Peter M Moyle

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Method for the synthesis of multi-epitopic Streptococcus pyogenes lipopeptide vaccines using native chemical ligation
    Peter M Moyle
    School of Pharmacy and School of Molecular and Microbial Sciences SMMS, University of Queensland, St Lucia, QLD, Australia
    J Org Chem 71:6846-50. 2006
  2. ncbi request reprint Self-adjuvanting lipopeptide vaccines
    Peter M Moyle
    School of Molecular and Microbial Sciences and School of Pharmacy, The University of Queensland, St Lucia 4072, QLD, Australia
    Curr Med Chem 15:506-16. 2008
  3. doi request reprint Development of a liposaccharide-based delivery system and its application to the design of group A streptococcal vaccines
    Pavla Simerska
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:1447-52. 2008
  4. ncbi request reprint Method for the synthesis of highly pure vaccines using the lipid core peptide system
    Peter M Moyle
    School of Molecular and Microbial Biosciences, The University of Queensland, St Lucia, Queensland, Australia
    J Pept Sci 12:800-7. 2006
  5. ncbi request reprint Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group a streptococcal vaccine candidates
    Abu Baker M Abdel-Aal
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:167-72. 2008
  6. ncbi request reprint Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A streptococcal vaccine, and subsequent immunological evaluation
    Peter M Moyle
    School of Pharmacy, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 49:6364-70. 2006
  7. ncbi request reprint Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines
    Peter M Moyle
    School of Pharmacy, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 50:4721-7. 2007
  8. doi request reprint Investigation toward multi-epitope vaccine candidates using native chemical ligation
    Yoshio Fujita
    School of Molecular and Microbial Sciences SMMS, The University of Queensland, Brisbane QLD 4072, Australia
    Biopolymers 90:624-32. 2008
  9. doi request reprint An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system
    Peter M Moyle
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia 4072, QLD, Australia Institute for Molecular Biosciences, The University of Queensland, St Lucia 4072, QLD, Australia Electronic address
    Nanomedicine 9:935-44. 2013
  10. pmc Differing Efficacies of Lead Group A Streptococcal Vaccine Candidates and Full-Length M Protein in Cutaneous and Invasive Disease Models
    Tania Rivera-Hernandez
    Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia
    MBio 7:. 2016

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Method for the synthesis of multi-epitopic Streptococcus pyogenes lipopeptide vaccines using native chemical ligation
    Peter M Moyle
    School of Pharmacy and School of Molecular and Microbial Sciences SMMS, University of Queensland, St Lucia, QLD, Australia
    J Org Chem 71:6846-50. 2006
    ..Intranasal immunization of the described tri-epitopic GAS lipopeptide with the mucosal adjuvant cholera toxin B subunit induced high serum IgG antibody titers specific for each of the incorporated peptide epitopes...
  2. ncbi request reprint Self-adjuvanting lipopeptide vaccines
    Peter M Moyle
    School of Molecular and Microbial Sciences and School of Pharmacy, The University of Queensland, St Lucia 4072, QLD, Australia
    Curr Med Chem 15:506-16. 2008
    ..g. monophosphoryl lipid A). The review also discusses the potential mechanisms of action for lipopeptide and glycolipopeptide vaccines, as well as structure activity relationships, and provides examples of studies utilising each system...
  3. doi request reprint Development of a liposaccharide-based delivery system and its application to the design of group A streptococcal vaccines
    Pavla Simerska
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:1447-52. 2008
    ..High serum IgG antibody titers against each of the incorporated peptide epitopes were detected following subcutaneous immunization of B10.BR (H-2 (k)) mice with the liposaccharide vaccine candidates...
  4. ncbi request reprint Method for the synthesis of highly pure vaccines using the lipid core peptide system
    Peter M Moyle
    School of Molecular and Microbial Biosciences, The University of Queensland, St Lucia, Queensland, Australia
    J Pept Sci 12:800-7. 2006
    ..Subcutaneous immunization of B10.BR (H-2(k)) mice with one of these vaccines, without the addition of any adjuvant, elicited high levels of systemic IgG antibodies against each of the incorporated peptides...
  5. ncbi request reprint Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group a streptococcal vaccine candidates
    Abu Baker M Abdel-Aal
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:167-72. 2008
    ..Overall, the best vaccines featured a C-terminal lipid moiety, conjugated through a lysine residue to P25 at the N-terminus, and J14 on the lysine side chain...
  6. ncbi request reprint Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A streptococcal vaccine, and subsequent immunological evaluation
    Peter M Moyle
    School of Pharmacy, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 49:6364-70. 2006
    ..Subcutaneous immunization of B10.BR (H-2(k)) mice with the synthesized vaccine, with or without the addition of complete Freund's adjuvant, elicited high serum IgG antibody titers against each of the incorporated peptide epitopes...
  7. ncbi request reprint Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines
    Peter M Moyle
    School of Pharmacy, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 50:4721-7. 2007
    ....
  8. doi request reprint Investigation toward multi-epitope vaccine candidates using native chemical ligation
    Yoshio Fujita
    School of Molecular and Microbial Sciences SMMS, The University of Queensland, Brisbane QLD 4072, Australia
    Biopolymers 90:624-32. 2008
    ..It was found that the difficulty in NCL of first two peptide antigen was associated with the steric hindrance. Using Thz instead of Cys(Acm) and Msc-Cys was important to reduce the steric hindrance and improve NCL yield...
  9. doi request reprint An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system
    Peter M Moyle
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia 4072, QLD, Australia Institute for Molecular Biosciences, The University of Queensland, St Lucia 4072, QLD, Australia Electronic address
    Nanomedicine 9:935-44. 2013
    ..pyogenes strains represented within the polytope sequence, with higher antibody levels observed where a dendritic cell targeting peptide (DCpep) was incorporated within the LCP adjuvant...
  10. pmc Differing Efficacies of Lead Group A Streptococcal Vaccine Candidates and Full-Length M Protein in Cutaneous and Invasive Disease Models
    Tania Rivera-Hernandez
    Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia
    MBio 7:. 2016
    ..In comparison with sham-immunized mice, all vaccines afforded protection against cutaneous challenge. However, only full-length M1 protein provided protection in the subcutaneous invasive disease model...
  11. ncbi request reprint Oral vaccine delivery--new strategies and technologies
    Pavla Simerska
    The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, 4072, Queensland, Australia
    Curr Drug Deliv 6:347-58. 2009
    ..Approaches to overcome these obstacles aim to provide new vaccines and delivery systems that are capable of eliciting protective immune responses, and are making an impact on current vaccine development...
  12. doi request reprint Group A Streptococcal vaccine candidate: contribution of epitope to size, antigen presenting cell interaction and immunogenicity
    Mehfuz Zaman
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia
    Nanomedicine (Lond) 9:2613-24. 2014
    ..Utilize lipopeptide vaccine delivery system to develop a vaccine candidate against Group A Streptococcus...
  13. doi request reprint Site-specific incorporation of three toll-like receptor 2 targeting adjuvants into semisynthetic, molecularly defined nanoparticles: application to group a streptococcal vaccines
    Peter M Moyle
    School of Pharmacy, The University of Queensland, Woolloongabba 4102, Queensland, Australia
    Bioconjug Chem 25:965-78. 2014
    ....
  14. doi request reprint Design and evaluation of a stearylated multicomponent peptide-siRNA nanocomplex for efficient cellular siRNA delivery
    Yu Wan
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    Nanomedicine (Lond) . 2017
    ..To develop a new synthetic peptide-based nanoparticulate siRNA delivery system...
  15. doi request reprint Nanosized, peptide-based multicomponent DNA delivery systems: optimization of endosome escape activity
    Yu Wan
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, 4072, QLD, Australia
    Nanomedicine (Lond) 11:907-19. 2016
    ..Herein, three endosome-disrupting peptides (HA2(1-20), GALA and KALA) were incorporated into a multicomponent oligonucleotide delivery system to identify which peptide imparted the most favorable endosome escape and toxicity profile...
  16. doi request reprint Investigation of bombesin peptide as a targeting ligand for the gastrin releasing peptide (GRP) receptor
    Anjuman Ara Begum
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia 4072, Australia School of Pharmacy, The University of Queensland, Woolloongabba 4102, Australia
    Bioorg Med Chem 24:5834-5841. 2016
    ..Overall, the information obtained from these studies provides useful information for the in vitro assessment of GRPR targeted therapeutics...
  17. pmc The contribution of non-human primate models to the development of human vaccines
    Tania Rivera-Hernandez
    School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, 4072, Australia
    Discov Med 18:313-22. 2014
    ..From understanding disease pathogenesis and mechanisms of protection, to assessing vaccine safety and efficacy, we discuss selected cases where the importance of the use of NHP models is highlighted. ..
  18. doi request reprint Peptide based DNA nanocarriers incorporating a cell-penetrating peptide derived from neurturin protein and poly-L-lysine dendrons
    Nurlina Rosli
    School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia 4072, Australia
    Bioorg Med Chem 23:2470-9. 2015
    ..There was also no significant difference between NRTN-30 and NRTN-17 for pDNA uptake, indicating that the truncated peptide alone is sufficient as a CPP for pDNA delivery. ..