The Scripps Research Institute

Summary

Organization: The Scripps Research Institute
Country: USA

Top Publications

  1. doi Total synthesis of englerin A
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences ICES, Agency for Science, Technology and Research A STAR, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667
    J Am Chem Soc 132:8219-22. 2010
  2. ncbi Hereditary hemochromatosis: screening and management
    Jill Waalen
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Hematol Rep 5:34-40. 2006
  3. ncbi Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 128:2859-72. 2006
  4. ncbi Performance of a linear ion trap-Orbitrap hybrid for peptide analysis
    John R Yates
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Anal Chem 78:493-500. 2006
  5. ncbi Small molecules and future regenerative medicine
    Sheng Ding
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Med Chem 5:383-95. 2005
  6. pmc Constant pH molecular dynamics with proton tautomerism
    Jana Khandogin
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    Biophys J 89:141-57. 2005
  7. ncbi Antigen-specific memory B cell development
    Louise J McHeyzer-Williams
    The Scripps Research Institute, Department of Immunology, La Jolla, CA 92037, USA
    Annu Rev Immunol 23:487-513. 2005
  8. ncbi Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2
    M Cecilia Subauste
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Biol Chem 280:5676-81. 2005
  9. ncbi Chemistry and biology of diazonamide A: second total synthesis and biological investigations
    K C Nicolaou
    Contribution from the Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 126:12897-906. 2004
  10. ncbi Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells
    Kristen E Bower
    Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4614, USA
    Oncogene 23:8805-14. 2004

Research Grants

  1. SYNTHESIS OF ANTIBIOTICS
    K C Nicolaou; Fiscal Year: 2010
  2. TOTAL SYNTHESIS OF AZASPIRACIDS
    K Nicolaou; Fiscal Year: 2006
  3. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2005
  4. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
  5. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2007
  6. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2007
  7. TOTAL SYNTHESIS OF KINAMYCINS AND LOMAIVITICINS
    K Nicolaou; Fiscal Year: 2007
  8. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
  9. Synthesis of Marine Neurotoxins
    K C Nicolaou; Fiscal Year: 2010
  10. Synthesis of Marine Neurotoxins
    K Nicolaou; Fiscal Year: 2007

Detail Information

Publications62

  1. doi Total synthesis of englerin A
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences ICES, Agency for Science, Technology and Research A STAR, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667
    J Am Chem Soc 132:8219-22. 2010
    ....
  2. ncbi Hereditary hemochromatosis: screening and management
    Jill Waalen
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Hematol Rep 5:34-40. 2006
    ..For most patients, phlebotomy is the preferred treatment option; iron chelation therapies are available for patients unable to tolerate phlebotomy...
  3. ncbi Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 128:2859-72. 2006
    ..In addition to the total synthesis of azaspiracid-1 (1), the syntheses of its C(1)-C(20) epimer (2) and of several truncated analogues for biological investigations are described...
  4. ncbi Performance of a linear ion trap-Orbitrap hybrid for peptide analysis
    John R Yates
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Anal Chem 78:493-500. 2006
    ..Tandem mass spectra from the linear ion trap and from the Orbitrap have very similar ion abundance ratios. We conclude this instrument will be well suited for shotgun proteomic types of analyses...
  5. ncbi Small molecules and future regenerative medicine
    Sheng Ding
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Med Chem 5:383-95. 2005
    ..Such molecules will likely provide new insights into stem cell biology, and may ultimately contribute to effective medicines for tissue repair and regeneration...
  6. pmc Constant pH molecular dynamics with proton tautomerism
    Jana Khandogin
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    Biophys J 89:141-57. 2005
    ..Based on the simulations of OMTKY3 and RNase A, the current work has demonstrated the capability of the CPHMD technique in revealing pH-coupled conformational dynamics of protein side chains...
  7. ncbi Antigen-specific memory B cell development
    Louise J McHeyzer-Williams
    The Scripps Research Institute, Department of Immunology, La Jolla, CA 92037, USA
    Annu Rev Immunol 23:487-513. 2005
    ..We review the cellular and molecular regulators of this dynamic process with emphasis on the multiple memory B cell fates that develop in vivo...
  8. ncbi Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2
    M Cecilia Subauste
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Biol Chem 280:5676-81. 2005
    ..These studies indicate that PTEN protein levels are dependent on the maintenance of beta-catenin-MAGI-2 interaction, in which vinculin plays a critical role...
  9. ncbi Chemistry and biology of diazonamide A: second total synthesis and biological investigations
    K C Nicolaou
    Contribution from the Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 126:12897-906. 2004
    ..We also disclose our complete studies regarding the chemical biology of diazonamide A and its structural congeners, and more fully delineate the scope of our protocol for Robinson-Gabriel cyclodehydration using pyridine-buffered POCl(3)...
  10. ncbi Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells
    Kristen E Bower
    Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4614, USA
    Oncogene 23:8805-14. 2004
    ..The results indicate that the mechanism of repression of matrix metalloproteinase-1 by p21SNFT may be exploited in inhibiting pathological matrix remodeling during cancer progression in vivo...
  11. ncbi Unfolded proteins and protein folding studied by NMR
    H Jane Dyson
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Rev 104:3607-22. 2004
  12. ncbi An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees
    Thomas J Kunicki
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Rd, MEM 150, La Jolla, CA 92037, USA
    Blood 104:2359-67. 2004
    ..02). These results establish that genetic differences in the adhesion receptor subunits alpha(2), alpha(IIb,) and GPVI can influence the phenotype of VWD type 1...
  13. pmc Reevaluation of the conclusion that IRES-activity reported within the 5' leader of the TIF4631 gene is due to promoter activity
    Vincent P Mauro
    Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA
    RNA 10:895-7; discussion 898. 2004
    ..We disagree with these conclusions and respond by showing that the data are most consistent with an internal initiation mechanism...
  14. ncbi Type IV pilus structure and bacterial pathogenicity
    Lisa Craig
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Microbiol 2:363-78. 2004
  15. ncbi Developmental changes in Ca2+-regulated functions of early postnatal Purkinje neurons
    D L Gruol
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    J Neurosci Res 83:1381-92. 2006
    ..This age dependence may play an important role in the normal developmental program and could contribute to the critical window of sensitivity observed for certain toxic agents during early development...
  16. ncbi Therapeutic potential of siRNA-mediated transcriptional gene silencing
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biotechniques . 2006
    ....
  17. ncbi A comprehensive mouse IBD database for the efficient localization of quantitative trait loci
    Alessandra C L Cervino
    Department of Informatics, Scripps Florida, 5353 Parkside Drive, RF A, Jupiter, FL 33458, USA
    Mamm Genome 17:565-74. 2006
    ..We have made our results available for data mining and download through a public website ( http://www.mouseibd.florida.scripps.edu )...
  18. doi Unusual reversal of enantioselectivity in the proline-mediated alpha-amination of aldehydes induced by tertiary amine additives
    Donna G Blackmond
    Department of Chemistry, Imperial College London SW7 2AZ, UK
    J Am Chem Soc 132:7598-9. 2010
    ..Implications for the prevailing stereochemical models for proline and related aminocatalytic transformations are discussed...
  19. pmc Fever
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    ScientificWorldJournal 10:490-503. 2010
    ..We also show how fever research provided new insights into temperature and energy homeostasis, and into treatment of infection and inflammation...
  20. doi Total synthesis of echinopines A and B
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667
    J Am Chem Soc 132:3815-8. 2010
    ..Their total synthesis involves a novel intramolecular rhodium-catalyzed cyclopropanation (4 --> 16) and a samarium diiodide-mediated ring closure (3 --> 37)...
  21. doi Sensors of the innate immune system: their link to rheumatic diseases
    Argyrios N Theofilopoulos
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Rev Rheumatol 6:146-56. 2010
    ..These findings have resulted in a critical reappraisal of pathogenetic mechanisms, and provide a basis for the development of novel diagnostic and therapeutic modalities for these diseases...
  22. ncbi Autophagy proteins promote hepatitis C virus replication
    Marlene Dreux
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA
    Autophagy 5:1224-5. 2009
    ..We propose that autophagy factors might support the delivery of incoming RNA to the translation apparatus and/or the recruitment of cellular factors required to initiate HCV translation...
  23. pmc Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory
    G F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Pharmacopsychiatry 42:S32-41. 2009
    ....
  24. pmc Malaria research in the post-genomic era
    Elizabeth Ann Winzeler
    Genomics Institute of the Novartis Research Foundation, San Diego, California and The Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 455:751-6. 2008
    ..This review will focus on the basic research discoveries that have depended, in part, on the availability of the Plasmodium genome sequences...
  25. pmc Neuropeptide Y suppresses ethanol drinking in ethanol-abstinent, but not non-ethanol-abstinent, Wistar rats
    Nicholas W Gilpin
    Department of Psychology, Program in Psychobiology of Addictions, Purdue School of Science, IUPUI, Indianapolis, IN 46202, USA
    Alcohol 42:541-51. 2008
    ..These results support the notion that dysregulation of brain NPY systems during chronic intermittent ethanol exposure is important in the motivational drive for subsequent relapse to ethanol drinking...
  26. ncbi Total synthesis of kinamycins C, F, and J
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 129:10356-7. 2007
  27. pmc The role of von Willebrand factor in thrombus formation
    Zaverio M Ruggeri
    The Scripps Research Institute, La Jolla, California, USA
    Thromb Res 120:S5-9. 2007
    ..This VWF-mediated process may be a key determinant of platelet accumulation in stenotic arteries leading to acute thrombotic occlusion...
  28. ncbi Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad
    Cindy L Ehlers
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 31:216-20. 2007
    ..The relationship between these alleles and alcohol-associated phenotypes has not been previously investigated in individuals living in the Caribbean...
  29. pmc Effects of dose and session duration on cocaine self-administration in rats
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 320:1134-43. 2007
    ..Therefore, high doses or prolonged access to cocaine are more likely to result in a pattern of cocaine intake that reflects compulsive use...
  30. ncbi Total synthesis of marinomycins A-C
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 45:6527-32. 2006
  31. ncbi Long-term outcomes in adults with chronic ITP after splenectomy failure
    Robert McMillan
    Scripps Research Institute, MEM 215, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 104:956-60. 2004
    ..We conclude that most patients with refractory ITP attain stable remission, though on average this occurs slowly. However, a subpopulation with severe, resistant disease experiences significant morbidity and mortality...
  32. ncbi DNA vaccines designed to inhibit tumor growth by suppression of angiogenesis
    Ralph A Reisfeld
    The Scripps Research Institute, La Jolla, Calif 92037, USA
    Int Arch Allergy Immunol 133:295-304. 2004
    ..Such research efforts may open up new possibilities for the rational design of future DNA vaccines effective for the prevention and treatment of cancer...
  33. ncbi Role of von Willebrand factor in platelet thrombus formation
    Z M Ruggeri
    Roon Research Center for Arteriosclerosis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Ann Med 32:2-9. 2000
    ..Advances in understanding the structure and function of von Willebrand factor indicate that this protein, for its unique biomechanical properties, may be a potentially useful target of antithrombotic drugs...
  34. ncbi P300 as a clinical assay: rationale, evaluation, and findings
    J Polich
    Department of Neuropharmacology, TPC 10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Int J Psychophysiol 38:3-19. 2000
    ..These results are discussed in terms of how to control inter-group ERP variability and the application of normative P300 data in clinical settings...
  35. ncbi Induced genome instability as a potential screening test for cancer susceptibility?
    F F Shadan
    Scripps Clinic, Department of Internal Medicine, Graduate Medical Education, La Jolla, California 92037, USA
    Med Hypotheses 55:69-72. 2000
    ..Induced genome instability therefore appears to be strongly linked to cancer predisposition, and prospective studies may yield a screening test utilizing a panel of mutagens to better identify populations at risk...
  36. ncbi Integrin cytoplasmic domain-binding proteins
    S Liu
    Department of Vascular Biology, VB 2, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Sci 113:3563-71. 2000
    ..These and other proteins (e.g. FAK, ILK and novel proteins such as TAP20) might also link integrins to signaling mechanisms and, in some cases (e.g. JAB1) mediate integrin-dependent gene regulation...
  37. ncbi Progressive and transient expression of tissue plasminogen activator during fetal development
    E G Levin
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 20:1668-74. 2000
    ..This study indicates that tPA expression is a dynamic process that responds to a changing arterial environment during vascular development...
  38. pmc T-cell proliferation in vivo and the role of cytokines
    J Sprent
    Department of Immunology, IMM4, The Scripps Research Institute, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 355:317-22. 2000
    ..Depending upon the experimental conditions used, IFN-I can either inhibit or enhance primary responses of naive T cells to specific antigen...
  39. ncbi Characterization of the inflammatory response during acute measles encephalitis in NSE-CD46 transgenic mice
    M Manchester
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Neuroimmunol 96:207-17. 1999
    ..These results further characterize the MV-induced encephalitis in CD46 transgenic mice and highlight similarities to MV infection of the human CNS...
  40. ncbi DNA immunization: mechanistic studies
    J L Whitton
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    Vaccine 17:1612-9. 1999
    ..We are attempting to determine how antigens are released from transfected cells, to interact with B-cells and induce antibodies, and are currently evaluating the CD4 responses induced by DNA vaccines...
  41. pmc Ontogeny of T cell tolerance to peripherally expressed antigens
    D J Morgan
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 96:3854-8. 1999
    ..Thus, lack of tolerance in the perinatal period correlated with lack of activation of antigen-specific CD8(+) T cells. This work provides evidence for the developmental regulation of peripheral tolerance induction...
  42. ncbi Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation
    M J Heeb
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Biochem 260:64-75. 1999
    ....
  43. ncbi P3a, perceptual distinctiveness, and stimulus modality
    M D Comerchero
    Department of Psychology, University of California, San Diego, La Jolla, CA 92037, USA
    Brain Res Cogn Brain Res 7:41-8. 1998
    ..Theoretical implications are discussed...
  44. pmc Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?
    E Beutler
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:8170-4. 1998
    ....
  45. ncbi New families with von Willebrand disease type 2M (Vicenza)
    B Zieger
    Univ Children s Hospital, Freiburg, Germany
    Thromb Res 87:57-64. 1997
    ..The patients with vWd type 2M (Vicenza) could be allocated into two subgroups: type "platelet normal" with normal vWf properties in platelets and type "platelet low" with reduced vWf: Ag levels in platelets...
  46. ncbi High-throughput docking for lead generation
    R Abagyan
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines, TCP 28, La Jolla, CA 92037, USA
    Curr Opin Chem Biol 5:375-82. 2001
    ....
  47. ncbi Resistance to xenobiotic-induced autoimmunity maps to chromosome 1
    D H Kono
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 167:2396-403. 2001
    ....
  48. ncbi Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters
    G Chang
    Department of Molecular Biology, MB 9, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 293:1793-800. 2001
    ..The structure of MsbA can serve as a model for the MDR-ABC transporters that confer multidrug resistance to cancer cells and infectious microorganisms...
  49. pmc Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab
    Subhash C Sinha
    The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:3095-9. 2004
    ..These findings might open new avenues for defined conjugations of small molecule drugs to mAbs in general and aldolase Abs in particular...
  50. ncbi Total synthesis of hybocarpone and analogues thereof. A facile dimerization of naphthazarins to pentacyclic systems
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 126:607-12. 2004
    ....
  51. ncbi Impact of patellofemoral design on patellofemoral forces and polyethylene stresses
    DARRYL D D'LIMA
    Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA
    J Bone Joint Surg Am 85:85-93. 2003
    ..The presence of a functioning posterior cruciate ligament and the design parameters of a total knee arthroplasty, such as trochlear groove alignment and cam-post configuration, can have a major effect on patellar biomechanics...
  52. ncbi Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm
    Hugh Rosen
    Department of Immunology and Committee for Advanced Human Therapeutics, The Scripps Research Institute, ICND 118 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Chem Biol 7:461-8. 2003
    ..These approaches can potentially be extended to a broad, related family of G-protein-coupled receptors that share ligands and ligand similarities...
  53. ncbi Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis
    K C Nicolaou
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 42:3649-53. 2003
  54. ncbi From phenomenon to phenotype and from phenotype to gene: forward genetics and the problem of sepsis
    Bruce Beutler
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Infect Dis 187:S321-6. 2003
    ..Which genes are involved in the pathogenesis of sepsis? As in the golden age of genetics, the answer requires the solution of phenotypic puzzles, which, in turn, requires the creation of phenotypes...
  55. ncbi Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence
    Glenn R Valdez
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol 29:55-60. 2003
    ..Results of the current experiment demonstrated that continuous exposure to ethanol over a 3-week period leads to an increased behavioral responsiveness to stress, which seems to be regulated by CRF...
  56. ncbi The enzymatic inactivation of the fatty acid amide class of signaling lipids
    Benjamin F Cravatt
    Departments of Cell Biology and Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Phys Lipids 121:135-48. 2002
    ....
  57. pmc Targeting and hematopoietic suppression of human CD34+ cells by measles virus
    Marianne Manchester
    Departments of Cell Biology, Center for Integrative Molecular Biosciences, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 76:6636-42. 2002
    ..These results suggest that MV-mediated defects in hematopoiesis contribute to the long-term immunosuppression seen in measles...
  58. ncbi Effects of adolescent ethanol exposure on ethanol consumption in adult rats
    Craig J Slawecki
    The Scripps Research Institute, Department of Neuropharmacology, CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol 26:23-30. 2002
    ..Overall, these findings indicate that forced exposure to ethanol vapor during adolescence does not seem to be sufficient to alter initiation or maintenance of limited-access ethanol self-administration...
  59. ncbi Catalytic antibodies: structure and function
    P Wentworth
    The Scripps Research Institute, Department of Chemistry, La Jolla, CA 92037, USA
    Cell Biochem Biophys 35:63-87. 2001
    ..This review details the evolving knowledge of the structure-function relationship for catalytic antibodies that accelerate a range of different reaction classes...
  60. ncbi Coupling of folding and binding for unstructured proteins
    H Jane Dyson
    Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 12:54-60. 2002
    ..Many new examples of coupled folding and binding events have been reported recently, providing new insights into mechanisms of molecular recognition...
  61. ncbi Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules
    D L Boger
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem 9:2511-8. 2001
    ..Utilizing a library of hairpin deoxyoligonucleotides containing all possible four base-pair sequences, the method provides a high resolution profile of the DNA binding properties of small molecules in a high throughput format...
  62. ncbi Structure of gap junction intercellular channels
    M Yeager
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 6:183-92. 1996
    ....

Research Grants62

  1. SYNTHESIS OF ANTIBIOTICS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  2. TOTAL SYNTHESIS OF AZASPIRACIDS
    K Nicolaou; Fiscal Year: 2006
    ..g. lung, liver, spleen and lymphocyte damage as well as cancer) health hazards. The project is also expected to advance our knowledge in chemical synthesis and impact favorably the drug discovery and development process. ..
  3. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2005
    ..The disease areas likely to benefit most from the proposed investigations are bacterial-caused diseases and malaria. ..
  4. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  5. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2007
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  6. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2007
    ....
  7. TOTAL SYNTHESIS OF KINAMYCINS AND LOMAIVITICINS
    K Nicolaou; Fiscal Year: 2007
    ..The significance of the proposed work will lie specifically in the area of cancer chemotherapy research, and in the development of new synthetic strategies and technologies for general use in the drug discovery and development process. ..
  8. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  9. Synthesis of Marine Neurotoxins
    K C Nicolaou; Fiscal Year: 2010
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..
  10. Synthesis of Marine Neurotoxins
    K Nicolaou; Fiscal Year: 2007
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..
  11. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  12. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  13. INVESTIGATIVE HEMATOLOGY
    Ernest Beutler; Fiscal Year: 2007
    ..The facilities for training are in the Department of Molecular and Experimental Medicine of The Scripps Research Institute. The training faculty for this program work in approximately 30,000 square feet of laboratory space ..
  14. Anemia in the Elderly: Pathogenesis
    Ernest Beutler; Fiscal Year: 2007
    ..If such differences also occur among controls they could account for the broad normal variation in hemoglobin levels. ..
  15. Hemochromatosis -- Epidemiology and Molecular Mechanisms
    Ernest Beutler; Fiscal Year: 2003
    ..The projected studies should improve our understanding of control of iron metabolism and make possible detection of those cases of hemochromatosis who are likely to become clinically affected. ..
  16. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2005
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  17. HEMOCHROMATOSIS--EPIDEMIOLOGY AND MOLECULAR MECHANISMS
    Ernest Beutler; Fiscal Year: 2002
    ..This will be done by using immunoprecipitating HLA-H containing complexes, determining HLA-H Fc receptor signaling properties and measuring the binding of peptides and other small molecules by HLA-H. ..
  18. Hemochromatosis -- Epidemiology and Molecular Mechanisms
    Ernest Beutler; Fiscal Year: 2006
    ..The projected studies should improve our understanding of control of iron metabolism and make possible detection of those cases of hemochromatosis who are likely to become clinically affected. ..
  19. FORMATION AND SURVIVAL OF RED BLOOD CELLS
    Ernest Beutler; Fiscal Year: 2001
    ..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..