THOMAS H GRIDLEY

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. pmc Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion
    Xuesong Feng
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 137:4191-9. 2010
  2. pmc Notch signaling regulates bile duct morphogenesis in mice
    Julie Lozier
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 3:e1851. 2008
  3. ncbi request reprint Notch signaling in vascular development and physiology
    Thomas Gridley
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Development 134:2709-18. 2007
  4. pmc Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects
    Hilda Lomeli
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma deMexico, Cuernavaca, Morelos, Mexico
    BMC Res Notes 2:22. 2009
  5. ncbi request reprint The long and short of it: somite formation in mice
    Thomas Gridley
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Dev Dyn 235:2330-6. 2006
  6. pmc Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 103:10300-4. 2006
  7. ncbi request reprint Snail1 gene function during early embryo patterning in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Cell Cycle 5:2566-70. 2006
  8. ncbi request reprint Notch signaling and inherited disease syndromes
    Thomas Gridley
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Hum Mol Genet 12:R9-13. 2003
  9. ncbi request reprint Kick it up a Notch: NOTCH1 activation in T-ALL
    Thomas Gridley
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Cancer Cell 6:431-2. 2004
  10. pmc Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genes Dev 18:2469-73. 2004

Research Grants

  1. GENETIC ANALYSIS OF THE NOTCH SIGNALING PATHWAY
    Thomas Gridley; Fiscal Year: 2007
  2. Modifiers of a Mouse Model of Alagille Syndrome
    Thomas Gridley; Fiscal Year: 2008

Collaborators

  • Brent McCright
  • Hiroshi Hamada
  • Yu Lan
  • Yukio Saijoh
  • Shigenori Nonaka
  • A Joutel
  • Kopan Raphael
  • R Kopan
  • Stephen A Murray
  • Luke T Krebs
  • Amy E Kiernan
  • Kathleen F Oram
  • Jingxia Xu
  • Ethan A Carver
  • Xuesong Feng
  • Hilda Lomeli
  • Julie Lozier
  • Gareth R Howell
  • Christa Starling
  • Mami Shindo
  • Stephen Murray
  • Gary A Churchill
  • Norman L Hawes
  • Lawriston A Wilson
  • Renhua Li
  • John C Schimenti
  • Ralf Cordes
  • Achim Gossler
  • Kenji Tanigaki
  • John R Shutter
  • Kevin L Stark
  • Tasuku Honjo
  • John P Sundberg
  • Naomi Iwai
  • Rulang Jiang
  • Yingzi Xue
  • Ian C Welsh
  • Christine R Norton
  • Paul Beatus
  • TIMOTHY P O'BRIEN
  • Urban Lendahl

Detail Information

Publications25

  1. pmc Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion
    Xuesong Feng
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 137:4191-9. 2010
    ..This new model for a common congenital heart defect provides novel insights into the genetic programs that underlie ductus arteriosus development and closure...
  2. pmc Notch signaling regulates bile duct morphogenesis in mice
    Julie Lozier
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 3:e1851. 2008
    ..However, our previous study did not establish whether bile duct paucity in Jag1/Notch2 double heterozygous mice resulted from impaired differentiation of bile duct precursor cells, or from defects in bile duct morphogenesis...
  3. ncbi request reprint Notch signaling in vascular development and physiology
    Thomas Gridley
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Development 134:2709-18. 2007
    ..Defects in Notch signaling also cause inherited vascular and cardiovascular diseases. In this review, I summarize recent findings and discuss the growing relevance of Notch pathway modulation for therapeutic applications in disease...
  4. pmc Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects
    Hilda Lomeli
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma deMexico, Cuernavaca, Morelos, Mexico
    BMC Res Notes 2:22. 2009
    ..Here we describe phenotypic defects that result in death of the mutant embryos by 9.5 days of gestation...
  5. ncbi request reprint The long and short of it: somite formation in mice
    Thomas Gridley
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Dev Dyn 235:2330-6. 2006
    ....
  6. pmc Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 103:10300-4. 2006
    ....
  7. ncbi request reprint Snail1 gene function during early embryo patterning in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Cell Cycle 5:2566-70. 2006
    ..These results shed new light on the role of Snail family genes in early mouse development, and raise interesting questions concerning the diversity of gene function among vertebrate species...
  8. ncbi request reprint Notch signaling and inherited disease syndromes
    Thomas Gridley
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Hum Mol Genet 12:R9-13. 2003
    ..Mouse models for these three diseases have been developed, and are leading to novel insights into the pathology of these diseases in humans...
  9. ncbi request reprint Kick it up a Notch: NOTCH1 activation in T-ALL
    Thomas Gridley
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Cancer Cell 6:431-2. 2004
    ..A recent paper by Weng et al. (2004) demonstrates that novel types of activating mutations in the NOTCH1 gene occur in more than half of all T-ALL cases, implicating NOTCH1 as a major player in the etiology of T-ALL...
  10. pmc Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genes Dev 18:2469-73. 2004
    ..These results demonstrate that vascular remodeling in the mouse embryo is sensitive to Dll4 gene dosage and that Notch activation in endothelial cells is essential for embryonic vascular remodeling...
  11. pmc Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, Maine 04660, USA
    Genetics 175:699-707. 2007
    ..We speculate that TAPT1 is a downstream effector of HOXC8 that may act by transducing or transmitting extracellular information required for axial skeletal patterning during development...
  12. ncbi request reprint A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency
    Brent McCright
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Development 129:1075-82. 2002
    ....
  13. ncbi request reprint Generation of a Snail1 (Snai1) conditional null allele
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genesis 44:7-11. 2006
    ..This conditional null allele will enable investigation of Snai1 function in a variety of developmental and pathological contexts...
  14. ncbi request reprint The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 132:4353-62. 2005
    ..Our results demonstrate that the Notch pathway plays a dual role in regulating cellular differentiation and patterning in the cochlea, acting both through lateral inhibition and the control of cellular proliferation...
  15. ncbi request reprint Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genesis 37:139-43. 2003
    ..These data demonstrate that the Notch3 gene is not essential for embryonic development or fertility in mice, and does not have a redundant function with the Notch1 gene during early embryogenesis...
  16. pmc Notch signaling regulates left-right asymmetry determination by inducing Nodal expression
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genes Dev 17:1207-12. 2003
    ..Our results demonstrate that Dll1-mediated Notch signaling is essential for generation of left-right asymmetry, and that the Notch pathway acts upstream of Nodal expression during left-right asymmetry determination in mice...
  17. ncbi request reprint Slug expression during organogenesis in mice
    Kathleen F Oram
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Anat Rec A Discov Mol Cell Evol Biol 271:189-91. 2003
    ..It is also highly expressed in craniofacial mesenchyme, in bone of both mesodermal and neural crest origin, and in the outflow tract and the endocardial cushions of the heart...
  18. ncbi request reprint Multiple functions of Snail family genes during palate development in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 134:1789-97. 2007
    ....
  19. pmc Notch signaling in the vasculature
    Thomas Gridley
    The Jackson Laboratory, Bar Harbor, ME, USA
    Curr Top Dev Biol 92:277-309. 2010
    ..This review summarizes recent studies that highlight the multiple roles the Notch signaling pathway plays during vascular development and physiology...
  20. pmc The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, Maine, USA
    PLoS Genet 2:e4. 2006
    ..These data demonstrate that JAG1-mediated Notch signaling is essential during early development for establishing the prosensory regions of the inner ear...
  21. pmc Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genetics 177:307-11. 2007
    ..Genome scans of N2 backcross mice identified a significant modifier locus on chromosome 7, as well as a suggestive locus on chromosome 14. We also analyzed modifiers of an eye defect in Jag1del1 heterozygous mice from this same cross...
  22. ncbi request reprint Generation of new Notch2 mutant alleles
    Brent McCright
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genesis 44:29-33. 2006
    ....
  23. pmc Mutations in snail family genes enhance craniosynostosis of Twist1 haplo-insufficient mice: implications for Saethre-Chotzen Syndrome
    Kathleen F Oram
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genetics 170:971-4. 2005
    ....
  24. pmc Generation of mice with a conditional null allele of the Jagged2 gene
    Jingxia Xu
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genesis 48:390-3. 2010
    ..This Jag2 conditional null allele will enable investigation of Jag2 function in a variety of tissue-specific contexts...
  25. ncbi request reprint Craniosynostosis in Twist heterozygous mice: a model for Saethre-Chotzen syndrome
    Ethan A Carver
    Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Anat Rec 268:90-2. 2002
    ....

Research Grants2

  1. GENETIC ANALYSIS OF THE NOTCH SIGNALING PATHWAY
    Thomas Gridley; Fiscal Year: 2007
    ..These studies will further our understanding of the roles of the Notch signaling pathway in mammalian development, and will be applicable to the study of both normal development and birth defects in humans. ..
  2. Modifiers of a Mouse Model of Alagille Syndrome
    Thomas Gridley; Fiscal Year: 2008
    ..These studies will enable us to create more representative mouse models of Alagille syndrome, and should provide insight into the variable phenotypic expression observed in Alagille syndrome patients. [unreadable] [unreadable]..