Genomes and Genes
Affiliation: The Ohio State University
- Secretin deficiency causes impairment in survival of neural progenitor cells in micePeter I Jukkola
Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
Hum Mol Genet 20:1000-7. 2011..Our studies demonstrate that secretin has important implications for neurogenesis in postnatal development, and affects neurobehavioral function in the adult mouse...
- A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal linesMelissa K Boles
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
BMC Genet 10:12. 2009..To functionally annotate the distal region of mouse chromosome 4, we performed an ENU-mutagenesis screen using a balancer chromosome targeted to this region of the genome...
- Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behaviorIchiko Nishijima
Center for Molecular and Human Genetics, Columbus Children s Research Institute, The Ohio State University, Columbus, OH 43205, USA
Hum Mol Genet 15:3241-50. 2006..Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior...
- Generation and maintenance of Dmbx1 gene-targeted mutant allelesAkihira Ohtoshi
Center of Molecular and Human Genetics, Children s Research Institute, 700 Children s Drive, Columbus, Ohio 43205, USA
Mamm Genome 17:744-50. 2006..To our knowledge, this is the first demonstration of the proof-of-principle of the maintenance of viable gene-targeted alleles using coat-color-tagged nonlethal balancer chromosomes...
- Ethanol-induced developmental neurodegeneration in secretin receptor-deficient miceDong Woo Hwang
Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
Neuroreport 20:698-701. 2009..The results suggest that secretin signal plays a neuroprotective role of neuronal progenitor cells against the neurotoxicity of ethanol...
- Characterization of a novel prospero-related homeobox gene, Prox2Ichiko Nishijima
Center of Molecular and Human Genetics, Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
Mol Genet Genomics 275:471-8. 2006..Prox2- homozygous mutant males produced elongated spermatids and were fertile. These results demonstrate that mouse Prox2 is dispensable for embryonic development, horizontal cell generation and fertility in contrast to mouse Prox1...
- Dmbx1, a novel evolutionarily conserved paired-like homeobox gene expressed in the brain of mouse embryosAkihira Ohtoshi
Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Mech Dev 110:241-4. 2002..Dmbx1 provides a unique marker of the developing anterior nervous system and should provide a useful molecular resource to elucidate the mechanisms that pattern the vertebrate brain...
- A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridizationYeun Jun Chung
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Genome Res 14:188-96. 2004..The resulting 3K mouse BAC microarrays reproducibly identified DNA copy number alterations in cell lines and primary tumors, such as single-copy deletions, regional amplifications, and aneuploidy...
- Mutagenic insertion and chromosome engineering resource (MICER)David J Adams
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambs, CB10 1SA, UK
Nat Genet 36:867-71. 2004..These indexed vectors constitute a public resource (Mutagenic Insertion and Chromosome Engineering Resource; MICER) for high-throughput, targeted manipulation of the mouse genome...