Genomes and Genes
Affiliation: The Children's Hospital of Philadelphia
- IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitroYuhong Liu
Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19014, USA
J Immunol 186:3197-205. 2011..The observation that human ATII cells secrete CXCL5 in a polarized fashion may represent a mechanism to recruit neutrophils in host defense in a fashion that discriminates the site of initial injury...
- Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in miceJunjie Mei
Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 122:974-86. 2012....
- CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infectionJunjie Mei
Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Immunity 33:106-17. 2010..This study presents a paradigm whereby platelets and red cells alter chemokine scavenging and neutrophil-chemokine interaction during inflammation...
- The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal miceHitesh S Deshmukh
1 Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA 2 Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
Nat Med 20:524-30. 2014..These data support a role for the intestinal microbiota in regulation of granulocytosis, neutrophil homeostasis and host resistance to sepsis in neonates. ..
- Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expressionKristin M Hudock
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Pearlman School of Medicine, University of Pennsylvania, Abramson Research Building, Rm 414E, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
Am J Respir Cell Mol Biol 47:436-44. 2012..In conclusion, Il-1rn(-/-) mice exhibit delayed resolution in acute lung inflammation after exposure to LPS, a process that appears to be mediated via the G-CSF/IL-17A axis...