Xiuqian Mu

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature"
    Nicolas O Fortunel
    Science 302:393; author reply 393. 2003
  2. pmc Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center and Graduate Training Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:6942-7. 2008
  3. ncbi request reprint A gene regulatory hierarchy for retinal ganglion cell specification and differentiation
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Semin Cell Dev Biol 15:115-23. 2004
  4. ncbi request reprint Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 15:525-30. 2005
  5. ncbi request reprint A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 280:467-81. 2005
  6. pmc Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development
    Xueyao Fu
    Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Dev Biol 299:424-37. 2006
  7. pmc Epitope-tagging Math5 and Pou4f2: new tools to study retinal ganglion cell development in the mouse
    Xueyao Fu
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Dev Dyn 238:2309-17. 2009
  8. pmc Retinal ganglion cell death and optic nerve degeneration by genetic ablation in adult mice
    Jang Hyeon Cho
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Exp Eye Res 88:542-52. 2009
  9. ncbi request reprint Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 131:1197-210. 2004
  10. pmc Overlapping spatiotemporal patterns of regulatory gene expression are required for neuronal progenitors to specify retinal ganglion cell fate
    Takae Kiyama
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Vision Res 51:251-9. 2011

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature"
    Nicolas O Fortunel
    Science 302:393; author reply 393. 2003
  2. pmc Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center and Graduate Training Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:6942-7. 2008
    ..They also reveal that identical RGC expression patterns are achieved by different combinations of divergent inputs from upstream transcription factors...
  3. ncbi request reprint A gene regulatory hierarchy for retinal ganglion cell specification and differentiation
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Semin Cell Dev Biol 15:115-23. 2004
    ..Future directions in RGC development will inevitably rely on combined genetic and genomics approaches...
  4. ncbi request reprint Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 15:525-30. 2005
    ..Intrinsic rather than extrinsic factors are likely to play the critical roles in determining retinal cell fate...
  5. ncbi request reprint A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 280:467-81. 2005
    ..The identification of multiple roles for Math5 provides new insights into the gene network that defines progenitor cell competence in the embryonic retina...
  6. pmc Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development
    Xueyao Fu
    Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Dev Biol 299:424-37. 2006
    ..The results further imply that retinal lamination and retinal cell differentiation are genetically separable processes...
  7. pmc Epitope-tagging Math5 and Pou4f2: new tools to study retinal ganglion cell development in the mouse
    Xueyao Fu
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Dev Dyn 238:2309-17. 2009
    ..The epitope-tagged alleles provide new and useful tools for analyzing gene regulatory networks underlying RGC development...
  8. pmc Retinal ganglion cell death and optic nerve degeneration by genetic ablation in adult mice
    Jang Hyeon Cho
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Exp Eye Res 88:542-52. 2009
    ..These events are hallmarks of progressive optic nerve degeneration observed in human retinal pathologies and demonstrate the validity of this model for use in developing stem cell therapies for replacing dead RGCs with healthy ones...
  9. ncbi request reprint Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 131:1197-210. 2004
    ..Our results demonstrate that a small but crucial fraction of the RGC transcriptome is dependent on Brn3b. The Brn3b-dependent gene sets therefore provide a unique molecular signature for the developing retina...
  10. pmc Overlapping spatiotemporal patterns of regulatory gene expression are required for neuronal progenitors to specify retinal ganglion cell fate
    Takae Kiyama
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Vision Res 51:251-9. 2011
    ..We conclude that RPCs have a complex regulatory gene expression program in which they acquire competence using highly integrated mechanisms...
  11. ncbi request reprint Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2
    Suzanna E Martin
    Department of Biochemistry and Molecular Biology, Unit 117, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Differentiation 73:18-27. 2005
    ..The results demonstrate that Brn3b regulates gene expression through the action of a strong transcriptional activation domain within its N-terminal sequence...
  12. ncbi request reprint Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database
    Shuguang Liang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Vis 10:773-86. 2004
    ....
  13. ncbi request reprint Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth
    Steven W Wang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 129:467-77. 2002
    ..Our results reveal a complex genetic relationship between Brn3b and Brn3c in regulating the retinal ganglion cell axon outgrowth...
  14. pmc Transcriptome of Atoh7 retinal progenitor cells identifies new Atoh7-dependent regulatory genes for retinal ganglion cell formation
    Zhiguang Gao
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030
    Dev Neurobiol 74:1123-40. 2014
    ..Our results expand current knowledge of the regulatory networks operating in Atoh7-expressing RPCs and offer new directions for exploring the earliest aspects of retinogenesis...
  15. ncbi request reprint Retinal ganglion cell differentiation in cultured mouse retinal explants
    Steven W Wang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Methods 28:448-56. 2002
    ....
  16. pmc The genome of the sea urchin Strongylocentrotus purpuratus
    Erica Sodergren
    Science 314:941-52. 2006
    ..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes...
  17. doi request reprint The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
    Przemyslaw Sapieha
    Research Center of Centre Hospitalier Universitaire Sainte Justine, Department of Pediatrics, Universite de Montreal, Montreal, Quebec H3T 1C5, Canada
    Nat Med 14:1067-76. 2008
    ..These findings provide a new therapeutic target for modulating revascularization...