Philip R Johnson

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
    Philip R Johnson
    The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Med 15:901-6. 2009
  2. pmc Emerging Vaccine Technologies
    Rebecca J Loomis
    The Children s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA
    Vaccines (Basel) 3:429-47. 2015
  3. doi request reprint Recombinant Adeno-Associated Virus Vector Genomes Take the Form of Long-Lived, Transcriptionally Competent Episomes in Human Muscle
    Bruce C Schnepp
    1 The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Hum Gene Ther 27:32-42. 2016
  4. doi request reprint Vector-mediated antibody gene transfer for infectious diseases
    Bruce C Schnepp
    Infectious Disease, The Children s Hospital of Philadelphia, Abramson Research Center, Room 1216J, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA
    Adv Exp Med Biol 848:149-67. 2015
  5. doi request reprint Gene-based vaccine approaches for respiratory syncytial virus
    Rebecca J Loomis
    Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Curr Top Microbiol Immunol 372:307-24. 2013
  6. pmc Adeno-associated virus delivery of broadly neutralizing antibodies
    Bruce C Schnepp
    The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin HIV AIDS 9:250-6. 2014
  7. pmc Genetic vaccines for anthrax based on recombinant adeno-associated virus vectors
    Te Hui Liu
    Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, Abramson Research Center, Philadelphia, Pennsylvania, USA
    Mol Ther 17:373-9. 2009

Collaborators

Detail Information

Publications7

  1. pmc Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
    Philip R Johnson
    The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Med 15:901-6. 2009
    ..In essence, this strategy bypasses the adaptive immune system and holds considerable promise as a unique approach to an effective HIV vaccine...
  2. pmc Emerging Vaccine Technologies
    Rebecca J Loomis
    The Children s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA
    Vaccines (Basel) 3:429-47. 2015
    ..The emergence of new technologies with a growing understanding of host-pathogen interactions and immunity may lead to efficacious vaccines against pathogens, previously thought impossible. ..
  3. doi request reprint Recombinant Adeno-Associated Virus Vector Genomes Take the Form of Long-Lived, Transcriptionally Competent Episomes in Human Muscle
    Bruce C Schnepp
    1 The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Hum Gene Ther 27:32-42. 2016
    ..Molecular clones of vector genomes derived directly from the biopsies were transcriptionally active, potentially identifying them as the source of serum AAT in the trial subjects. ..
  4. doi request reprint Vector-mediated antibody gene transfer for infectious diseases
    Bruce C Schnepp
    Infectious Disease, The Children s Hospital of Philadelphia, Abramson Research Center, Room 1216J, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA
    Adv Exp Med Biol 848:149-67. 2015
    ..This strategy eliminates the need for immunogen design and interaction with the adaptive immune system to generate protection, a strategy that so far has shown limited promise. ..
  5. doi request reprint Gene-based vaccine approaches for respiratory syncytial virus
    Rebecca J Loomis
    Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Curr Top Microbiol Immunol 372:307-24. 2013
    ..It is likely that multiple candidate vaccines will reach human testing in the next few years. ..
  6. pmc Adeno-associated virus delivery of broadly neutralizing antibodies
    Bruce C Schnepp
    The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin HIV AIDS 9:250-6. 2014
    ..With vector-mediated gene transfer, the antibody gene is delivered to the host, resulting in long-term endogenous antibody expression from the injected muscle that confers protective immunity...
  7. pmc Genetic vaccines for anthrax based on recombinant adeno-associated virus vectors
    Te Hui Liu
    Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, Abramson Research Center, Philadelphia, Pennsylvania, USA
    Mol Ther 17:373-9. 2009
    ..The finding of robust neutralizing antibody responses after a single injection of these rAAV1-based vectors supports their further development as candidate anthrax vaccines...