Edward M Behrens

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Apoptotic cell-mediated immunoregulation of dendritic cells does not require iC3b opsonization
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Division of Rheumatology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Immunol 181:3018-26. 2008
  2. pmc Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes
    Frank Pessler
    Klinik und Poliklinik für Kinder und Jugendmedizin, Technische Universitat Dresden, Fetscherstrasse, 01307 Dresden, Germany
    Arthritis Res Ther 10:R64. 2008
  3. ncbi request reprint Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR)
    Edward M Behrens
    Department of Pediatrics, Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Rheumatol 35:343-8. 2008
  4. doi request reprint Macrophage activation syndrome in rheumatic disease: what is the role of the antigen presenting cell?
    Edward M Behrens
    Department of Pediatrics, Division of Rheumatology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Autoimmun Rev 7:305-8. 2008
  5. ncbi request reprint Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Immunol 178:6268-79. 2007
  6. pmc Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice
    Edward M Behrens
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:2264-77. 2011
  7. ncbi request reprint IL-4 suppresses dendritic cell response to type I interferons
    Uma Sriram
    Laboratory of Dendritic Cell Biology, Joseph Stokes Jr Research Institute, Division of Rheumatology, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol 179:6446-55. 2007
  8. pmc Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset
    Uma Sriram
    Laboratory of Dendritic Cell Biology, Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 189:80-91. 2012
  9. ncbi request reprint Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis
    Edward M Behrens
    Departments of Pathology and Pediatrics, Division of Rheumatology, Children s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Rheumatol 34:1133-8. 2007
  10. pmc ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice
    Julia E Rood
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pa Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    Blood 127:426-35. 2016

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Apoptotic cell-mediated immunoregulation of dendritic cells does not require iC3b opsonization
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Division of Rheumatology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Immunol 181:3018-26. 2008
    ..We conclude that the apoptotic cell receptor system on DCs is sufficiently redundant such that the absence of CR3 engagement does not significantly affect the normal anti-inflammatory processing of apoptotic cells...
  2. pmc Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes
    Frank Pessler
    Klinik und Poliklinik für Kinder und Jugendmedizin, Technische Universitat Dresden, Fetscherstrasse, 01307 Dresden, Germany
    Arthritis Res Ther 10:R64. 2008
    ..Injection of monosodium urate (MSU) crystals into the pouch elicits an acute inflammatory response similar to human gout. We conducted the present study to identify mRNAs that were highly regulated by MSU crystals in the pouch membrane...
  3. ncbi request reprint Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR)
    Edward M Behrens
    Department of Pediatrics, Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Rheumatol 35:343-8. 2008
    ..To characterize the initial clinical and laboratory features of patients with systemic onset juvenile rheumatoid arthritis (soJRA) through a Web-based registry...
  4. doi request reprint Macrophage activation syndrome in rheumatic disease: what is the role of the antigen presenting cell?
    Edward M Behrens
    Department of Pediatrics, Division of Rheumatology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Autoimmun Rev 7:305-8. 2008
    ..We review the proposed pathogenesis of MAS/HLH, what role macrophages may play in the disease, and the relationship of MAS to its most common associated rheumatic disease, SJIA...
  5. ncbi request reprint Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Immunol 178:6268-79. 2007
    ..We propose that CR3 provides a "nondanger" signal that suppresses the stimulatory capacity of DCs...
  6. pmc Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice
    Edward M Behrens
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:2264-77. 2011
    ..Our data provide insight into MAS-like syndromes in patients with inflammatory diseases in which there is chronic innate immune activation but no genetic defects in cytotoxic cell function...
  7. ncbi request reprint IL-4 suppresses dendritic cell response to type I interferons
    Uma Sriram
    Laboratory of Dendritic Cell Biology, Joseph Stokes Jr Research Institute, Division of Rheumatology, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol 179:6446-55. 2007
    ..This inhibition could explain the increased susceptibility to viral infections observed during Th2-inducing parasitoses...
  8. pmc Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset
    Uma Sriram
    Laboratory of Dendritic Cell Biology, Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 189:80-91. 2012
    ..We propose that Sle1,2,3 mice are useful tools to study the role of the IFN signature in lupus pathogenesis...
  9. ncbi request reprint Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis
    Edward M Behrens
    Departments of Pathology and Pediatrics, Division of Rheumatology, Children s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Rheumatol 34:1133-8. 2007
    ..Accordingly, many patients with SJIA may have evidence of mild MAS that is not appreciated clinically. We investigated the prevalence of occult MAS in children with SJIA by reviewing bone marrow aspirates (BMA)...
  10. pmc ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice
    Julia E Rood
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pa Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    Blood 127:426-35. 2016
    ..Furthermore, this study provides evidence to support blockade of ST2 as a novel therapeutic strategy for FHL. ..
  11. pmc Interferon-γ mediates anemia but is dispensable for fulminant toll-like receptor 9-induced macrophage activation syndrome and hemophagocytosis in mice
    Scott W Canna
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Arthritis Rheum 65:1764-75. 2013
    ..This study was undertaken to investigate the inflammatory contributors to a murine model of Toll-like receptor 9 (TLR-9)-induced fulminant MAS...
  12. ncbi request reprint The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity
    Edward M Behrens
    University of Pennsylvania, Philadelphia, USA
    Eur J Immunol 33:2160-7. 2003
    ..Taken together, these studies show mer expression on cells of the innate immune system. Mer, through its binding of lipid antigens, may not only mediate ingestion of apoptotic cells, but also signal events in NK cells, NKT cells, and DC...
  13. pmc TLR9-mediated inflammation drives a Ccr2-independent peripheral monocytosis through enhanced extramedullary monocytopoiesis
    Lehn K Weaver
    Division of Pediatric Rheumatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 113:10944-9. 2016
    ..These findings help to explain how chronic TLR-mediated inflammation may be perpetuated in autoimmune diseases and increase our understanding of how monocytes are produced and positioned during systemic inflammatory responses. ..
  14. doi request reprint IL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation
    Julia E Rood
    Division of Rheumatology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Leukoc Biol . 2016
    ....
  15. pmc Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility
    Terri H Finkel
    Division of Rheumatology, The Children s Hospital of Philadelphia, 19104, Philadelphia, PA, USA
    BMC Med Genet 17:24. 2016
    ..Our aim was to identify novel genetic variants that predispose to JIA...
  16. pmc Toll-like receptor 9 and interferon-γ receptor signaling suppress the B-cell fate of uncommitted progenitors in mice
    Sheena R Baratono
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Eur J Immunol 45:1313-25. 2015
    ....
  17. pmc The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling
    Rohan P Joshi
    1Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sci Signal 6:ra102. 2013
    ..The enhanced effective enzymatic production of PA by DGKζ is therefore one possible mechanism underlying the dominant functions of DGKζ in modulating T(reg) cell development...
  18. pmc Spleen tyrosine kinase (Syk)-dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor α (TNFα) in innate immune cells
    Sheila Rao
    Division of Pediatric Rheumatology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 288:12448-58. 2013
    ..Our data report a novel pathway for TNFα regulation and provide insight into non-transcriptional mechanisms for shaping cytokine responses...
  19. pmc Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer
    Scott M Lieberman
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Eur J Immunol 42:1429-35. 2012
    ....
  20. pmc Making sense of the cytokine storm: a conceptual framework for understanding, diagnosing, and treating hemophagocytic syndromes
    Scott W Canna
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Clin North Am 59:329-44. 2012
    ....
  21. doi request reprint Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis
    Edward M Behrens
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Arthritis Rheum 58:2206-7. 2008
  22. ncbi request reprint Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis
    Edward M Behrens
    Department of Pathology and Pediatrics, Division of Rheumatology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Rheumatol 33:2081-4. 2006
    ....
  23. pmc BIRC4 Mutation: An Important Rare Cause of Uveitis
    Matthew L Basiaga
    From the Division of Rheumatology, Children s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
    J Clin Rheumatol 21:444-7. 2015
    ..We conclude that male patients with chronic idiopathic uveitis should be questioned about a history of hemophagocytic lymphocytic histiocytosis during their workup and screened for BIRC4 mutation if appropriate. ..
  24. pmc Patient-reported Outcomes across Categories of Juvenile Idiopathic Arthritis
    Alysha J Taxter
    From the Department of Pediatric Rheumatology, and Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia Center for Epidemiology and Biostatistics, The University of Pennsylvania, Philadelphia, Pennsylvania, USA A J Taxter, MD, Fellow, Department of Pediatric Rheumatology, The Children s Hospital of Philadelphia E P Wileyto, PhD, Associate Professor, Center for Epidemiology and Biostatistics, The University of Pennsylvania E M Behrens, MD, Associate Professor, Department of Pediatric Rheumatology, The Children s Hospital of Philadelphia P F Weiss, MD, MSCE, Associate Professor, Department of Pediatric Rheumatology, and Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia
    J Rheumatol 42:1914-21. 2015
    ..The purpose of our study was to assess PRO across JIA categories, including pain, quality of life, and physical function, and to determine clinical factors associated with differences in these measures across categories...
  25. pmc Genetic sharing and heritability of paediatric age of onset autoimmune diseases
    Yun R Li
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nat Commun 6:8442. 2015
    ....
  26. pmc Measuring cytotoxicity by bioluminescence imaging outperforms the standard chromium-51 release assay
    Mobin A Karimi
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e89357. 2014
    ..We conclude that the (BLI)-based measurement of cytotoxicity offers a superior non-radioactive alternative to the chromium-release assay that is more robust and quicker to perform. ..
  27. ncbi request reprint A tumor-associated glycoprotein that blocks MHC class II-dependent antigen presentation by dendritic cells
    Ralf Gutzmer
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 173:1023-32. 2004
    ..These results demonstrate a novel mechanism by which tumors may evade CD4(+) T cell-dependent immune responses through expression of a TAA...
  28. doi request reprint Enthesitis in an inception cohort of enthesitis-related arthritis
    Pamela F Weiss
    The Children s Hospital of Philadelphia, Pennsylvania, USA
    Arthritis Care Res (Hoboken) 63:1307-12. 2011
    ..To describe an enthesitis-related arthritis (ERA) inception cohort and determine which entheses and joints are most commonly affected...
  29. pmc Not all hemophagocytes are created equally: appreciating the heterogeneity of the hemophagocytic syndromes
    Scott W Canna
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Rheumatol 24:113-8. 2012
    ..We will review the latest literature from both human and murine models related to the diagnosis, etiology, and treatment of hemophagocytic syndromes including MAS...
  30. ncbi request reprint Juvenile idiopathic arthritis classification criteria: loopholes and diagnosis software
    Edward M Behrens
    J Rheumatol 34:234; author reply 234-5. 2007