Richard Behringer

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Developmental biology. Dance of the embryo
    Richard R Behringer
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 316:697-8. 2007
  2. pmc Horizontal basal cells are multipotent progenitors in normal and injured adult olfactory epithelium
    Naomi Iwai
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Stem Cells 26:1298-306. 2008
  3. doi request reprint Human-animal chimeras in biomedical research
    Richard R Behringer
    Department of Molecular Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Stem Cell 1:259-62. 2007
  4. pmc CA125/MUC16 is dispensable for mouse development and reproduction
    Dong Joo Cheon
    Program in Genes and Development, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA
    PLoS ONE 4:e4675. 2009
  5. pmc Conditional expression of Wnt4 during chondrogenesis leads to dwarfism in mice
    Hu Hui Lee
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 2:e450. 2007
  6. pmc Resurrection of DNA function in vivo from an extinct genome
    Andrew J Pask
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 3:e2240. 2008
  7. pmc Stromal-to-epithelial transition during postpartum endometrial regeneration
    Cheng Chiu Huang
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 7:e44285. 2012
  8. pmc CTNNB1 in mesenchyme regulates epithelial cell differentiation during Müllerian duct and postnatal uterine development
    C Allison Stewart
    Department of Genetics, University of Texas MD Anderson Cancer Center, University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA
    Mol Endocrinol 27:1442-54. 2013
  9. doi request reprint Symposium in honor of Ralph L. Brinster celebrating 50 years of scientific breakthroughs
    Richard R Behringer
    Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Int J Dev Biol 57:333-9. 2013
  10. pmc Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failure
    M David Stewart
    Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Endocrinol 26:1847-56. 2012

Research Grants

  1. TRANSGENIC MOUSE MODELS OF CRANIOFACIAL DEVELOPMENT
    Richard Behringer; Fiscal Year: 2001
  2. Color-coded transposor-mediated rat mutagenesis
    Richard Behringer; Fiscal Year: 2007

Detail Information

Publications88

  1. ncbi request reprint Developmental biology. Dance of the embryo
    Richard R Behringer
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 316:697-8. 2007
  2. pmc Horizontal basal cells are multipotent progenitors in normal and injured adult olfactory epithelium
    Naomi Iwai
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Stem Cells 26:1298-306. 2008
    ..Our findings demonstrate a crucial role for HBCs as multipotent progenitors in the adult OE, acting during normal neuronal turnover as well as in acute regeneration upon injury...
  3. doi request reprint Human-animal chimeras in biomedical research
    Richard R Behringer
    Department of Molecular Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Stem Cell 1:259-62. 2007
    ..Ironically, human-animal chimeras with human blood, neurons, germ cells, and other tissues have been generated for decades. This has facilitated human biological studies and therapeutic strategies for disease...
  4. pmc CA125/MUC16 is dispensable for mouse development and reproduction
    Dong Joo Cheon
    Program in Genes and Development, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA
    PLoS ONE 4:e4675. 2009
    ..These knockout mice provide a unique platform for future studies to identify the role of CA125/MUC16 in organ homeostasis and ovarian cancer...
  5. pmc Conditional expression of Wnt4 during chondrogenesis leads to dwarfism in mice
    Hu Hui Lee
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 2:e450. 2007
    ..The data indicate that Wnt4 levels must be regulated in chondrocytes for normal growth plate development and skeletogenesis. Decreased VEGF expression suggests that defects in vascularization may contribute to the dwarf phenotype...
  6. pmc Resurrection of DNA function in vivo from an extinct genome
    Andrew J Pask
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 3:e2240. 2008
    ..Our method using transgenesis can be used to explore the function of regulatory and protein-coding sequences obtained from any extinct species in an in vivo model system, providing important insights into gene evolution and diversity...
  7. pmc Stromal-to-epithelial transition during postpartum endometrial regeneration
    Cheng Chiu Huang
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 7:e44285. 2012
    ..These findings identify potential progenitor cells within the endometrial stromal compartment that produce long-term epithelial tissue during postpartum endometrial regeneration...
  8. pmc CTNNB1 in mesenchyme regulates epithelial cell differentiation during Müllerian duct and postnatal uterine development
    C Allison Stewart
    Department of Genetics, University of Texas MD Anderson Cancer Center, University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA
    Mol Endocrinol 27:1442-54. 2013
    ..These studies indicate that regulated CTNNB1 in mesenchyme is important for epithelial cell differentiation during female reproductive tract development. ..
  9. doi request reprint Symposium in honor of Ralph L. Brinster celebrating 50 years of scientific breakthroughs
    Richard R Behringer
    Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Int J Dev Biol 57:333-9. 2013
    ..The Symposium program and the complete lectures can be found at the following link: www.vet.upenn.edu/BrinsterSymposium. ..
  10. pmc Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failure
    M David Stewart
    Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Endocrinol 26:1847-56. 2012
    ..These results suggest decreased GnRH receptor signaling in the mutant animal, compared with wild type. Our findings suggest that a threshold level of GnRH receptor activity is required for ovulation...
  11. pmc Desert hedgehog is a mammal-specific gene expressed during testicular and ovarian development in a marsupial
    William A O'Hara
    Department of Molecular and Cellular Biology, The University of Connecticut, Storrs, CT 06269, USA
    BMC Dev Biol 11:72. 2011
    ....
  12. pmc Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice
    You Tzung Chen
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Nephrol 7:1. 2006
    ..Conditional ablation of Lim1 in the metanephric mesenchyme blocks the formation of nephrons at the nephric vesicle stage, leading to the production of small, non-functional kidneys that lack nephrons...
  13. pmc Genetic regulation of mammalian diversity
    R R Behringer
    Department of Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cold Spring Harb Symp Quant Biol 74:297-302. 2009
    ..Our studies indicate that cis-regulatory elements contribute to the morphological differences that have evolved among mammalian species...
  14. ncbi request reprint Mammalian diversity: gametes, embryos and reproduction
    Richard R Behringer
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Reprod Fertil Dev 18:99-107. 2006
    ..This diversity creates challenges and opportunities for gamete and embryo collection, culture and transfer technologies...
  15. ncbi request reprint Developmental potential and behavior of tetraploid cells in the mouse embryo
    Guy S Eakin
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 288:150-9. 2005
    ..These findings suggest that the results of previously published tetraploid complementation assays may be influenced by the presence of tetraploid cells in the otherwise diploid embryonic regions...
  16. ncbi request reprint Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development
    Jennifer Selever
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, TX 77030, USA
    Dev Biol 276:268-79. 2004
    ..Our data show that Bmp4 in limb mesoderm regulates AER induction and maturation and implicate signaling from the AER in regulation of digit number and identity...
  17. ncbi request reprint Diversity of germ layer and axis formation among mammals
    Guy S Eakin
    Program in Developmental Biology, Baylor College of Medicine and Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Semin Cell Dev Biol 15:619-29. 2004
    ..We suggest that more studies of embryonic development in diverse mammalian species are required for an understanding of germ layer and axis formation to provide insights into human biology and disease...
  18. pmc The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome
    Fei Gao
    Department of Molecular Genetics Cancer Genetics, Box 011, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77025, USA
    Mol Cell Biol 24:9899-910. 2004
    ..Thus, it will be a powerful and biologically relevant model for investigating the pathobiology of the earliest events in glomerulosclerosis...
  19. pmc Interactions between Sox9 and beta-catenin control chondrocyte differentiation
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:1072-87. 2004
    ..Our results strongly suggest that chondrogenesis is controlled by interactions between Sox9 and the Wnt/beta-catenin signaling pathway...
  20. ncbi request reprint Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
    Akio Kobayashi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2809-23. 2005
    ..We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Mullerian duct, the anlage of the female reproductive tract...
  21. ncbi request reprint BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning
    Dmitry A Ovchinnikov
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Dev Biol 295:103-15. 2006
    ..These findings suggest that signaling through BMPR-IA in limb mesenchyme is essential for distal outgrowth and also influences AP and DV patterning...
  22. ncbi request reprint A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice
    Smita M Purandare
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 129:2293-302. 2002
    ..The phenotype of these mice correctly models the defects found in human HTX1 and indicates an important role for Zic3 in both left-right and axial patterning...
  23. ncbi request reprint Lim1 is essential for the correct laminar positioning of retinal horizontal cells
    Ross A Poche
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:14099-107. 2007
    ..This study is the first to describe a cell type-specific genetic program that is essential for targeting a discrete retinal neuron population to the proper lamina...
  24. pmc Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo
    Qiyong Hu
    Department of Molecular Genetics, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    EMBO Rep 5:734-9. 2004
    ..This suggests that the amino-terminal basic amino-acid motif of mature BMP4 controls long-range activity for dorsoventral patterning of the vertebrate neural tube...
  25. ncbi request reprint Requirement of Lim1 for female reproductive tract development
    Akio Kobayashi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 131:539-49. 2004
    ..These studies demonstrate an essential role for Lim1 in female reproductive tract development...
  26. ncbi request reprint The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation
    Anuradha Bhattacharya
    Department of Molecular Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:8167-72. 2003
    ..We conclude that the CBF transcription factor complex is essential for cell proliferation and viability...
  27. pmc Somal positioning and dendritic growth of horizontal cells are regulated by interactions with homotypic neighbors
    Ross A Poche
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA
    Eur J Neurosci 27:1607-14. 2008
    ..These results demonstrate directly that positioning and dendritic growth are regulated by interactions with homotypic neighbors, whereas afferents instruct the differentiation of dendritic patterning...
  28. pmc Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:14665-70. 2005
    ..Thus, our results strongly suggest that all osteo-chondroprogenitor cells, as well as progenitors in a variety of tissues, are derived from Sox9-expressing precursors during mouse embryogenesis...
  29. pmc Neonatal lethality, dwarfism, and abnormal brain development in Dmbx1 mutant mice
    Akihira Ohtoshi
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Biol 24:7548-58. 2004
    ..These results demonstrate that Dmbx1 is required for postnatal survival, growth, and brain development...
  30. pmc Wt1 negatively regulates beta-catenin signaling during testis development
    Hao Chang
    The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA
    Development 135:1875-85. 2008
    ..However, the suppression of beta-catenin signaling in these cells is essential for proper testis formation and Wt1 is a negative regulator of beta-catenin signaling during this developmental process...
  31. ncbi request reprint Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis
    Kin Ming Kwan
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 39:10-25. 2004
    ....
  32. pmc Morphometric analysis of testis cord formation in Sox9-EGFP mice
    Liesl Nel-Themaat
    Department of Genetics, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Dyn 238:1100-10. 2009
    ..These results suggest that cord formation is a highly dynamic process that subsequently becomes refined to establish the final number of seminiferous tubule precursors...
  33. doi request reprint Bmp4-directed nuclear cyan fluorescent protein provides a tool for live imaging and reveals cellular resolution of Bmp4 expression patterns during embryogenesis
    Chuan Wei Jang
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Int J Dev Biol 54:931-8. 2010
    ..In addition, these studies reveal a novel view of the arrangement and dynamic changes of Bmp4-expressing cells of different stage hair follicles...
  34. ncbi request reprint Angiomotin regulates visceral endoderm movements during mouse embryogenesis
    Akihiko Shimono
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Curr Biol 13:613-7. 2003
    ..These results suggest that amot acts within subregions of the VE to regulate morphogenetic movements that are required for embryo viability...
  35. pmc Dicer is required for female reproductive tract development and fertility in the mouse
    Gabriel Gonzalez
    Department of Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Reprod Dev 76:678-88. 2009
    ....
  36. ncbi request reprint Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1
    Akihira Ohtoshi
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Curr Biol 14:530-6. 2004
    ..Thus, Vsx1 is required for cone bipolar cell differentiation and regulates photopic vision perception...
  37. ncbi request reprint Conditional inactivation of Lim1 function
    Kin Ming Kwan
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 32:118-20. 2002
  38. pmc Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6502-7. 2004
    ..We propose that loss of Sox9 inhibits epithelial-mesenchymal transformation after delamination and initial migration, but before definitive mesenchymal transformation...
  39. pmc Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton
    Wenchu Lin
    Program in Genes and Development, and Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Growth Differ 50:321-30. 2008
    ..These data provide the first evidence that Gcn5 contributes to Hox gene regulation and is required for normal anteroposterior patterning of the mouse skeleton...
  40. pmc Cellular mechanisms of Müllerian duct formation in the mouse
    Grant D Orvis
    Program in Genes and Development, The University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA
    Dev Biol 306:493-504. 2007
    ..Our studies define cellular and molecular mechanisms for Müllerian duct formation...
  41. pmc Impaired angiogenesis in aminopeptidase N-null mice
    Roberto Rangel
    Department of Genitourinary Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:4588-93. 2007
    ..Finally, in addition to vascular biology research, APN-null mice may be useful reagents in other medical fields such as malignant, cardiovascular, immunological, or infectious diseases...
  42. doi request reprint Illuminating testis morphogenesis in the mouse
    Liesl Nel-Themaat
    Department of Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Androl 31:5-10. 2010
    ..Transgenic mice that express fluorescent protein reporters offer new opportunities for time-lapse imaging to visualize live cells and their behaviors during testis differentiation and morphogenesis...
  43. pmc Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage
    Stephen P Henry
    Department of Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Genesis 47:805-14. 2009
    ..In conclusion, we have generated a mouse model in which genes implicated in cartilage degenerative diseases can be inactivated in a spatial and temporal fashion in postnatal and adult mice...
  44. pmc Dual fluorescent protein reporters for studying cell behaviors in vivo
    M David Stewart
    Department of Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Genesis 47:708-17. 2009
    ..This set of new FP reporters should be a useful tool for labeling distinct cell populations and studying their behaviors in complex tissues in vivo...
  45. pmc Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse
    Hao Chang
    Program in Genes and Development, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA
    Biol Reprod 81:842-9. 2009
    ..These studies show a causal link between overactive WNT/beta-catenin signaling and Sertoli cell tumor development and provide a novel mouse model for the study of Sertoli cell tumor biology...
  46. ncbi request reprint Generation of a Twist1 conditional null allele in the mouse
    You Tzung Chen
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 45:588-92. 2007
    ..Here, we report the generation of a Twist1 conditional null allele in mice that functions like a wild-type allele but can be converted to a null allele upon Cre-mediated recombination...
  47. ncbi request reprint Developmental genetics of the female reproductive tract in mammals
    Akio Kobayashi
    Program in Developmental Biology, Baylor College of Medicine and Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nat Rev Genet 4:969-80. 2003
    ..We also show that these pathways might be conserved between invertebrates and mammals...
  48. pmc Regulatory divergence modifies limb length between mammals
    Chris J Cretekos
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 22:141-51. 2008
    ....
  49. doi request reprint A mesenchymal perspective of Müllerian duct differentiation and regression in Amhr2-lacZ mice
    Nelson A Arango
    Program in Genes and Development, The University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA
    Mol Reprod Dev 75:1154-62. 2008
    ..This pattern was similar to that observed using a Müllerian duct mesoepithelium lacZ reporter, indicating a coordinated loss of Müllerian duct mesoepithelium and Amhr2-expressing mesenchyme...
  50. pmc Embryonic staging system for the Black Mastiff Bat, Molossus rufus (Molossidae), correlated with structure-function relationships in the adult
    Mark J Nolte
    Department of Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas
    Anat Rec (Hoboken) 292:155-68, spc 1. 2009
    ..This embryonic staging system will facilitate further developmental studies of M. rufus, a model species for one of the largest and most successful chiropteran families, the Molossidae...
  51. pmc MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse
    Ying Wang
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Differentiation 76:1081-92. 2008
    ..These findings document the presence of MUC16 in murine ovarian cancer and in normal tissues and provide a foundation for future functional studies...
  52. doi request reprint Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller glial cell development
    Ross A Poche
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Comp Neurol 510:237-50. 2008
    ..Furthermore, by employing a conditional knockout approach, we show that Sox9 is essential for the differentiation and/or survival of postnatal Müller glial cells...
  53. ncbi request reprint Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma
    Sonali Sonnylal
    University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Arthritis Rheum 56:334-44. 2007
    ..To directly assess the effect of sustained TGFbeta signaling in SSc, we established a novel mouse model in which the TGFbeta signaling pathway is activated in fibroblasts postnatally...
  54. ncbi request reprint Dmbx1, a novel evolutionarily conserved paired-like homeobox gene expressed in the brain of mouse embryos
    Akihira Ohtoshi
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mech Dev 110:241-4. 2002
    ..Dmbx1 provides a unique marker of the developing anterior nervous system and should provide a useful molecular resource to elucidate the mechanisms that pattern the vertebrate brain...
  55. pmc Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis
    Chun Ming Chen
    Department of Molecular Genetics, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 18:320-32. 2004
    ..The close linkage of OVCA1 and p53 on human Chromosome 17 suggests that coordinated loss may be an important mechanism for the evolution of ovarian, breast, and other tumor phenotypes...
  56. ncbi request reprint Granulosa cell-specific inactivation of follistatin causes female fertility defects
    Carolina J Jorgez
    Program in Developmental Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Endocrinol 18:953-67. 2004
    ..These studies are the first report of a granulosa cell-specific deletion of a gene in the postnatal ovary and have important implications for future endeavors to generate ovary-specific knockout mouse models...
  57. ncbi request reprint Genetic studies of the AMH/MIS signaling pathway for Müllerian duct regression
    Soazik P Jamin
    Department of Molecular Genetics, MD Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Endocrinol 211:15-9. 2003
    ..These results suggest that when AMH is overexpressed, other TGF-beta family type I receptors can potentially transduce AMH signals...
  58. pmc Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress
    Shamima Akhter
    University of Texas M D Anderson Cancer Center, Department of Molecular Genetics, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Biol 24:10448-55. 2004
    ..These findings suggest that Snm1 is a component of a mitotic stress checkpoint that negatively targets the APC prior to chromosome condensation...
  59. ncbi request reprint Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
    ..Our data uncover a Bmp4-Bmpr1a genetic pathway that functions in lip fusion, and reveal that Bmp signaling has distinct roles in lip and palate fusion...
  60. ncbi request reprint Hoxd13 expression in the developing limbs of the short-tailed fruit bat, Carollia perspicillata
    Chih Hsin Chen
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Evol Dev 7:130-41. 2005
    ..These findings, compared with the Hoxd13 expression profiles of other vertebrates, suggest that divergent Hoxd13 expression patterns may contribute to limb morphological variation...
  61. ncbi request reprint Recent innovations in tissue-specific gene modifications in the mouse
    Yasuhide Furuta
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Birth Defects Res C Embryo Today 75:43-57. 2005
    ..In this review, we focus on these recent innovations and new technical issues that impact the success of these conditional gene modification approaches...
  62. ncbi request reprint Tetraploid development in the mouse
    Guy S Eakin
    Program in Developmental Biology, Baylor College of Medicine, and Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Dyn 228:751-66. 2003
    ..Thus, the range of developmental potentials of tetraploid embryos remains in large part unexplored. Here, we review the biological consequences and experimental utility of tetraploid mammals, in particular the mouse...
  63. ncbi request reprint Embryonic staging system for the short-tailed fruit bat, Carollia perspicillata, a model organism for the mammalian order Chiroptera, based upon timed pregnancies in captive-bred animals
    Chris J Cretekos
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Dev Dyn 233:721-38. 2005
    ..This staging system provides a framework for studying Carollia embryogenesis and should prove useful as a guide for embryological studies of other bat species and for comparisons with other orders of mammals...
  64. ncbi request reprint Requirement of Bmpr1a for Müllerian duct regression during male sexual development
    Soazik P Jamin
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 32:408-10. 2002
    ..Because Bmpr1a is evolutionarily conserved, these findings indicate that a component of the BMP signaling pathway has been co-opted during evolution for male sexual development in amniotes...
  65. ncbi request reprint Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development
    Derek Boerboom
    Department of Molecular and Cellular Biology and Center for Comparative Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 65:9206-15. 2005
    ..5 months of age. Together, these studies show a causal link between misregulated Wnt/beta-catenin signaling and GCT development and provide a novel model system for the study of GCT biology...
  66. pmc Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection
    Shamima Ahkter
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Mol Cell Biol 25:10071-8. 2005
    ..Taken together, these findings demonstrate that Snm1 is a tumor suppressor in mice that in addition has a role in immunity...
  67. ncbi request reprint The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 108:17-29. 2002
    ..Thus, Osx acts downstream of Runx2/Cbfa1. Because Osx null preosteoblasts express typical chondrocyte marker genes, we propose that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells...
  68. ncbi request reprint Transition nuclear proteins are required for normal chromatin condensation and functional sperm development
    Ming Zhao
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 38:200-13. 2004
    ..Thus, in mammals TPs are required for normal chromatin condensation, for reducing the number of DNA breaks, and for preventing the formation of secondary defects in spermatozoa, eventual loss of genomic integrity, and sterility...
  69. pmc Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
    Natalia Soshnikova
    Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, 13125Berlin, Germany
    Genes Dev 17:1963-8. 2003
    ..Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling...
  70. ncbi request reprint Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo
    Kenneth Soo
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Dev Biol 247:251-70. 2002
    ..Twist is also required for the proper differentiation of the first arch tissues into bone, muscle, and teeth...
  71. ncbi request reprint Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo
    Masamichi Yamamoto
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 428:387-92. 2004
    ....
  72. ncbi request reprint Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation
    Umashankar Singh
    Department of Development and Genetics, Uppsala University, Uppsala, Sweden
    Dev Dyn 230:149-64. 2004
    ..These genes common to different abnormal placental growth genotypes are likely to be important in the occurrence of placentopathy...
  73. ncbi request reprint Regionalization of cell fates and cell movement in the endoderm of the mouse gastrula and the impact of loss of Lhx1(Lim1) function
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute, University of Sydney, New South Wales, Australia
    Dev Biol 274:171-87. 2004
    ..The inefficient movement of the anterior endoderm, and the abnormal differentiation highlighted by the lack of Sox17 and Foxa2 expression, may underpin the malformation of the head of Lhx1 mutant embryos...
  74. ncbi request reprint Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling
    Yuji Mishina
    Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 279:27560-6. 2004
    ..These results demonstrate essential and age-dependent roles for BMP signaling mediated by BMPRIA (a type IA receptor for BMP) in osteoblasts for bone remodeling...
  75. pmc Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium
    Eiichi Hinoi
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Genes Dev 20:2937-42. 2006
    ..This study identifies a transcriptional basis for the inhibition of chondrocyte maturation by perichondrium and reveals that Runx2 fulfills antagonistic functions during chondrogenesis...
  76. ncbi request reprint Generation and maintenance of Dmbx1 gene-targeted mutant alleles
    Akihira Ohtoshi
    Center of Molecular and Human Genetics, Children s Research Institute, 700 Children s Drive, Columbus, Ohio 43205, USA
    Mamm Genome 17:744-50. 2006
    ..To our knowledge, this is the first demonstration of the proof-of-principle of the maintenance of viable gene-targeted alleles using coat-color-tagged nonlethal balancer chromosomes...
  77. ncbi request reprint Laser capture-microarray analysis of Lim1 mutant kidney development
    S Steven Potter
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Genesis 45:432-9. 2007
    ..This was confirmed by in situ hybridizations. It is interesting to note that Lim1 and Dkk1 mutant mice have striking similarities in phenoytpe. These results suggest that the Dkk1 gene might be a key downstream effector of Lim1 function...
  78. ncbi request reprint Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks
    Aitana Perea-Gomez
    IGBMC CNRS INSERM, Universite Louis Pasteur, 67404 Illkirch Cedex, CU de, Strasbourg, France
    Dev Cell 3:745-56. 2002
    ..Both antagonists are also required for proper patterning of the primitive streak...
  79. pmc The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours
    Kirsten K Youngren
    Department of Genetics and
    Nature 435:360-4. 2005
    ..TGCT development in the 129-Ter mouse strain models paediatric TGCT in humans. This work will have important implications for our understanding of the genetic control of TGCT pathogenesis and PGC biology...
  80. pmc Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction
    Hidemasa Oh
    Center for Cardiovascular Development, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:12313-8. 2003
    ..By using a Cre/Lox donor/recipient pair (alphaMHC-Cre/R26R), differentiation was shown to occur roughly equally, with and without fusion to host cells...
  81. ncbi request reprint Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
    Markus Morkel
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin, Germany
    Development 130:6283-94. 2003
    ..Our data assign a key role to beta-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation...
  82. ncbi request reprint Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex
    Noriyuki Nishioka
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Development 132:2535-46. 2005
    ..These results suggest that Ssdp1 regulates the development of late head organizer tissues and body growth by functioning as an essential activator component of a Lim1 complex through interaction with Ldb1...
  83. pmc Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta
    Geng Tian
    Department of Animal Genetics and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Dev Dyn 237:1517-25. 2008
    ..However, absence of both LIM-3 genes did not interfere with placental transport nor consistently with expression of target genes such as Gnrhr. Thus, LHX3 and LHX4 appear to be dispensable for placental development and function...
  84. ncbi request reprint Cell-specific knockout of steroidogenic factor 1 reveals its essential roles in gonadal function
    Pancharatnam Jeyasuria
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Mol Endocrinol 18:1610-9. 2004
    ..Collectively, these studies establish definitively that SF-1 expression in the gonads is essential for normal reproductive development and function...
  85. ncbi request reprint A morphological and immunohistochemical comparison of mammary tissues from the short-tailed fruit bat (Carollia perspicillata) and the mouse
    Jennifer L Evarts
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Reprod 70:1573-9. 2004
    ..The present study demonstrates that whereas the epithelial compartment and the presence of differentiation markers are conserved between the mouse and bat, differences exist in the stromal compartment...
  86. pmc Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo
    Joshua W Mugford
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 319:396-405. 2008
    ..This program maintains tubule forming progenitors and instructs a metanephric specific pattern of nephron differentiation...
  87. ncbi request reprint Functional analysis of Sox8 and Sox9 during sex determination in the mouse
    Marie Christine Chaboissier
    INSERM U470, Centre de Biochimie, Parc Valrose, 06108 Nice Cedex 2, France
    Development 131:1891-901. 2004
    ..Finally, double knock-out analyses suggest that Sox8 reinforces Sox9 function in testis differentiation of mice...
  88. ncbi request reprint BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways
    Byeong S Yoon
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 133:4667-78. 2006
    ..These results provide a genetic in vivo demonstration that the progression of chondrocytes through the growth plate is controlled by antagonistic BMP and FGF signaling pathways...

Research Grants2

  1. TRANSGENIC MOUSE MODELS OF CRANIOFACIAL DEVELOPMENT
    Richard Behringer; Fiscal Year: 2001
    ..This knowledge should be useful for understanding the etiology and pathogenesis of craniofacial defects. ..
  2. Color-coded transposor-mediated rat mutagenesis
    Richard Behringer; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..