Affiliation: The Salk Institute
- A simple white noise analysis of neuronal light responsesE J Chichilnisky
Systems Neurobiology, The Salk Institute, La Jolla, CA 92037 1099, USA
Network 12:199-213. 2001..Advantages and disadvantages of the technique relative to classical approaches are discussed...
- Information processing in the primate retina: circuitry and codingG D Field
The Salk Institute, La Jolla, California 92037, USA
Annu Rev Neurosci 30:1-30. 2007..The functional importance of this structure is revealed by computational analysis of encoding and decoding, an approach that may be applicable to understanding the function of other neural circuits...
- Functional connectivity in the retina at the resolution of photoreceptorsGreg D Field
Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 467:673-7. 2010..These measurements reveal computations in a neural circuit at the elementary resolution of individual neurons...
- Detection sensitivity and temporal resolution of visual signals near absolute threshold in the salamander retinaE J Chichilnisky
Systems Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
J Neurosci 25:318-30. 2005....
- Temporal resolution of ensemble visual motion signals in primate retinaE J Chichilnisky
Systems Neurobiology, The Salk Institute and University of California, San Diego, La Jolla, California 92037, USA
J Neurosci 23:6681-9. 2003..These findings suggest that cortical neurons could filter their inputs on a time scale of tens of milliseconds, rather than relying on the precise times of individual input spikes, to sense motion most reliably...
- Functional asymmetries in ON and OFF ganglion cells of primate retinaE J Chichilnisky
Systems Neurobiology, The Salk Institute, La Jolla, California 92037, USA
J Neurosci 22:2737-47. 2002..These findings suggest specific mechanistic asymmetries in retinal ON and OFF circuits and differences in visual performance on the basis of the activity of ON and OFF parasol cells...
- Trichromatic opponent color classificationE J Chichilnisky
Department of Psychology, Stanford University, CA 94305, USA
Vision Res 39:3444-58. 1999..The effect of background light on classification was largely explained by separate gain changes in increment and decrement cone signals...
- Receptive-field microstructure of blue-yellow ganglion cells in primate retinaE J Chichilnisky
Department of Neurobiology, Stanford University, School of Medicine, Stanford, California 94305, USA
Nat Neurosci 2:889-93. 1999..Neighboring BY cells received common but unequal inputs from one or more S cones. Inputs from individual S cones differed in strength, indicating different synaptic weights, and summed approximately linearly to control BY cell firing...
- Adaptation to temporal contrast in primate and salamander retinaD Chander
Systems Neurobiology, The Salk Institute, La Jolla, California 92037-1099, USA
J Neurosci 21:9904-16. 2001..Functionally defined subclasses of ON and OFF cells also exhibited asymmetric adaptation. These findings indicate that contrast adaptation differs in parallel retinal circuits that convey distinct visual signals to the brain...
- Fidelity of the ensemble code for visual motion in primate retinaE S Frechette
The Salk Institute and University of California, San Diego, USA
J Neurophysiol 94:119-35. 2005..These findings reveal how faithfully the retinal population code conveys information about stimulus speed and the consequences for motion sensing in the brain...
- Direction selectivity in the retina is established independent of visual experience and cholinergic retinal wavesJustin Elstrott
Neuroscience Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA
Neuron 58:499-506. 2008..These data suggest that direction selectivity in the retina is established largely independent of patterned activity and is therefore likely to emerge as a result of complex molecular interactions...
- Precision of spike trains in primate retinal ganglion cellsV J Uzzell
Systems Neurobiology, The Salk Institute, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
J Neurophysiol 92:780-9. 2004..These findings were consistent with a model in which firing probability was determined by a stimulus-driven free firing rate modulated by a recovery function representing the action potential absolute and relative refractory period...
- Electrical stimulation of mammalian retinal ganglion cells with multielectrode arraysChris Sekirnjak
The Salk Institute for Biological Studies, San Diego, California, USA
J Neurophysiol 95:3311-27. 2006..We review previous epiretinal stimulation studies and discuss our results in the context of 32 other publications, comparing threshold parameters and safety limits...
- High-resolution electrical stimulation of primate retina for epiretinal implant designChris Sekirnjak
Systems Neurobiology Laboratory, The Salk Institute for Biological Studies, San Diego, California 92037, USA
J Neurosci 28:4446-56. 2008..The low-threshold, temporally precise, and spatially specific responses hold promise for the application of high-density arrays of small electrodes in epiretinal implants...
- Receptive fields in primate retina are coordinated to sample visual space more uniformlyJeffrey L Gauthier
Salk Institute for Biological Studies, La Jolla, California, United States of America
PLoS Biol 7:e1000063. 2009..These results show that the primate retina encodes light with an exquisitely coordinated array of RF shapes, illustrating a higher degree of functional precision in the neural circuitry than previously appreciated...
- The structure of large-scale synchronized firing in primate retinaJonathon Shlens
The Salk Institute, La Jolla, California 92037, USA
J Neurosci 29:5022-31. 2009..In sum, large-scale synchronized firing in the entire population of ON-parasol cells appears to reflect simple neighbor interactions, rather than a unique visual signal or a highly redundant coding scheme...
- Spatial properties and functional organization of small bistratified ganglion cells in primate retinaGreg D Field
Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 27:13261-72. 2007..Thus, despite their distinctive morphology and chromatic properties, SBCs exhibit two features of other retinal ganglion cell types: center-surround antagonism and regular mosaic sampling of visual space...
- Estimating information rates with confidence intervals in neural spike trainsJonathon Shlens
Salk Institute, La Jolla, CA 92037, USA
Neural Comput 19:1683-719. 2007..Finally, we apply these ideas to a recording from a guinea pig retinal ganglion cell and compare results to a simple linear decoder...
- Correlated firing among major ganglion cell types in primate retinaMartin Greschner
Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA
J Physiol 589:75-86. 2011..Collectively, these results provide an overview of correlated firing across cell types in the primate retina, and constraints on the underlying mechanisms...
- The structure of multi-neuron firing patterns in primate retinaJonathon Shlens
Department of Systems Neurobiology, The Salk Institute, La Jolla, California 92037, USA
J Neurosci 26:8254-66. 2006..This approach provides a way to define limits on the complexity of network interactions and thus may be relevant for probing the function of many neural circuits...
- Cone inputs to simple and complex cells in V1 of awake macaqueGregory D Horwitz
Vision Center Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
J Neurophysiol 97:3070-81. 2007..These results extend the findings on distinctions between simple and complex cell chromatic tuning observed in previous studies in anesthetized monkeys...
- Blue-yellow signals are enhanced by spatiotemporal luminance contrast in macaque V1Gregory D Horwitz
Vision Center Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
J Neurophysiol 93:2263-78. 2005..These findings indicate that important aspects of the cortical representation of color cannot be described by classical linear analysis, and reveal a possible neural correlate of perceptual color-luminance interactions...
- High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retinaGreg D Field
Salk Institute for Biological Studies, La Jolla, California, USA
Nat Neurosci 12:1159-64. 2009..Third, rod input to SBCs may be the substrate for behavioral biases toward perception of blue at mesopic light levels...
- Loss of responses to visual but not electrical stimulation in ganglion cells of rats with severe photoreceptor degenerationChris Sekirnjak
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
J Neurophysiol 102:3260-9. 2009..These findings suggest that high-resolution epiretinal prosthetic devices may be effective in treating vision loss resulting from photoreceptor degeneration...
- Uniform signal redundancy of parasol and midget ganglion cells in primate retinaJeffrey L Gauthier
Salk Institute for Biological Studies, 10010 NorthTorrey Pines Road, La Jolla, CA 92037, USA
J Neurosci 29:4675-80. 2009....
- Seeing gray through the ON and OFF pathwaysE J Chichilnisky
Department of Neurobiology, Stanford University, CA 94305, USA
Vis Neurosci 13:591-6. 1996..We interpret these asymmetries as differences in mechanisms of adaptation in the ON and OFF pathways, and suggest that they evolved to accommodate the range and physical sources of color signals in the two pathways...
- Estimating entropy rates with Bayesian confidence intervalsMatthew B Kennel
Institute for Nonlinear Science, University of California, San Diego, La Jolla, CA 92093 0402, USA
Neural Comput 17:1531-76. 2005..In related work, we apply these ideas to estimate the information rates between sensory stimuli and neural responses in experimental data (Shlens, Kennel, Abarbanel, & Chichilnisky, in preparation)...
- Changes in physiological properties of rat ganglion cells during retinal degenerationChris Sekirnjak
Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
J Neurophysiol 105:2560-71. 2011..These results advance our understanding of the functional changes associated with retinal degeneration...
- ENSEMBLE CODING OF VISUAL INFORMATION IN THE RETINAEDUARDO CHICHILNISKY; Fiscal Year: 2004..Aim 3. Does retinal signaling limit accuracy of behavioral and cortical motion sensing? This part will include psychophysical studies as well as correlation with recordings in MT obtained from other investigators. ..
- Synchronized Firing in the RetinaEDUARDO CHICHILNISKY; Fiscal Year: 2009....
- CRCNS: Complete functional characterization of a population of retinal ganglion cEDUARDO J CHICHILNISKY; Fiscal Year: 2010..In summary, knowing how the entire retinal network encodes the visual scene in spike trains is a key element in understanding the healthy visual system and designing prosthetic treatments for retinas damaged by disease. ..