Chen Gu

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Astrocytes differentially respond to inflammatory autoimmune insults and imbalances of neural activity
    Peter Jukkola
    Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Acta Neuropathol Commun 1:70. 2013
  2. pmc Kv3 channel assembly, trafficking and activity are regulated by zinc through different binding sites
    Yuanzheng Gu
    182 Rightmire Hall, 1060 Carmack Road, The Ohio State University, Columbus, OH 43210, USA
    J Physiol 591:2491-507. 2013
  3. pmc Alternative splicing regulates kv3.1 polarized targeting to adjust maximal spiking frequency
    Yuanzheng Gu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 287:1755-69. 2012
  4. ncbi The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting
    Chen Gu
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 52:803-16. 2006
  5. pmc Function and mechanism of axonal targeting of voltage-sensitive potassium channels
    Chen Gu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, USA
    Prog Neurobiol 94:115-32. 2011
  6. pmc Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons
    Chen Gu
    Department of Neuroscience and Center for Molecular Neurobiology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:25835-47. 2011
  7. pmc Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels
    Joshua Barry
    Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    J Cell Sci 126:2027-41. 2013
  8. pmc Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons
    Joshua Barry
    Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Dev Cell 28:117-31. 2014
  9. pmc Kinesin I transports tetramerized Kv3 channels through the axon initial segment via direct binding
    Mingxuan Xu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, OH 43210, USA
    J Neurosci 30:15987-6001. 2010
  10. ncbi A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels
    Chen Gu
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143 0725, USA
    Science 301:646-9. 2003

Collaborators

  • YUH JAN
  • Peter J Mohler
  • HOWARD GU
  • Andrei Goga
  • Wei Zhou
  • Manojkumar A Puthenveedu
  • Yuanzheng Gu
  • Joshua Barry
  • Peter Jukkola
  • Mingxuan Xu
  • Bi Tzen Juang
  • Asa Gardner
  • Jill A Green
  • Peter I Jukkola
  • Brian O'Neill
  • Keerthi Thirtamara Rajamani
  • Karen E Smith
  • Noelle D L'Etoile
  • Tomás Guerrero
  • Andrew W Dangel
  • Francesca Palladino
  • Chandra Shrestha
  • Linda Starnes
  • Victoria Gray
  • Scott Kennedy
  • Amy E Lovett-Racke
  • David Terman
  • Scott S Zamvil
  • Robert McDougel
  • Kirk Mykytyn
  • Ruifeng Cao
  • Rui Xiao
  • Michael X Zhu
  • Kent A Fagan
  • Dermot M F Cooper
  • Biao Hu

Detail Information

Publications21

  1. pmc Astrocytes differentially respond to inflammatory autoimmune insults and imbalances of neural activity
    Peter Jukkola
    Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Acta Neuropathol Commun 1:70. 2013
    ..Astrocyte endfeet cover more than 90% of brain capillaries and interact with synapses and nodes of Ranvier. The roles of astrocytes in neurovascular coupling in the CNS remain poorly understood...
  2. pmc Kv3 channel assembly, trafficking and activity are regulated by zinc through different binding sites
    Yuanzheng Gu
    182 Rightmire Hall, 1060 Carmack Road, The Ohio State University, Columbus, OH 43210, USA
    J Physiol 591:2491-507. 2013
    ..Therefore, our studies provide novel mechanistic insights into the multifaceted regulation of Kv3 channel activity and localization by divalent heavy metal ions...
  3. pmc Alternative splicing regulates kv3.1 polarized targeting to adjust maximal spiking frequency
    Yuanzheng Gu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 287:1755-69. 2012
    ..Taken together, our studies have demonstrated that alternative splicing controls neuronal firing rates by regulating the polarized targeting of Kv3.1 channels...
  4. ncbi The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting
    Chen Gu
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 52:803-16. 2006
    ..In addition, we found that Kvbeta2 associates with KIF3/kinesin II as well. Indeed, Kv1 channels rely on both KIF3/kinesin II and EB1 for their axonal targeting...
  5. pmc Function and mechanism of axonal targeting of voltage-sensitive potassium channels
    Chen Gu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, USA
    Prog Neurobiol 94:115-32. 2011
    ..This research field can contribute to generating novel therapeutic strategies through manipulating neuronal excitability in treating neurological diseases, such as multiple sclerosis, neuropathic pain, and Alzheimer's disease...
  6. pmc Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons
    Chen Gu
    Department of Neuroscience and Center for Molecular Neurobiology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:25835-47. 2011
    ..This effect was eliminated by the Tyr⁴⁵⁸ mutation or by cholesterol depletion. Taken together, our studies suggest that myelin regulates both trafficking and activity of Kv1 channels along hippocampal axons through TAG-1...
  7. pmc Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels
    Joshua Barry
    Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    J Cell Sci 126:2027-41. 2013
    ....
  8. pmc Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons
    Joshua Barry
    Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Dev Cell 28:117-31. 2014
    ..2, channels in mouse cerebellum. These results indicate that AnkG functions as an adaptor to link Nav channels to KIF5 during axonal transport before anchoring them to the AIS and nodes of Ranvier. ..
  9. pmc Kinesin I transports tetramerized Kv3 channels through the axon initial segment via direct binding
    Mingxuan Xu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, OH 43210, USA
    J Neurosci 30:15987-6001. 2010
    ..1 channels colocalize and comove with KIF5B along axons revealed by two-color time-lapse imaging. Our findings suggest that the binding to KIF5 ensures properly assembled and functioning Kv3.1 channels to be transported into axons...
  10. ncbi A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels
    Chen Gu
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143 0725, USA
    Science 301:646-9. 2003
    ..Moreover, T1 mutations eliminating Kvbeta association compromised axonal targeting, but not surface expression, of CD4-T1 fusion proteins. Thus, proper association of Kvbeta with the Kv1 T1 domain is essential for axonal targeting...
  11. pmc Polarized targeting of L1-CAM regulates axonal and dendritic bundling in vitro
    Joshua Barry
    Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH, USA
    Eur J Neurosci 32:1618-31. 2010
    ..Taken together, our results suggest that precise localization of L1-CAM is important for establishing proper cell-cell contacts in neural circuits...
  12. pmc Dynamics of Kv1 channel transport in axons
    Yuanzheng Gu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio, USA
    PLoS ONE 5:e11931. 2010
    ..2 tetramers in axonal puncta. Taken together, our results suggest that proper amounts of Kv1 channels and their associated proteins are required for efficient transport of Kv1 channel proteins along axons...
  13. ncbi The axon-dendrite targeting of Kv3 (Shaw) channels is determined by a targeting motif that associates with the T1 domain and ankyrin G
    Mingxuan Xu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 27:14158-70. 2007
    ..1a and Kv3.1b. We conclude that the conditional ATM masked by the T1 domain in Kv3.1a is exposed by the splice domain in Kv3.1b, and is subsequently recognized by ankyrin G to target Kv3.1b into the axon...
  14. pmc Myelination of rodent hippocampal neurons in culture
    Asa Gardner
    Neuroscience Graduate Studies Program, The Ohio State University, Columbus, Ohio, USA
    Nat Protoc 7:1774-82. 2012
    ..This coculture is particularly useful for studying myelin-mediated regulation of ion channel trafficking and for understanding how neuronal excitability and synaptic transmission are regulated by myelination...
  15. pmc Coupling mechanical forces to electrical signaling: molecular motors and the intracellular transport of ion channels
    Joshua Barry
    The Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Neuroscientist 19:145-59. 2013
    ..These studies contribute to understanding how mechanical forces are coupled to electrical signaling and illuminating pathogenic mechanisms in neurodegenerative diseases...
  16. pmc Physiological and pathological functions of mechanosensitive ion channels
    Yuanzheng Gu
    Department of Neuroscience, Ohio State University, 182 Rightmire Hall, 1060 Carmack Road, Columbus, OH, USA
    Mol Neurobiol 50:339-47. 2014
    ..In sum, mechanosensation appears to be achieved in a variety of ways by different proteins and plays a fundamental role in the function of various organs under normal and abnormal conditions. ..
  17. pmc Regulation of neurovascular coupling in autoimmunity to water and ion channels
    Peter Jukkola
    Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Autoimmun Rev 14:258-67. 2015
    ..More channel proteins are found in astrocytes under normal and abnormal conditions. This research field will contribute to a better understanding of pathogenic mechanisms underlying autoimmune disorders. ..
  18. pmc Endogenous nuclear RNAi mediates behavioral adaptation to odor
    Bi Tzen Juang
    Departments of Cell and Tissue Biology and Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0512, USA
    Cell 154:1010-22. 2013
    ..This class of siRNA may act broadly as a rheostat allowing prolonged stimulation to dampen gene expression and promote cellular memory formation. PAPERFLICK: ..
  19. pmc K+ channel alterations in the progression of experimental autoimmune encephalomyelitis
    Peter I Jukkola
    Integrated Biomedical Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Neurobiol Dis 47:280-93. 2012
    ..Taken together, our studies reveal myelin-dependent and -independent alterations of Kv channels in the progression of EAE and lay a solid foundation for future study in search of a better treatment for MS...
  20. pmc Heteromerization of ciliary G protein-coupled receptors in the mouse brain
    Jill A Green
    Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 7:e46304. 2012
    ..As GPCR heteromerization can affect ligand binding properties as well as downstream signaling, our findings add an additional layer of complexity to neuronal ciliary signaling...
  21. ncbi Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry
    Karen E Smith
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:6025-31. 2002
    ....