Daniel L Popkin

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner
    Daniel L Popkin
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Host Microbe 9:212-22. 2011
  2. pmc Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection
    Amanda L Blasius
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    PLoS Pathog 8:e1002915. 2012
  3. pmc Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: protein production, antibody production, and in vivo assessment of biological function of genes of interest
    Daniel L Popkin
    The Scripps Research Institute, Department of Immunology and Microbial Sciences IMM 6, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 85:7928-32. 2011
  4. pmc Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037 Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 112:E5706-14. 2015

Collaborators

Detail Information

Publications4

  1. pmc Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner
    Daniel L Popkin
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Host Microbe 9:212-22. 2011
    ..These results support in vivo targeting of Mbtps1 in the treatment of arenavirus infections and demonstrate a critical role for dendritic cells in persistent viral infections...
  2. pmc Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection
    Amanda L Blasius
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    PLoS Pathog 8:e1002915. 2012
    ..Ultimately, infection persisted in feeble mice. We conclude that pDCs are likely required for efficient T cell priming and subsequent viral clearance. Our data suggest that reduced pDC functionality may lead to chronic infection...
  3. pmc Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: protein production, antibody production, and in vivo assessment of biological function of genes of interest
    Daniel L Popkin
    The Scripps Research Institute, Department of Immunology and Microbial Sciences IMM 6, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 85:7928-32. 2011
    ..These findings demonstrate the utility of tripartite LCMV in vitro and in vivo to study genes in the context of a well-defined model system...
  4. pmc Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037 Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 112:E5706-14. 2015
    ..Antiviral immunity was also compromised, with Kdelr1 mutant mice unable to clear an otherwise self-limiting viral infection. These data reveal a nonredundant cellular function for KDELR1, upon which lymphocytes distinctly depend. ..