Wei Hu

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Increased expression of fascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tumors
    W Hu
    Section of Gynecologic and Medical Therapeutics, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Clin Exp Metastasis 18:83-8. 2000
  2. ncbi request reprint Proteomic identification of heat shock protein 70 as a candidate target for enhancing apoptosis induced by farnesyl transferase inhibitor
    Wei Hu
    Department of Gynecologic Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Proteomics 3:1904-11. 2003
  3. ncbi request reprint Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer
    Wei Hu
    Department of Gynecologic Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oncol Res 15:49-57. 2005
  4. ncbi request reprint Increased expression of heat shock protein 70 in adherent ovarian cancer and mesothelioma following treatment with manumycin, a farnesyl transferase inhibitor
    Wei Hu
    Department of Gynecologic and Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Anticancer Res 22:665-72. 2002
  5. ncbi request reprint Activity of ALRT 1550, a new retinoid, with interferon-gamma on ovarian cancer cell lines
    Wei Hu
    Department of Gynecologic Medical Oncology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Gynecol Cancer 12:202-7. 2002
  6. pmc Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer
    Yu Kang
    Affiliations of authors Department of Gynecologic Oncology and Repro ductive Medicine YK, WH, CI, CVP, HJD, BZ, TL, JH, NBJ, RR, MT, TM, SP, SYW, CL, YW, AKS, Center for RNAi and Non Coding RNA CI, AKS, Department of Pathology JH, Jl, and Department of Cancer Biology AKS, The University of Texas MD Anderson Cancer Center, Houston, TX Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College of Fudan University, Shanghai, China YK Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China TL
    J Natl Cancer Inst 105:1485-95. 2013
  7. pmc Targeting SRC and tubulin in mucinous ovarian carcinoma
    Tao Liu
    Authors Affiliations Departments of Gynecologic Oncology and Reproductive Medicine, Genitourinary Medical Oncology, Bioinformatics and Computational Biology, and Cancer Biology Division of Cancer Medicine Center for RNA Interference and Non Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas Kinex Pharmaceuticals LLC, New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Department of Gynecology, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai, P R China
    Clin Cancer Res 19:6532-43. 2013
  8. pmc Notch3 pathway alterations in ovarian cancer
    Wei Hu
    Authors Affiliations Departments of Gynecologic Oncology and Reproductive Medicine, Systems Biology, Pathology, Experimental Therapeutics, Bioinformatics and Computational Biology, Cancer Biology, Thoracic Head and Neck Medical Oncology, and the Center for RNA Interference and non Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer Res 74:3282-93. 2014
  9. pmc Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3
    Siqing Fu
    Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cancer Biol Ther 13:1034-41. 2012
  10. pmc Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer
    Yu Kang
    Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, P R China Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Clin Cancer Res 22:1713-24. 2016

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Increased expression of fascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tumors
    W Hu
    Section of Gynecologic and Medical Therapeutics, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Clin Exp Metastasis 18:83-8. 2000
    ..Therefore, our data suggest that fascin could serve as a prognostic factor for abnormal ovarian epithelial pathology and could be a novel target for the treatment of ovarian cancer...
  2. ncbi request reprint Proteomic identification of heat shock protein 70 as a candidate target for enhancing apoptosis induced by farnesyl transferase inhibitor
    Wei Hu
    Department of Gynecologic Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Proteomics 3:1904-11. 2003
    ....
  3. ncbi request reprint Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer
    Wei Hu
    Department of Gynecologic Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oncol Res 15:49-57. 2005
    ..Overexpression of STK15 with coordinate loss of wild-type p53 function thus appears to play an important role in ovarian tumorigenesis and offers a novel molecular target in designing effective therapy of human ovarian cancer...
  4. ncbi request reprint Increased expression of heat shock protein 70 in adherent ovarian cancer and mesothelioma following treatment with manumycin, a farnesyl transferase inhibitor
    Wei Hu
    Department of Gynecologic and Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Anticancer Res 22:665-72. 2002
    ..HSPs may therefore be an important molecular target for drug intervention strategies...
  5. ncbi request reprint Activity of ALRT 1550, a new retinoid, with interferon-gamma on ovarian cancer cell lines
    Wei Hu
    Department of Gynecologic Medical Oncology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Gynecol Cancer 12:202-7. 2002
    ..Combining these two biologic modifiers for the treatment of ovarian cancer may lower the effective dose of the retinoids, thus decreasing their side effects...
  6. pmc Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer
    Yu Kang
    Affiliations of authors Department of Gynecologic Oncology and Repro ductive Medicine YK, WH, CI, CVP, HJD, BZ, TL, JH, NBJ, RR, MT, TM, SP, SYW, CL, YW, AKS, Center for RNAi and Non Coding RNA CI, AKS, Department of Pathology JH, Jl, and Department of Cancer Biology AKS, The University of Texas MD Anderson Cancer Center, Houston, TX Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College of Fudan University, Shanghai, China YK Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China TL
    J Natl Cancer Inst 105:1485-95. 2013
    ..We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian cancer to taxanes; however, the mechanisms are not well understood...
  7. pmc Targeting SRC and tubulin in mucinous ovarian carcinoma
    Tao Liu
    Authors Affiliations Departments of Gynecologic Oncology and Reproductive Medicine, Genitourinary Medical Oncology, Bioinformatics and Computational Biology, and Cancer Biology Division of Cancer Medicine Center for RNA Interference and Non Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas Kinex Pharmaceuticals LLC, New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Department of Gynecology, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai, P R China
    Clin Cancer Res 19:6532-43. 2013
    ..To investigate the antitumor effects of targeting Src and tubulin in mucinous ovarian carcinoma...
  8. pmc Notch3 pathway alterations in ovarian cancer
    Wei Hu
    Authors Affiliations Departments of Gynecologic Oncology and Reproductive Medicine, Systems Biology, Pathology, Experimental Therapeutics, Bioinformatics and Computational Biology, Cancer Biology, Thoracic Head and Neck Medical Oncology, and the Center for RNA Interference and non Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer Res 74:3282-93. 2014
    ..Collectively, these data identify previously unknown mechanisms underlying Notch3 signaling and identify new, biomarker-driven approaches for therapy...
  9. pmc Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3
    Siqing Fu
    Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cancer Biol Ther 13:1034-41. 2012
    ..The growth-inhibitory effect was accompanied by reduction in expression of histone 3 and an increase in apoptosis. We conclude that VE 465 enhances the efficacy of carboplatin agents in ovarian carcinoma...
  10. pmc Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer
    Yu Kang
    Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, P R China Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Clin Cancer Res 22:1713-24. 2016
    ..The focus of the current study was to determine the functional and biologic effects of adrenergic pathways on response to chemotherapy in the context of ovarian cancer...
  11. pmc Randomised phase II study of docetaxel plus vandetanib versus docetaxel followed by vandetanib in patients with persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma: SWOG S0904
    Robert L Coleman
    University of Texas, M D Anderson Cancer Center, Houston, TX, USA Electronic address
    Eur J Cancer 50:1638-48. 2014
    ..We explored the efficacy, safety and toxicity of docetaxel and vandetanib in women with recurrent ovarian cancer (OC)...
  12. pmc Epigenetic analysis of the Notch superfamily in high-grade serous ovarian cancer
    Cristina Ivan
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Gynecol Oncol 128:506-11. 2013
    ..We used The Cancer Genome Atlas (TCGA) data to study the clinical relevance of epigenetic modifications of Notch superfamily genes...
  13. pmc Update on aurora kinase inhibitors in gynecologic malignancies
    Xia Tao
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Recent Pat Anticancer Drug Discov 3:162-77. 2008
    ..In this review, we summarize the most recent advances in preclinical studies and clinical trials of patented Aurora kinase inhibitors for gynecologic tumors...
  14. doi request reprint Azacitidine enhances sensitivity of platinum-resistant ovarian cancer cells to carboplatin through induction of apoptosis
    Yanfang Li
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Obstet Gynecol 200:177.e1-9. 2009
    ..The objective of the study was to investigate whether azacitidine sensitizes platinum-resistant ovarian cancer cells to carboplatin and the possible mechanisms involved...
  15. doi request reprint Nuclear cyclin B1 is overexpressed in low-malignant-potential ovarian tumors but not in epithelial ovarian cancer
    Hong Zheng
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Am J Obstet Gynecol 201:367.e1-6. 2009
    ..To investigate the role of cyclin G1 and cyclin B1 in ovarian tumorigenesis...
  16. pmc Regulation of tumor angiogenesis by EZH2
    Chunhua Lu
    Department of Gynecologic Oncology, U T M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 18:185-97. 2010
    ..Collectively, these data support the potential for targeting ezh2 as an important therapeutic approach...
  17. pmc Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer
    Siqing Fu
    Department of Investigational Cancer Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 117:1661-9. 2011
    ..A phase 1b-2a clinical trial of this sequential combination of azacitidine and carboplatin was initiated in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer...
  18. pmc Methylation and histone deacetylase inhibition in combination with platinum treatment in patients with advanced malignancies
    Gerald S Falchook
    Department of Investigational Cancer Therapeutics Phase I Program, The University of Texas MD Anderson Cancer Center, Unit 455, 1515 Holcombe Boulevard, Houston, TX, 77030, USA
    Invest New Drugs 31:1192-200. 2013
    ..Clinical correlates included evaluation of epigenetic changes, methylation patterns, and histone acetylation levels in peripheral blood mononuclear cells...
  19. ncbi request reprint Targeted therapies in gynecologic cancers
    Hye Sook Chon
    Department of Gynecologic Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA
    Curr Cancer Drug Targets 6:333-63. 2006
    ..In this review, we will focus on potential novel targets in gynecologic cancer and the development of targeted therapy and its clinical applications in gynecologic cancer...
  20. doi request reprint Diammine dicarboxylic acid platinum enhances cytotoxicity in platinum-resistant ovarian cancer cells through induction of apoptosis and S-phase cell arrest
    Hong Zheng
    Department of Gynecologic Oncology, Unit 1362, The University of Texas M D Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    Pharm Res 25:2272-82. 2008
    ..DDAP improves platinum solubility which may reduce systemic toxicity and be more efficacious than cisplatin in killing tumor cells...
  21. ncbi request reprint Establishment and characterization of cancer cell cultures and xenografts derived from primary or metastatic Mullerian cancers
    Claire F Verschraegen
    Department of Gynecologic Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:845-52. 2003
    ..The purpose of this study was to characterize cell cultures and xenografts derived from patients with ovarian cancer...
  22. ncbi request reprint Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-gamma expression
    Bohuslav Melichar
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gynecol Oncol 93:149-54. 2004
    ..CDDO is a ligand for the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of the present study was to evaluate CDDO activity in EOC cell lines in vitro...
  23. pmc PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer
    Duangmani Thanapprapasr
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Mol Cancer Ther 14:1466-75. 2015
    ..Therefore, PTEN could be a biomarker for predicting response to FAK-targeted therapy during clinical development...
  24. pmc Erythropoietin Stimulates Tumor Growth via EphB4
    Sunila Pradeep
    Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77584, USA
    Cancer Cell 28:610-22. 2015
    ..These results identify EphB4 as a critical mediator of erythropoietin-induced tumor progression and further provide clinically significant dimension to the biology of erythropoietin. ..
  25. pmc XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A
    Takahito Miyake
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Clin Cancer Res 21:3286-97. 2015
    ..In this study, we explored the usefulness of selective inhibitors of nuclear export (SINE) compounds that are specific inhibitors of XPO1...
  26. pmc Differential platelet levels affect response to taxane-based therapy in ovarian cancer
    Justin Bottsford-Miller
    Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Clin Cancer Res 21:602-10. 2015
    ..We hypothesized that platelet levels during therapy could serve as a biomarker for response to therapy and that manipulation of platelet levels could impact responsiveness to chemotherapy...
  27. pmc Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer
    Yunfei Wen
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Clin Cancer Res 21:448-59. 2015
    ..Targeting overexpressed folate receptor alpha (FRα) in cancer cells offers a therapeutic opportunity. We investigated the functional mechanisms of MORAB-003 (farletuzumab), a humanized mAb against FRα, in ovarian cancer models...
  28. ncbi request reprint Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias
    Marina Konopleva
    Section of Molecular Hematology and Therapy and Department of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 3:1249-62. 2004
    ....
  29. pmc Metronomic activity of CD44-targeted hyaluronic acid-paclitaxel in ovarian carcinoma
    Sun Joo Lee
    Department of Gynecologic Oncology and Reproductive Medicine, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 18:4114-21. 2012
    ....
  30. ncbi request reprint A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for 5 days every 3 weeks to patients with advanced ovarian, tubal or peritoneal cancer resistant to platinum, taxane and topotecan
    Claire F Verschraegen
    Section of Gynecologic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer Chemother Pharmacol 53:1-7. 2004
    ....
  31. pmc Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth
    Jie Huang
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Mol Cancer Ther 15:1344-52. 2016
    ..These findings identify that dual targeting of Dll4 and VEGF is an attractive therapeutic approach. Mol Cancer Ther; 15(6); 1344-52. ©2016 AACR. ..
  32. pmc Biological roles of the Delta family Notch ligand Dll4 in tumor and endothelial cells in ovarian cancer
    Wei Hu
    Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 71:6030-9. 2011
    ....
  33. pmc Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer
    Ju Won Roh
    Authors Affiliations Departments of Gynecologic Oncology and Reproductive Medicine and Cancer Biology, Center for RNA Interference and Non Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas University of Southern California, Los Angeles, California Department of Obstetrics and Gynecology, Dongguk University Departments of Systems Biology and Obstetrics and Gynecology, Konkuk University, Seoul, Korea and Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandAuthors Affiliations Departments of Gynecologic Oncology and Reproductive Medicine and Cancer Biology, Center for RNA Interference and Non Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas University of Southern California, Los Angeles, California Department of Obstetrics and Gynecology, Dongguk University Departments of Systems Biology and Obstetrics and Gynecology, Konkuk University, Seoul, Korea and Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Clin Cancer Res 20:2740-50. 2014
    ..This preclinical study evaluated the biologic significance of PDGFRα and PDGFRα blockade (using a fully humanized monoclonal antibody, 3G3) in uterine cancer...
  34. pmc Biological significance of HORMA domain containing protein 1 (HORMAD1) in epithelial ovarian carcinoma
    Mian M K Shahzad
    Department of Gynecologic Oncology, U T M D Anderson Cancer Center, Houston, TX 77030, United States
    Cancer Lett 330:123-9. 2013
    ..HORMAD1 gene silencing resulted in significantly reduced VEGF protein levels and microvessel density compared to controls. Our data suggest that HORMAD1 may be an important therapeutic target...
  35. ncbi request reprint Targeting Aurora kinases in ovarian cancer
    Siqing Fu
    Department of Gynecologic Medical Oncology, The University of Texas, MD Anderson Cancer Center, PO Box 301439, Houston, Texas 77230 1439, USA
    Expert Opin Ther Targets 10:77-85. 2006
    ..The authors propose that Aurora kinase inhibitors be developed as molecular therapeutic agents in order to minimise their toxicities and maximise their antitumour activities for ovarian cancer treatment...
  36. pmc Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
    Anil K Sood
    Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 120:1515-23. 2010
    ....
  37. pmc Moving beyond VEGF for anti-angiogenesis strategies in gynecologic cancer
    Duangmani Thanapprapasr
    Department of Gynecologic Oncology, University of Texas, M D Anderson Cancer Center, 1155 Herman Pressler Dr CPB 6 3271, Houston, TX 77030, USA
    Curr Pharm Des 18:2713-9. 2012
    ..Herein, we review the role of these new targets in tumor angiogenesis and the rationale for further clinical development...
  38. pmc Paraneoplastic thrombocytosis in ovarian cancer
    Rebecca L Stone
    Department of Gynecologic Oncology and Reproductive Medicine, University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    N Engl J Med 366:610-8. 2012
    ..The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear...
  39. ncbi request reprint Proteomics in cancer screening and management in gynecologic cancer
    Wei Hu
    Department of Gynecologic Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 401, Houston, TX 77030, USA
    Curr Oncol Rep 6:456-62. 2004
    ..This article reviews proteomic techniques and their potential applications in gynecologic cancer screening and management...
  40. ncbi request reprint Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometry
    Weiguo Wu
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Clin Exp Metastasis 19:319-26. 2002
    ..The results also suggest an important complementary role for proteomics in identification of molecular abnormalities important in cancer development and progression...
  41. doi request reprint Poor survival outcome with moderate and severe hypercalcemia in gynecologic malignancy patients
    Atthapon Jaishuen
    Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 1439, USA
    Int J Gynecol Cancer 19:178-85. 2009
    ..Determine the incidence of hypercalcemia in gynecologic malignancy patients and their survival outcome...
  42. pmc Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer
    Yan Huang
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Mol Cancer Ther 15:2894-2904. 2016
    ..We also found that both aspirin-PC and aspirin have robust antineoplastic action in the presence of VEGF-blocking drugs. Mol Cancer Ther; 15(12); 2894-904. ©2016 AACR...
  43. pmc New ways to successfully target tumor vasculature in ovarian cancer
    Xiaoyun Yang
    aDepartment of Gynecologic Oncology and Reproductive Medicine bDepartment of Cancer Biology cCenter for RNA Interference and Non Coding RNAs dDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Xiaoyun Yang and Fangrong Shen contributed equally to the writing of the article
    Curr Opin Obstet Gynecol 27:58-65. 2015
    ..The aim of this article was to review the recent literature on potential therapeutic strategies for overcoming resistance to antivascular endothelial growth factor drugs in ovarian cancer...
  44. pmc Prognostic biomarkers in ovarian cancer
    Jie Huang
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Biomark 8:231-51. 2010
    ....
  45. doi request reprint Chemotherapy for recurrent and metastatic cervical cancer
    Xia Tao
    Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Gynecol Oncol 110:S67-71. 2008
    ..Our purpose is to review the chemotherapy for recurrent and metastatic cervical cancer...
  46. ncbi request reprint Pegylated liposomal doxorubicin treatment in recurrent gynecologic cancer patients with renal dysfunction
    Yanfang Li
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, 1155 Pressler Street, Houston, TX 77030, USA
    Gynecol Oncol 106:375-80. 2007
    ..We sought to investigate the toxicity and efficacy of PLD in gynecologic cancer patients with CKD...
  47. pmc Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy
    Lingegowda S Mangala
    Department of Gynecologic Oncology and Reproductive Medicine, Center for RNA Interference and Non coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    JCI Insight 1:e87754. 2016
    ..These findings could have implications for improving vascular-targeted therapy...
  48. pmc Molecular biomarkers of residual disease after surgical debulking of high-grade serous ovarian cancer
    Susan L Tucker
    Authors Affiliations Departments of Bioinformatics and Computational Biology, Gynecologic Oncology and Reproductive Medicine, Experimental Therapeutics, Cancer Biology, and Center for RNA interference and non coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas and Fred Hutchinson Cancer Research Center, Seattle, Washington
    Clin Cancer Res 20:3280-8. 2014
    ..Our goal was to identify and validate molecular markers associated with high rates of residual disease...
  49. ncbi request reprint Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers
    Jiuhong Yuan
    Department of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:4174-80. 2003
    ..Other epigenetic modifications such as hypermethylation in CpG island III may also contribute to the loss of ARHI expression...
  50. ncbi request reprint Phase II study of cetrorelix, a luteinizing hormone-releasing hormone antagonist in patients with platinum-resistant ovarian cancer
    Claire F Verschraegen
    Multidisciplinary Gynecologic Oncology Center, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Gynecol Oncol 90:552-9. 2003
    ..About 80% of primary ovarian cancers and cell lines bear LHRH receptors. Cetrorelix has anticancer activity in in vitro and in vivo ovarian cancer models...
  51. ncbi request reprint Cervical chromosome 9 polysomy: validation and use as a surrogate endpoint biomarker in a 4-HPR chemoprevention trial
    Heung Gon Kim
    Department of Cellular and Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gynecol Oncol 99:S32-7. 2005
    ..Chromosomal instability is a feature of most human cancers and is probably an early event in the process...
  52. ncbi request reprint Anticancer therapy targeting the apoptotic pathway
    Wei Hu
    Department of Gynecologic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030 4009, USA
    Lancet Oncol 4:721-9. 2003
    ..In this article, we review the development and clinical efficacy of proapoptotic drugs that have shown promise...
  53. ncbi request reprint The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells
    Marina Konopleva
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Br J Haematol 118:521-34. 2002
    ..These findings could be used in the development of therapies that selectively induce apoptosis in quiescent leukaemic progenitor cells...
  54. ncbi request reprint Resistance to chemotherapy-induced apoptosis via decreased caspase-3 activity and overexpression of antiapoptotic proteins in ovarian cancer
    Xiaokui Yang
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, PR China
    J Cancer Res Clin Oncol 130:423-8. 2004
    ....
  55. ncbi request reprint Dysregulation of the TGF-beta postreceptor signaling pathway in cell lines derived from primary or metastatic ovarian cancer
    Ling Xi
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
    J Huazhong Univ Sci Technolog Med Sci 24:62-5. 2004
    ..This overexpression of CDC25A correlates with increased tumorigenicity of ovarian cancer cell lines. The loss of sensitivity to TGF-beta is not associated with a lack of TbetaR II...
  56. ncbi request reprint Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:113-22. 2005
    ..To study the role of the peritoneum in fostering tumor invasion, we analyzed differences between the transcriptional repertoires of peritoneal tissue lacking detectable cancer in patients with EOC versus benign gynecologic disease...
  57. ncbi request reprint Transcriptomics tool for the human Schistosoma blood flukes using microarray gene expression profiling
    Geoffrey N Gobert
    Queensland Institute of Medical Research and Australian Centre for International Health and Nutrition, Brisbane, QLD, Australia
    Exp Parasitol 114:160-72. 2006
    ..This is the first microarray commercially manufactured for studying schistosomes, and the large size and verified quality of the resource demonstrate its power for characterising the schistosome transcriptome...
  58. ncbi request reprint Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance
    Julianne M Davis
    Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
    Clin Cancer Res 9:1161-70. 2003
    ..These observations suggest both independent and overlapping roles for Raf-1 and Bcl-2 oncogenes in the resistance to growth inhibition by doxorubicin...
  59. pmc Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos
    De Sheng Pei
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    BMC Dev Biol 8:29. 2008
    ..Gene expression analysis of cross-species cloned embryos will yield new insights into the regulatory mechanisms involved in cross-species nuclear transfer and embryonic development...
  60. ncbi request reprint Antisense-Snail transfer inhibits tumor metastasis by inducing E-cadherin expression
    Ali Zhang
    Cancer Biology Research Center, Tongji Hospital, Wuhan, Hubei 430040, China
    Anticancer Res 28:621-8. 2008
    ..These findings suggest that Snail plays a critical role in EMT and subsequent invasiveness. Snail inhibition may serve as a promising target for therapeutic strategies to prevent tumor metastasis...
  61. pmc Expression, immunolocalization and serodiagnostic value of a myophilin-like protein from Schistosoma japonicum
    Hailin Peng
    Shanghai Institute of Hematology, Ruijin Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Exp Parasitol 119:117-24. 2008
    ..4%. Taken together, the myophilin-like protein may prove useful for monitoring the therapeutic effect of praziquantel rather than in serodiagnosis of schistosomiasis...
  62. ncbi request reprint Expression of CD40 and growth-inhibitory activity of CD40 ligand in ovarian cancer cell lines
    Bohuslav Melichar
    Department of Oncology and Radiotherapy and Medicine, Charles University Medical School, Hradec Kralove, Czech Republic
    Gynecol Oncol 104:707-13. 2007
    ..Soluble recombinant human CD40 ligand trimer (rhuCD40Lt) has shown antitumor activity in preclinical and clinical studies. We evaluated the effect of rhuCD40Lt on epithelial ovarian carcinoma (EOC) cell lines...
  63. ncbi request reprint Simple sequence repeat analyses of interspecific hybrids and MAALs of Oryza officinalis and Oryza sativa
    Gang Li
    Key Laboratory of Ministry of Education for Plant Development Biology, College of Life Sciences, Wuhan University, Wuhan, 430072, China
    Genetica 134:169-80. 2008
    ..1%) showed duplication in the C-genome. Sequencing analysis revealed that indels, substitution and duplication contribute to the diversity of SSR loci between the genomes of O. sativa and O. officinalis...
  64. ncbi request reprint Mutation and a high-throughput screening method for improving the production of Epothilones of Sorangium
    Guo li Gong
    State Key Libratory of Microbial Technology, College of Life Science, Shan Dong University, Jinan 250100, People s Republic of China
    J Ind Microbiol Biotechnol 34:615-23. 2007
    ..Furthermore, the production was greatly increased by the genome shuffling. For epothilone B, the production of one fusant was increased about 130 times compared to the starting strain, increasing from 0.8 mg l(-1) to 104 mg l(-1)...
  65. ncbi request reprint Isolation, sequence analysis, and expression studies of florally expressed cDNAs in Arabidopsis
    Wei Hu
    Department of Biology, and the Huck Institute of Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Plant Mol Biol 53:545-63. 2003
    ..We suggest that the genes encoding putative regulatory proteins and at least some proteins with currently unknown functions might play important roles during flowering...
  66. ncbi request reprint Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes
    Wei Sun
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    J Invest Dermatol 128:389-97. 2008
    ..These results strongly suggest that upregulation of haCER1 and AC mediates the Ca2+(o)-induced growth arrest and differentiation of HEKs by generating SPH and S1P...
  67. ncbi request reprint Interleukin 23 in acute inflammatory demyelination of the peripheral nerve
    Wei Hu
    Department of Neurology, Research Group for Clinical and Experimental Neuroimmunology, Heinrich Heine University, Dusseldorf, Germany
    Arch Neurol 63:858-64. 2006
    ..Recent evidence suggests that IL-23 rather than IL-12 is critically involved in the pathogenesis of various immune-mediated disorders...
  68. ncbi request reprint Molecular cloning and characterization of carp (Cyprinus carpio L.) CD8beta and CD4-like genes
    Xiao Feng Sun
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Fish Shellfish Immunol 23:1242-55. 2007
    ..The results from this study can be used to understand the evolution of both the CD8beta and CD4 molecules which can be used as markers for cytotoxic and helper T cells in carp...
  69. ncbi request reprint Relationship of C-reactive protein with hypertension and interactions between increased C-reactive protein and other risk factors on hypertension in Mongolian people, China
    Tan Xu
    Department of Epidemiology, Soochow University School of Radiation Medicine and Public Health, Suzhou, China
    Circ J 72:1324-8. 2008
    ..The relationship between C-reactive protein (CRP) concentration and hypertension and interactions between CRP and other risk factors on hypertension have not been studied in Mongolian people of Inner Mongolia, China...
  70. ncbi request reprint [Prokaryotic expression of gene encoding Schistosoma japonicum SjE16 and its potential application in immunodiagnosis]
    Zhao jun Wang
    Department of Pathogenic Biology, Shanghai Second Medical University, Shanghai 200025
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 21:76-9. 2003
    ..To sub-clone and express the gene encoding Schistosoma japonicum calcium-binding protein (SjE16) and study its immunological response...
  71. ncbi request reprint [Cloning, expression and phylogenetic analysis of Schistosoma japonicum calcyphosine gene]
    Chuan Ju
    National Institute of Parasite Diseases, Chinese Centre for Disease Control and Prevention, Collaborating Center for Malaria, Schistosomiastis and Filariasis, Shanghai 200025, China
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 24:360-5. 2006
    ..To clone and express Schistosoma japonicum (Sj) calcyphosine gene, and purify the expressed protein...
  72. ncbi request reprint Zebrafish GAPDH can be used as a reference gene for expression analysis in cross-subfamily cloned embryos
    De Sheng Pei
    State Key Laboratory of Freshwater Ecology and Biotechnology, Wuhan 430072, China
    Anal Biochem 363:291-3. 2007
  73. ncbi request reprint Insight into the host-parasite interplay by proteomic study of host proteins copurified with the human parasite, Schistosoma japonicum
    Feng Liu
    Department of Chemistry, Fudan University and Chinese National Human Genome Center at Shanghai, Shanghai, P R China
    Proteomics 7:450-62. 2007
    ....
  74. ncbi request reprint Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P
    Ruijuan Xu
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    FASEB J 20:1813-25. 2006
    ..Taken together, these results suggest that haCER2 is important for the generation of S1P and S1P-mediated cell proliferation and survival, but that its overexpression may cause cell growth arrest due to an accumulation of sphingosine...
  75. ncbi request reprint Schistosome transcriptomes: new insights into the parasite and schistosomiasis
    Wei Hu
    Department of Tropical Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Trends Mol Med 10:217-25. 2004
    ..In addition, new potential vaccine candidates and drug targets have been predicted...
  76. ncbi request reprint Oncosis in human esophageal squamous cell carcinoma and its relationship with apoptosis and microvessel density
    Gao Feng Zhao
    Department of Thoracic Surgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
    Chin Med J (Engl) 120:1999-2001. 2007
    ..The aim of this study was to detect oncosis in human esophageal squamous cell carcinoma (ESCC), and to investigate its relationship with apoptosis and microvessel density (MVD)...
  77. pmc New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum
    Feng Liu
    Chinese National Human Genome Center, Shanghai, China
    PLoS Pathog 2:e29. 2006
    ....
  78. pmc The genomic determinants of alcohol preference in mice
    Boris Tabakoff
    Department of Pharmacology, University of Colorado Denver School of Medicine, Mail Stop F 8303, P O Box 6511, Aurora, CO 80045 0511, USA
    Mamm Genome 19:352-65. 2008
    ..The importance of olfactory cues, learning and memory formation (Pavlovian conditioning), and cortical executive function, for regulating alcohol intake by animals (including humans), is discussed...
  79. ncbi request reprint Expression of CLC-K chloride channels in the rat cochlea
    Chunyan Qu
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Suite 309, P O Box 250908, Charleston, SC 29425, USA
    Hear Res 213:79-87. 2006
    ..These data support the hypothesis that both isoforms of ClC-K are co-expressed in some cell membranes and account for the preservation of hearing in the presence of a mutation in only one channel isoform...
  80. ncbi request reprint The solution structure of Escherichia coli Wzb reveals a novel substrate recognition mechanism of prokaryotic low molecular weight protein-tyrosine phosphatases
    Ewen Lescop
    Beijing Nuclear Magnetic Resonance Center, College of Life Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    J Biol Chem 281:19570-7. 2006
    ..The current studies provide the structural basis for rational drug design against the pathogenic bacteria...
  81. ncbi request reprint Identification and characterization of engrafted human cells in human/goat xenogeneic transplantation chimerism
    Fanyi Zeng
    Shanghai Institute of Medical Genetics, Shanghai Children s Hospital, Shanghai Jiao Tong University, People s Republic of China
    DNA Cell Biol 24:403-9. 2005
    ..Our results demonstrate that this in utero xenograft model should be useful for expansion of human HSC and possibly for the evaluating the effectiveness of prenatal treatment of human genetic diseases...
  82. ncbi request reprint Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9
    Elizabeth J Blink
    Nuclear Signalling Laboratory, Division for Biochemistry and Molecular Biology, John Curtin School of Medical Research, Canberra City, Australia
    J Cell Biochem 95:598-610. 2005
    ..We conclude that GrB nuclear import exhibits complex regulation by IMPs; that heterodimerization with PI-9 can modulate the interaction has implications for protection against apoptosis...
  83. doi request reprint Structure, organization and expression of common carp (Cyprinus carpio L.) SLP-76 gene
    Rong Huang
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Fish Shellfish Immunol 24:530-41. 2008
    ..These results suggest that the expression level of SLP-76 gene may be related to thymocyte development in teleosts...
  84. pmc Golgi fragmentation is associated with ceramide-induced cellular effects
    Wei Hu
    Department of Medicine and Biochemistry, Medical University of South Carolina, Charleston, SC 28425, USA
    Mol Biol Cell 16:1555-67. 2005
    ..Together, these results suggest that sphingosine generated from hydrolysis of ceramide causes the GC disruption, leading to various cellular effects...
  85. ncbi request reprint Cloning and expression analysis in mature individuals of two chicken type-II GnRH (cGnRH-II) genes in common carp (Cyprinus carpio)
    Shuangfei Li
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Sci China C Life Sci 47:349-58. 2004
    ..Then, the expression of cGnRH-II genes in pituitary and gonad suggested that cGnRH-II might act as the autocrine or paracrine regulator...
  86. pmc Identification of nuclear import and export signals within Fli-1: roles of the nuclear import signals in Fli-1-dependent activation of megakaryocyte-specific promoters
    Wei Hu
    Centre for Thrombosis and Vascular Research, Department of Medicine, SXt George Clinical School, University of New South Wales, Sydney, New South Wales 2217, Australia
    Mol Cell Biol 25:3087-108. 2005
    ....
  87. ncbi request reprint [Study on the relationship between hepatitis C virus infection and sharing injection equipment, sexual behavior among injecting drug users]
    Feng Zhou
    Peking Union Medical College, Union School of Public Health, Beijing 100021, China
    Zhonghua Liu Xing Bing Xue Za Zhi 25:329-32. 2004
    ..To study hepatitis C virus (HCV) transmission through different modes of sharing injection equipment and sexual behavior among injecting drug users (IDUs) in Liangshan of Sichuan province...
  88. ncbi request reprint A high-throughput model for screening anti-tumor agents capable of promoting polymerization of tubulin in vitro
    Wei Hu
    State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Ji nan 250100, China
    Acta Pharmacol Sin 25:775-82. 2004
    ..To establish a high-throughput model for screening anti-tumor agents capable of promoting the polymerization of tubulin in vitro...
  89. ncbi request reprint [Reversion of multidrug resistance (MDR) in human glioma cells by RNA interference (RNAi)]
    Peng Zhao
    Beijing Neurosurgical Institute, Beijing 100050, China
    Zhonghua Zhong Liu Za Zhi 28:183-7. 2006
    ..To explore whether the constructed vector of short haprin in vivo can induce human glioma cell line BT325 to produce RNAi duplexes and reverse the expression of MDR1 gene...
  90. ncbi request reprint Cyclo-oxygenases and prostaglandins in acute inflammatory demyelination of the peripheral nerve
    Wei Hu
    Department of Neurology, Research Group for Clinical and Experimental Neuroimmunology, Heinrich Heine University, Dusseldorf, Germany
    Neurology 61:1774-9. 2003
    ..To investigate the expression of cyclo-oxygenases (COX), key enzymes in propagating inflammatory responses by converting arachidonic acid to prostaglandins, in inflammatory demyelinating disorders of the peripheral nervous system (PNS)...