K Mrozek

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi Prognostic value of cytogenetic findings in adults with acute myeloid leukemia
    K Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Authur G James Cancer Hospital, The Ohio State University, Columbus 43210 1228, USA
    Int J Hematol 72:261-71. 2000
  2. ncbi Spectral karyotyping reveals 17;22 fusions in a cytogenetically atypical dermatofibrosarcoma protuberans with a large marker chromosome as a sole abnormality
    K Mrozek
    Division of Hematology and Oncology, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Genes Chromosomes Cancer 31:182-6. 2001
  3. ncbi Comparison of cytogenetic and molecular genetic detection of t(8;21) and inv(16) in a prospective series of adults with de novo acute myeloid leukemia: a Cancer and Leukemia Group B Study
    K Mrozek
    Division of Hematology and Oncology, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210 1228, USA
    J Clin Oncol 19:2482-92. 2001
  4. ncbi Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q
    Krzysztof Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 1228, USA
    Genes Chromosomes Cancer 34:137-53. 2002
  5. ncbi Molecular cytogenetic characterization of the KG-1 and KG-1a acute myeloid leukemia cell lines by use of spectral karyotyping and fluorescence in situ hybridization
    Krzysztof Mrozek
    Division of Hematology and Oncology, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Genes Chromosomes Cancer 38:249-52. 2003
  6. ncbi Cytogenetics in acute leukemia
    Krzysztof Mrozek
    Division of Hematology and Oncology, The Comprehensive Cancer Center, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, Room 1248B, The Ohio State University, Columbus, OH 43210 1228, USA
    Blood Rev 18:115-36. 2004
  7. pmc GAS6 expression identifies high-risk adult AML patients: potential implications for therapy
    S P Whitman
    The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
    Leukemia 28:1252-8. 2014
  8. ncbi Low Meningioma 1 (MN1) gene expression to predict outcome in cytogenetically normal acute myeloid leukemia (CN-AML): A Cancer and Leukemia Group B (CALGB) study
    C Langer
    The Ohio State University, Columbus, OH Duke University Medical Center, Durham, NC North Shore University Hospital, Manhasset, NY University of Chicago, Chicago, IL
    J Clin Oncol 26:7011. 2008
  9. ncbi Improving the molecular risk classification for younger (<60 years) de novo cytogenetically normal acute myeloid leukemia (CN AML) patients (pts)
    G Marcucci
    Ohio State University, Columbus, OH Universitätsklinikum Frankfurt, Frankfurt, Germany Charité University Hospital, Berlin, Germany Universitätsklinikum Ulm, Ulm, Germany North Shore University Hospital, Manhasset, NY University of Chicago, Chicago, IL
    J Clin Oncol 27:7002. 2009
  10. ncbi NPM1 mutations as an independent prognosticator for older cytogenetically normal acute myeloid leukemia (CN AML)
    H Becker
    The Ohio State University, Columbus, OH University of Maryland, Baltimore, MD University of Chicago, Chicago, IL
    J Clin Oncol 27:7000. 2009

Collaborators

Detail Information

Publications16

  1. ncbi Prognostic value of cytogenetic findings in adults with acute myeloid leukemia
    K Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Authur G James Cancer Hospital, The Ohio State University, Columbus 43210 1228, USA
    Int J Hematol 72:261-71. 2000
    ..In this review, we present an overview of major cytogenetic findings in AML and discuss associations between karyotype and clinical outcome of adults with AML...
  2. ncbi Spectral karyotyping reveals 17;22 fusions in a cytogenetically atypical dermatofibrosarcoma protuberans with a large marker chromosome as a sole abnormality
    K Mrozek
    Division of Hematology and Oncology, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Genes Chromosomes Cancer 31:182-6. 2001
    ..Furthermore, our case demonstrates the usefulness of SKY in detection of a diagnostically relevant 17;22 fusion in DFSP patients who have unusual karyotypic features...
  3. ncbi Comparison of cytogenetic and molecular genetic detection of t(8;21) and inv(16) in a prospective series of adults with de novo acute myeloid leukemia: a Cancer and Leukemia Group B Study
    K Mrozek
    Division of Hematology and Oncology, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210 1228, USA
    J Clin Oncol 19:2482-92. 2001
    ....
  4. ncbi Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q
    Krzysztof Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 1228, USA
    Genes Chromosomes Cancer 34:137-53. 2002
    ..We conclude that SKY considerably enhances the accuracy of karyotype interpretation, and that amplification of chromosomal material may play a greater role in leukemogenesis than has been recognized...
  5. ncbi Molecular cytogenetic characterization of the KG-1 and KG-1a acute myeloid leukemia cell lines by use of spectral karyotyping and fluorescence in situ hybridization
    Krzysztof Mrozek
    Division of Hematology and Oncology, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Genes Chromosomes Cancer 38:249-52. 2003
    ....
  6. ncbi Cytogenetics in acute leukemia
    Krzysztof Mrozek
    Division of Hematology and Oncology, The Comprehensive Cancer Center, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, Room 1248B, The Ohio State University, Columbus, OH 43210 1228, USA
    Blood Rev 18:115-36. 2004
    ..This review summarizes current views on clinical relevance of major cytogenetic findings in adult AML and ALL...
  7. pmc GAS6 expression identifies high-risk adult AML patients: potential implications for therapy
    S P Whitman
    The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
    Leukemia 28:1252-8. 2014
    ....
  8. ncbi Low Meningioma 1 (MN1) gene expression to predict outcome in cytogenetically normal acute myeloid leukemia (CN-AML): A Cancer and Leukemia Group B (CALGB) study
    C Langer
    The Ohio State University, Columbus, OH Duke University Medical Center, Durham, NC North Shore University Hospital, Manhasset, NY University of Chicago, Chicago, IL
    J Clin Oncol 26:7011. 2008
    ..e., CEBPAmut, WT1mut, ERG and BAALC expression levels)...
  9. ncbi Improving the molecular risk classification for younger (<60 years) de novo cytogenetically normal acute myeloid leukemia (CN AML) patients (pts)
    G Marcucci
    Ohio State University, Columbus, OH Universitätsklinikum Frankfurt, Frankfurt, Germany Charité University Hospital, Berlin, Germany Universitätsklinikum Ulm, Ulm, Germany North Shore University Hospital, Manhasset, NY University of Chicago, Chicago, IL
    J Clin Oncol 27:7002. 2009
    ..Here, we assess if adding CEBPA and WT1 mutation and ERG expression testing improves the currently used CN AML molecular risk classification...
  10. ncbi NPM1 mutations as an independent prognosticator for older cytogenetically normal acute myeloid leukemia (CN AML)
    H Becker
    The Ohio State University, Columbus, OH University of Maryland, Baltimore, MD University of Chicago, Chicago, IL
    J Clin Oncol 27:7000. 2009
    ..7000 Background: In younger CN AML without FLT3-ITD, NPM1 mutations predict favorable outcome. Their prognostic impact in older [≥60 years (y)] patients (pts) requires further evaluation...
  11. ncbi Core binding factor acute myeloid leukemia. Cancer and Leukemia Group B (CALGB) Study 8461
    C D Bloomfield
    The Ohio State University, Columbus, OH, USA
    Ann Hematol 83:S84-5. 2004
  12. ncbi MicroRNA 181a (miR-181a) expression as a prognosticator in cytogenetically normal acute myeloid leukemia (CN AML)
    S Schwind
    Ohio State University, Columbus, OH Universitätsklinikum Frankfurt, Frankfurt, Germany North Shore University Hospital, Manhasset, NY University of Chicago, Chicago, IL
    J Clin Oncol 27:7001. 2009
    ..Here we tested if miR-181a expression can predict outcome independently...
  13. ncbi Clinical importance of cytogenetics in acute myeloid leukaemia
    K Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Room 1248B, Columbus, OH, 43210 1228, USA
    Best Pract Res Clin Haematol 14:19-47. 2001
    ..This review presents current information on chromosome abnormalities in AML, and on associations between karyotype and clinical characteristics and outcome of AML patients...
  14. pmc Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia
    C Niederwieser
    The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
    Leukemia 29:567-75. 2015
    ..Gene expression analyses suggest that DNMT3B is involved in the modulation of several genes, although the regulatory mechanisms remain to be investigated to devise therapeutic approaches specific for these patients...
  15. pmc BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia
    S M Tanner
    Human Cancer Genetics Program, Ohio State University, 646 Medical Research Facility, 420 West 12th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 98:13901-6. 2001
    ..Our data suggest that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions...
  16. pmc A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia
    K H Metzeler
    The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
    Leukemia 27:2023-31. 2013
    ..Fifteen miRs were upregulated in both younger and older CE(high) patients, including miRs relevant for stem cell function. Our results support the clinical relevance of LSCs and improve risk stratification in AML. ..