Amal Amer

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. doi Modulation of caspases and their non-apoptotic functions by Legionella pneumophila
    Amal O Amer
    Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine and the Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 12:140-7. 2010
  2. pmc Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages
    Arwa Abu Khweek
    Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, College of Medicine, The Ohio State University Columbus, OH, USA
    Front Cell Infect Microbiol 3:18. 2013
  3. pmc Cell intrinsic roles of apoptosis-associated speck-like protein in regulating innate and adaptive immune responses
    Hoda Hassan
    Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    ScientificWorldJournal 11:2418-23. 2011
  4. pmc Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages
    Dalia H A Abdelaziz
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University Columbus, OH, USA
    Front Microbiol 2:18. 2011
  5. pmc Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes
    Dalia H Abdelaziz
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:3203-8. 2011
  6. pmc Replication of Legionella Pneumophila in Human Cells: Why are We Susceptible?
    Arwa Abu Khweek
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University Columbus, OH, USA
    Front Microbiol 1:133. 2010
  7. pmc Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway
    Murugesan V S Rajaram
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 4:e7919. 2009
  8. pmc Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy
    Jonathan P Butchar
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
    Clin Cancer Res 16:2065-75. 2010
  9. pmc Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages
    Sheetal Kotrange
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Leukoc Biol 89:481-8. 2011
  10. pmc MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response
    Thomas J Cremer
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 4:e8508. 2009

Collaborators

  • Jonathan P Butchar
  • Thirumala Devi Kanneganti
  • Susheela Tridandapani
  • Mikhail A Gavrilin
  • Clay Marsh
  • William E Carson
  • Judy M Hickman-Davis
  • John C Byrd
  • M A Valvano
  • Andrea I Doseff
  • Arwa Abu Khweek
  • Anwari Akhter
  • Kyle Caution
  • Sheetal Kotrange
  • Mark D Wewers
  • Dalia H Abdelaziz
  • Hoda Hassan
  • Basant A Abdulrahman
  • Thomas J Cremer
  • Famke Aeffner
  • Basant Abdulrahman
  • Dalia H A Abdelaziz
  • Zeinab A Hassan
  • Murugesan V S Rajaram
  • Larry S Schlesinger
  • Paul M Janssen
  • David M Bedwell
  • Ian C Davis
  • Natalia S Fernández Dávila
  • Mia Tazi
  • Eric J Sorscher
  • Laura A Novotny
  • Lauren O Bakaletz
  • Ximena Ortega
  • Slade A Loutet
  • Dennis Guttridge
  • Simranjit S Bedi
  • Karen McCoy
  • Dalia Abdelaziz
  • Katherine Ladner
  • M Elba Gonzalez-Mejia
  • Fathia Z El-Sharkawi
  • Mahmoud Mostafa
  • Benjamin Kopp
  • Jaykumar Grandhi
  • Khaled Amr
  • David H Ravneberg
  • Dominique Limoli
  • Terry S Elton
  • Corey D Clay
  • Melissa G Piper-Hunter
  • Songcerae Washington
  • Laura Frantz
  • Kishore V L Parsa
  • John S Gunn
  • Colby Day
  • Anasuya Sarkar
  • Christie Newland
  • Cameron Ditty

Detail Information

Publications14

  1. doi Modulation of caspases and their non-apoptotic functions by Legionella pneumophila
    Amal O Amer
    Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine and the Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 12:140-7. 2010
    ..This review will examine the novel activation pathways of caspases by L. pneumophila and discuss their role in genetic restriction and permissiveness to infection...
  2. pmc Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages
    Arwa Abu Khweek
    Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, College of Medicine, The Ohio State University Columbus, OH, USA
    Front Cell Infect Microbiol 3:18. 2013
    ..This study advances our understanding of the innate immune response to biofilm-derived L. pneumophila and closely reproduces the natural mode of infection in human...
  3. pmc Cell intrinsic roles of apoptosis-associated speck-like protein in regulating innate and adaptive immune responses
    Hoda Hassan
    Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    ScientificWorldJournal 11:2418-23. 2011
    ..This paper will emphasize the major roles of ASC during pathogen infection, the mechanisms by which it mediates inflammation, and discuss its more recently discovered functions...
  4. pmc Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages
    Dalia H A Abdelaziz
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University Columbus, OH, USA
    Front Microbiol 2:18. 2011
    ..Taken together, our data demonstrate that L. pneumophila infection in murine macrophages is controlled by several mechanisms: Asc-independent activation of caspase-1 and Asc-dependent regulation of NF-κB and caspase-3 activation...
  5. pmc Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes
    Dalia H Abdelaziz
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:3203-8. 2011
    ..pneumophila manipulates ASC levels to evade inflammasome activation and grow in human monocytes. By targeting ASC, L. pneumophila modulates the inflammasome, the apoptosome, and NF-κB pathway simultaneously...
  6. pmc Replication of Legionella Pneumophila in Human Cells: Why are We Susceptible?
    Arwa Abu Khweek
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University Columbus, OH, USA
    Front Microbiol 1:133. 2010
    ..Therefore, these in vitro models can be applicable and are reproducible when investigating L. pneumophila/phagocyte interactions at the molecular and cellular levels in the human host...
  7. pmc Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway
    Murugesan V S Rajaram
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 4:e7919. 2009
    ..These data identify for the first time host cell signaling pathways that regulate the phagosomal escape of Francisella, leading to the induction of Fas and subsequent host cell death...
  8. pmc Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy
    Jonathan P Butchar
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
    Clin Cancer Res 16:2065-75. 2010
    ..Here, we wished to test the effect of TLR7/8 activation on monocyte Fcgamma receptor (FcgammaR) function, as they are critical mediators of antibody therapy...
  9. pmc Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages
    Sheetal Kotrange
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Leukoc Biol 89:481-8. 2011
    ..Taken together, we identified eukaryotic and bacterial factors that contribute to inflammation during B. cenocepacia infection, which may aid in the design of novel approaches to control pulmonary inflammation...
  10. pmc MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response
    Thomas J Cremer
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 4:e8508. 2009
    ..However, impaired miR-155 induction by SCHU S4 may help explain the lack of both SHIP down-regulation and pro-inflammatory response and may account for the virulence of Type A Francisella...
  11. pmc Heterozygosity for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel attenuates influenza severity
    Famke Aeffner
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Infect Dis 208:780-9. 2013
    ..The purpose of this study was to determine the contribution of this effect to influenza pathogenesis in mice with reduced CFTR activity...
  12. pmc Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
    Anwari Akhter
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, OH, USA
    PLoS Pathog 5:e1000361. 2009
    ..These results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against an intracellular bacterium...
  13. pmc Nlrc4/Ipaf/CLAN/CARD12: more than a flagellin sensor
    Dalia H Abdelaziz
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, OH 43210, United States
    Int J Biochem Cell Biol 42:789-91. 2010
    ..On the other hand, new reports showed that Nlrc4 can restrict bacterial infection independently of caspase-1. Therefore, Nlrc4 maybe involved in sensing more than one bacterial molecule and may participate in several immune complexes...