Seiji Kondo

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells
    H Takeuchi
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 64, Houston, TX 77030, USA
    Br J Cancer 90:1069-75. 2004
  2. pmc Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide
    T Kanzawa
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    Br J Cancer 89:922-9. 2003
  3. pmc Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells
    T Komata
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    Br J Cancer 88:1277-80. 2003
  4. doi Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells
    Takashi Shingu
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 124:1060-71. 2009
  5. ncbi Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3
    Hiroshi Aoki
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Autophagy 4:467-75. 2008
  6. ncbi Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in apoptosis and autophagy
    Keishi Fujiwara
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Biol Chem 283:388-97. 2008
  7. ncbi Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells
    Hiroshi Aoki
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    FASEB J 21:2918-30. 2007
  8. pmc The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
    Zhen Lu
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 118:3917-29. 2008
  9. ncbi Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy
    Keishi Fujiwara
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 31:753-60. 2007
  10. ncbi Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirus
    Hideaki Ito
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 98:625-36. 2006

Research Grants

Collaborators

Detail Information

Publications67

  1. pmc Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells
    H Takeuchi
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 64, Houston, TX 77030, USA
    Br J Cancer 90:1069-75. 2004
    ..Together these findings imply a new concept of autophagy for PDGF autocrine inhibition in malignant gliomas...
  2. pmc Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide
    T Kanzawa
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    Br J Cancer 89:922-9. 2003
    ..Therefore, quantification of telomerase activity during or after treatment with TMZ may be a useful marker to detect treatment efficacy...
  3. pmc Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells
    T Komata
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    Br J Cancer 88:1277-80. 2003
    ..Overall, our findings suggest that gene transfer of p27(KIP1) may be a promising approach for the therapy of malignant gliomas...
  4. doi Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells
    Takashi Shingu
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 124:1060-71. 2009
    ..Our findings suggest that therapeutic efficiency of imatinib for malignant glioma may be augmented by inhibition of autophagy at a late stage, and that appropriate modulation of autophagy may sensitize tumor cells to anticancer therapy...
  5. ncbi Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3
    Hiroshi Aoki
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Autophagy 4:467-75. 2008
    ..Anti-LC3B antibody provides a useful tool for monitoring the induction of autophagy in cancer cells and tissues...
  6. ncbi Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in apoptosis and autophagy
    Keishi Fujiwara
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Biol Chem 283:388-97. 2008
    ..These results suggest that p21 plays an essential role in determining the type of cell death, positively for apoptosis and negatively for autophagy...
  7. ncbi Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells
    Hiroshi Aoki
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    FASEB J 21:2918-30. 2007
    ..0065 and P=0.043, respectively). These results indicate that T-oligos stimulate the induction of nonapoptotic autophagic also known as type II programmed cell death and are thus promising in the treatment of malignant glioma...
  8. pmc The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
    Zhen Lu
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 118:3917-29. 2008
    ..Thus, ARHI can induce autophagic cell death, but can also promote tumor dormancy in the presence of factors that promote survival in the cancer microenvironment...
  9. ncbi Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy
    Keishi Fujiwara
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 31:753-60. 2007
    ..Thus, Akt inhibitors may represent a promising new therapy as a single treatment or used in combination with radiation for malignant gliomas, including radioresistant ones that express DeltaEGFR...
  10. ncbi Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirus
    Hideaki Ito
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 98:625-36. 2006
    ..Conditionally replicating adenoviruses (CRAds) can be engineered to replicate selectively in cancer cells and cause cancer-specific cell lysis; thus they are considered a promising cancer therapy...
  11. doi Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death
    Marta M Alonso
    Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Mol Ther 16:487-93. 2008
    ..This is the first report showing that Delta-24-RGD plus RAD001 causes autophagic cell death, and dramatically increases long-term survival rates of glioma-bearing animals...
  12. pmc Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status
    Hideaki Ito
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Gene Ther 16:685-98. 2005
    ..These results indicate that PUMA, which is regulated under a tumor-specific expression system such as the hTERT promoter, may be better than p53 as a therapeutic tool for malignant gliomas...
  13. ncbi Down-regulation of telomerase activity in malignant glioma cells by p27KIP1
    Takao Kanzawa
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Oncol 23:1703-8. 2003
    ..This inhibitory effect was partially induced by interfering with binding sites of the hTERT core promoter for transcription factors Myc and Sp1. These findings identify a novel role for p27KIP1 in down-regulation of telomerase activity...
  14. ncbi Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3
    Takao Kanzawa
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 24:980-91. 2005
    ..This study adds a new concept to characterize the pathways by which As(2)O(3) acts to induce autophagic cell death in malignant glioma cells...
  15. ncbi Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma
    Hiroshi Aoki
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 13:6603-9. 2007
    ..Thus, we examined patterns of Pak1 expression in glioblastoma and sought to determine whether the level of phosphorylated Pak1 in glioblastoma cells is associated with patient survival time...
  16. ncbi Combination of caspase transfer using the human telomerase reverse transcriptase promoter and conventional therapies for malignant glioma cells
    Hayato Takeuchi
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 25:57-63. 2004
    ..These results suggest that agents, which induce apoptosis without inhibiting telomerase activity are a promising counterpart to combine with hTERT/rev-caspase-6 therapy for the management of malignant gliomas...
  17. pmc The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells
    Takashi Shingu
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Neuro Oncol 12:1269-77. 2010
    ..The cells that survived entered a senescent state associated with mitotic catastrophe in 2 of the cell lines. Together, our data show that the response to treatment with a single agent is complex and changes over time...
  18. ncbi Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy
    Shigeru Daido
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 65:4368-75. 2005
    ..The specific inhibition of DNA-PKcs may be promising as a new therapy to radiosensitize malignant glioma cells by inducing autophagy...
  19. ncbi Eupalmerin acetate, a novel anticancer agent from Caribbean gorgonian octocorals, induces apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway
    Arifumi Iwamaru
    Department of Neurosurgery, Unit BSRB1004, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 6:184-92. 2007
    ..01, on day 19). These results indicate that EPA is therapeutically effective against malignant glioma cells in vitro and in vivo and that it, or a similar marine-based compound, may hold promise as a clinical anticancer agent...
  20. ncbi Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide
    Takao Kanzawa
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, New York, USA
    J Neurosurg 99:1047-52. 2003
    ..In this study the authors investigated the ability of O6-benzylguanine (BG), an AGT inhibitor, to sensitize a glioblastoma cell line resistant to TMZ...
  21. ncbi Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells
    Hideaki Ito
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 26:1401-10. 2005
    ..Our results suggest that autophagy inhibitors may represent a new application of radiosensitization for malignant glioma cells...
  22. ncbi Combined effect of 2-5A-linked antisense against telomerase RNA and conventional therapies on human malignant glioma cells in vitro and in vivo
    Eiji Iwado
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Oncol 31:1087-95. 2007
    ..Interestingly, treatment with TMZ increased the incidence of apoptosis in subcutaneous tumor cells treated with 2-5A-anti-hTR. These results suggest that 2-5A-anti-hTR is preferable in combination with established cancer therapies...
  23. ncbi Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells
    Shigeru Daido
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 64:4286-93. 2004
    ..This study adds a new concept to characterize the pathways by which ceramide acts to induce nonapoptotic autophagic cell death in malignant gliomas...
  24. ncbi Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death
    Hong Jiang
    Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 99:1410-4. 2007
    ..Our results show for the first time that brain tumor stem cells are susceptible to adenovirus-mediated cell death via autophagy in vitro and in vivo...
  25. ncbi Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways
    Hiroshi Aoki
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Pharmacol 72:29-39. 2007
    ..These results suggest that curcumin has high anticancer efficacy in vitro and in vivo by inducing autophagy and warrant further investigation toward possible clinical application in patients with malignant glioma...
  26. ncbi Telomerase RNA inhibition using antisense oligonucleotide against human telomerase RNA linked to a 2',5'-oligoadenylate
    Yasuko Kondo
    Department of Neurosurgery, Anderson Cancer Center, Houston, TX, USA
    Methods Mol Biol 405:97-112. 2007
    ..Therefore, we have synthesized the antisense oligonucleotide against human telomerase RNA component (hTR) linked to 2-5A (2-5A-anti-hTR) and have demonstrated its antitumor effect on telomerase-positive cancer cells in vitro and in vivo...
  27. ncbi Identifying the estrogen receptor coactivator PELP1 in autophagosomes
    Kazufumi Ohshiro
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 67:8164-71. 2007
    ....
  28. ncbi Tumor suppressor 101F6 and ascorbate synergistically and selectively inhibit non-small cell lung cancer growth by caspase-independent apoptosis and autophagy
    Shoichiro Ohtani
    Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:6293-303. 2007
    ....
  29. ncbi Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor
    Tong Xin Xie
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 33:5-15. 2008
    ....
  30. ncbi Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors
    Hayato Takeuchi
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 65:3336-46. 2005
    ....
  31. ncbi Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy
    Naoki Shinojima
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Autophagy 3:635-7. 2007
    ..Here, we discuss the therapeutic role of two autophagic pathways influenced by curcumin...
  32. pmc Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis
    Yunfei Zhou
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 286:32843-53. 2011
    ..Inhibition of glycolysis may be an effective strategy to eradicate residual cancer stem cells that are otherwise resistant to chemotherapeutic agents in their hypoxic niches...
  33. ncbi Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells
    Ugur Akar
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Autophagy 4:669-79. 2008
    ....
  34. doi Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma
    Victor Y Yazbeck
    Department of Lymphoma Myeloma, The University of Texas M D Anderson Cancer Center, Houston, Tex 77030, USA
    Exp Hematol 36:443-50. 2008
    ..To investigate the mechanisms of antiproliferative effect induced by the mammalian target of rapamycin (mTOR) inhibitor temsirolimus in mantle cell lymphoma (MCL)...
  35. ncbi Induction of autophagic cell death in malignant glioma cells by arsenic trioxide
    Takao Kanzawa
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 63:2103-8. 2003
    ..These findings suggest that As(2)O(3) at a clinically safe concentration may be an effective chemotherapeutic agent for malignant gliomas...
  36. ncbi Microtubule inhibitor D-24851 induces p53-independent apoptotic cell death in malignant glioma cells through Bcl-2 phosphorylation and Bax translocation
    Hideaki Ito
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 26:589-96. 2005
    ..The results of this study make D-24851 even more promising as a therapeutic agent, especially because many malignant gliomas have a heterogeneous p53 status...
  37. doi Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
    Tianhong Pan
    Parkinson Disease Research Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Neurobiol Dis 32:16-25. 2008
    ....
  38. ncbi American Association for Cancer Research--97th annual meeting
    Yasuko Kondo
    The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    IDrugs 9:409-11. 2006
  39. pmc PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival
    Chandra Bartholomeusz
    Breast Cancer Translational Research Laboratory, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:9302-10. 2008
    ..973; P = 0.0167). Our findings indicate that PEA-15 expression is an important prognostic marker in ovarian cancer...
  40. ncbi Roles of mTOR and STAT3 in autophagy induced by telomere 3' overhang-specific DNA oligonucleotides
    Tomohisa Yokoyama
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Autophagy 3:496-8. 2007
    ..Here, we discuss evidence for T-oligos' effects on cell signaling pathways that may explain their ability to stimulate autophagy by inhibiting STAT3 as well as mTOR...
  41. ncbi The role of autophagy in cancer development and response to therapy
    Yasuko Kondo
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nat Rev Cancer 5:726-34. 2005
    ..What is the present state of our knowledge about the role of autophagy in cancer development, and in response to therapy? And how can the autophagic process be manipulated to improve anticancer therapeutics?..
  42. ncbi Molecular targeting for malignant gliomas (Review)
    Yasuko Kondo
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 24:1101-9. 2004
    ..Therapies targeting specific molecules may result in killing tumor cells effectively while keeping normal cells intact...
  43. ncbi The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
    Jiyong Liang
    Department of Molecular Therapeutics, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Cell Biol 9:218-24. 2007
    ..This may contribute to tumour-cell survival under conditions of growth factor deprivation, disrupted nutrient and energy metabolism, or during stress of chemotherapy...
  44. ncbi Autophagy and cancer therapy
    Yasuko Kondo
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Autophagy 2:85-90. 2006
    ..Tumor suppressors such as Beclin 1, PTEN and p53 also play an important role in autophagy induction. Taken together, these accumulating data may lead to development of new cancer therapies that manipulate autophagy...
  45. ncbi Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity
    Takashi Shingu
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Autophagy 5:537-9. 2009
    ....
  46. ncbi OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action
    Yan Zhou
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1781-5. 2005
    ..The promising anticancer activity of OSW-1 and its unique mechanism of action make this compound worthy of further investigation for its potential to overcome drug resistance...
  47. doi The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
    Tianhong Pan
    Parkinson s Disease Research Laboratory, Baylor College of Medicine, Houston, TX 77030, USA
    Brain 131:1969-78. 2008
    ..In this review, we summarize the recent findings related to this topic and discuss the unique role of the ALP in this neurogenerative disorder and the putative therapeutic potential through ALP enhancement...
  48. pmc Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells
    Ismael Samudio
    Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 7:1130-9. 2008
    ..CDDO-Me is in clinical trials and shows signs of clinical activity, with minimal side effects and complete lack of cardiotoxicity. Studies in leukemias are in preparation...
  49. ncbi Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy
    Kevin C Yao
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, New York, USA
    J Neurosurg 98:378-84. 2003
    ..In this report, the authors characterize the response of GBM cells to ionizing radiation and elucidate factors that correlate with the radiosensitivity of these tumors...
  50. ncbi Mild hyperthermia plus adenoviral p53 over-expression additively inhibits the viability of human malignant glioma cells
    Takeo Nashimoto
    Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan
    Int J Hyperthermia 21:615-29. 2005
    ....
  51. ncbi Ectopic expression of tyrosinase increases melanin synthesis and cell death following UVB irradiation in fibroblasts from familial atypical multiple mole and melanoma (FAMMM) patients
    Akihiro Yoneta
    Department of Dermatology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Melanoma Res 14:387-94. 2004
    ..All of these processes may be involved in the genomic instability and development of melanoma in FAMMM patients...
  52. ncbi Mild heat shock induces autophagic growth arrest, but not apoptosis in U251-MG and U87-MG human malignant glioma cells
    Tadashi Komata
    Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurooncol 68:101-11. 2004
    ..Inhibition of autophagy with bafilomycin A1 may increase the anti-tumor efficacy of mild heat shock against some malignant glioma cells...
  53. ncbi Tumor-specific expression of the RGD-alpha3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice
    Toru Miyoshi
    Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    FASEB J 20:1904-6. 2006
    ..In conclusion, our findings demonstrate that tumor-specific anti-angiogenic gene therapy utilizing RGD-alpha3(IV)NC1 under the hTERT promoter inhibited angiogenesis in tumors, resulting in an antitumor effect...
  54. ncbi Telomerase as a therapeutic target for malignant gliomas
    Tadashi Komata
    The Center for Surgery Research, The Cleveland Clinic Foundation, Cleveland, Ohio, OH 44195, USA
    Oncogene 21:656-63. 2002
    ..These telomerase-associated therapies are very promising for the treatment of malignant gliomas...
  55. ncbi 2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells
    Noriyuki Yatabe
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Gene Ther 9:624-30. 2002
    ....
  56. ncbi Caspase-8 gene therapy using the human telomerase reverse transcriptase promoter for malignant glioma cells
    Tadashi Komata
    The Center for Surgery Research and Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Gene Ther 13:1015-25. 2002
    ..These results suggest that the telomerase-specific expression of caspase-8 under hTERT-378 promoter is a novel targeting approach for the treatment of telomerase-positive malignant gliomas...
  57. ncbi Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases
    Seiji Kondo
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry and Biodental Research Center, Okayama University Dental School, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Carcinogenesis 23:769-76. 2002
    ..This cascade may play critical roles in the hypoxia-induced neovascularization that accompanies tumor invasion in vivo...
  58. ncbi Expression and enzymatic activity of MMP-2 during healing process of the acute supraspinatus tendon tear in rabbits
    Ho Rim Choi
    Department of Orthopaedic Surgery, School of Medicine, Nagoya University, Japan
    J Orthop Res 20:927-33. 2002
    ..These results suggest that MMP-2 is expressed and activated during the healing process of acute supraspinatus tendon tear and can play an important role in the remodeling process...
  59. ncbi Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes
    Gen Yosimichi
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8525, Japan
    Bone 38:853-63. 2006
    ..The requirement of PI3K in transmitting the signal for terminal differentiation and PKC-independent signaling pathways for the promotion of chondrocytic growth and differentiation, which was mediated by JNK, were also uncovered...
  60. ncbi Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells
    Tomohisa Yokoyama
    First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Autophagy 4:629-40. 2008
    ..These data demonstrate that autophagy and apoptosis can be simultaneously induced by VK2. However, autophagy becomes prominent when the cells are protected from rapid apoptotic death by a high expression level of Bcl-2...
  61. ncbi Enforced expression of a truncated form of Bax-alpha (tBax) driven by human telomerase reverse transcriptase (hTERT) promoter sensitizes tumor cells to chemotherapeutic agents or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Hiroko Toyota
    Department of Immunology and Intractable Immune Disease Research Center, Tokyo Medical University, Shinjuku ku 160 8402, Tokyo, Japan
    Anticancer Res 26:99-105. 2006
    ..In the present study, whether efficient cell death is induced by tBax expression from human telomerase reverse transcriptase (hTERT) promoter, which is highly active in tumor but not normal cells, was examined...
  62. doi Targeting the alpha 1 subunit of the sodium pump to combat glioblastoma cells
    Florence Lefranc
    Department of Neurosurgery, Erasme Hospital, Free University of Brussels, Route de Lennik, 808, 1070 Brussels, Belgium
    Neurosurgery 62:211-21; discussion 221-2. 2008
    ..However, the specific role of Na/K-ATPase (the sodium pump) and, in particular, its alpha1 subunit, has remained unexplored in GBMs...
  63. ncbi Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines
    Takanori Eguchi
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1, Shikata cho, Okayama 700 8525, Japan
    Biochimie 89:278-88. 2007
    ....
  64. pmc Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression
    Hideyuki Yanai
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 104:3402-7. 2007
    ..These results, together with the dual regulation of IRF5 gene expression by IFN signaling and p53, may provide a new link in the transcriptional network underlying antiviral immunity and tumor suppression...
  65. ncbi Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes
    Takeshi Yanagita
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    FEBS J 274:1655-65. 2007
    ..These findings indicate that WISP1v thus plays a critical role in chondrocyte differentiation toward endochondral ossification, whereas HCS-2/8-specific WISP1vx may be associated with the transformed phenotypes of chondrosarcomas...
  66. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...

Research Grants2

  1. Telomerase Specific Caspase Transfer for Gliomas
    Seiji Kondo; Fiscal Year: 2004
    ..We anticipate that the studies described in the current proposal will lead to a novel and promising targeting approach for malignant gliomas expressing telomerase activity. ..