Maureen E Murphy

Summary

Affiliation: The Wistar Institute
Country: USA

Publications

  1. pmc Ironing out how p53 regulates ferroptosis.
    Maureen E Murphy
    Proc Natl Acad Sci U S A 113:12350-12352. 2016
  2. pmc The HSP70 family and cancer
    Maureen E Murphy
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Carcinogenesis 34:1181-8. 2013
  3. pmc Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53
    Stephen M Sykes
    Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:20197-205. 2009
  4. pmc Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function
    Julia Pimkina
    Program in Developmental Therapeutics, Philadelphia, PA, USA
    Cancer Biol Ther 12:503-9. 2011
  5. pmc Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain
    E Christine Pietsch
    Division of Medical Sciences and Program in Biomolecular Structure and Function, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Biol Chem 283:21294-304. 2008
  6. pmc ARF induces autophagy by virtue of interaction with Bcl-xl
    Julia Pimkina
    Division of Medical Sciences, the Smolensk State Medical Academy Graduate Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Biol Chem 284:2803-10. 2009
  7. pmc Wild-type and mutant p53 proteins interact with mitochondrial caspase-3
    Amanda K Frank
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer Biol Ther 11:740-5. 2011
  8. pmc An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model
    Matthew Jennis
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA Program in Molecular and Cellular Biology and Genetics, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Genes Dev 30:918-30. 2016
  9. pmc HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cancer Res 9:936-47. 2011
  10. pmc A small molecule inhibitor of inducible heat shock protein 70
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    Mol Cell 36:15-27. 2009

Collaborators

  • Qin Liu
  • Monica Hollstein
  • Yan Zhou
  • Hong Wu
  • Wei Xu
  • Gordon B Mills
  • Ravi K Amaravadi
  • Ashani T Weeraratna
  • Jack T Zilfou
  • Neil Beeharry
  • Subhasree Basu
  • Che Pei Kung
  • Donna L George
  • Julia I Ju Leu
  • Julia Pimkina
  • Anna Budina-Kolomets
  • Matthew Jennis
  • J I Ju Leu
  • E Christine Pietsch
  • Amanda K Frank
  • Sakina Khaku
  • Amanda Frank
  • Stephen M Sykes
  • Olivier Humbey
  • Jaruwan Chatwichien
  • Xuting Wang
  • Pingfeng Zhang
  • Gregor M Balaburski
  • Gregory Azzam
  • Roland L Dunbrack
  • Patrick Dumont
  • Michal Jarnik
  • Steven B McMahon
  • Hestia Mellert
  • Jeremy P Scott
  • David S Garlick
  • Devin K Porter
  • Rexford S Ahima
  • Xiaowei Xu
  • Clemens Krepler
  • Kathy Q Cai
  • Frederick Anokye-Danso
  • Thibaut Barnoud
  • Marie R Webster
  • Giorgos Karakousis
  • Jeffrey D Winkler
  • Michelle R Campbell
  • Douglas A Bell
  • Yiling Lu
  • Xiaoxian Li
  • Lynn Schuchter
  • Matthew Reiss
  • Xiangfan Yin
  • Andrew V Kossenkov
  • Anastasia Guerrini
  • Ronen Marmorstein
  • Tim Yen
  • Douglas Bell
  • Mark D Andrake
  • Gao Zhang
  • Seth Hayik
  • Jessie Villanueva
  • Meenhard Herlyn
  • Karthik Devarajan
  • Pooja Pandey
  • Tatiana Nedelko
  • Andres Klein-Szanto
  • Joy Tao
  • Timothy J Stanek
  • Adrian A Canutescu
  • Carmen Dominguez-Brauer
  • Christine M Eischen
  • Erin Perchiniak
  • Guoli Wang
  • Darren J Burgess

Detail Information

Publications29

  1. pmc Ironing out how p53 regulates ferroptosis.
    Maureen E Murphy
    Proc Natl Acad Sci U S A 113:12350-12352. 2016
  2. pmc The HSP70 family and cancer
    Maureen E Murphy
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Carcinogenesis 34:1181-8. 2013
    ..In this review, the history, regulation, mechanism of action and role in cancer of the HSP70 family are reviewed. Additionally, the promise of pharmacologically targeting this protein for cancer therapy is addressed...
  3. pmc Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53
    Stephen M Sykes
    Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:20197-205. 2009
    ..These data support a model whereby Lys-120 acetylation contributes to both the transcription-dependent and -independent apoptotic pathways induced by p53...
  4. pmc Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function
    Julia Pimkina
    Program in Developmental Therapeutics, Philadelphia, PA, USA
    Cancer Biol Ther 12:503-9. 2011
    ..High levels of ARF are characteristic of tumor cells with enhanced MAPK signaling and advanced stage; therefore, these data support the premise that PES may show preferential cytotoxicity to advanced stage cancers...
  5. pmc Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain
    E Christine Pietsch
    Division of Medical Sciences and Program in Biomolecular Structure and Function, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Biol Chem 283:21294-304. 2008
    ..The combined data point to the H2 helix and L1 and L3 loops of p53 as novel functional domains contributing to transcription-independent apoptosis by this tumor suppressor protein...
  6. pmc ARF induces autophagy by virtue of interaction with Bcl-xl
    Julia Pimkina
    Division of Medical Sciences, the Smolensk State Medical Academy Graduate Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Biol Chem 284:2803-10. 2009
    ..The combined data support the premise that ARF induces autophagy in a p53-independent manner in part by virtue of its interaction with Bcl-xl...
  7. pmc Wild-type and mutant p53 proteins interact with mitochondrial caspase-3
    Amanda K Frank
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer Biol Ther 11:740-5. 2011
    ..The combined data suggest that tumor-derived mutants of p53 may be selected for in tumor cells due to their ability to bind and inhibit the activation of caspase-3...
  8. pmc An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model
    Matthew Jennis
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA Program in Molecular and Cellular Biology and Genetics, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Genes Dev 30:918-30. 2016
    ..These data also confirm the potential relevance of metabolism and ferroptosis to tumor suppression by p53...
  9. pmc HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cancer Res 9:936-47. 2011
    ..Overall, PES simultaneously disrupts several cancer critical survival pathways, supporting the idea of targeting HSP70 as a potential approach for cancer therapeutics...
  10. pmc A small molecule inhibitor of inducible heat shock protein 70
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    Mol Cell 36:15-27. 2009
    ....
  11. pmc The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction
    Che Pei Kung
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Cell Rep 14:2413-25. 2016
    ..Gene expression analyses and studies with small-molecule inhibitors indicate that the p53 target genes Tnf and Npc1l1 underlie this phenotype. These results shed light on the role of p53 in obesity, metabolism, and inflammation...
  12. pmc A modified HSP70 inhibitor shows broad activity as an anticancer agent
    Gregor M Balaburski
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cancer Res 11:219-29. 2013
    ..PES-Cl is thus a promising new anticancer compound with several notable mechanisms of action...
  13. ncbi request reprint The tetramerization domain of p53 is required for efficient BAK oligomerization
    E Christine Pietsch
    Program in Cell and Developmental Biology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 6:1576-83. 2007
    ..These data indicate that pro-apoptotic BAK, unlike other BCL2 family members, may serve as a major receptor for p53 on the mitochondria...
  14. pmc Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes
    Che Pei Kung
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania
    Mol Cancer Res 13:250-62. 2015
    ..These data indicate that TRIML2 is part of a feed-forward loop that activates p53 in cells expressing the R72 variant, particularly after prolonged stress...
  15. pmc The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation
    Amanda K Frank
    Fox Chase Cancer Center, W209, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mol Cell Biol 31:1201-13. 2011
    ..Consistent with this, we show that P72 mice have a markedly enhanced response to inflammatory challenge compared to that of R72 mice. Our data indicate that the codon 72 polymorphism impacts p53's role in inflammation...
  16. pmc The ARF tumor suppressor can promote the progression of some tumors
    Olivier Humbey
    Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 68:9608-13. 2008
    ..These data are the first to show that ARF can act in a p53-independent manner to promote the progression of some tumors...
  17. pmc A link between TP53 polymorphisms and metabolism
    Che Pei Kung
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA
    Mol Cell Oncol 3:e1173769. 2016
    ..Using a humanized knock-in mouse model for these TP53 variants, we show that this polymorphism has a significant impact on the metabolic response to a high-fat diet. ..
  18. pmc Genetic Modifiers of the p53 Pathway
    Subhasree Basu
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104
    Cold Spring Harb Perspect Med 6:a026302. 2016
    ..regarding genetic modifiers of the p53 pathway: Why did these variants arise? Were they under selection pressure? And, is there compelling evidence to support genotyping these variants to better predict disease risk and prognosis?..
  19. pmc The African-specific S47 polymorphism of p53 alters chemosensitivity
    Subhasree Basu
    a Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA
    Cell Cycle 15:2557-2560. 2016
    ..They also offer hope that cisplatin and paclitaxel may be effective chemotherapeutic drugs for S47 individuals with cancer...
  20. doi request reprint PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline
    Jaruwan Chatwichien
    Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Bioorg Med Chem Lett 26:4884-4887. 2016
    ....
  21. pmc Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate
    Pingfeng Zhang
    Program in Gene Expression and Regulation, The Wistar Institute, Philadelphia, Pennsylvania, United States of America Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e103518. 2014
    ....
  22. pmc The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver
    Julia I Ju Leu
    Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Liver 2:. 2013
    ..When taken together, these data point to the p53 codon 72 polymorphism as an important molecular mediator of events contributing to hepatic inflammation and metabolic homeostasis...
  23. ncbi request reprint The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain
    Hestia Mellert
    Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cell Cycle 6:1304-6. 2007
    ..We demonstrate here that both the DNA damage response pathway and the p19ARF/oncogene stress pathway induce the acetylation of p53 at lysine 120...
  24. pmc ARF, autophagy and tumor suppression
    Julia Pimkina
    Division of Medical Sciences, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Autophagy 5:397-9. 2009
    ..Rather, ARF-silencing enhances sarcoma development. These data suggest that the survival-benefit of ARF, and possibly also of autophagy, may be restricted to certain tumor types...
  25. pmc HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
    Anna Budina-Kolomets
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania
    Cancer Res 76:2720-30. 2016
    ..Cancer Res; 76(9); 2720-30. ©2016 AACR. ..
  26. pmc CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest
    Gregory Azzam
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e74297. 2013
    ..Finally, these data may explain the association of the P72 variant and the CSF1/CSF1R pathway with increased senescence and radio-resistance in some epithelial tumor types. ..
  27. ncbi request reprint Regulation of cell death in oncogenesis
    Maureen E Murphy
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 65:8069-71. 2005
  28. ncbi request reprint A novel cancer therapy approach targeting microtubule function
    Maureen E Murphy
    Program in Cell and Developmental Biology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 5:1721-3. 2006
  29. ncbi request reprint p53 moves to mitochondria: a turn on the path to apoptosis
    Maureen E Murphy
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cell Cycle 3:836-9. 2004
    ..New data, however, suggest that p53 itself also has a direct role in accomplishing cell death, at the mitochondria...