J Christopher Edgar

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc Superior temporal gyrus spectral abnormalities in schizophrenia
    J Christopher Edgar
    Department of Psychology, Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Psychophysiology 45:812-24. 2008
  2. doi request reprint Resting-state alpha in autism spectrum disorder and alpha associations with thalamic volume
    J Christopher Edgar
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Wood Building, Suite 2115, Philadelphia, PA, 10104, USA
    J Autism Dev Disord 45:795-804. 2015
  3. pmc Neuromagnetic oscillations predict evoked-response latency delays and core language deficits in autism spectrum disorders
    J Christopher Edgar
    Department of Radiology, Lurie Family Foundations MEG Imaging Center, The Children s Hospital of Philadelphia, Wood Bldg, Suite 2115, 34th St and Civic Center Blvd, Philadelphia, PA, 19104, USA
    J Autism Dev Disord 45:395-405. 2015
  4. pmc Temporal and frontal cortical thickness associations with M100 auditory activity and attention in healthy controls and individuals with schizophrenia
    J Christopher Edgar
    Department of Neuroradiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Schizophr Res 140:250-7. 2012
  5. pmc Depression and anxious apprehension distinguish frontocingulate cortical activity during top-down attentional control
    Rebecca Levin Silton
    Department of Psychology, University of Illinois at Urbana Champaign, IL, USA
    J Abnorm Psychol 120:272-85. 2011
  6. pmc MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism
    Timothy P L Roberts
    Department of Radiology, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Autism Res 3:8-18. 2010
  7. ncbi request reprint Cross-modal generality of the gating deficit
    J Christopher Edgar
    Department of Psychology and Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana Champaign, Urbana, IL 61820, USA
    Psychophysiology 42:318-27. 2005
  8. pmc Auditory magnetic mismatch field latency: a biomarker for language impairment in autism
    Timothy P L Roberts
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Biol Psychiatry 70:263-9. 2011
  9. pmc Maturational differences in thalamocortical white matter microstructure and auditory evoked response latencies in autism spectrum disorders
    Timothy P L Roberts
    Lurie Family Foundation s MEG Imaging Center, Department of Radiology, The Children s Hospital of Philadelphia, Wood Building, Suite 2115, 34th Street and Civic Center Boulevard, Philadelphia, PA, USA Electronic address
    Brain Res 1537:79-85. 2013
  10. pmc Time course of processing emotional stimuli as a function of perceived emotional intelligence, anxiety, and depression
    Joscelyn E Fisher
    Department of Psychology, University of Illinois at Urbana Champaign, USA
    Emotion 10:486-97. 2010

Collaborators

Detail Information

Publications42

  1. pmc Superior temporal gyrus spectral abnormalities in schizophrenia
    J Christopher Edgar
    Department of Psychology, Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Psychophysiology 45:812-24. 2008
    ..Compared to controls, patients with schizophrenia showed more low-frequency phase variability, and the decreased 100-ms S1 evoked response observed in patients was best predicted by the STG phase-locking measure...
  2. doi request reprint Resting-state alpha in autism spectrum disorder and alpha associations with thalamic volume
    J Christopher Edgar
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Wood Building, Suite 2115, Philadelphia, PA, 10104, USA
    J Autism Dev Disord 45:795-804. 2015
    ..The lack of thalamic and alpha associations in ASD suggests thalamic contributions to RS alpha abnormalities in ASD. ..
  3. pmc Neuromagnetic oscillations predict evoked-response latency delays and core language deficits in autism spectrum disorders
    J Christopher Edgar
    Department of Radiology, Lurie Family Foundations MEG Imaging Center, The Children s Hospital of Philadelphia, Wood Bldg, Suite 2115, 34th St and Civic Center Blvd, Philadelphia, PA, 19104, USA
    J Autism Dev Disord 45:395-405. 2015
    ....
  4. pmc Temporal and frontal cortical thickness associations with M100 auditory activity and attention in healthy controls and individuals with schizophrenia
    J Christopher Edgar
    Department of Neuroradiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Schizophr Res 140:250-7. 2012
    ..The present study sought to better understand GM abnormalities in SCZ by examining associations between GM and two putative functional SCZ biomarkers: weak 100 ms (M100) auditory responses and impairment on tests of attention...
  5. pmc Depression and anxious apprehension distinguish frontocingulate cortical activity during top-down attentional control
    Rebecca Levin Silton
    Department of Psychology, University of Illinois at Urbana Champaign, IL, USA
    J Abnorm Psychol 120:272-85. 2011
    ..Results indicate that depression and anxious apprehension modulate temporally and functionally distinct aspects of the frontocingulate network involved in top-down attention control...
  6. pmc MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism
    Timothy P L Roberts
    Department of Radiology, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Autism Res 3:8-18. 2010
    ..Given similar findings in language impaired and non-language impaired ASD subjects, a right-hemisphere M100 latency delay appears to be an electrophysiological endophenotype for autism...
  7. ncbi request reprint Cross-modal generality of the gating deficit
    J Christopher Edgar
    Department of Psychology and Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana Champaign, Urbana, IL 61820, USA
    Psychophysiology 42:318-27. 2005
    ..Patients showed abnormal auditory M50 gating but normal somatosensory M20 gating. Results argue against a cross-modal gating deficit in primary somatosensory cortex...
  8. pmc Auditory magnetic mismatch field latency: a biomarker for language impairment in autism
    Timothy P L Roberts
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Biol Psychiatry 70:263-9. 2011
    ..The present study assessed associations between language impairment and the amplitude and latency of the superior temporal gyrus magnetic mismatch field (MMF) in response to changes in an auditory stream of tones or vowels...
  9. pmc Maturational differences in thalamocortical white matter microstructure and auditory evoked response latencies in autism spectrum disorders
    Timothy P L Roberts
    Lurie Family Foundation s MEG Imaging Center, Department of Radiology, The Children s Hospital of Philadelphia, Wood Building, Suite 2115, 34th Street and Civic Center Boulevard, Philadelphia, PA, USA Electronic address
    Brain Res 1537:79-85. 2013
    ....
  10. pmc Time course of processing emotional stimuli as a function of perceived emotional intelligence, anxiety, and depression
    Joscelyn E Fisher
    Department of Psychology, University of Illinois at Urbana Champaign, USA
    Emotion 10:486-97. 2010
    ..Depression was not differentially associated with any emotion processing stage indexed by ERPs. Research in this area may lead to the development of therapies that focus on minimization of anxiety to foster successful emotion regulation...
  11. pmc Time course of attentional bias in anxiety: emotion and gender specificity
    Sarah M Sass
    Department of Psychology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Psychophysiology 47:247-59. 2010
    ..Healthy controls showed gender differences at both early and later processing stages. The conjunction of valence, arousal, and gender is critical in the time course of attentional bias...
  12. pmc Attentional bias to negative emotion as a function of approach and withdrawal anger styles: an ERP investigation
    Jennifer L Stewart
    Department of Psychology, University of Arizona, Tucson, AZ 85721, USA
    Int J Psychophysiol 76:9-18. 2010
    ..Findings indicating that anger-out and anger-in were associated with divergent patterns of brain activity provide support for distinguishing approach- and withdrawal-related anger styles...
  13. ncbi request reprint Lateralization of auditory sensory gating and neuropsychological dysfunction in schizophrenia
    Robert J Thoma
    Psychiatry Service, Department of Radiology, New Mexico VA Health Care System, VAMC 116A, 1501 San Pedro SE, Albuquerque, NM 87108, USA
    Am J Psychiatry 160:1595-605. 2003
    ....
  14. pmc Frontal slow-wave activity as a predictor of negative symptoms, cognition and functional capacity in schizophrenia
    Yu Han Chen
    Yu Han Chen, PhD, The Children s Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia Breannan Stone Howell, MS, New Mexico Raymond G Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico J Christopher Edgar, PhD, The Children s Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California Cassandra Wootton, BS, New Mexico Raymond G Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico Michael A Hunter, BS, New Mexico Raymond G Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico Brett Y Lu, MD, PhD, Marseille
    Br J Psychiatry 208:160-7. 2016
    ..The frontal lobe is associated with negative symptoms and cognitive abilities such as attention, with negative symptoms and impaired attention associated with poor functional capacity...
  15. ncbi request reprint A parietal-frontal network studied by somatosensory oddball MEG responses, and its cross-modal consistency
    Ming Xiong Huang
    Department of Radiology, University of California, San Diego, 92103 8756, USA
    Neuroimage 28:99-114. 2005
    ....
  16. doi request reprint Developmental correlation of diffusion anisotropy with auditory-evoked response
    Timothy P L Roberts
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Neuroreport 20:1586-91. 2009
    ....
  17. pmc Cortical thickness as a contributor to abnormal oscillations in schizophrenia?
    J Christopher Edgar
    The Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA
    Neuroimage Clin 4:122-9. 2014
    ..Given changes in brain activity as a function of age, age-related associations in STG oscillatory activity were also examined...
  18. doi request reprint The time course of activity in dorsolateral prefrontal cortex and anterior cingulate cortex during top-down attentional control
    Rebecca Levin Silton
    Department of Psychology, University of Illinois at Urbana Champaign, Urbana, IL 61820, USA
    Neuroimage 50:1292-302. 2010
    ..Overall, results were consistent with the temporal course of regional brain function proposed by the cascade-of-control model...
  19. pmc Resting-state oscillatory activity in autism spectrum disorders
    Lauren Cornew
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children s Hospital of Philadelphia, 2nd Floor Wood Bldg, Room 2115, Mail Stop W02 1010, Philadelphia, PA 19104 4399, USA
    J Autism Dev Disord 42:1884-94. 2012
    ..Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest...
  20. pmc Validating γ oscillations and delayed auditory responses as translational biomarkers of autism
    Michael J Gandal
    Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104, USA
    Biol Psychiatry 68:1100-6. 2010
    ..This study assessed the translational potential of auditory evoked-response endophenotypes of autism in parallel mouse and human studies of autism...
  21. pmc Alpha-to-gamma phase-amplitude coupling methods and application to autism spectrum disorder
    Jeffrey I Berman
    1 Department of Radiology, Lurie Family Foundations MEG Imaging Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
    Brain Connect 5:80-90. 2015
    ..Finally, simulations and the human data highlighted the need to consider the interplay between alpha power, epoch length, and choice of signal processing methods on PAC estimates. ..
  22. pmc Variable bandwidth filtering for improved sensitivity of cross-frequency coupling metrics
    Jeffrey I Berman
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Brain Connect 2:155-63. 2012
    ..The variable bandwidth method of filtering an amplitude modulated signal is proposed to preserve amplitude modulation and enable accurate CFC measurements...
  23. pmc Electrophysiological signatures: magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders
    Timothy P L Roberts
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, United States
    Int J Psychophysiol 68:149-60. 2008
    ..These findings offer promise for the comprehensive assessment of developmental neuropsychiatric disorders...
  24. pmc Maturation of auditory neural processes in autism spectrum disorder - A longitudinal MEG study
    Russell G Port
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Neuroimage Clin 11:566-77. 2016
    ..The present study took a first step in examining magnetoencephalography (MEG) evidence of abnormal auditory response maturation in ASD via the use of a longitudinal design...
  25. pmc Translating Adult Electrophysiology Findings to Younger Patient Populations: Difficulty Measuring 40-Hz Auditory Steady-State Responses in Typically Developing Children and Children with Autism Spectrum Disorder
    J Christopher Edgar
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Dev Neurosci 38:1-14. 2016
    ....
  26. pmc Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia
    Michael J Gandal
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropharmacology 62:1504-18. 2012
    ..Finally, we propose that analogous signal-to-noise deficits in the flow of cortical information in preclinical models are useful targets for the development of new drugs that target the treatment-resistant symptoms of schizophrenia...
  27. ncbi request reprint Reduced auditory M100 asymmetry in schizophrenia and dyslexia: applying a developmental instability approach to assess atypical brain asymmetry
    J Christopher Edgar
    Department of Psychology and Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana Champaign, Urbana, IL 61820, and Center for Functional Imaging, New Mexico VA Healthcare System, Albuquerque, NM, USA
    Neuropsychologia 44:289-99. 2006
    ..Findings suggest that M100 positional asymmetry is not a diagnostically specific feature in several neurodevelopmental conditions. Continued research examining DI and brain asymmetry relationships is warranted...
  28. ncbi request reprint Normal Fetal Long Bone Length from Computed Tomography: Potential Value in the Prenatal Evaluation of Skeletal Dysplasias
    Teresa Victoria
    Radiology Department, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Fetal Diagn Ther . 2016
    ..Low-dose fetal computed tomography (CT) is a helpful adjunct in evaluating the fetus with severe abnormalities, but its use is limited by lack of data on normal fetal bone length...
  29. doi request reprint Auditory Evoked M100 Response Latency is Delayed in Children with 16p11.2 Deletion but not 16p11.2 Duplication
    Julian Jenkins
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cereb Cortex 26:1957-64. 2016
    ..Present results indicate that 16p11.2 deletion is associated with auditory processing delays analogous to (but substantially more pronounced than) those previously reported in "idiopathic" ASD. ..
  30. pmc On characterizing population commonalities and subject variations in brain networks
    Yasser Ghanbari
    Center for Biomedical Image Computing and Analytics, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States Electronic address
    Med Image Anal . 2015
    ..These hubs are then used to compare ASD and TDCs. Our method is generalizable to any population whose connectivity (structural or functional) can be captured via non-negative network graphs...
  31. doi request reprint Magnetoencephalography
    Erin Simon Schwartz
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Radiol 40:50-8. 2010
    ..Research applications that appear promising for near-future clinical translation include the evaluation of children with autism spectrum disorder, traumatic brain injury, and schizophrenia...
  32. doi request reprint Intra- and inter-observer variability of functional MR urography (fMRU) assessment in children
    Dmitry Khrichenko
    Department of Radiology, The Children s Hospital of Philadelphia CHOP, 34th Street and Civic Center Boulevard, Philadelphia, PA, 19104, USA
    Pediatr Radiol 46:666-73. 2016
    ..Functional MR urography (fMRU) provides comprehensive functional data that can be subject to variability. To interpret the results of fMRU, it is essential to know the intra- and inter-observer variability of the measured parameters...
  33. doi request reprint Comparison Between 1.5-T and 3-T MRI for Fetal Imaging: Is There an Advantage to Imaging With a Higher Field Strength?
    Teresa Victoria
    1 All authors Radiology Department, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 10104
    AJR Am J Roentgenol 206:195-201. 2016
    ..5 T and 3 T. We hypothesized that the visualization and anatomic detail of fetal structures would be better at 3 T than at 1.5 T...
  34. doi request reprint Lower Extremity Vascular Access in Neonates and Infants: A Single Institutional Experience
    Marian Gaballah
    Department of Radiology, Children s Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104 Electronic address
    J Vasc Interv Radiol 26:1660-8. 2015
    ..To demonstrate feasibility and evaluate outcomes of direct-stick saphenous and single-incision tunneled femoral noncuffed central venous catheters (CVCs) placed in a large series of neonates and infants at a single institution...
  35. ncbi request reprint Improved test-retest reliability of 50-ms paired-click auditory gating using magnetoencephalography source modeling
    Brett Y Lu
    Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico, USA
    Psychophysiology 44:86-90. 2007
    ..Paired-click gating ratio reliability can be improved by examining the individual PACs rather than composite scalp-recorded activity...
  36. pmc ECoG gamma activity during a language task: differentiating expressive and receptive speech areas
    Vernon L Towle
    Department of Neurology, MC 2030, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Brain 131:2013-27. 2008
    ....
  37. ncbi request reprint Time-frequency discriminant analysis of MEG signals
    Moon ho Ringo Ho
    Division of Psychology, School of Humanities and Social Sciences, Nanyang Avenue, Nanyang Technological University, Singapore
    Neuroimage 40:174-86. 2008
    ..The method was then applied to magnetoencephalographic data from a standard paired-click paradigm. Discrimination between individuals with schizophrenia and a healthy comparison group confirmed the utility of the method...
  38. ncbi request reprint Comparison of different cortical connectivity estimators for high-resolution EEG recordings
    Laura Astolfi
    Dipartimento Informatica e Sistemistica, Universita La Sapienza, Rome, Italy
    Hum Brain Mapp 28:143-57. 2007
    ....
  39. ncbi request reprint Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in schizophrenia
    Brett Y Lu
    Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico 87108, USA
    Biol Psychiatry 62:822-5. 2007
    ..The role of prefrontal dopamine on P50 gating was investigated, using catechol-O-methyltransferase (COMT) valine (val)(158)methionine (met) polymorphism as a predictor of prefrontal dopamine activity...
  40. ncbi request reprint Frequency domain analysis of human subdural recordings
    Vernon L Towle
    Department of Neurology, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Neurophysiol 24:205-13. 2007
    ....
  41. ncbi request reprint Efficacy of olanzapine and risperidone in schizophrenia: a randomized double-blind crossover design
    Jose M Canive
    Psychiatry Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA
    Psychopharmacol Bull 39:105-16. 2006
    ..Despite the small number of subjects, this study shows the potential of a within-subject design to elucidate differences in efficacy...
  42. ncbi request reprint Distinct M50 and M100 auditory gating deficits in schizophrenia
    Faith M Hanlon
    Center for Functional Brain Imaging, New Mexico VA Health Care System, Albuquerque, New Mexico 87108, USA
    Psychophysiology 42:417-27. 2005
    ..In contrast, a right-hemisphere M100 gating deficit was unrelated to M50 gating in either hemisphere. Investigations of interhemisphere gating relations may clarify group differences in regional connectivity and their role in gating...