D A Nielsen

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, New York 10065, USA
    Ann N Y Acad Sci 1187:184-207. 2010
  2. pmc Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts
    David A Nielsen
    Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuropsychopharmacology 34:867-73. 2009
  3. pmc Genotype patterns that contribute to increased risk for or protection from developing heroin addiction
    D A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Mol Psychiatry 13:417-28. 2008
  4. doi request reprint TPH2 and TPH1: association of variants and interactions with heroin addiction
    David A Nielsen
    Laboratory of Biology of the Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10065, USA
    Behav Genet 38:133-50. 2008
  5. ncbi request reprint The BiolAD-DB system : an informatics system for clinical and genetic data
    David A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Mol Diagn Ther 11:15-9. 2007
  6. pmc Genetic susceptibility to heroin addiction: a candidate gene association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Genes Brain Behav 7:720-9. 2008
  7. pmc Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women
    Bronson E Oosterhuis
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Am J Med Genet B Neuropsychiatr Genet 147:793-8. 2008
  8. pmc Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians
    Judith A Briant
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York 10065, USA
    Psychiatr Genet 20:65-72. 2010
  9. pmc Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts
    David A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York 10065, USA
    Hum Genet 127:639-49. 2010
  10. pmc A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuropsychopharmacology 34:1185-97. 2009

Research Grants

Detail Information

Publications18

  1. pmc Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, New York 10065, USA
    Ann N Y Acad Sci 1187:184-207. 2010
    ..Finally, we describe the development and application of a novel technique: molecular haplotyping for studies in genetics of drug addiction...
  2. pmc Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts
    David A Nielsen
    Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuropsychopharmacology 34:867-73. 2009
    ..080). Both the -18 and the +84 CpG sites are located in potential Sp1 transcription factor-binding sites. Methylation of these CpG sites may lead to reduced OPRM1 expression in the lymphocytes of these former heroin addicts...
  3. pmc Genotype patterns that contribute to increased risk for or protection from developing heroin addiction
    D A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Mol Psychiatry 13:417-28. 2008
    ..This approach has identified several new genes potentially associated with heroin addiction and has confirmed the role of OPRM1 in this disease...
  4. doi request reprint TPH2 and TPH1: association of variants and interactions with heroin addiction
    David A Nielsen
    Laboratory of Biology of the Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10065, USA
    Behav Genet 38:133-50. 2008
    ..022), and with the TPH2 rs4290270 variant and heroin addiction (P=0.011). In the African-American group, a significant association of a specific TPH2 haplotype with heroin addiction also was found (SNPHAP, P=0.004; PHASE P=0.036)...
  5. ncbi request reprint The BiolAD-DB system : an informatics system for clinical and genetic data
    David A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Mol Diagn Ther 11:15-9. 2007
    ..BiolAD-DB tools further provide functionalities for generating customized reports and views. The BiolAD-DB system schema, client, and installation instructions are freely available at http://www.rockefeller.edu/biolad-db/...
  6. pmc Genetic susceptibility to heroin addiction: a candidate gene association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Genes Brain Behav 7:720-9. 2008
    ..0005). None of these associations remained significant after adjustment for multiple testing. This study suggests the involvement of several genes and variants in heroin addiction, which is worthy of future study...
  7. pmc Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women
    Bronson E Oosterhuis
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Am J Med Genet B Neuropsychiatr Genet 147:793-8. 2008
    ..05) after correction for multiple testing. No significant association was found with haplotypes of the three most common SNPs. Linkage disequilibrium patterns were similar for the three ethnic/cultural groups...
  8. pmc Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians
    Judith A Briant
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York 10065, USA
    Psychiatr Genet 20:65-72. 2010
    ..In this study, we examined five variants of OPRL1 and their role in determining vulnerability to develop opiate addiction...
  9. pmc Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts
    David A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York 10065, USA
    Hum Genet 127:639-49. 2010
    ..These changes in methylation of the OPRM1 promoter region may lead to altered expression of the mu-opioid receptor gene in the lymphocytes of former heroin addicts who are stabilized in methadone maintenance treatment...
  10. pmc A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuropsychopharmacology 34:1185-97. 2009
    ....
  11. ncbi request reprint Genes associated with addiction: alcoholism, opiate, and cocaine addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuromolecular Med 5:85-108. 2004
    ..A few selected genetic variants that currently look promising for the study of alcohol, opiate, and cocaine addiction are discussed in this article...
  12. ncbi request reprint Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    Nat Neurosci 8:1450-7. 2005
    ..Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases...
  13. ncbi request reprint Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments
    Mary Jeanne Kreek
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, New York 10021, USA
    Pharmacol Rev 57:1-26. 2005
    ..Variants in genes encoding proteins involved in metabolism or biotransformation of drugs of abuse and also of treatment agents are reviewed...
  14. ncbi request reprint Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction
    Vadim Yuferov
    aLaboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Pharmacogenetics 14:793-804. 2004
    ..0742, 0.1015 and 0.0041. Combining ethnicities by Fisher's method yields an empirical significance level of P = 0.0020...
  15. pmc Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs
    Vadim Yuferov
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10065, USA
    Pharmacogenet Genomics 21:185-96. 2011
    ..Expression of the prodynorphin gene (PDYN) is critical for rewarding properties of drugs of abuse and stress-induced responses. Epigenetic factors, such as DNA methylation, play an important role in modulation of gene expression...
  16. pmc Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction
    David A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York 10065, USA
    Psychiatr Genet 20:207-14. 2010
    ..We have used genome-wide association studies to identify variants that are associated with vulnerability to develop heroin addiction...
  17. pmc Bidirectional translational research: Progress in understanding addictive diseases
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuropharmacology 56:32-43. 2009
    ....
  18. ncbi request reprint The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor
    Thomas Kroslak
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    J Neurochem 103:77-87. 2007
    ..In contrast, transiently expressed variant receptors showed only a minor difference in cell surface binding capacity compared to the prototype, and no differences in cAMP EC(50) values...

Research Grants1

  1. DNA Methylation of Promoter CpG Dinucleotides in Opiate Addiction
    David Nielsen; Fiscal Year: 2007
    ..Findings of the studies in this application may help to alleviate individual suffering and the tremendous cost to society caused by drug and alcohol addiction. [unreadable] [unreadable] [unreadable]..