- Genome function and nuclear architecture: from gene expression to nanoscienceTIMOTHY P O'BRIEN
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Genome Res 13:1029-41. 2003..Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists...
- Moving forward with chemical mutagenesis in the mouseTIMOTHY P O'BRIEN
The Jackson Laboratory, Bar Harbor, ME, USA
J Physiol 554:13-21. 2004..The unique advantages offered using chemical mutagenesis compare favourably to and complement the spectrum of approaches available for functional annotation of the mammalian genome...
- Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequenceLindsay S Shopland
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Cell Biol 174:27-38. 2006..Together, these data suggest dynamic, probabilistic 3D folding states for a contiguous megabase-scale chromosomal region, supporting the diverse activities of multiple genes and their conserved primary sequence organization...