Affiliation: The Procter and Gamble Company
- Summary--imaging of bones and jointsBabul Borah
Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA
J Musculoskelet Neuronal Interact 4:371-2. 2004
- Three-dimensional microimaging (MRmicroI and microCT), finite element modeling, and rapid prototyping provide unique insights into bone architecture in osteoporosisB Borah
Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040 9462, USA
Anat Rec 265:101-10. 2001..The integration of these techniques provide us with an unique ability to investigate the role of bone architecture in osteoporotic fractures and to support the development of new therapies...
- Risedronate preserves bone architecture in postmenopausal women with osteoporosis as measured by three-dimensional microcomputed tomographyBabul Borah
Procter and Gamble Pharmaceuticals, Cincinnati, OH 45201, USA
Bone 34:736-46. 2004..The preservation of architecture may be a contributory mechanism by which risedronate reduces the risk of vertebral fractures in osteoporotic women...
- The effect of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: correlation to histomorphometric indices of turnoverBabul Borah
Procter and Gamble Pharmaceuticals, Inc, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA
Bone 37:1-9. 2005..The results demonstrate that the reduction of turnover by risedronate increased the degree of mineralization and reduced the ratio of low- to high-mineralized bone fractions which may increase bone's resistance to fracture...
- Long-term risedronate treatment normalizes mineralization and continues to preserve trabecular architecture: sequential triple biopsy studies with micro-computed tomographyB Borah
Procter and Gamble Pharmaceuticals, Inc Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA
Bone 39:345-52. 2006..Overall, risedronate provided sustained benefits on mineralization and architecture, two key determinants of bone strength, over 5 years lending support for its long-term efficacy in fracture risk reduction...
- Risedronate preserves bone architecture in early postmenopausal women in 1 year as measured by three-dimensional microcomputed tomographyT E Dufresne
Procter and Gamble Pharmaceuticals, Cincinnati, OH 45040, USA
Calcif Tissue Int 73:423-32. 2003..Although there is no direct link in this study between fracture and preservation of architecture, it is reasonable to infer that the preservation of bone architecture may play a role in risedronate's anti-fracture efficacy...
- Application of LC-NMR and LC-MS to the identification of degradation products of a protease inhibitor in dosage formulationsS X Peng
The Procter and Gamble Company, Health Care Research Center, Mason, OH 45040, USA
J Pharm Biomed Anal 20:75-89. 1999..This work demonstrated the usefulness of this integrated approach for the rapid and unambiguous identification of drug compounds and their degradation products in dosage formulations...
- Risedronate reduces intracortical porosity in women with osteoporosisBabul Borah
New Drug Development, Procter and Gamble Pharmaceuticals, Mason, OH 45040, USA
J Bone Miner Res 25:41-7. 2010..02 and .04, respectively). Risedronate is likely to maintain bone strength and reduce nonvertebral fracture risk in part by reducing remodeling and therefore the number and size of intracortical cavities...
- Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by three-dimensional microcomputed tomographyBabul Borah
Procter and Gamble Pharmaceuticals, Mason, Ohio 45040, USA
J Bone Miner Res 17:1139-47. 2002..The study showed that risedronate preserved trabecular architecture in the vertebra of OVX minipigs, and that bone strength is tightly coupled to bone mass and architecture...