Bruce S McEwen

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Studies of hormone action in the hippocampal formation: possible relevance to depression and diabetes
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    J Psychosom Res 53:883-90. 2002
  2. doi request reprint Steroid hormone receptor expression and function in microglia
    Amanda Sierra
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Glia 56:659-74. 2008
  3. pmc Cellular and subcellular localization of estrogen and progestin receptor immunoreactivities in the mouse hippocampus
    Katherine L Mitterling
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 518:2729-43. 2010
  4. doi request reprint Accumulation of resident and peripheral dendritic cells in the aging CNS
    Ulrike W Kaunzner
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Neurobiol Aging 33:681-693.e1. 2012
  5. pmc Uncovering the mechanisms of estrogen effects on hippocampal function
    Joanna L Spencer
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1300 York Avenue, New York, NY 10065, USA
    Front Neuroendocrinol 29:219-37. 2008
  6. pmc Age- and hormone-regulation of opioid peptides and synaptic proteins in the rat dorsal hippocampal formation
    Tanya J Williams
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA
    Brain Res 1379:71-85. 2011
  7. pmc Ovarian steroids alter mu opioid receptor trafficking in hippocampal parvalbumin GABAergic interneurons
    Annelyn Torres-Reveron
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, 407 East 61st Street, New York, NY 10065, USA
    Exp Neurol 219:319-27. 2009
  8. pmc Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids
    Richard G Hunter
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10065, USA
    Brain Res 1325:141-6. 2010
  9. pmc Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala
    Richard G Hunter
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York, NY 10021, USA
    Brain Res 1152:234-40. 2007
  10. ncbi request reprint Behavioral and biological effects of chronic S18986, a positive AMPA receptor modulator, during aging
    Erik B Bloss
    The Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Exp Neurol 210:109-17. 2008

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint Studies of hormone action in the hippocampal formation: possible relevance to depression and diabetes
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    J Psychosom Res 53:883-90. 2002
    ..The hippocampus is also vulnerable to damage by stroke and head trauma and susceptible to damage during aging and repeated stress, and is sensitive to the effects of diabetes...
  2. doi request reprint Steroid hormone receptor expression and function in microglia
    Amanda Sierra
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Glia 56:659-74. 2008
    ....
  3. pmc Cellular and subcellular localization of estrogen and progestin receptor immunoreactivities in the mouse hippocampus
    Katherine L Mitterling
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 518:2729-43. 2010
    ....
  4. doi request reprint Accumulation of resident and peripheral dendritic cells in the aging CNS
    Ulrike W Kaunzner
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Neurobiol Aging 33:681-693.e1. 2012
    ..Collectively, the numerical and phenotypic changes in bDC indicate these cells may serve as an important immune component in the functional and anatomic alterations associated with aging...
  5. pmc Uncovering the mechanisms of estrogen effects on hippocampal function
    Joanna L Spencer
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1300 York Avenue, New York, NY 10065, USA
    Front Neuroendocrinol 29:219-37. 2008
    ..Finally, estrogen may signal through both nuclear and extranuclear hippocampal estrogen receptors to achieve its downstream effects...
  6. pmc Age- and hormone-regulation of opioid peptides and synaptic proteins in the rat dorsal hippocampal formation
    Tanya J Williams
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA
    Brain Res 1379:71-85. 2011
    ..Moreover, they lend credence to the "window of opportunity" hypothesis during which hormone replacement can modulate hippocampal structure and circuitry to improve cognitive outcomes...
  7. pmc Ovarian steroids alter mu opioid receptor trafficking in hippocampal parvalbumin GABAergic interneurons
    Annelyn Torres-Reveron
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, 407 East 61st Street, New York, NY 10065, USA
    Exp Neurol 219:319-27. 2009
    ....
  8. pmc Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids
    Richard G Hunter
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10065, USA
    Brain Res 1325:141-6. 2010
    ..While the mechanism behind these observations is as yet unclear, they may be neuroprotective against the damaging effects of CRS or an example of adaptation to the allostatic load produced by CRS...
  9. pmc Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala
    Richard G Hunter
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York, NY 10021, USA
    Brain Res 1152:234-40. 2007
    ..Our data establish that CART expression is regulated by stress in a regionally and time specific manner and that CART is regulated by corticosteroid actions in the hippocampus...
  10. ncbi request reprint Behavioral and biological effects of chronic S18986, a positive AMPA receptor modulator, during aging
    Erik B Bloss
    The Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Exp Neurol 210:109-17. 2008
    ..These results provide a framework for further studies of the potentially beneficial effects of AMPAR modulators on brain aging...
  11. pmc The influences of reproductive status and acute stress on the levels of phosphorylated delta opioid receptor immunoreactivity in rat hippocampus
    Suzanne R Burstein
    Brain and Mind Research Institute, Weill Cornell Medical College, 407 East 61st Street, New York, NY 10065, USA
    Brain Res 1518:71-81. 2013
    ..These findings suggest that hippocampal levels of phosphorylated DORs vary with estrous cycle phase and that acute stress may dampen the differential effects of hormones on DOR activation in females...
  12. pmc Estrogen and aging affect the synaptic distribution of estrogen receptor β-immunoreactivity in the CA1 region of female rat hippocampus
    Elizabeth M Waters
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Brain Res 1379:86-97. 2011
    ..This suggests that synaptic ERβ may be a more responsive target to E, particularly in aged females...
  13. pmc Interactive effects of stress and aging on structural plasticity in the prefrontal cortex
    Erik B Bloss
    Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 30:6726-31. 2010
    ..The data presented here provide evidence that aging is accompanied by selective impairments in long-term neocortical morphological plasticity...
  14. ncbi request reprint Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1006:28-35. 2004
    ....
  15. pmc Ovarian steroids modulate leu-enkephalin levels and target leu-enkephalinergic profiles in the female hippocampal mossy fiber pathway
    Annelyn Torres-Reveron
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, 411 East 69th Street, New York, NY 10021, USA
    Brain Res 1232:70-84. 2008
    ..The present studies indicate that estrogen can modulate LENK in subregions of the MF pathway in a dose-and time-dependent manner. These effects might be triggered by direct activation of ERbeta or PR in LENK-containing terminals...
  16. pmc Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus
    Elizabeth M Waters
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Brain Res 1290:1-11. 2009
    ..Moreover, the effects of estradiol treatment on PSD-95 expression are consistent with a growing body of evidence that this postsynaptic protein is a key marker of estrogen action related to spine synapse formation...
  17. pmc Disruption of circadian clocks has ramifications for metabolism, brain, and behavior
    Ilia N Karatsoreos
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:1657-62. 2011
    ....
  18. ncbi request reprint Estrogen levels regulate the subcellular distribution of phosphorylated Akt in hippocampal CA1 dendrites
    Vladimir Znamensky
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 23:2340-7. 2003
    ..These findings suggest that estrogens may regulate spine formation in CA1 pyramidal neurons via Akt-mediated signaling events...
  19. pmc Stress differentially alters mu opioid receptor density and trafficking in parvalbumin-containing interneurons in the female and male rat hippocampus
    Teresa A Milner
    Brain and Mind Research Institute, Weill Cornell Medical College, 407 East 61st Street, New York, New York, 10065 Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York, 10065
    Synapse 67:757-72. 2013
    ..Furthermore, they suggest that CIS could affect principal cell excitability in a manner that maintains learning processes in females but not males...
  20. pmc Chronic antidepressant treatment impairs the acquisition of fear extinction
    Nesha S Burghardt
    Department of Neuroscience, Columbia University, New York, NY 10032 2695, USA
    Biol Psychiatry 73:1078-86. 2013
    ..To gain further insight into how SSRIs affect fear learning, we tested the effects of chronic SSRI treatment on the acquisition of extinction...
  21. pmc Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats
    Lisa Eiland
    Weill Cornell Medical College, Department of Pediatrics, New York, NY, USA
    Psychoneuroendocrinology 37:39-47. 2012
    ..Further, the absence of sex differences in our reported stress responses, likely speaks to the decreased sensitivity of immature HPA regulating brain regions to sex hormones...
  22. ncbi request reprint Stress history and pubertal development interact to shape hypothalamic-pituitary-adrenal axis plasticity
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Endocrinology 147:1664-74. 2006
    ..These data indicate that experience-dependent plasticity of the hypothalamic-pituitary-adrenal neuroendocrine axis is significantly influenced by pubertal maturation...
  23. ncbi request reprint Glucocorticoid receptor mRNA expression in the hippocampal formation of male rats before and after pubertal development in response to acute or repeated stress
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
    Neuroendocrinology 87:160-7. 2008
    ..These data point to a dissociation between differential stress-induced corticosterone responses and regulation of hippocampal GR levels in prepubertal and adult animals...
  24. pmc Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus
    Richard G Hunter
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 4:e4328. 2009
    ....
  25. ncbi request reprint Sex differences in hippocampal estradiol-induced N-methyl-D-aspartic acid binding and ultrastructural localization of estrogen receptor-alpha
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, New York, NY 10021, USA
    Neuroendocrinology 81:391-9. 2005
    ....
  26. ncbi request reprint Pubertal maturation and time of day differentially affect behavioral and neuroendocrine responses following an acute stressor
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Horm Behav 50:463-8. 2006
    ..These data indicate that pubertal development and time of day interact to modulate post-stress behavior and demonstrate a dissociation between post-stress hormonal and behavioral responses...
  27. ncbi request reprint Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 26:3509-17. 2007
    ....
  28. ncbi request reprint Age-specific threats induce CRF expression in the paraventricular nucleus of the hypothalamus and hippocampus of young rats
    Christoph P Wiedenmayer
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Horm Behav 47:139-50. 2005
    ..Hippocampal CRF mRNA expression levels did not parallel cat odor or male-induced immobility, indicating that CRF is not involved in this response in young rats but may be involved in aspects of learning and memory...
  29. pmc Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice
    Chenjian Li
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2185-90. 2004
    ....
  30. doi request reprint Microglia express functional 11 beta-hydroxysteroid dehydrogenase type 1
    Andres Gottfried-Blackmore
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10065, USA
    Glia 58:1257-66. 2010
    ..We propose that 11 beta HSD-1 may provide microglia with an intrinsic mechanism to autoregulate and inhibit proinflammatory mediator production through CORT formation...
  31. pmc Distribution of phosphorylated TrkB receptor in the mouse hippocampal formation depends on sex and estrous cycle stage
    Joanna L Spencer-Segal
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 31:6780-90. 2011
    ..These findings suggest that presynaptic TrkB is positioned to modulate estradiol-mediated and BDNF-dependent synaptic plasticity. Furthermore, they suggest a novel role for TrkB in microglial function in the neuroimmune system...
  32. doi request reprint 7α-hydroxylation of dehydroepiandrosterone does not interfere with the activation of glucocorticoids by 11β-hydroxysteroid dehydrogenase in E(t)C cerebellar neurons
    Andres Gottfried-Blackmore
    Harold and Margaret Milliken Hatch, Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    J Steroid Biochem Mol Biol 138:290-7. 2013
    ..Our investigation on the metabolism of DHEA in E(t)C neuronal cells suggest that other alternate mechanisms must be at play to explain the in vivo anti-glucocorticoid properties of DHEA and its 7-OH-metabolites. ..
  33. pmc Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines
    Keith T Akama
    Laboratory of Neuroendocrinology, The Rockefeller University, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 288:6438-50. 2013
    ....
  34. pmc Morphological and molecular changes in aging rat prelimbic prefrontal cortical synapses
    Erik B Bloss
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 34:200-10. 2013
    ..Because pLIMK is known to inhibit actin filament plasticity, these data support the hypothesis that age-related increases in pLIMK may explain the stability of large synapses at the expense of their plasticity...
  35. pmc Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivo
    Matthew N Hill
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Psychoneuroendocrinology 35:1333-8. 2010
    ..These data provide in vivo support for non-genomic steroid effects in mammals and suggest that AEA is a mediator of these effects...
  36. ncbi request reprint The effects of acute stress and pubertal development on metabolic hormones in the rat
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Stress 10:101-6. 2007
    ..Furthermore, though stage of development significantly affects the levels of peripheral metabolic hormones such as insulin, T4 and T3, acute stress does not appreciably influence their secretion before or after puberty...
  37. ncbi request reprint Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    J Comp Neurol 452:103-14. 2002
    ....
  38. pmc Alterations in corticolimbic dendritic morphology and emotional behavior in cannabinoid CB1 receptor-deficient mice parallel the effects of chronic stress
    Matthew N Hill
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Cereb Cortex 21:2056-64. 2011
    ....
  39. pmc Effects of estrogen and aging on the synaptic distribution of phosphorylated Akt-immunoreactivity in the CA1 region of the female rat hippocampus
    Murat Yildirim
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1379:98-108. 2011
    ..However, the observation that E can still increase pAkt-IR in aged synapses presents this signaling component as a candidate target for hormone replacement therapies...
  40. ncbi request reprint Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress
    Jason J Radley
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Neurol 196:199-203. 2005
    ..These results suggest that stress-induced dendritic plasticity in the medial PFC is reversible and may have implications for the functional recovery of medial PFC function following prolonged psychological stress...
  41. ncbi request reprint Testosterone cannot activate an adult-like stress response in prepubertal male rats
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA
    Neuroendocrinology 79:125-32. 2004
    ..Thus, we conclude that the HPA neuroendocrine axis is further shaped during pubertal development to allow for the emergence of a more tightly regulated stress response in adulthood...
  42. pmc Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells
    Andres Gottfried-Blackmore
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:20918-23. 2009
    ..Activated bDC were also able to stimulate naïve CD8 T cells. Collectively, these data reveal the Th1 cytokine IFNgamma, but not the Th2 cytokine IL4, induces bDC to up-regulate MHC-II and become competent APC...
  43. pmc Brain dendritic cells in ischemic stroke: time course, activation state, and origin
    Jennifer C Felger
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Brain Behav Immun 24:724-37. 2010
    ..High levels of MHC II and the co-stimulatory molecule CD80 on bDC at 72 h corresponded to peak lymphocyte infiltration, and suggested a functional interaction between these two immune cell populations...
  44. pmc Regulation of hippocampal H3 histone methylation by acute and chronic stress
    Richard G Hunter
    Laboratory of Neuroendocrinology, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:20912-7. 2009
    ....
  45. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
    ..A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  46. pmc Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice
    Kevin G Bath
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA
    Biol Psychiatry 72:499-504. 2012
    ..Although BDNF expression can be directly influenced by estrogen and progesterone, the potential impact of the BDNF Val66Met SNP on sensitivity to reproductive hormone changes remains an open question...
  47. pmc Depletion of polysialic acid from neural cell adhesion molecule (PSA-NCAM) increases CA3 dendritic arborization and increases vulnerability to excitotoxicity
    Trudy McCall
    Laboratory of Neuroendocrinology, The Rockefeller University, New York NY 10065, USA
    Exp Neurol 241:5-12. 2013
    ..These findings support the hypothesis that CA3 arbor plasticity plays a protective role during prolonged stress and clarify the role of PSA-NCAM in stress-induced dendritic plasticity...
  48. pmc Ovarian hormones influence corticotropin releasing factor receptor colocalization with delta opioid receptors in CA1 pyramidal cell dendrites
    Tanya J Williams
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA
    Exp Neurol 230:186-96. 2011
    ..These studies provide new insights on opioid-stress system interaction in the hippocampus of both males and females and establish potential mechanisms through which DOR activation may influence CRF receptor activity...
  49. doi request reprint CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain
    Karen Bulloch
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 508:687-710. 2008
    ..Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population...
  50. pmc Brain microglia express steroid-converting enzymes in the mouse
    Andres Gottfried-Blackmore
    Laboratory of Neuroendocrinology, Rockefeller University, 1230 York Avenue, New York, NY 10065, United States
    J Steroid Biochem Mol Biol 109:96-107. 2008
    ..Collectively, our results suggest that microglia utilize steroid-converting enzymes and related proteins to influence inflammation and neurodegeneration within microenvironments of the brain...
  51. ncbi request reprint Transcriptional activity of estrogen receptors ERalpha and ERbeta in the EtC.1 cerebellar granule cell line
    Andres Gottfried-Blackmore
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY, USA
    Brain Res 1186:41-7. 2007
    ..The data suggest that ERalpha plays a predominant role in E2-mediated transcription in E(t)C.1 cells. Our data are discussed in view of other reports alluding to the complexity and cell-type specificity of E2-mediated transcription...
  52. ncbi request reprint Subcellular relationships between cholinergic terminals and estrogen receptor-alpha in the dorsal hippocampus
    Laura A Towart
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 463:390-401. 2003
    ....
  53. ncbi request reprint Mood disorders and allostatic load
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Biol Psychiatry 54:200-7. 2003
    ..Allostatic load is seen in major depressive illness and may also be expressed in other chronic anxiety disorders such as PTSD and should be documented...
  54. pmc Stress-induced structural remodeling in hippocampus: prevention by lithium treatment
    Gwendolyn E Wood
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:3973-8. 2004
    ....
  55. pmc Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks
    Matthew N Hill
    The Hotchkiss Brain Institute, Department of Cell Biology and Anatomy and Psychiatry, University of Calgary, Calgary, AB, Canada Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA Electronic address
    Psychoneuroendocrinology 38:2952-61. 2013
    ..Future work will aim to replicate these findings and extend their relevance to clinical pathophysiology, as well as to neuroendocrine and molecular markers of PTSD. ..
  56. pmc Estrogen promotes stress sensitivity in a prefrontal cortex-amygdala pathway
    Rebecca M Shansky
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cereb Cortex 20:2560-7. 2010
    ..These data demonstrate both independent effects of estrogen on pyramidal cell morphology and effects that are interactive with stress, with the BLA-projecting neurons being sensitive to both kinds of effects...
  57. ncbi request reprint Characterization of a cerebellar granule progenitor cell line, EtC.1, and its responsiveness to 17-beta-estradiol
    Andres Gottfried-Blackmore
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Brain Res 1186:29-40. 2007
    ..Collectively, our results show that the E(t)C.1 cell line may serve as a model to study early development of cerebellar progenitor granule cells, and their responsiveness to E2...
  58. pmc BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function
    Joanna L Spencer
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:4395-400. 2010
    ..The variant BDNF Val66Met should therefore be considered as a strong candidate for mediating genetic differences in ovarian steroid-related behavioral changes and disorders...
  59. pmc Diurnal regulation of the gastrin-releasing peptide receptor in the mouse circadian clock
    Ilia N Karatsoreos
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Eur J Neurosci 23:1047-53. 2006
    ..Together, the present findings reveal that changes in GRPr are light driven and not endogenously organized. Diurnal variation in GRPr activity probably underlies intra-SCN signaling important for entrainment and phase shifting...
  60. ncbi request reprint Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting
    Conor Liston
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:7870-4. 2006
    ..This study provides the first direct evidence that dendritic remodeling in the prefrontal cortex may underlie the functional deficits in attentional control that are symptomatic of stress-related mental illnesses...
  61. doi request reprint Chronic immobilization stress alters aspects of emotionality and associative learning in the rat
    Gwendolyn E Wood
    The Laboratory of Neuroendocrinology The Rockefeller University, New York, NY 10065, USA
    Behav Neurosci 122:282-92. 2008
    ..e., struggling and helplessness). These results emphasize the emotional and learned responses to CIS evident during and after the stress treatment, as well as the importance of individual differences...
  62. pmc Ultrastructural localization of extranuclear progestin receptors in the rat hippocampal formation
    Elizabeth M Waters
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 511:34-46. 2008
    ....
  63. pmc Stress-induced dendritic remodeling in the prefrontal cortex is circuit specific
    Rebecca M Shansky
    Department of Neuroscience Mount Sinai School of Medicine, New York, NY 10029, USA
    Cereb Cortex 19:2479-84. 2009
    ..Such region- and circuit-specificity in response to stress could contribute to the development of stress-related mental illnesses...
  64. ncbi request reprint Differential stress reactivity in intact and ovariectomized prepubertal and adult female rats
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroendocrinology 80:387-93. 2004
    ..Furthermore, these data demonstrate additional development of the HPA axis during pubertal maturation, resulting in a more quickly terminated stress response in adulthood...
  65. pmc Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response
    Richard G Hunter
    Laboratory of Neurobiology and Behavior, Laboratory of Neuroendocrinology, and Genomics Resource Center, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:17657-62. 2012
    ..These results are a unique demonstration of the regulatory effect of environmental stress, via an epigenetic mark, on the vast genomic terra incognita represented by transposable elements...
  66. doi request reprint Basal anxiety-like behavior predicts differences in dendritic morphology in the medial prefrontal cortex in two strains of rats
    Melinda M Miller
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Ave, New York, NY 10065, USA
    Behav Brain Res 229:280-8. 2012
    ..These results illustrate significant variability in dendritic morphology in the prefrontal cortex of healthy adult male rats prior to experimental manipulation that correlates with baseline levels of anxiety-like behavior...
  67. ncbi request reprint Glucocorticoids, depression, and mood disorders: structural remodeling in the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Metabolism 54:20-3. 2005
    ..Yet, these are not necessarily "damaged" and may be treatable with the right medications. The mechanisms that distinguish between protection and damage of brain cells from stress are discussed in this context...
  68. ncbi request reprint Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats
    Kazuo Yamada
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Exp Brain Res 152:52-9. 2003
    ..The present results suggest that stress affects synaptic plasticity differently at the two hippocampal subfields and that the effects are time-dependent and involve the stress-induced surge of glucocorticoids...
  69. pmc Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids
    Matthew N Hill
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10065, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:791-7. 2010
    ..Collectively, these studies reveal a complex interplay between endocannabinoids and the HPA axis, and further identify endocannabinoid signaling as a critical regulator of the stress response...
  70. pmc Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse
    Ilia N Karatsoreos
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    Endocrinology 151:2117-27. 2010
    ....
  71. pmc Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex
    Erik B Bloss
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 31:7831-9. 2011
    ....
  72. ncbi request reprint Age- and stress-induced changes in corticotropin-releasing hormone mRNA expression in the paraventricular nucleus of the hypothalamus
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Neuroendocrinology 85:199-206. 2007
    ..Interestingly, in response to repeated restraint, neither age nor stress significantly influence CRH expression. Together, these data indicate that both age and experience with stress interact to modulate CRH expression in the PVN...
  73. pmc Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine
    Lawrence P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2179-84. 2004
    ....
  74. ncbi request reprint Extranuclear estrogen receptor beta immunoreactivity is on doublecortin-containing cells in the adult and neonatal rat dentate gyrus
    Scott P Herrick
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10021, USA
    Brain Res 1121:46-58. 2006
    ..These findings are consistent with data showing that estrogens can exert non-genomic effects directly and indirectly on newly generated cells in neonatal and adult rat dentate gyrus...
  75. ncbi request reprint Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex
    Jason J Radley
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cereb Cortex 16:313-20. 2006
    ..Dendritic atrophy and spine loss may be important cellular features of stress-related psychiatric disorders where the PFC is functionally impaired...
  76. ncbi request reprint Maternal separation suppresses TGF alpha mRNA expression in the prefrontal cortex of male and female neonatal C57BL/6 mice
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Ave, Box 165, New York, NY 10021, USA
    Brain Res Dev Brain Res 152:73-7. 2004
    ..TGF alpha expression was unaffected by MS in the hippocampus. These data indicate that MS leads to a brain region-specific suppression of TGF alpha expression early in development...
  77. pmc Estrogen and the aging brain: an elixir for the weary cortical network
    Dani Dumitriu
    Department of Neuroscience, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, USA
    Ann N Y Acad Sci 1204:104-12. 2010
    ....
  78. ncbi request reprint Estrogen and aging affect the subcellular distribution of estrogen receptor-alpha in the hippocampus of female rats
    Michelle M Adams
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Henry L Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 22:3608-14. 2002
    ..Such a role for spinous ER-alpha has important implications for age-related attenuation of estrogen-induced hippocampal plasticity...
  79. ncbi request reprint NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
    Juan Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neurobiol Aging 24:273-84. 2003
    ..Injection of the NMDA receptor antagonist to aged rats increases significantly the number of proliferating cells, new neurons and radial glia-like cells in the hippocampus...
  80. ncbi request reprint Microglia derived from aging mice exhibit an altered inflammatory profile
    Amanda Sierra
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA
    Glia 55:412-24. 2007
    ..Gender differences were not overall observed across the treatments (age, LPS). The low but sustained production of pro-inflammatory cytokines by aging microglia may have a profound impact in the brain aging process...
  81. ncbi request reprint Estrogen and ovariectomy regulate mRNA and protein of glutamic acid decarboxylases and cation-chloride cotransporters in the adult rat hippocampus
    Nozomu H Nakamura
    Laboratory of Neuroendocrinology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuroendocrinology 80:308-23. 2004
    ....
  82. ncbi request reprint Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology Rockefeller University, New York, NY 10021, USA
    Eur Neuropsychopharmacol 14:S497-502. 2004
    ..Chronic treatment with the antidepressant tianeptine may prevent these effects in hippocampus and amygdala...
  83. ncbi request reprint GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus
    Lawrence P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 932:129-34. 2002
    ..These results demonstrate that GLUT8 is a neuron-specific glucose transporter expressed in the neuronal cell bodies of excitatory and inhibitory neurons in the rat hippocampus...
  84. ncbi request reprint Sex, stress and the hippocampus: allostasis, allostatic load and the aging process
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neurobiol Aging 23:921-39. 2002
    ..This review discusses the current status of work on underlying mechanisms for protection and damage...
  85. pmc Hippocampal formation: shedding light on the influence of sex and stress on the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, 1300 York Avenue, New York, NY 10021, USA
    Brain Res Rev 55:343-55. 2007
    ..This new view is consistent with the predictions of Cajal in his book "The Structure of Ammon's horn", 1892...
  86. ncbi request reprint Protective and damaging effects of stress mediators: the good and bad sides of the response to stress
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Metabolism 51:2-4. 2002
  87. ncbi request reprint Establishing an agenda for translational research on PTSD
    Melinda M Miller
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 1071:294-312. 2006
    ....
  88. ncbi request reprint Anxiety and fear behaviors in adult male and female C57BL/6 mice are modulated by maternal separation
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Horm Behav 43:561-7. 2003
    ..These results indicate that the emotionality of adult male and female mice can be modulated by maternal separation. However, this effect is dependent on the sex of the offspring and the phase of the estrous cycle of the female...
  89. ncbi request reprint The neurobiology and neuroendocrinology of stress. Implications for post-traumatic stress disorder from a basic science perspective
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Box 165, 1230 York Avenue, Rockefeller University, New York, NY 10021, USA
    Psychiatr Clin North Am 25:469-94, ix. 2002
    ..Hormones associated with stress and allostatic load protect the body in the short run and promote adaptation, but in the long run allostatic load causes changes in the body that lead to disease...
  90. ncbi request reprint Early life influences on life-long patterns of behavior and health
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Ment Retard Dev Disabil Res Rev 9:149-54. 2003
    ..Although prevention is clearly the preferable route, some degree of reversal of psychopathology and pathophysiology caused by early life adversity appears to be an achievable goal...
  91. ncbi request reprint Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus
    Kara Pham
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 17:879-86. 2003
    ..These studies may help us understand the basis for hippocampal shrinkage and raise questions about the ultimate reversibility of the effects of chronic stress...
  92. ncbi request reprint Interacting mediators of allostasis and allostatic load: towards an understanding of resilience in aging
    Bruce S McEwen
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Metabolism 52:10-6. 2003
    ..This article discusses the mediators of allostasis and their contributions to allostatic load as well as their role in resilience of the aging organism to stressful experiences...
  93. ncbi request reprint Effects of chronic stress on hippocampal long-term potentiation
    Constantine Pavlides
    The Rockefeller University, New York, New York 10021, USA
    Hippocampus 12:245-57. 2002
    ..Furthermore, they suggest that chronic stress produces changes in the input-output relationship in the hippocampal trisynaptic circuit which could affect information flow through this structure...
  94. ncbi request reprint Glucose transporter expression in the central nervous system: relationship to synaptic function
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Pharmacol 490:13-24. 2004
    ..In addition, we will discuss the regulation, activity and insulin-stimulated trafficking of GLUTs in the CNS, especially in relation to the centrally mediated actions of insulin and glucose...
  95. pmc Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Ann N Y Acad Sci 1186:190-222. 2010
    ..This review focuses specifically on the links between stress-related processes embedded within the social environment and embodied within the brain, which is viewed as the central mediator and target of allostasis and allostatic load...
  96. pmc Rapid and reversible changes in intrahippocampal connectivity during the course of hibernation in European hamsters
    Ana Maria Magarinos
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:18775-80. 2006
    ..The reported reductions in morphological connectivity between the dentate gyrus and the CA3 subregions could underlie the cessation of exploratory activity and spatial navigation skills during hibernation...
  97. ncbi request reprint Dihydrotestosterone increases hippocampal N-methyl-D-aspartate binding but does not affect choline acetyltransferase cell number in the forebrain or choline transporter levels in the CA1 region of adult male rats
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, New York, New York 10021, USA
    Endocrinology 146:2091-7. 2005
    ..However, unlike E-treated females, these data suggest that DHT does not influence cholinergic inputs to the hippocampus...
  98. ncbi request reprint Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 1032:1-7. 2004
    ..Yet, these are not necessarily "damaged" and may be treatable with the right medications...
  99. pmc Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfields
    Matthew N Hill
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Eur J Pharmacol 614:66-9. 2009
    ....
  100. ncbi request reprint Thinking outside the pyramidal cell: unexplored contributions of interneurons and neuropeptide Y to estrogen-induced synapse formation in the hippocampus
    Nozomu H Nakamura
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
    Rev Neurosci 18:1-13. 2007
    ....
  101. pmc Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein
    Laibaik Park
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:1347-52. 2008
    ..The findings unveil a previously unrecognized role of Nox2-derived radicals in the behavioral deficits of Tg2576 mice and provide a link between the neurovascular dysfunction and cognitive decline associated with amyloid pathology...