collaborators

Detail Information

Publications46

  1. ncbi FcRn: the neonatal Fc receptor comes of age
    Derry C Roopenian
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:715-25. 2007
    ..This Review summarizes these two areas of FcRn biology...
  2. ncbi The immunogenomics of minor histocompatibility antigens
    Derry Roopenian
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Immunol Rev 190:86-94. 2002
    ..The now well-characterized mouse minor H antigen system should provide a vehicle to assess the degree to which immunodominant alloantigens contribute to transplant rejection...
  3. pmc Clinical ramifications of the MHC family Fc receptor FcRn
    Derry C Roopenian
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Clin Immunol 30:790-7. 2010
    ..While it is well established that so-called neonatal Fc receptor, FcRn, acts throughout life to confer these unusual properties, its ramifications on clinical medicine and therapeutic uses are not broadly appreciated...
  4. ncbi The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs
    Derry C Roopenian
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 170:3528-33. 2003
    ..FcRn is therefore a promising therapeutic target for enhancing protective humoral immunity, treating autoimmune disease, and improving drug efficacy...
  5. pmc IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice
    Caroline G McPhee
    The Jackson Laboratory, Bar Harbor, ME 04609
    J Immunol 191:4581-8. 2013
    ..These results indicate that IL-21 has both disease-promoting and disease-suppressive effects in the autoimmune disease of BXSB.Yaa mice. ..
  6. ncbi Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease
    Stefka B Petkova
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Int Immunol 18:1759-69. 2006
    ....
  7. ncbi Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide
    Eun Young Choi
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Immunity 17:593-603. 2002
    ..Understanding why the H60 peptide is so immunogenic has important implications in tissue transplantation and vaccine design...
  8. doi Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies
    Derry C Roopenian
    The Jackson Laboratory, Bar Harbor, ME, USA
    Methods Mol Biol 602:93-104. 2010
    ..We describe human FcRn transgenic mouse models and how they can be exploited productively for the preclinical pharmacokinetic evaluation of therapeutic antibodies...
  9. pmc MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis
    Caroline G McPhee
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 187:4695-704. 2011
    ..These results indicate that the predominant role of the MHC class I protein family in such immunological disorders is to protect from more aggressive diseases...
  10. pmc Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice
    Thomas J Sproule
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Genet 10:e1004068. 2014
    ..Overall the results provide an explanation for how normally innocuous allelic variants can act epistatically with a disease causing mutation to impact the severity of a rare, heritable mechanobullous disorder. ..
  11. pmc Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor Fc gamma RIIB
    Stefka B Petkova
    The Jackson Laboratory, Bar Harbor, ME 04605, USA
    J Exp Med 203:275-80. 2006
    ..Our results suggest that humoral autoimmunity can contribute directly to autoimmune arthritis, and that FcgammaRIIB-/- mice are a promising model to evaluate the arthritogenic potential of human autoAbs...
  12. ncbi Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature
    Motonobu Ueno
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Invest Ophthalmol Vis Sci 46:4097-106. 2005
    ..The present study was conducted to investigate healing of alkali-burned corneas in MRL/MpJ (MRL) mice...
  13. pmc Searching QTL by gene expression: analysis of diabesity
    Aaron C Brown
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    BMC Genet 6:12. 2005
    ..Quantitative trait loci (QTL) are phenotypically-defined chromosomal regions that contribute to allelically variant biological traits, and by overlaying QTL on the transcriptome, the search for candidate genes becomes extremely focused...
  14. pmc A direct method to determine the strength of the dermal-epidermal junction in a mouse model for epidermolysis bullosa
    Thomas J Sproule
    The Jackson Laboratory, Bar Harbor, ME, USA
    Exp Dermatol 21:453-5. 2012
    ....
  15. ncbi Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease
    Eun Young Choi
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 100:4259-65. 2002
    ....
  16. pmc A mouse model of generalized non-Herlitz junctional epidermolysis bullosa
    Jason A Bubier
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Invest Dermatol 130:1819-28. 2010
    ..This model faithfully recapitulates human JEB and provides an important preclinical tool to test therapeutic approaches...
  17. doi Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies
    Derry C Roopenian
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA
    Methods Mol Biol 1438:103-14. 2016
    ..We describe human FcRn transgenic mouse models and how they can be exploited productively for the preclinical pharmacokinetic evaluation of therapeutic antibodies. ..
  18. pmc A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
    Jason A Bubier
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 106:1518-23. 2009
    ..IL-21 arising from an abnormal population of CD4 T cells is thus central to the development of this lethal disease, and, more generally, could play an important role in human SLE and related autoimmune disorders...
  19. doi Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ
    C Herbert Pratt
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA Electronic address
    Exp Mol Pathol . 2016
    ..Together these data suggest that M. pahari have altered extracellular matrix development resulting in separation of the skin below the level of the dermis with moderate force similar to the African spiny mouse (Acomys spp.)...
  20. pmc Humanized FcRn mouse models for evaluating pharmacokinetics of human IgG antibodies
    Gabriele Proetzel
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA Electronic address
    Methods 65:148-53. 2014
    ..With the advance of genetic engineering mouse models have been established expressing human FcRn, and lacking mouse FcRn protein. These models have become highly relevant tools for serum half-life analysis of Fc-containing compounds. ..
  21. doi The Cinderella effect: searching for the best fit between mouse models and human diseases
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine, USA
    J Invest Dermatol 133:2509-13. 2013
    ..Closely coordinated human and model organism studies are essential to provide traction for translational research. ..
  22. pmc Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages
    Stefka B Petkova
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 34:304-14. 2008
    ..The data from this study are available as part of the Mouse Phenome Database at http://www.jax.org/phenome...
  23. pmc A mouse model of heritable cerebrovascular disease
    Thomas J Sproule
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 5:e15327. 2010
    ..Targeted resequencing of the entire interval did not reveal any provocative changes; thus, the causative molecular lesion has not been identified...
  24. pmc Genetically engineered humanized mouse models for preclinical antibody studies
    Gabriele Proetzel
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA
    BioDrugs 28:171-80. 2014
    ..Here, we provide an overview of genetic engineering methods, as well as the development of humanized neonatal Fc receptor (FcRn) models and their use for monoclonal antibody in vivo studies. ..
  25. ncbi ExQuest, a novel method for displaying quantitative gene expression from ESTs
    Aaron C Brown
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Genomics 83:528-39. 2004
    ..These interactive "transcriptome" maps provide a novel tool for investigating the genomic basis of gene expression as well as prioritizing candidate genes within genetically mapped mutant and quantitative trait loci...
  26. pmc Dependence of antibody-mediated presentation of antigen on FcRn
    Shuo Wang Qiao
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:9337-42. 2008
    ....
  27. pmc Podocytes use FcRn to clear IgG from the glomerular basement membrane
    Shreeram Akilesh
    Department of Pathology and Immunology, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:967-72. 2008
    ....
  28. ncbi Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism
    Shreeram Akilesh
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 179:4580-8. 2007
    ....
  29. pmc NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Immunol 179:2999-3011. 2007
    ..Together, these data provide the first evidence that NF-kappaB signaling via intronic sequences regulates FcRn expression and function...
  30. pmc The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Exp Med 197:315-22. 2003
    ..These results affirm the hypothesis that the major histocompatibility complex-related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both...
  31. ncbi An immunodominant minor histocompatibility alloantigen that initiates corneal allograft rejection
    Zdenka Haskova
    The Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Transplantation 75:1368-74. 2003
    ..We hypothesize that certain immunodominant minor H alloantigens are extremely immunogenic when expressed in corneal tissue, terminate ocular immune privilege, and initiate corneal allograft rejection...
  32. ncbi Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
    Masaru Yoshida
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunity 20:769-83. 2004
    ..These results explain how IgG is secreted onto mucosal surfaces and scavenges luminal antigens for recognition by the immune system...
  33. ncbi Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Immunol 173:5361-71. 2004
    ..Finally, BXSB-Yaa mice, which develop a systemic lupus erythematosus-like disease, have greatly elevated IL-21, suggesting a role for IL-21 in the development of autoimmune disease...
  34. ncbi Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces
    Jonghan Kim
    Department of Internal Medicine, The Ohio State University, 425 Davis Heart and Lung Research Institute, 473 West Twelfth Ave, Columbus, OH 43210, USA
    Am J Physiol Gastrointest Liver Physiol 290:G352-60. 2006
    ....
  35. ncbi Generation and characterization of a novel tetravalent anti-CD22 antibody with improved antitumor activity and pharmacokinetics
    Xiao Yun Liu
    The Cancer Immunobiology Center, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, NB9 210, Dallas, Texas 75390 8576, USA
    Int Immunopharmacol 6:791-9. 2006
    ..Based on the improved in vitro performance and pharmacokinetics of the tetravalent antibody it will now be tested for its antitumor activity in vivo...
  36. pmc Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
    Masaru Yoshida
    Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 116:2142-2151. 2006
    ....
  37. pmc Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases
    Ning Li
    Department of Dermatology, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:3440-50. 2005
    ..These data demonstrate that the therapeutic efficacy of HDIG treatment in the pemphigus and pemphigoid models is dependent on FcRn. Thus, FcRn is a promising therapeutic target for treating such IgG-mediated autoimmune diseases...
  38. pmc In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules
    Jingbo Yan
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Exp Med 203:647-59. 2006
    ..These findings reveal an important in vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules...
  39. ncbi Genetic susceptibility to chronic periodontal disease
    Pamela J Baker
    Biology Department, Bates College, 44 Campus Avenue, Lewiston, ME 04240, USA
    Microbes Infect 4:1157-67. 2002
    ..Data from both clinical studies and studies using animal models are reviewed here. Also outlined are the genomic methods that are now available for identifying susceptibility and resistance loci...
  40. ncbi Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Cancer Institute, NIH, Rockville, Maryland 20852, USA
    Cancer Res 67:2439-47. 2007
    ..Selecting specific types of mouse plasmacytomas that relate most closely to subtypes of human multiple myeloma may provide new opportunities for preclinical testing of drugs for treatment of the human disease...
  41. pmc Survival and function of MiHA epitope-specific host CD8 TM cells following ablative conditioning and HCT
    Alwi M Shatry
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Biol Blood Marrow Transplant 13:293-8. 2007
    ..In summary, these observations highlight the increased risk of resistance in the presence of antidonor antigen-specific CD8 TM due to their ability to survive and function even following rigorous conditioning and HCT...
  42. ncbi The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications
    Rajwardhan Yadav
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 170:5133-42. 2003
    ..Although we document the above process in the minor H Ag system, posttranslational modifications made possible by subtle amino acid changes could also contribute to immunogenicity and immune dominance in tumor immunotherapeutic settings...
  43. ncbi Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D
    Adelheid Cerwenka
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 168:3131-4. 2002
    ..Ligands of the human NKG2D receptor are remarkably polymorphic, suggesting that these may also serve as minor histocompatibility Ags...
  44. ncbi Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]
    Aleksandar K Stanic
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 171:4539-51. 2003
    ..Our findings demonstrate that iNKT cell functions are controlled by affinity thresholds for glycolipid Ags and reveal a novel property of their Ag receptor apparatus that may have an important role in iNKT cell activation...
  45. ncbi Duration of alloantigen presentation and avidity of T cell antigen recognition correlate with immunodominance of CTL response to minor histocompatibility antigens
    Yoshitaka Yoshimura
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 172:6666-74. 2004
    ..These properties of CTL Ag presentation and recognition that contribute to immunodominance have implications not only for tissue transplantation, but also for autoimmunity and tumor vaccine design...
  46. ncbi T cell knockout mice have diminished alveolar bone loss after oral infection with Porphyromonas gingivalis
    Pamela J Baker
    Biology Department, Bates College, 44 Campus Avenue, Lewiston, ME 04240, USA
    FEMS Immunol Med Microbiol 34:45-50. 2002
    ..Antigen-activated T lymphocytes are known to induce osteoclastogenesis; here we demonstrate that T cell deletion decreases the amount of alveolar bone loss induced by infection of the murine oral cavity...