Elodie Ghedin

Summary

Affiliation: The Institute for Genomic Research
Country: USA

Publications

  1. ncbi request reprint Gene synteny and evolution of genome architecture in trypanosomatids
    Elodie Ghedin
    Parasity Genomics, The Institute for Genomics Research, 9712 Medical Center Dr Rockville, MD 20850, USA
    Mol Biochem Parasitol 134:183-91. 2004
  2. pmc Use of a multi-virus array for the study of human viral and retroviral pathogens: gene expression studies and ChIP-chip analysis
    Elodie Ghedin
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Retrovirology 1:10. 2004
  3. ncbi request reprint First sequenced genome of a parasitic nematode
    Elodie Ghedin
    Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Trends Parasitol 20:151-3. 2004
  4. ncbi request reprint The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
    Najib M El-Sayed
    Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA
    Science 309:409-15. 2005
  5. ncbi request reprint Comparative genomics of trypanosomatid parasitic protozoa
    Najib M El-Sayed
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:404-9. 2005
  6. pmc Mimivirus relatives in the Sargasso sea
    Elodie Ghedin
    Department of Parasite and Virus Genomics, The Institute for Genomic Research, Rockville, MD 20850, USA
    Virol J 2:62. 2005
  7. ncbi request reprint Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes
    Julie C Dunning Hotopp
    Institute for Genomic Research, J Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 317:1753-6. 2007
  8. pmc The sequence and analysis of Trypanosoma brucei chromosome II
    Najib M A El-Sayed
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Nucleic Acids Res 31:4856-63. 2003
  9. pmc Viral genome sequencing by random priming methods
    Appolinaire Djikeng
    Viral Genomics Group, J, Craig Venter Institute, Rockville, MD 20850, USA
    BMC Genomics 9:5. 2008
  10. ncbi request reprint Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution
    Elodie Ghedin
    The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
    Nature 437:1162-6. 2005

Detail Information

Publications38

  1. ncbi request reprint Gene synteny and evolution of genome architecture in trypanosomatids
    Elodie Ghedin
    Parasity Genomics, The Institute for Genomics Research, 9712 Medical Center Dr Rockville, MD 20850, USA
    Mol Biochem Parasitol 134:183-91. 2004
    ..major by examining the regions near breakage points of the synteny. This is the first such element found in L. major suggesting that retroelements were found in the common ancestor of all three species...
  2. pmc Use of a multi-virus array for the study of human viral and retroviral pathogens: gene expression studies and ChIP-chip analysis
    Elodie Ghedin
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Retrovirology 1:10. 2004
    ..Therefore, a multi-virus array containing eight human viruses implicated in AIDS pathogenesis was developed and its efficacy in various applications was characterized...
  3. ncbi request reprint First sequenced genome of a parasitic nematode
    Elodie Ghedin
    Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Trends Parasitol 20:151-3. 2004
  4. ncbi request reprint The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
    Najib M El-Sayed
    Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA
    Science 309:409-15. 2005
    ....
  5. ncbi request reprint Comparative genomics of trypanosomatid parasitic protozoa
    Najib M El-Sayed
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:404-9. 2005
    ..Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont...
  6. pmc Mimivirus relatives in the Sargasso sea
    Elodie Ghedin
    Department of Parasite and Virus Genomics, The Institute for Genomic Research, Rockville, MD 20850, USA
    Virol J 2:62. 2005
    ..Their isolation and genome sequencing could prove invaluable in understanding the origin and diversity of large DNA viruses, and shed some light on the role they eventually played in the emergence of eukaryotes...
  7. ncbi request reprint Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes
    Julie C Dunning Hotopp
    Institute for Genomic Research, J Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 317:1753-6. 2007
    ..Therefore, heritable lateral gene transfer occurs into eukaryotic hosts from their prokaryote symbionts, potentially providing a mechanism for acquisition of new genes and functions...
  8. pmc The sequence and analysis of Trypanosoma brucei chromosome II
    Najib M A El-Sayed
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Nucleic Acids Res 31:4856-63. 2003
    ....
  9. pmc Viral genome sequencing by random priming methods
    Appolinaire Djikeng
    Viral Genomics Group, J, Craig Venter Institute, Rockville, MD 20850, USA
    BMC Genomics 9:5. 2008
    ..Of increasing importance therefore is a better understanding of global viral diversity to enable better surveillance and prediction of pandemic threats; this will require rapid and flexible methods for complete viral genome sequencing...
  10. ncbi request reprint Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution
    Elodie Ghedin
    The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
    Nature 437:1162-6. 2005
    ..All data from this project are being deposited, without delay, in public archives...
  11. ncbi request reprint A virus with big ambitions
    Elodie Ghedin
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Trends Microbiol 13:56-7. 2005
  12. ncbi request reprint The Trypanosoma cruzi L1Tc and NARTc non-LTR retrotransposons show relative site specificity for insertion
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, UMR 5162 Centre National de la Recherche Scientifique, Universite Victor Segalen Bordeaux 2, Bordeaux Cedex, France
    Mol Biol Evol 23:411-20. 2006
    ..This analysis clearly indicates that the L1Tc and NARTc elements display relative site specificity for insertion, which suggests that the APE activity is not responsible for first-strand cleavage of the target site...
  13. pmc Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918
    Martha I Nelson
    Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS Pathog 4:e1000012. 2008
    ..Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized...
  14. pmc Stochastic processes are key determinants of short-term evolution in influenza a virus
    Martha I Nelson
    Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS Pathog 2:e125. 2006
    ..Thus, predicting future patterns of influenza virus evolution for vaccine strain selection is inherently complex and requires intensive surveillance, whole-genome sequencing, and phenotypic analysis...
  15. pmc Members of a large retroposon family are determinants of post-transcriptional gene expression in Leishmania
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    PLoS Pathog 3:1291-307. 2007
    ..To our knowledge, this is the first example in eukaryotes of the domestication and expansion of a family of mobile elements that have evolved to fulfill a critical cellular function...
  16. ncbi request reprint Identification of non-autonomous non-LTR retrotransposons in the genome of Trypanosoma cruzi
    Frederic Bringaud
    Laboratoire de Parasitologie Moleculaire, Université Victor Segalen Bordeaux II, UMR 5016 CNRS, 146 rue Leo Saignat, Bordeaux, France
    Mol Biochem Parasitol 124:73-8. 2002
    ..In addition, the genome of Leishmania major contains the same conserved motif present in the trypanosome retroelements, whicle no transposable elements have been detected so far in Leishmania sp...
  17. pmc Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses
    Edward C Holmes
    Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA
    PLoS Biol 3:e300. 2005
    ....
  18. ncbi request reprint The genome of the African trypanosome Trypanosoma brucei
    Matthew Berriman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Science 309:416-22. 2005
    ..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified...
  19. ncbi request reprint Mechanisms of HTLV-1 transformation
    Kylene Kehn
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
    Front Biosci 9:2347-72. 2004
    ..Animal models of both Tax and the accessory proteins are also included based on the essential information on the transformation process in vivo that they provide...
  20. pmc The evolutionary genetics and emergence of avian influenza viruses in wild birds
    Vivien G Dugan
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 4:e1000076. 2008
    ....
  21. ncbi request reprint A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling
    David B Guiliano
    Department of Biological Sciences, Imperial College of Science and Technology, London SW7 2AY, UK
    Mol Biochem Parasitol 136:227-42. 2004
    ....
  22. pmc The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode
    Jeremy Foster
    Molecular Parasitology Division, New England Biolabs, Beverly, Massachusetts, USA
    PLoS Biol 3:e121. 2005
    ..Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosymbiont evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease...
  23. ncbi request reprint Genomic and proteomic approaches for Chagas' disease: critical analysis of diagnostic methods
    Jorge A Huete-Pérez
    Sandler Center for Basic Research in Parasitic Diseases, University of California, QB3 Building, Box 2550, 1700 4 Street, San Francisco, CA 94143, USA
    Expert Rev Mol Diagn 5:521-30. 2005
    ..These advances will certainly bring about major developments not only in our understanding of Trypanosoma cruzi biology, but also in the application of new technologies to disease prevention and control...
  24. ncbi request reprint The ingi and RIME non-LTR retrotransposons are not randomly distributed in the genome of Trypanosoma brucei
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, UMR 5162 CNRS, Université Victor Segalen Bordeaux II, Bordeaux, France
    Mol Biol Evol 21:520-8. 2004
    ..In conclusion, the ingi and RIME retroelements are not randomly distributed in the genome of T. brucei and are preceded by a conserved sequence, which may be the recognition site of the ingi-encoded endonuclease...
  25. ncbi request reprint Evolution of non-LTR retrotransposons in the trypanosomatid genomes: Leishmania major has lost the active elements
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, Universite Victor Segalen Bordeaux 2, UMR 5162 CNRS, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Mol Biochem Parasitol 145:158-70. 2006
    ....
  26. doi request reprint Role of transposable elements in trypanosomatids
    Frederic Bringaud
    Laboratoire de Résonance Magnétique des Systèmes Biologiques, Universite Victor Segalen Bordeaux 2, UMR 5536 CNRS, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Microbes Infect 10:575-81. 2008
    ..In this review, we highlight the remarkable role extinct transposable elements can play as the source of potential new functions...
  27. ncbi request reprint Genes encoding putative biogenic amine receptors in the parasitic nematode Brugia malayi
    Katherine A Smith
    Department of Biological Sciences, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, USA
    Invert Neurosci 7:227-44. 2007
    ..Our results provide a framework for how G-protein coupled receptors may be targeted for drug development in medically important parasitic nematodes...
  28. pmc Mining predicted essential genes of Brugia malayi for nematode drug targets
    Sanjay Kumar
    Division of Parasitology, New England Biolabs, Inc, Ipswich, Massachusetts, United States of America
    PLoS ONE 2:e1189. 2007
    ..By virtue of the selection procedure, the potential B. malayi drug targets highlight components of key processes in nematode biology such as central metabolism, molting and regulation of gene expression...
  29. pmc Draft genome of the filarial nematode parasite Brugia malayi
    Elodie Ghedin
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Science 317:1756-60. 2007
    ..malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design...
  30. pmc Sequences necessary for trans-splicing in transiently transfected Brugia malayi
    Canhui Liu
    Gorgas Center for Geographic Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Biochem Parasitol 156:62-73. 2007
    ..malayi genes found homologues for the BmHSP70 TSM in roughly 25%. Thus, while the BmHSP70 TSM is necessary and sufficient to direct trans-splicing in some genomic contexts, independent trans-splicing signals are employed by other genes...
  31. pmc Genome analysis linking recent European and African influenza (H5N1) viruses
    Steven L Salzberg
    University of Maryland Center for Bioinformatics and Computational Biology, College Park, Maryland 20742, USA
    Emerg Infect Dis 13:713-8. 2007
    ..One isolate provides evidence that 2 of these sublineages have recently reassorted...
  32. pmc Biologic, antigenic, and full-length genomic characterization of a bovine-like coronavirus isolated from a giraffe
    Mustafa Hasoksuz
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    J Virol 81:4981-90. 2007
    ..Our results confirm the existence of a bovine-like CoV transmissible to cattle from wild ruminants, namely, giraffes, but with certain genetic properties different from those of BCoVs...
  33. ncbi request reprint Detection of HHV-6B in post-mortem central nervous system tissue of a post-bone marrow transplant recipient: a multi-virus array analysis
    Karen Yao
    Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Virol 37:S57-62. 2006
    ..HHV-6 has been implicated in a number of neurological disorders. Recent evidence has suggested high incidence of HHV-6 infection in patients (46%) undergoing allogeneic bone marrow transplant (BMT)...
  34. pmc Complete genomic sequences, a key residue in the spike protein and deletions in nonstructural protein 3b of US strains of the virulent and attenuated coronaviruses, transmissible gastroenteritis virus and porcine respiratory coronavirus
    Xinsheng Zhang
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Ave, Wooster, OH 44691, USA
    Virology 358:424-35. 2007
    ..Phylogenetic analyses showed that virulence is an evolutionarily labile trait in TGEV and that TGEV strains as a group share a common ancestor with PRCV...
  35. ncbi request reprint Differential HHV-6A gene expression in T cells and primary human astrocytes based on multi-virus array analysis
    Karen Yao
    Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Glia 53:789-98. 2006
    ....
  36. ncbi request reprint Molecular dissection of the functional domains of a unique, tartrate-resistant, surface membrane acid phosphatase in the primitive human pathogen Leishmania donovani
    Alison M Shakarian
    Cell Biology Section, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    J Biol Chem 277:17994-8001. 2002
    ..Further, we used a variety of green fluorescent protein chimeric constructs as reporters in a homologous leishmanial expression system to dissect the functional domains of this unique, tartrate-resistant, surface membrane enzyme...
  37. ncbi request reprint Role of viral regulatory and accessory proteins in HIV-1 replication
    Anila Seelamgari
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
    Front Biosci 9:2388-413. 2004
    ..In this review, we attempt to integrate information on the role of these regulatory and accessory proteins, emphasizing their interactions with other viral and cellular components, and the subsequent effect on viral replication...
  38. pmc Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States
    Martha I Nelson
    Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS Pathog 4:e1000133. 2008
    ....