Laura A Kresty

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. doi request reprint Cranberry proanthocyanidins induce apoptosis and inhibit acid-induced proliferation of human esophageal adenocarcinoma cells
    Laura A Kresty
    Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 56:676-80. 2008
  2. ncbi request reprint Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients
    Laura A Kresty
    Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    Nutr Cancer 54:148-56. 2006
  3. pmc Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus 43210, USA
    Nutr Cancer 54:33-46. 2006
  4. pmc Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus
    Rashmeet K Reen
    Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
    Cancer Res 67:6484-92. 2007
  5. pmc Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions
    Brian S Shumway
    Department of Oral and Maxillofacial Surgery, Anesthesiology and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
    Clin Cancer Res 14:2421-30. 2008
  6. ncbi request reprint Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:3714-7. 2004
  7. doi request reprint A phase I pilot study evaluating the beneficial effects of black raspberries in patients with Barrett's esophagus
    Laura A Kresty
    Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Oncotarget . 2016
  8. ncbi request reprint Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer
    Junan Li
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 31:2683-92. 2011
  9. pmc Cranberry proanthocyanidins modulate reactive oxygen species in Barrett's and esophageal adenocarcinoma cell lines
    Katherine M Weh
    Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Berry Res 6:125-136. 2016
  10. pmc Black raspberries in cancer clinical trials: Past, present and future
    Laura A Kresty
    Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Berry Res 6:251-261. 2016

Collaborators

Detail Information

Publications16

  1. doi request reprint Cranberry proanthocyanidins induce apoptosis and inhibit acid-induced proliferation of human esophageal adenocarcinoma cells
    Laura A Kresty
    Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 56:676-80. 2008
    ..These findings support that further mechanistic studies are warranted to more fully elucidate the inhibitory potential of PAC against esophageal cancer...
  2. ncbi request reprint Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients
    Laura A Kresty
    Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    Nutr Cancer 54:148-56. 2006
    ....
  3. pmc Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus 43210, USA
    Nutr Cancer 54:33-46. 2006
    ..Based upon the preclinical data on rodents, we have initiated prevention trials in humans to determine if berries might exhibit chemopreventive effects in the esophagus...
  4. pmc Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus
    Rashmeet K Reen
    Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
    Cancer Res 67:6484-92. 2007
    ..Samples obtained from animals treated with PEITC alone or cotreated with PEITC + NMBA were more similar to controls than to samples treated with NMBA alone...
  5. pmc Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions
    Brian S Shumway
    Department of Oral and Maxillofacial Surgery, Anesthesiology and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
    Clin Cancer Res 14:2421-30. 2008
    ..Previously, our laboratories have shown that FBRs are well tolerated and possess potent antioxidant, apoptotic, and differentiation-inducing properties...
  6. ncbi request reprint Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:3714-7. 2004
    ..These observations suggest that iNOS plays a role in tumor development and that its selective inhibitor, PBIT, significantly inhibits esophageal tumor progression presumably through reducing the production of NO...
  7. doi request reprint A phase I pilot study evaluating the beneficial effects of black raspberries in patients with Barrett's esophagus
    Laura A Kresty
    Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Oncotarget . 2016
    ..Still, LBR may need to be formulated differently, administered at higher concentrations or multiple times a day to increase efficacy...
  8. ncbi request reprint Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer
    Junan Li
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 31:2683-92. 2011
    ..In this study, the levels of gankyrin mRNA and protein expression were assessed in human oral epithelial cell lines, at-risk normal oral tissues, premalignant oral lesions, and primary oral squamous cell carcinomas (OSCCs)...
  9. pmc Cranberry proanthocyanidins modulate reactive oxygen species in Barrett's and esophageal adenocarcinoma cell lines
    Katherine M Weh
    Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Berry Res 6:125-136. 2016
    ..EAC is characterized by high morbidity and mortality rates supporting development of improved preventive interventions...
  10. pmc Black raspberries in cancer clinical trials: Past, present and future
    Laura A Kresty
    Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Berry Res 6:251-261. 2016
    ..Promising preclinical results have led to clinical evaluations in cancer patients or patients at increased risk for cancer development...
  11. pmc The effects of reactive species on the tumorigenic phenotype of human head and neck squamous cell carcinoma (HNSCC) cells
    Jennifer E Bradburn
    Integrated Biomedical Sciences Graduate Program, School of Biomedical Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Anticancer Res 27:3819-27. 2007
    ....
  12. ncbi request reprint Chemoprevention of oral cancer by black raspberries
    Bruce C Casto
    Division of Environmental Health Sciences, School of Public Health, Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 22:4005-15. 2002
    ..These experiments support previous studies from our laboratories showing the chemopreventive activity of black raspberries and show, for the first time, that dietary black raspberries will inhibit tumor formation in the oral cavity...
  13. pmc Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents
    Katherine M Weh
    Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Antioxidants (Basel) 5:. 2016
    ..Given the emerging positive preclinical effects of cranberries, future clinical directions targeting cancer or premalignancy in high risk cohorts should be considered. ..
  14. pmc Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation
    Laura A Kresty
    Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Oncotarget 6:33438-55. 2015
    ....
  15. ncbi request reprint Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia
    Laura A Kresty
    Division of Environmental Health Sciences, School of Public Health, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Cancer Res 62:5295-300. 2002
    ..These data support that INK4a/ARF locus alterations are frequent events preceding the development of oral cancer and that p16(INK4a) inactivation occurs to a greater extent in oral dysplasia than does p14(ARF) inactivation...
  16. ncbi request reprint In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometry
    Kevin J Chalut
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Cancer Epidemiol Biomarkers Prev 16:223-7. 2007
    ....

Research Grants1

  1. Targeting Histone Deacetylation: A Tool for Chemopevention of Esophageal Cancer
    Laura Kresty; Fiscal Year: 2008
    ..goal of identifying and translating efficacious preventive agents into the clinic for evaluation in high risk human cohorts, including patients with long standing Barrett's esophagus or [unreadable] [unreadable] [unreadable]..