Rebecca D Jackson
Affiliation: The Ohio State University
- Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) studyMegan D Fesinmeyer
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis MN, USA
BMC Med Genet 14:98. 2013..In contrast, few studies have been conducted within minority groups, which carry the highest burden of impaired glucose homeostasis and type 2 diabetes in the U.S...
- Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profilingRoss L Prentice
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98102, USA
Genome Med 2:48. 2010..However, even though many affected proteins are in pathways relevant to the observed clinical effects, the relationships of these proteins to CHD and stroke risk among postmenopausal women remains substantially unknown...
- Postmenopausal estrogen and progestin effects on the serum proteomeSharon J Pitteri
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Genome Med 1:121. 2009..The biologic mechanisms underlying these effects, and these differences, have yet to be fully elucidated...
- Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findingsHiroyuki Katayama
Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Fairview Avenue North, Seattle, WA 98109, USA
Genome Med 1:47. 2009....
- Epidemiology of fracture risk in the Women's Health InitiativeRebecca D Jackson
Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, 1581 Dodd Drive, Suite 485, Columbus, OH 43210, USA
Curr Osteoporos Rep 6:155-61. 2008..To address the growing incidence of fractures in minority women, clinical risk factors for fracture have been identified. These data demonstrate that we can better identify women, irrespective of race or ethnicity, at risk for fracture...
- The role of hormone therapy and calcium plus vitamin D for reduction of bone loss and risk for fractures: lessons learned from the Women's Health InitiativeRebecca D Jackson
Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University, 1581 Dodd Drive, Suite 485, Columbus, OH 43210, USA
Curr Osteoporos Rep 5:153-9. 2007..But, that argument gains credibility for women over age 60-as a 21% reduction in hip fractures attests-showing that calcium plus vitamin D has a positive effect on bone health in older postmenopausal women...
- Calcium plus vitamin D supplementation has limited effects on femoral geometric strength in older postmenopausal women: the Women's Health InitiativeRebecca D Jackson
College of Medicine, Division of Endocrinology, Diabetes and Metabolism, Center for Clinical and Translational Science, The Ohio State University, Columbus, 43210, USA
Calcif Tissue Int 88:198-208. 2011..CaD supplementation is associated with modest beneficial effects on hip structural features at the narrow neck, which may explain some of the benefit of CaD in reducing hip fracture risk...
- Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational StudyTonya S Orchard
Department of Human Nutrition, College of Education and Human Ecology TSO and the Division of Endocrinology, Diabetes, and Metabolism, College of Medicine NA and RDJ, The Ohio State University, Columbus, OH TSO the Fred Hutchinson Cancer Research Center, Seattle, WA JCL and AZL the Nationwide Children s Hospital, Columbus, OH SB T the Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA JAC the Epidemiology and Biostatistics Division, University of Arizona, Tucson, AZ ZC and the Departments of Social and Preventive Medicine and Gynecology Obstetrics, University at Buffalo, Buffalo, NY JW W
Am J Clin Nutr 99:926-33. 2014..Magnesium is a necessary component of bone, but its relation to osteoporotic fractures is unclear...
- Anatomically anchored template-based level set segmentation: application to quadriceps muscles in MR images from the Osteoarthritis InitiativeJeffrey W Prescott
Dept of Biomedical Informatics, The Ohio State University, 333 W 10th Ave, Columbus, OH 43210, USA
J Digit Imaging 24:28-43. 2011..78 ± 0.12; vastus intermedius, 0.79 ± 0.10; vastus lateralis, 0.82 ± 0.08; and vastus medialis, 0.69 ± 0.16...
- Cardiovascular Health and Incident Cardiovascular Disease and Cancer: The Women's Health InitiativeRandi E Foraker
Division of Epidemiology, The Ohio State University, Columbus, Ohio Electronic address
Am J Prev Med 50:236-40. 2016..CVH predicts incident cardiovascular disease (CVD) in younger populations, but has not been studied in a large, diverse population of aging postmenopausal women. The extent to which CVH predicts cancer in postmenopausal women is unknown...
- Associations of serum sex hormone-binding globulin and sex hormone concentrations with hip fracture risk in postmenopausal womenJennifer S Lee
Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA
J Clin Endocrinol Metab 93:1796-803. 2008..Endogenous estradiol, testosterone, and SHBG may influence the risk of hip fracture...
- The association of red blood cell n-3 and n-6 fatty acids with bone mineral density and hip fracture risk in the women's health initiativeTonya S Orchard
Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
J Bone Miner Res 28:505-15. 2013..Contrastingly, a higher RBC n-6/n-3 ratio may predict higher hip fracture risk in postmenopausal women...
- TNF Receptors Predict Hip Fracture Risk in the WHI Study and Fatty Acid Intake Does Not Modify This AssociationSteven W Ing
Division of Endocrinology, Diabetes, and Metabolism S W I, R d J, Department of Human Sciences, Human Nutrition Program T S O, and Division of Biostatistics B L, The Ohio State University, Columbus, Ohio 43210 Department of Epidemiology and Environmental Health M J L, University at Buffalo State University of New York, Buffalo, New York 14260 Division of Population Health K E B, Arthritis Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30431 and Department of Epidemiology J A C, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
J Clin Endocrinol Metab 100:3380-7. 2015..Chronic inflammation may increase the risk of fracture, and omega-3 polyunsaturated fatty acids (PUFAs) may reduce fracture risk via down-regulation of inflammatory cytokine gene expression and other mechanisms...
- Effects of conjugated equine estrogen on risk of fractures and BMD in postmenopausal women with hysterectomy: results from the women's health initiative randomized trialRebecca D Jackson
Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University, Columbus, OH 43210, USA
J Bone Miner Res 21:817-28. 2006..The fracture reduction at the hip did not differ appreciably among risk strata. These data do not support overall benefit over risk, even in women at highest risk for fracture...
- Fatty acid consumption and risk of fracture in the Women's Health InitiativeTonya S Orchard
Department of Human Nutrition, College of Education and Human Ecology, The Ohio State University, Columbus, OH, USA
Am J Clin Nutr 92:1452-60. 2010..Fatty acids (FAs) may be important dietary components that modulate osteoporotic fracture risk...
- Electronic health record-based assessment of cardiovascular health: The stroke prevention in healthcare delivery environments (SPHERE) studyRandi E Foraker
The Ohio State University College of Public Health, Columbus, OH 43210, United States The Ohio State University College of Medicine, Columbus, OH 43210, United States
Prev Med Rep 4:303-8. 2016..Future work is needed to assess how to best harness the potential of such tools in order to have the greatest impact on the CVH of a larger patient population. ..
- A systematic review of omega-3 fatty acids and osteoporosisTonya S Orchard
The Ohio State University, College of Education and Human Ecology, Department of Human Nutrition, Columbus, OH, USA
Br J Nutr 107:S253-60. 2012....
- Calcium plus vitamin D supplementation and the risk of fracturesRebecca D Jackson
Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
N Engl J Med 354:669-83. 2006..The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal...
- Applying knowledge-anchored hypothesis discovery methods to advance clinical and translational research: the OAMiner projectPhilip R O Payne
Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA
J Am Med Inform Assoc 19:1110-4. 2012..We believe that this 'test bed' project and the lessons learned during its execution are both generalizable and representative of common clinical and translational research paradigms...
- An automated method to detect interstitial adipose tissue in thigh muscles for patients with osteoarthritisJeffrey W Prescott
Department of Biomedical Informatics, Ohio State University, Columbus, OH 43210, USA
Conf Proc IEEE Eng Med Biol Soc 2009:6360-3. 2009..Finally, we specify a protocol for further exploration of IAT by leveraging the massive imaging dataset of the Osteoarthritis Initiative (OAI)...
- Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitusLeigh E Norris
Department of Human Nutrition, The Ohio State University, Columbus, 43210, USA
Am J Clin Nutr 90:468-76. 2009..Weight loss may improve glucose control in persons with type 2 diabetes. The effects of fat quality, as opposed to quantity, on weight loss are not well understood...
- The Women's Health Initiative calcium-vitamin D trial: overview and baseline characteristics of participantsRebecca D Jackson
College of Medicine and Public Health, Ohio State University, Columbus, OH, USA
Ann Epidemiol 13:S98-106. 2003
- Serum 25-hydroxyvitamin D concentrations and risk for hip fracturesJane A Cauley
University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, Crabtree A524, Pittsburgh, PA 15261, USA
Ann Intern Med 149:242-50. 2008..The relationship between serum 25-hydroxyvitamin D [25(OH) vitamin D] concentration and hip fractures is unclear...
- Calcium, vitamin D supplementation, and physical function in the Women's Health InitiativeRobert L Brunner
University of Nevada School of Medicine, PMB 251, MS 145, Reno, NV 89557, USA
J Am Diet Assoc 108:1472-9. 2008..Now we examine whether the treatment affected self-reported physical functioning and objective measures of physical functioning...
- Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trialJacques E Rossouw
Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
JAMA 288:321-33. 2002..Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain...
- Cystatin-C, renal function, and incidence of hip fracture in postmenopausal womenAndrea Z LaCroix
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Am Geriatr Soc 56:1434-41. 2008..To evaluate the association between chronic kidney disease and incident hip fracture using serum cystatin-C as a biomarker of renal function calculated without reference to muscle mass...
- Oophorectomy, hormone therapy, and subclinical coronary artery disease in women with hysterectomy: the Women's Health Initiative coronary artery calcium studyMatthew A Allison
University of California San Diego, La Jolla, CA, USA
Menopause 15:639-47. 2008..In this study, we aimed to determine the associations between coronary artery calcium (CAC) and hysterectomy, oophorectomy, and hormone therapy use with a focus on the duration of menopause for which there was no hormone therapy use...
- Factors associated with 5-year risk of hip fracture in postmenopausal womenJohn Robbins
Department of Internal Medicine, University of California at Davis School of Medicine, Sacramento, CA 95817, USA
JAMA 298:2389-98. 2007..The 329,000 hip fractures that annually occur in the United States are associated with high morbidity, mortality, and cost. Identification of those at high risk is a step toward prevention...
- Calcium plus vitamin D supplementation and the risk of colorectal cancerJean Wactawski-Wende
Department of Social and Preventive Medicine, University at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA
N Engl J Med 354:684-96. 2006..However, randomized-trial evidence that calcium with vitamin D supplementation is beneficial in the primary prevention of colorectal cancer is lacking...
- Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification TrialShirley A A Beresford
Department of Epidemiology, University of Washington, Seattle, WA 98195 7236, USA
JAMA 295:643-54. 2006..Observational studies and polyp recurrence trials are not conclusive regarding the effects of a low-fat dietary pattern on risk of colorectal cancer, necessitating a primary prevention trial...
- Postmenopausal hormone therapy and body composition--a substudy of the estrogen plus progestin trial of the Women's Health InitiativeZhao Chen
Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA
Am J Clin Nutr 82:651-6. 2005..It has been suggested that hormone therapy may help counter undesirable changes in body composition in older women...
- Validity of self-report for fractures among a multiethnic cohort of postmenopausal women: results from the Women's Health Initiative observational study and clinical trialsZhao Chen
University of Arizona, Tucson, AZ, USA
Menopause 11:264-74. 2004..The purpose of this study is to examine the validity of, and factors associated with, the accuracy of self-report (participant-report and proxy-report) for fractures...
- Efficacy of risedronate on clinical vertebral fractures within six monthsChristian Roux
Cochin Hospital, Rene Descartes University, Paris, France
Curr Med Res Opin 20:433-9. 2004..Risedronate has been shown to reduce the incidence of radiographically-defined vertebral fractures by approximately two-thirds within 1 year...
- Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trialJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
JAMA 290:1729-38. 2003..In the Women's Health Initiative trial of estrogen-plus-progestin therapy, women assigned to active treatment had fewer fractures...
- Statin use, clinical fracture, and bone density in postmenopausal women: results from the Women's Health Initiative Observational StudyAndrea Z LaCroix
Women s Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 1002, PO Box 19024, Seattle, Washington 98109 1024, USA
Ann Intern Med 139:97-104. 2003..While early epidemiologic studies showed lower risk for hip fracture among statin users than nonusers, subsequent studies have produced mixed results...
- Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trialSally A Shumaker
Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27104, USA
JAMA 289:2651-62. 2003..On July 8, 2002, the study drugs, estrogen plus progestin, in the Women's Health Initiative (WHI) trial were discontinued because of certain increased health risks in women receiving combined hormone therapy...
- Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational studyAruna D Pradhan
Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
JAMA 288:980-7. 2002..Several inflammatory biomarkers, including CRP, are associated with increased cardiovascular risk. However, whether the effect of HRT on CRP represents a clinical hazard is unknown...