Gareth R Howell

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. pmc Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, Maine, USA
    BMC Genet 8:45. 2007
  2. pmc Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma
    Gareth R Howell
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA Electronic address
    Neurobiol Dis 71:44-52. 2014
  3. pmc Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease
    Harriet M Jackson
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    BMC Genomics 14:831. 2013
  4. pmc Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice
    Gareth R Howell
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
    J Neuroinflammation 10:76. 2013
  5. pmc Intrinsic axonal degeneration pathways are critical for glaucomatous damage
    Gareth R Howell
    The Howard Hughes Medical Institute, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Exp Neurol 246:54-61. 2013
  6. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
  7. pmc Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma
    Gareth R Howell
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    J Clin Invest 121:1429-44. 2011
  8. pmc Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma
    Gareth R Howell
    Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Clin Invest 122:1246-61. 2012
  9. doi request reprint Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection
    Gareth R Howell
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Prog Brain Res 173:303-21. 2008
  10. pmc Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease
    Ileana Soto
    The Jackson Laboratory, Bar Harbor, ME, USA Department of Biological Science, Rowan University, Glassboro, NJ, USA Department of Biomedical and Translational Sciences, Rowan University, Glassboro, NJ, USA
    Neurobiol Aging 42:50-60. 2016

Collaborators

Detail Information

Publications24

  1. pmc Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, Maine, USA
    BMC Genet 8:45. 2007
    ..We have shown previously that mutations in two genes, Gpnmb and Tyrp1, initiate the iris disease. However, mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear...
  2. pmc Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma
    Gareth R Howell
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA Electronic address
    Neurobiol Dis 71:44-52. 2014
    ..Remarkably, 80% of DBA/2J eyes subjected to this combined inhibition developed no detectable glaucoma. This opens an exciting new avenue for neuroprotection in glaucoma. ..
  3. pmc Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease
    Harriet M Jackson
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    BMC Genomics 14:831. 2013
    ..To identify these early events we used transcriptional profiling of mouse brains combined with computational approaches including singular value decomposition and hierarchical clustering...
  4. pmc Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice
    Gareth R Howell
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
    J Neuroinflammation 10:76. 2013
    ....
  5. pmc Intrinsic axonal degeneration pathways are critical for glaucomatous damage
    Gareth R Howell
    The Howard Hughes Medical Institute, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Exp Neurol 246:54-61. 2013
    ..For developing new therapies, it will be necessary to clearly define and order the molecular events that lead from glaucomatous insults to axon degeneration. ..
  6. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
    ..These experiments provide strong evidence for a local insult to axons in the optic nerve...
  7. pmc Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma
    Gareth R Howell
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    J Clin Invest 121:1429-44. 2011
    ..Targeting early molecular events, such as complement and endothelin induction, may provide effective new treatments for human glaucoma...
  8. pmc Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma
    Gareth R Howell
    Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Clin Invest 122:1246-61. 2012
    ..Together, these data support a model of glaucomatous damage involving monocyte entry into the optic nerve...
  9. doi request reprint Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection
    Gareth R Howell
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Prog Brain Res 173:303-21. 2008
    ..We describe how mouse models are adding to both the understanding of glaucomatous neurodegeneration and the development of neuroprotective strategies...
  10. pmc Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease
    Ileana Soto
    The Jackson Laboratory, Bar Harbor, ME, USA Department of Biological Science, Rowan University, Glassboro, NJ, USA Department of Biomedical and Translational Sciences, Rowan University, Glassboro, NJ, USA
    Neurobiol Aging 42:50-60. 2016
    ..APB(Tg) mice. Neuronal cell loss corresponds with a significant decrease in plaque-associated microvessels, further supporting a synergistic effect of vascular compromise and amyloid deposition on neuronal cell dysfunction in AD. ..
  11. pmc Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data
    Gareth R Howell
    The Howard Hughes Medical Institute, Bar Harbor, Maine, USA
    BMC Genomics 12:429. 2011
    ..This reusable software system complements existing repositories such as NCBI GEO or EBI ArrayExpress as it allows the construction of searchable databases to maximize understanding of user-selected transcription profiling datasets...
  12. pmc Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model
    Richard T Libby
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    BMC Neurosci 8:108. 2007
    ..To test the importance of NOS2 for an inherited glaucoma, in this study we both genetically and pharmacologically decreased NOS2 activity in the DBA/2J mouse glaucoma model...
  13. pmc Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases
    Laura G Reinholdt
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 7:e50081. 2012
    ..We also demonstrate the utility of DBA/2J ES cells with the creation of conditional knockout allele for Endothelin-2 (Edn2) directly on the DBA/2J strain background...
  14. pmc DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease
    Harriet M Jackson
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 10:e0125897. 2015
    ..APPswePSEN1de9 mice. The reduction in plaque deposition appears to be independent of microglia numbers, reactive astrocytosis and complement C5 activity. ..
  15. pmc Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma
    Pete A Williams
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    PLoS ONE 8:e72282. 2013
    ..These data may highlight alternative pathways to retinal ganglion cell loss in DBA/2J glaucoma. ..
  16. pmc Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma
    Pete A Williams
    The Jackson Laboratory, Bar Harbor, ME, 04609, USA
    Mol Neurodegener 11:26. 2016
    ..In addition, recent evidence has shown the role of the complement cascade in synaptic pruning in glaucoma and other diseases...
  17. pmc APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction
    Ileana Soto
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Biol 13:e1002279. 2015
    ....
  18. pmc Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease
    Leah C Graham
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME, USA
    Sci Rep 6:21568. 2016
    ..This study lays the foundation to fully investigate the impact of a western diet on glial responses in aging and Alzheimer's disease. ..
  19. pmc DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation
    Ileana Soto
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 9:e107291. 2014
    ..This may be due to a DBA/2J-specific genetic modifier(s) that could provide novel and important avenues for developing new therapies for diabetic retinopathy and possibly glaucoma. ..
  20. pmc Toward more predictive genetic mouse models of Alzheimer's disease
    Kristen D Onos
    The Jackson Laboratory, Bar Harbor, ME, United States
    Brain Res Bull 122:1-11. 2016
    ..We summarize widely used biomarkers and behavioral tests for mouse models of AD and highlight best practices that will maximize translatability of preclinical findings. ..
  21. pmc Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice
    K Saidas Nair
    Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine, USA
    Nat Genet 43:579-84. 2011
    ..Together, these data suggest that alterations of this serine protease may contribute to a spectrum of human ocular conditions including reduced ocular size and ACG...
  22. pmc Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, Maine 04660, USA
    Genetics 175:699-707. 2007
    ..We speculate that TAPT1 is a downstream effector of HOXC8 that may act by transducing or transmitting extracellular information required for axial skeletal patterning during development...
  23. ncbi request reprint Identification of a cryptic lethal mutation in the mouse t(w73) haplotype
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genet Res 84:153-9. 2004
    ....
  24. ncbi request reprint The classical complement cascade mediates CNS synapse elimination
    Beth Stevens
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 131:1164-78. 2007
    ..These findings support a model in which unwanted synapses are tagged by complement for elimination and suggest that complement-mediated synapse elimination may become aberrantly reactivated in neurodegenerative disease...