John M Robinson

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Dramatic alterations in the protein biosynthetic machinery accompany trophoblast fusion
    John M Robinson
    Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA
    J Nippon Med Sch 80:95-6. 2013
  2. ncbi request reprint Enhanced labeling efficiency using ultrasmall immunogold probes: immunocytochemistry
    J M Robinson
    Department of Physiology, Ohio State University, Columbus, Ohio, USA
    J Histochem Cytochem 48:487-92. 2000
  3. pmc Proteomics of the human placenta: promises and realities
    J M Robinson
    Department of Physiology and Cell Biology, Ohio State University, Columbus, OH 43210, USA
    Placenta 29:135-43. 2008
  4. pmc Reactive oxygen species in phagocytic leukocytes
    John M Robinson
    Department of Physiology and Cell Biology, Ohio State University, Columbus, OH 43210, USA
    Histochem Cell Biol 130:281-97. 2008
  5. pmc Placental proteomics: a shortcut to biological insight
    J M Robinson
    Department of Physiology and Cell Biology, Ohio State University, Columbus, OH 43210, USA
    Placenta 30:S83-9. 2009
  6. doi request reprint Phagocytic leukocytes and reactive oxygen species
    John M Robinson
    Department of Physiology and Cell Biology, Ohio State University, 304 Hamilton Hall, Columbus, OH 43210, USA
    Histochem Cell Biol 131:465-9. 2009
  7. ncbi request reprint Regulation of the NADPH-oxidase complex of phagocytic leukocytes. Recent insights from structural biology, molecular genetics, and microscopy
    John M Robinson
    Department of Physiology and Cell Biology, Ohio State University, 302 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210 1239, USA
    Histochem Cell Biol 122:293-304. 2004
  8. ncbi request reprint Active oxygen and nitrogen species in biology: from cytocidal agents to signaling intermediates
    John M Robinson
    Department of Physiology and Cell Biology, 304 Hamilton Hall, Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA
    Histochem Cell Biol 122:273-5. 2004
  9. pmc While dysferlin and myoferlin are coexpressed in the human placenta, only dysferlin expression is responsive to trophoblast fusion in model systems
    John M Robinson
    Departments of Physiology and Cell Biology and Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio 43210, USA
    Biol Reprod 81:33-9. 2009
  10. pmc Isolation of highly enriched apical plasma membranes of the placental syncytiotrophoblast
    John M Robinson
    Department of Physiology and Cell Biology, Ohio State University, 1645 Neil Ave, 304 Hamilton Hall, Columbus, OH 43210, USA
    Anal Biochem 387:87-94. 2009

Research Grants

  1. IGG PLACENTAL TRANSPORT: ENDOTHELIAL CAVEOLAE
    John Robinson; Fiscal Year: 2004

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Dramatic alterations in the protein biosynthetic machinery accompany trophoblast fusion
    John M Robinson
    Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA
    J Nippon Med Sch 80:95-6. 2013
    ..This report represents a summary of a seminar presentation at Nippon Medical School on September 24, 2012. It is a synopsis of some of our research on trophoblast fusion...
  2. ncbi request reprint Enhanced labeling efficiency using ultrasmall immunogold probes: immunocytochemistry
    J M Robinson
    Department of Physiology, Ohio State University, Columbus, Ohio, USA
    J Histochem Cytochem 48:487-92. 2000
    ..This article considers the advantages and disadvantages associated with ultrasmall immunogold particles as the reporter system in immunocytochemical applications...
  3. pmc Proteomics of the human placenta: promises and realities
    J M Robinson
    Department of Physiology and Cell Biology, Ohio State University, Columbus, OH 43210, USA
    Placenta 29:135-43. 2008
    ....
  4. pmc Reactive oxygen species in phagocytic leukocytes
    John M Robinson
    Department of Physiology and Cell Biology, Ohio State University, Columbus, OH 43210, USA
    Histochem Cell Biol 130:281-97. 2008
    ....
  5. pmc Placental proteomics: a shortcut to biological insight
    J M Robinson
    Department of Physiology and Cell Biology, Ohio State University, Columbus, OH 43210, USA
    Placenta 30:S83-9. 2009
    ..Thus discovery-based and hypothesis-based research are complimentary approaches that when coupled together can hasten scientific discoveries...
  6. doi request reprint Phagocytic leukocytes and reactive oxygen species
    John M Robinson
    Department of Physiology and Cell Biology, Ohio State University, 304 Hamilton Hall, Columbus, OH 43210, USA
    Histochem Cell Biol 131:465-9. 2009
    ..This review also points out the important role of microscopy in complementing biochemical studies to understand better the cell biology of the phagocyte respiratory burst...
  7. ncbi request reprint Regulation of the NADPH-oxidase complex of phagocytic leukocytes. Recent insights from structural biology, molecular genetics, and microscopy
    John M Robinson
    Department of Physiology and Cell Biology, Ohio State University, 302 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210 1239, USA
    Histochem Cell Biol 122:293-304. 2004
    ..Cytochemistry and immunofluorescence microscopy have provided new insights into the assembly of the oxidase and reveal a level of complexity not previously appreciated...
  8. ncbi request reprint Active oxygen and nitrogen species in biology: from cytocidal agents to signaling intermediates
    John M Robinson
    Department of Physiology and Cell Biology, 304 Hamilton Hall, Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA
    Histochem Cell Biol 122:273-5. 2004
  9. pmc While dysferlin and myoferlin are coexpressed in the human placenta, only dysferlin expression is responsive to trophoblast fusion in model systems
    John M Robinson
    Departments of Physiology and Cell Biology and Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio 43210, USA
    Biol Reprod 81:33-9. 2009
    ..Regarding expression, these trophoblastic cell lines recapitulate the distribution of dysferlin in mononuclear cytotrophoblasts and the syncytiotrophoblast in vivo...
  10. pmc Isolation of highly enriched apical plasma membranes of the placental syncytiotrophoblast
    John M Robinson
    Department of Physiology and Cell Biology, Ohio State University, 1645 Neil Ave, 304 Hamilton Hall, Columbus, OH 43210, USA
    Anal Biochem 387:87-94. 2009
    ..Our goal was to develop methods for isolating highly enriched preparations of this apical plasma membrane compatible with high-quality proteomics analysis and herein describe the properties of these isolated membranes...
  11. doi request reprint Correlative fluorescence and electron microscopy in tissues: immunocytochemistry
    J M Robinson
    Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio, USA
    J Microsc 235:259-72. 2009
    ..This approach permits the examination of exactly the same sub-cellular structures in both fluorescence and electron microscopy with a high level of spatial resolution...
  12. ncbi request reprint Evaluation of neutrophil structure and function by electron microscopy: cytochemical studies
    J M Robinson
    Department of Physiology and Cell Biology, Ohio State University, 302 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210, USA
    J Immunol Methods 232:169-78. 1999
    ..These methods provide unique information which, when coupled with biochemical studies, provide for the most complete analysis of neutrophil structure and function...
  13. ncbi request reprint Antigen retrieval in cells and tissues: enhancement with sodium dodecyl sulfate
    J M Robinson
    Department of Physiology and Cell Biology, Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA
    Histochem Cell Biol 116:119-30. 2001
    ..This postfixation and prelabeling step dramatically improves immunolabeling for a number of antigens in both cells and cryosections of tissue...
  14. ncbi request reprint Correlative fluorescence and electron microscopy on ultrathin cryosections: bridging the resolution gap
    J M Robinson
    Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Histochem Cytochem 49:803-8. 2001
    ..Here we review two different methodologies for correlative fluorescence and electron microscopy using ultrathin cryosections and the advantages attendant on this approach. (J Histochem Cytochem 49:803-808, 2001)..
  15. ncbi request reprint Applications of gold cluster compounds in immunocytochemistry and correlative microscopy: comparison with colloidal gold
    J M Robinson
    Department of Physiology and Cell Biology, Ohio State University, 302 Hamilton Hall, 165 Neil Avenue, Columbus, OH 43210, USA
    J Microsc 199:163-79. 2000
    ..Using ultrathin cryosections of human neutrophils as a model system, we demonstrate that a single immunoprobe (i.e. a fluorescently tagged gold cluster compound) is a robust probe for correlative fluorescence and electron microscopy...
  16. doi request reprint Beta 2-microglobulin deficient mice catabolize IgG more rapidly than FcRn- alpha-chain deficient mice
    Jonghan Kim
    Department of Internal Medicine, The Ohio State University, 012K Davis Heart and Lung Research Institute, 473 West Twelfth Avenue, Columbus, OH 43210, USA
    Exp Biol Med (Maywood) 233:603-9. 2008
    ..These results suggest that a beta 2m-associated effect other than FcRn prolongs the survival of both IgG and albumin, although leaky gene transcription in the AK strain cannot be ruled out...
  17. ncbi request reprint Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Nutr 136:2993-8. 2006
    ....
  18. ncbi request reprint Dysferlin is expressed in human placenta but does not associate with caveolin
    Dale D Vandre
    Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio 43210, USA
    Biol Reprod 77:533-42. 2007
    ..As the current literature indicates that few cell types express DYSF, it is of interest that the two major syncytial structures in the human body, skeletal muscle and the STB, express this protein...
  19. pmc IgG is transported across the mouse yolk sac independently of FcgammaRIIb
    Sudhasri Mohanty
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Reprod Immunol 84:133-44. 2010
    ..It is not clear whether RIIb in the human placental villus might mediate an IgG transport function in light of the mouse yolk sac equivalent failing to do so...
  20. pmc FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus
    Jonghan Kim
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 182:2583-9. 2009
    ..The similarities of these results to human placental FcRn expression and function are striking...
  21. ncbi request reprint A novel Fc gamma R-defined, IgG-containing organelle in placental endothelium
    Toshihiro Takizawa
    Department of Physiology and Cell Biology, Ohio State University, Columbus 43210, USA
    J Immunol 175:2331-9. 2005
    ..No IgG-containing organelles are associated with caveolin. These findings are compatible with Fc gammaRIIb-mediated transfer of IgG across the villus endothelium, independent of caveolae...
  22. pmc Trophoblast cell fusion and differentiation are mediated by both the protein kinase C and a pathways
    Waka Omata
    Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e81003. 2013
    ..Thus different biochemical markers of trophoblast fusion behave in concert supporting the hypothesis that activation of both protein kinase C and A pathways lead to trophoblastic differentiation. ..
  23. ncbi request reprint Albumin binding to FcRn: distinct from the FcRn-IgG interaction
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 45:4983-90. 2006
    ..Our results suggest that the FcRn-albumin interaction has unique features distinct from FcRn-IgG binding despite the overall similarity in the pH-dependent binding mechanism by which both ligands are protected from degradation...
  24. pmc Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model
    Jonghan Kim
    Department of Internal Medicine, The Ohio State University, 425 Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
    Clin Immunol 122:146-55. 2007
    ..A simulation study demonstrates that the plasma concentrations of IgG and albumin could be dynamically controlled by both FcRn-related and -unrelated parameters...
  25. pmc Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene
    Manzoor A Wani
    Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:5084-9. 2006
    ..This experiment of nature affirms our hypothesis that FcRn binds IgG and albumin, salvages both from a degradative fate, and maintains their physiologic concentrations...
  26. ncbi request reprint A new method to enhance contrast of ultrathin cryosections for immunoelectron microscopy
    Toshihiro Takizawa
    Department of Physiology, Ohio State University, Columbus, Ohio 43210, USA
    J Histochem Cytochem 51:31-9. 2003
    ..We have developed a positive staining method for achieving contrast in ultrathin cryosections, from tissue fixed only in paraformaldehyde, that provides excellent contrast at the electron microscopic level...
  27. pmc Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein
    Zhili Yao
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210
    J Immunol 197:2390-9. 2016
    ..These results lead us to propose a new paradigm of LSEC and HDL in clearing LPS with a potential to avoid inflammation during sepsis. ..
  28. pmc FcγRIIb on liver sinusoidal endothelium clears small immune complexes
    Latha P Ganesan
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 189:4981-8. 2012
    ..5 h, respectively. RIIb on LSEC, a major scavenger, keeps SIC blood concentrations low and minimizes pathologic deposition of inflammatory immune complex...
  29. ncbi request reprint Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces
    Jonghan Kim
    Department of Internal Medicine, The Ohio State University, 425 Davis Heart and Lung Research Institute, 473 West Twelfth Ave, Columbus, OH 43210, USA
    Am J Physiol Gastrointest Liver Physiol 290:G352-60. 2006
    ....
  30. pmc Abundant intracellular IgG in enterocytes and endoderm lacking FcRn
    Sudhasri Mohanty
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e70863. 2013
    ..Further, IgG was present in the intercellular clefts and the cores of FcRn(+/+) but not FcRn(-/-) jejunum. FcRn specificity for ligand could be determined within the cell...
  31. ncbi request reprint Ultrathin cryosections: an important tool for immunofluorescence and correlative microscopy
    Toshihiro Takizawa
    Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Histochem Cytochem 51:707-14. 2003
    ..Using a particle counting procedure and electron microscopy, we compared the labeling obtained with colloidal gold and FluoroNanogold and found a higher number of particles with silver-enhanced FluoroNanogold than with colloidal gold...
  32. pmc Rapid and efficient clearance of blood-borne virus by liver sinusoidal endothelium
    Latha P Ganesan
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS Pathog 7:e1002281. 2011
    ..Electron microscopy confirmed our results. In contrast with much prior work claiming the main scavenger to be the KC, our results locate the clearance mechanism to the LSEC and identify this cell as a key site of antiviral activity...
  33. ncbi request reprint Nuclear factor-kappa B regulates inducible prostaglandin E synthase expression in human amnion mesenchymal cells
    William E Ackerman
    Department of Obstetrics and Gynecology, Laboratory of Perinatal Research and Division of Maternal Fetal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Biol Reprod 78:68-76. 2008
    ..By coordinately regulating PTGS2 and PTGES, NFkappaB may contribute to an inducible PGE(2) biosynthesis pathway during human parturition...
  34. pmc Despite transcriptional and functional coordination, cyclooxygenase-2 and microsomal prostaglandin E synthase-1 largely reside in distinct lipid microdomains in WISH epithelial cells
    William E Ackerman
    Laboratory of Perinatal Research, Department of Obstetrics and Gynecology, The Ohio State University, 5th Floor Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    J Histochem Cytochem 53:1391-401. 2005
    ....
  35. ncbi request reprint Tertiary and quaternary structure formation of voltage-gated potassium channels
    John M Robinson
    Department of Physiology, University of Pennsylvania, Philadelphia, USA
    Methods Mol Biol 337:41-52. 2006
    ..A biogenic intermediate (i.e., nascent chain attached to transfer RNA and the ribosome) is used to probe events inside and at the exit port of the ribosomal tunnel...
  36. doi request reprint Cell fusion mediates dramatic alterations in the actin cytoskeleton, focal adhesions, and E-cadherin in trophoblastic cells
    Atsuko Ishikawa
    Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Cytoskeleton (Hoboken) 71:241-56. 2014
    ..Thus, extensive remodeling of the actin cytoskeleton and focal adhesions accompanies cell fusion and differentiation and appears related to alterations in E-cadherin in trophoblastic cells...
  37. ncbi request reprint Rapid association of cytoskeletal remodeling proteins with the developing phagosomes of human neutrophils
    John M Robinson
    Department of Physiology and Cell Biology, College of Medicine and Public Health, Ohio State University, Columbus, OH 43210, USA
    Histochem Cell Biol 118:117-25. 2002
    ..These data provide insights into the molecular mechanisms that trigger changes in the actin cytoskeleton during phagocytosis...
  38. pmc Scavenger receptor B1, the HDL receptor, is expressed abundantly in liver sinusoidal endothelial cells
    Latha P Ganesan
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, United States
    Sci Rep 6:20646. 2016
    ..Assessing mRNA of SR-B1 by real time PCR we found messenger expression in LSEC to be about 5 times higher than in hepatocytes. ..
  39. pmc Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes
    Pam Massullo
    Bone Marrow Transplant Program, The Ohio State University, A437A Starling Loving Hall, 320 W Tenth Ave, Columbus, OH, USA
    Blood 105:3397-404. 2005
    ....
  40. pmc The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Exp Med 197:315-22. 2003
    ..These results affirm the hypothesis that the major histocompatibility complex-related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both...
  41. ncbi request reprint The endothelium but not the syncytiotrophoblast of human placenta expresses caveolae
    Timothy W Lyden
    Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    Placenta 23:640-52. 2002
    ..These results have important implications for further understanding placental biology and for the role of caveolae in cell regulation in this organ...
  42. ncbi request reprint Coupled tertiary folding and oligomerization of the T1 domain of Kv channels
    John M Robinson
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 45:223-32. 2005
    ..A threshold level of tertiary folding is required for monomers to oligomerize. Coupling between tertiary and quaternary structure formation may be a common feature in the biogenesis of multimeric proteins...
  43. ncbi request reprint Human cytomegalovirus disrupts constitutive MHC class II expression
    Colleen M Cebulla
    Department of Pathology, Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    J Immunol 169:167-76. 2002
    ..These defects in MHC class II expression combined with previously identified CMV strategies for decreasing MHC class I expression enables infected cells to evade T lymphocyte immunosurveillance...
  44. ncbi request reprint Thin is better!: ultrathin cryosection immunocytochemistry
    Toshihiro Takizawa
    Department of Anatomy, Nippon Medical School, 1 1 5 Sendagi, Bunnkyo ku, Tokyo 113 8602, Japan
    J Nippon Med Sch 71:306-7. 2004
    ..Ultrathin cryosection immunocytochemistry should be an important technique for functional genomics research, especially for the analysis of the in situ expression of target molecules(2,3)...
  45. ncbi request reprint Correlative microscopy of ultrathin cryosections in placental research
    Toshihiro Takizawa
    Department of Anatomy, Nippon Medical School, Tokyo, Japan
    Methods Mol Med 121:351-69. 2006
    ..The use of ultrathin cryosections is a powerful approach for placental research, especially for the investigation of the in situ localization of antigens in the complex structure of the human placenta...
  46. ncbi request reprint Kinetics of conformational transitions in cardiac troponin induced by Ca2+ dissociation determined by Förster resonance energy transfer
    Wen Ji Dong
    Department of Biochemistry and Molecular Genetics, University of Alabama, Birmingham, AL 35294 0005, USA
    J Biol Chem 278:42394-402. 2003
    ..The kinetic results define the magnitudes of structural changes relevant in Ca2+ switching between activation and deactivation of cardiac muscle contraction...
  47. pmc Development of ichthyosiform skin compensates for defective permeability barrier function in mice lacking transglutaminase 1
    Nobuo Kuramoto
    Department of Dermatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Clin Invest 109:243-50. 2002
    ..We suggest that the ichthyosiform skin phenotype in TGase 1 deficiency develops the massive hyperkeratosis as a physical compensation for the defective cutaneous permeability barrier required for survival in a terrestrial environment...
  48. ncbi request reprint Ca2+-induced conformational transition in the inhibitory and regulatory regions of cardiac troponin I
    Wen Ji Dong
    Department of Biochemistry and Molecular Genetics, University of Alabama, Birmingham 35294 2041, USA
    J Biol Chem 278:8686-92. 2003
    ..We have used the data to construct a structural model of the cTnI inhibitory and regulatory regions in the Mg(2+)- and Ca(2+)-saturated states...
  49. ncbi request reprint Histochemistry for placenta research: theory and application
    Toshihiro Takizawa
    Department of Molecular Anatomy, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 74:268-73. 2007
    ..This review article is based on a presentation given in a workshop entitled Histochemistry: Theory and Application at the 12th International Federation of Placenta Associations Meeting held in Kobe, Japan, on September 9, 2006...
  50. ncbi request reprint Ultrahigh-resolution immunofluorescence microscopy using ultrathin cryosections: subcellular distribution of caveolin-1alpha and CD31 in human placental endothelial cells
    Miki Mori
    Department of Molecular Anatomy, Nippon Medical School 1 1 5 Sendagi, Tokyo 113 8602, Japan
    J Electron Microsc (Tokyo) 55:107-12. 2006
    ..5 times more CD31 was expressed on the luminal surface of cells than on the abluminal surface. Our results demonstrate that ultrathin cryosections can serve as excellent substrates for ultrahigh-resolution IF microscopy...
  51. ncbi request reprint Antibody-specific detection of caveolin-1 in subapical compartments of MDCK cells
    William S Bush
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 718 Light Hall, Nashville, TN 37232, USA
    Histochem Cell Biol 126:27-34. 2006
    ..Consequently, the subcellular distribution of caveolin-1 may be much broader than currently believed...
  52. ncbi request reprint The cytotrophoblast layer of human chorionic villi becomes thinner but maintains its structural integrity during gestation
    Miki Mori
    Department of Molecular Anatomy, Nippon Medical School, Tokyo 113 8602, Japan
    Biol Reprod 76:164-72. 2007
    ..These results suggest that the structural integrity of the SPINT1-positive CTB layer may play an important role in villous differentiation and in maintenance of the villous tree via the HGF signaling system during gestation...

Research Grants1

  1. IGG PLACENTAL TRANSPORT: ENDOTHELIAL CAVEOLAE
    John Robinson; Fiscal Year: 2004
    ..Our approaches to testing the predictions of this hypothesis incorporate methods of cell biology, immunology, biochemistry, ultrastructural analysis, and molecular biology. ..