Hema Bashyam

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc CTLA-4: From conflict to clinic
    Hema Bashyam
    J Exp Med 204:1243. 2007
  2. pmc Sabine Ehrt: searching for mycobacterial stress points. Interview by Hema Bashyam
    Sabine Ehrt
    J Exp Med 205:2184-5. 2008
  3. pmc Ralph Steinman: dendritic cells bring home the Lasker
    Hema Bashyam
    J Exp Med 204:2245-8. 2007
  4. pmc Susan Allen: confronting HIV in Africa. Interview by Hema Bashyam
    Susan Allen
    J Exp Med 205:1000-1. 2008
  5. pmc Vamsi Mootha: taking an inventory of mitochondria. Interview by Hema Bashyam
    Vamsi Mootha
    J Exp Med 205:1248-9. 2008
  6. pmc Caetano Reis e Sousa: harnessing DC power. Interview by Hema Bashyam
    Caetano Reis E Sousa
    J Exp Med 205:1946-7. 2008
  7. pmc Facundo Batista: watching B cells spread and grab antigens. Interview by Hema Bashyam
    Facundo Batista
    J Exp Med 205:1718-9. 2008
  8. pmc Jane Skok: choreography of allelic exclusion. [Interview by Hema Bashyam]
    Jane Skok
    J Exp Med 205:1514-5. 2008
  9. pmc Uncovering the dark side of TNF
    Hema Bashyam
    J Exp Med 204:2013. 2007
  10. pmc Michael T. McManus: Interrupting biology [interview by Hema Bashyam]
    Michael T McManus
    J Exp Med 205:506-7. 2008

Collaborators

  • David Bartel
  • Caetano Reis E Sousa
  • Sabine Ehrt
  • Anthony De Tomaso
  • Robert Korngold
  • Michael T McManus
  • Jonathan Sprent
  • Carl F Nathan
  • BRIAN DAVID HARFE
  • Peter T Nelson
  • Yong Zhao
  • Amy E Pasquinelli
  • Jianzhu Chen
  • GARY B RUVKUN
  • Mark Anderson
  • Trinna L Cuellar
  • Tigwa H Davis
  • Jennifer H Mansfield
  • Ivan Osokine
  • Xuyu Zhou
  • Jane Skok
  • Gabriel B Loeb
  • Gregory Ku
  • Vamsi Mootha
  • Scott J Harvey
  • Susan Allen
  • Facundo Batista
  • Francis C Lynn
  • Jill R Crittenden
  • Jason R O'Rourke
  • Kelley S Harris
  • Eran Hornstein
  • John P Morris
  • Clifford J Tabin
  • Phillip A Sharp
  • Douglas A Rubinson
  • Qing Ge
  • Seth Goldberg
  • Thomas Benzing
  • Ruby Hsu
  • Erik M Ullian
  • Shirley Zhu
  • Jeffrey H Miner
  • Allison J Barker
  • Erik Ullian
  • Lukas T Jeker
  • George Jarad
  • Selina M Koch
  • Bernhard Schermer
  • Brian T Fife
  • Jeanette Cunningham
  • Jeffrey A Bluestone
  • Michael S German
  • Maurice S Swanson
  • Yasuhiro Kosaka
  • Stephen J Tapscott
  • Howard R Seay
  • Amy Heidersbach
  • Sara A Georges
  • David J Goldhamer
  • Peter Skewes-Cox
  • Zhen Zhang
  • Xin Sun
  • Jimmy Kuang Hsien Hu
  • Soraya Yekta
  • Scott Baskerville
  • Raphael Farzan-Kashani
  • Aadel Chaudhuri
  • Jalagani Srineel
  • Robert Nissen
  • John Obenauer
  • Michael Zuker
  • Frank B Gertler
  • Mingdi Zhang
  • Johnny Kopinja
  • Martin L Scott
  • Adam V Kwiatkowski
  • Herman N Eisen
  • Luk Van Parijs
  • Christopher P Dillon
  • Ching Hung Shen
  • Lili Yang
  • Melanie M Ihrig
  • Dina L Rooney
  • Claudia Sievers
  • Tam Nguyen

Detail Information

Publications40

  1. pmc CTLA-4: From conflict to clinic
    Hema Bashyam
    J Exp Med 204:1243. 2007
    ..CTLA-4 has since scored in the clinic as a target for antitumor therapy and as a soluble inhibitor of autoimmunity...
  2. pmc Sabine Ehrt: searching for mycobacterial stress points. Interview by Hema Bashyam
    Sabine Ehrt
    J Exp Med 205:2184-5. 2008
  3. pmc Ralph Steinman: dendritic cells bring home the Lasker
    Hema Bashyam
    J Exp Med 204:2245-8. 2007
    ..Yet the man behind the research holds his praise for the many other scientists-in the U.S. and abroad-who have further advanced the therapeutic promise of DCs...
  4. pmc Susan Allen: confronting HIV in Africa. Interview by Hema Bashyam
    Susan Allen
    J Exp Med 205:1000-1. 2008
  5. pmc Vamsi Mootha: taking an inventory of mitochondria. Interview by Hema Bashyam
    Vamsi Mootha
    J Exp Med 205:1248-9. 2008
  6. pmc Caetano Reis e Sousa: harnessing DC power. Interview by Hema Bashyam
    Caetano Reis E Sousa
    J Exp Med 205:1946-7. 2008
  7. pmc Facundo Batista: watching B cells spread and grab antigens. Interview by Hema Bashyam
    Facundo Batista
    J Exp Med 205:1718-9. 2008
  8. pmc Jane Skok: choreography of allelic exclusion. [Interview by Hema Bashyam]
    Jane Skok
    J Exp Med 205:1514-5. 2008
  9. pmc Uncovering the dark side of TNF
    Hema Bashyam
    J Exp Med 204:2013. 2007
    ..They soon found out that their malevolent cytokine already had another name-tumor necrosis factor (TNF)-and was being lauded as a potential antitumor agent...
  10. pmc Michael T. McManus: Interrupting biology [interview by Hema Bashyam]
    Michael T McManus
    J Exp Med 205:506-7. 2008
  11. pmc Receptor editing: how B cells stay tolerant
    Hema Bashyam
    J Exp Med 204:1735. 2007
    ..This process, called "receptor editing," has since gained prominence as the main mechanism of B cell tolerance...
  12. pmc Lewis Dahl and the genetics of salt-induced hypertension
    Hema Bashyam
    J Exp Med 204:1507. 2007
  13. pmc Robert Menard: Tailing malaria parasites to the red blood cell. Interviewed by Hema Bashyam
    Hema Bashyam
    J Exp Med 205:744-5. 2008
  14. pmc Anthony De Tomaso: Finding the origins of adaptive immunity. Interview by Hema Bashyam
    Anthony De Tomaso
    J Exp Med 205:264-5. 2008
  15. pmc Crossing barriers in transplantation
    Hema Bashyam
    J Exp Med 204:459. 2007
    ..T cell depletion of donor grafts has since become a staple of transplantation strategies to combat leukemia and other inherited blood disorders...
  16. pmc Th1/Th2 cross-regulation and the discovery of IL-10
    Hema Bashyam
    J Exp Med 204:237. 2007
    ..Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells...
  17. pmc IFNgamma: issuing macrophages a license to kill
    Hema Bashyam
    J Exp Med 204:3. 2007
    ..In 1983, Carl Nathan proved that this start signal comes in the form of the secreted cytokine IFNgamma...
  18. pmc Essential role for Dicer during skeletal muscle development
    Jason R O'Rourke
    Department of Molecular Genetics and Microbiology and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32610 0266, USA
    Dev Biol 311:359-68. 2007
    ..These observations demonstrate key roles for Dicer in skeletal muscle and implicate miRNAs as critical components required for embryonic myogenesis...
  19. ncbi request reprint A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
    Douglas A Rubinson
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Genet 33:401-6. 2003
    ..They may also provide new approaches for gene therapy...
  20. pmc Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity
    Xuyu Zhou
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:1983-91. 2008
    ..These results support a central role for miRNAs in maintaining the stability of differentiated T reg cell function in vivo and homeostasis of the adaptive immune system...
  21. ncbi request reprint Small interfering RNA-mediated gene silencing in T lymphocytes
    Michael T McManus
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street E17 526, Cambridge, MA 02139, USA
    J Immunol 169:5754-60. 2002
    ..Using primary differentiated T lymphocytes, we provide the first evidence of siRNA-mediated RNAi gene silencing in normal nontransformed somatic mammalian lymphocytes...
  22. pmc Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease
    Scott J Harvey
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Soc Nephrol 19:2150-8. 2008
    ..The unique architecture of podocytes may make them especially susceptible to cytoskeletal alterations initiated by aberrant miRNA dynamics...
  23. pmc RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription
    Qing Ge
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:2718-23. 2003
    ..The findings reveal that newly synthesized NP and PA proteins are required for influenza virus transcription and replication and provide a basis for the development of siRNAs as prophylaxis and therapy for influenza infection in humans...
  24. ncbi request reprint MicroRNAs and cancer
    Michael T McManus
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, Cambridge, MA 02139, USA
    Semin Cancer Biol 13:253-8. 2003
    ..Recent data suggests that a special class of ncRNAs called microRNAs might be involved in human disease. This review proposes a role for microRNAs in oncogenesis...
  25. ncbi request reprint MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression
    Jennifer H Mansfield
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 36:1079-83. 2004
    ..Furthermore, miR-196a negatively regulates Hoxb8, indicating that its restricted expression pattern probably reflects a role in the patterning function of the Hox complex...
  26. pmc Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus
    Tigwa H Davis
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 28:4322-30. 2008
    ....
  27. ncbi request reprint Lentiviral strategies for RNAi knockdown of neuronal genes
    Jill R Crittenden
    Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Curr Protoc Neurosci . 2007
    ..Additional protocols describe production and titering of the lentivirus, as well as safety testing. Finally, methods are provided for infecting neurons in culture and in vivo with RNAi lentivirus...
  28. pmc The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 102:10898-903. 2005
    ..Thus, Dicer is required for the formation of normal mouse limbs. Strikingly, however, we did not detect defects in basic patterning or in tissue-specific differentiation of Dicer-deficient limb buds...
  29. pmc Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration
    Trinna L Cuellar
    Department of Microbiology and Immunology, Diabetes Center, Biomedical Sciences Graduate Program, and Departments of Ophthalmology and Physiology, University of California, San Francisco, CA 94122 0534, USA
    Proc Natl Acad Sci U S A 105:5614-9. 2008
    ..These studies highlight the complicated nature of Dicer ablation in the brain and provide a useful mouse model for studying dopaminoceptive neuron function...
  30. ncbi request reprint Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
    Yong Zhao
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Cell 129:303-17. 2007
    ..These findings indicate that subtle alteration of miRNA dosage can have profound consequences in mammals and demonstrate the utility of mammalian loss-of-function models in revealing physiologic miRNA targets...
  31. ncbi request reprint MicroRNA expression is required for pancreatic islet cell genesis in the mouse
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0534, USA
    Diabetes 56:2938-45. 2007
    ..We tested the hypothesis that microRNAs (miRNAs), which limit gene expression through posttranscriptional silencing, modulate the gene expression cascades involved in pancreas development...
  32. pmc Dicer function is essential for lung epithelium morphogenesis
    Kelley S Harris
    Laboratory of Genetics, University of Wisconsin, 425 G Henry Mall, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:2208-13. 2006
    ..The aberrant Fgf10 expression may contribute to the Dicer morphological defects. However, the mechanism by which DICER functions in the epithelium to influence Fgf10 expression in the mesenchyme remains unknown...
  33. ncbi request reprint MicroRNAs and endocrine biology
    Trinna L Cuellar
    UCSF Diabetes Center, Department of Microbiology and Immunology, University of California, San Francisco, California 94122 0534, USA
    J Endocrinol 187:327-32. 2005
    ..This review provides a general background regarding current knowledge about miRNA biogenesis and the potential contributions of these RNAs to endocrine function...
  34. doi request reprint Behind the scenes of a small RNA gene-silencing pathway
    Gregory Ku
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Francisco, San Francisco, CA 94122, USA
    Hum Gene Ther 19:17-26. 2008
    ..This review discusses advances in the biogenesis of miRNAs, their modes of action, and implications for RNA-based treatments...
  35. pmc Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report
    Ivan Osokine
    Department of Microbiology and Immunology, University of California San Francisco Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 4:e34. 2008
    ..These data also raise the possibility that many knockout studies may need to be reexamined to determine if loss of a microRNA contributes to the phenotypic consequences attributed to loss of a protein-encoding gene...
  36. ncbi request reprint The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development
    Eran Hornstein
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 438:671-4. 2005
    ....
  37. ncbi request reprint Slowing down the Ras lane: miRNAs as tumor suppressors?
    John P Morris
    UCSF Diabetes Center, Department of Microbiology and Immunology, University of California, San Francisco, CA 94122 0534, USA
    Sci STKE 2005:pe41. 2005
    ....
  38. ncbi request reprint Gene silencing in mammals by small interfering RNAs
    Michael T McManus
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street E17 526, Cambridge, Massachusetts 02139, USA
    Nat Rev Genet 3:737-47. 2002
    ..Although the use of siRNAs to silence genes in vertebrate cells was only reported a year ago, the emerging literature indicates that most vertebrate genes can be studied with this technology...