Stephen T Abedon

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. doi request reprint Bacteriophage exploitation of bacterial biofilms: phage preference for less mature targets?
    Stephen T Abedon
    Department of Microbiology, The Ohio State University Mansfield, OH 44906, USA
    FEMS Microbiol Lett 363:. 2016
  2. pmc Ecology of Anti-Biofilm Agents II: Bacteriophage Exploitation and Biocontrol of Biofilm Bacteria
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, 1680 University Dr, Mansfield, OH 44906, USA
    Pharmaceuticals (Basel) 8:559-89. 2015
  3. pmc Ecology of Anti-Biofilm Agents I: Antibiotics versus Bacteriophages
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, 1680 University Dr, Mansfield, OH 44906, USA
    Pharmaceuticals (Basel) 8:525-58. 2015
  4. doi request reprint Bacteriophage secondary infection
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, Mansfield, OH, 44906, USA
    Virol Sin 30:3-10. 2015
  5. ncbi request reprint Bacteriophages and their enzymes in biofilm control
    Benjamin K Chan
    Department of Microbiology, Ohio State University, 1680 University Dr, Mansfield, OH 44906
    Curr Pharm Des 21:85-99. 2015
  6. pmc Why bacteriophage encode exotoxins and other virulence factors
    Stephen T Abedon
    Department of Microbiology, Ohio State University, Mansfield, Ohio, USA
    Evol Bioinform Online 1:97-110. 2007
  7. pmc Archaeal viruses, not archaeal phages: an archaeological dig
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, 1680 University Drive, Mansfield, OH 44906, USA
    Archaea 2013:251245. 2013
  8. pmc Spatial vulnerability: bacterial arrangements, microcolonies, and biofilms as responses to low rather than high phage densities
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, 1680 University Dr, Mansfield, OH 44906, USA
    Viruses 4:663-87. 2012
  9. ncbi request reprint Phage therapy pharmacology
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, 1680 University Dr, Mansfield, OH 44906, USA
    Curr Pharm Biotechnol 11:28-47. 2010
  10. ncbi request reprint Bacteriophage T4 resistance to lysis-inhibition collapse
    S T Abedon
    Department of Microbiology, Ohio State University, Mansfield 44906, USA
    Genet Res 74:1-11. 1999

Collaborators

Detail Information

Publications25

  1. doi request reprint Bacteriophage exploitation of bacterial biofilms: phage preference for less mature targets?
    Stephen T Abedon
    Department of Microbiology, The Ohio State University Mansfield, OH 44906, USA
    FEMS Microbiol Lett 363:. 2016
    ..Phage tendencies toward only partial exploitation of even single-species biofilms could be consistent with observations that chronic bacterial infections in the clinic can require more aggressive or extensive phage therapy to eradicate. ..
  2. pmc Ecology of Anti-Biofilm Agents II: Bacteriophage Exploitation and Biocontrol of Biofilm Bacteria
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, 1680 University Dr, Mansfield, OH 44906, USA
    Pharmaceuticals (Basel) 8:559-89. 2015
    ....
  3. pmc Ecology of Anti-Biofilm Agents I: Antibiotics versus Bacteriophages
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, 1680 University Dr, Mansfield, OH 44906, USA
    Pharmaceuticals (Basel) 8:525-58. 2015
    ..In nature, lytic predators of bacteria likely can meet these criteria whereas antibiotic production, in and of itself, largely may not. ..
  4. doi request reprint Bacteriophage secondary infection
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, Mansfield, OH, 44906, USA
    Virol Sin 30:3-10. 2015
    ..I suggest in particular that secondary infection, as distinctly different phenomena, can in multiple ways influence the success of phage-mediated biocontrol of bacteria, also known as, phage therapy. ..
  5. ncbi request reprint Bacteriophages and their enzymes in biofilm control
    Benjamin K Chan
    Department of Microbiology, Ohio State University, 1680 University Dr, Mansfield, OH 44906
    Curr Pharm Des 21:85-99. 2015
    ..Here we consider these phage-based anti-biofilm strategies with emphasis on ecological aspects of their action and with particular consideration of EPS depolymerases...
  6. pmc Why bacteriophage encode exotoxins and other virulence factors
    Stephen T Abedon
    Department of Microbiology, Ohio State University, Mansfield, Ohio, USA
    Evol Bioinform Online 1:97-110. 2007
    ..Such phage-fitness enhancing mechanisms could apply particularly given VF expression within microbiologically heterogeneous environments, ie, ones where phage have some reasonable potential to acquire phage-susceptible bacteria...
  7. pmc Archaeal viruses, not archaeal phages: an archaeological dig
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, 1680 University Drive, Mansfield, OH 44906, USA
    Archaea 2013:251245. 2013
    ..Altogether we identify in excess of one dozen variations on how the viruses of domain Archaea are described, and document the timing of both their introduction and use...
  8. pmc Spatial vulnerability: bacterial arrangements, microcolonies, and biofilms as responses to low rather than high phage densities
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, 1680 University Dr, Mansfield, OH 44906, USA
    Viruses 4:663-87. 2012
    ..I consider these ideas of bacterial 'spatial vulnerability' in part within a phage therapy context...
  9. ncbi request reprint Phage therapy pharmacology
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, 1680 University Dr, Mansfield, OH 44906, USA
    Curr Pharm Biotechnol 11:28-47. 2010
    ....
  10. ncbi request reprint Bacteriophage T4 resistance to lysis-inhibition collapse
    S T Abedon
    Department of Microbiology, Ohio State University, Mansfield 44906, USA
    Genet Res 74:1-11. 1999
    ..From these data it is inferred that wild-type T4-infected cells display resistance to lysis-inhibition collapse by a mechanism resembling resistance to lysis from without...
  11. doi request reprint Kinetics of phage-mediated biocontrol of bacteria
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, Mansfield, Ohio 44906, USA
    Foodborne Pathog Dis 6:807-15. 2009
    ..I conclude suggesting that phage therapy ultimately may be rationally guided by theoretical considerations of the impact of phage properties on rates of phage population growth...
  12. pmc Bacteriophage latent-period evolution as a response to resource availability
    S T Abedon
    Department of Microbiology, Ohio State University, Mansfield, Ohio 44906, USA
    Appl Environ Microbiol 67:4233-41. 2001
    ..By taking care to differentiate latent-period phenotypic plasticity from latent-period evolution, we argue that the impact of host quality on phage latent-period evolution may be relatively small...
  13. pmc Experimental examination of bacteriophage latent-period evolution as a response to bacterial availability
    Stephen T Abedon
    Department of Microbiology, Ohio State University, Mansfield, Ohio, USA
    Appl Environ Microbiol 69:7499-506. 2003
    ..From these observations we suggest that phage displaying very short latent periods may be viewed as specialists for propagation when bacteria within cultures are highly prevalent and transmission between cultures is easily accomplished...
  14. ncbi request reprint Optimizing bacteriophage plaque fecundity
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, Mansfield, OH 44906, USA
    J Theor Biol 249:582-92. 2007
    ....
  15. ncbi request reprint Bacteriophage evolution given spatial constraint
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, Mansfield, OH 44906, USA
    J Theor Biol 248:111-9. 2007
    ..Overall, we provide a snapshot of how phage populations may respond evolutionarily to selection for more-rapid propagation during spatially constrained growth...
  16. doi request reprint Practical methods for determining phage growth parameters
    Paul Hyman
    MedCentral College of Nursing, Mansfield, OH, USA
    Methods Mol Biol 501:175-202. 2009
    ..In this chapter we present protocols for determining phage growth parameters, particularly phage rate of adsorption, latent period, eclipse period, and burst size...
  17. doi request reprint Bacteriophage host range and bacterial resistance
    Paul Hyman
    MedCentral College of Nursing, Mansfield, Ohio, USA
    Adv Appl Microbiol 70:217-48. 2010
    ..Contrasting especially bacteria mutation to adsorption resistance, these latter mechanisms likely are an underappreciated avenue of bacterial resistance to phage attack...
  18. doi request reprint Phage evolution and ecology
    Stephen T Abedon
    Department of Microbiology, College of Biological Sciences, The Ohio State University, Mansfield, Ohio 44906, USA
    Adv Appl Microbiol 67:1-45. 2009
    ....
  19. doi request reprint Bacteriophage plaques: theory and analysis
    Stephen T Abedon
    Department of Microbiology, The Ohio State University, Mansfield, OH, USA
    Methods Mol Biol 501:161-74. 2009
    ..We also will consider problems with inferring phage broth growth fitness as a function of plaque characteristics (Note 2)...
  20. pmc Human Escherichia coli O157:H7 genetic marker in isolates of bovine origin
    Jeffrey T Lejeune
    Ohio State University, Wooster, Ohio 44691, USA
    Emerg Infect Dis 10:1482-5. 2004
    ..5% of bovine isolates. Shiga toxin production was higher in Q933-positive isolates than Q933-negative isolates. This genetic marker may provide a useful molecular tool for epidemiologic studies...
  21. ncbi request reprint Host density impacts relative fitness of bacteriophage Phi6 genotypes in structured habitats
    John J Dennehy
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520 8106, USA
    Evolution 61:2516-27. 2007
    ..We discuss the relevance of our findings for selection occurring in natural phage populations and for the general evolutionary epidemiology of infectious parasites...