Mihaela Lorger

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis
    Mihaela Lorger
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM 150, La Jolla, CA 92037, USA
    Am J Pathol 176:2958-71. 2010
  2. pmc Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis
    Karin Staflin
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Clin Exp Metastasis 27:217-31. 2010
  3. pmc Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream
    Martin R Weber
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Thromb Res 140:S27-36. 2016
  4. doi An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation
    Heiko Wurdak
    The Skaggs Institute of Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 6:37-47. 2010
  5. pmc Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain
    Mihaela Lorger
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 150, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:10666-71. 2009

Collaborators

Detail Information

Publications5

  1. pmc Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis
    Mihaela Lorger
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM 150, La Jolla, CA 92037, USA
    Am J Pathol 176:2958-71. 2010
    ..Thus, information on the initial interplay between brain homing tumor cells and reactive host cells may help develop strategies for prevention and treatment of symptomatic breast cancer brain metastases...
  2. pmc Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis
    Karin Staflin
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Clin Exp Metastasis 27:217-31. 2010
    ..Inhibition of advanced metastatic disease by treatment with cancer patient derived single chain antibodies against the activated conformer of integrin alphavbeta3 identifies this form of the receptor as a suitable target for therapy...
  3. pmc Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream
    Martin R Weber
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Thromb Res 140:S27-36. 2016
    ..Thus, this study identifies the high affinity conformer of integrin αvβ3 and its interaction with platelets as critical for early steps during hematogenous metastasis and target for prevention of metastatic disease. ..
  4. doi An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation
    Heiko Wurdak
    The Skaggs Institute of Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 6:37-47. 2010
    ..TRRAP knockdown also significantly suppressed tumor formation upon intracranial BTIC implantation into mice. Together, these findings support a critical role for TRRAP in maintaining a tumorigenic, stem cell-like state...
  5. pmc Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain
    Mihaela Lorger
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 150, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:10666-71. 2009
    ..Targeting this molecular mechanism could prove valuable for the inhibition of brain metastasis...