The Jackson Laboratory

Summary

Organization: The Jackson Laboratory
Country: USA

Top Publications

  1. pmc MeCP2 is required for normal development of GABAergic circuits in the thalamus
    Zhong Wei Zhang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Neurophysiol 103:2470-81. 2010
  2. ncbi From information to understanding: the role of model organism databases in comparative and functional genomics
    C J Bult
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Anim Genet 37:28-40. 2006
  3. ncbi The long and short of it: somite formation in mice
    Thomas Gridley
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Dev Dyn 235:2330-6. 2006
  4. ncbi FIMRe: Federation of International Mouse Resources: global networking of resource centers
    Muriel Davisson
    The Jackson Laboratory, 600 Main St, Bar Harbor, Maine 04609, USA
    Mamm Genome 17:363-4. 2006
  5. ncbi Beyond the data deluge: data integration and bio-ontologies
    Judith A Blake
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Biomed Inform 39:314-20. 2006
  6. ncbi Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration
    Bonnie L Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Invest Ophthalmol Vis Sci 47:1201-9. 2006
  7. ncbi Mouse oocytes control metabolic co-operativity between oocytes and cumulus cells
    John Eppig
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Reprod Fertil Dev 17:1-2. 2005
  8. ncbi Mutagenesis as an unbiased approach to identify novel contraceptive targets
    Mary Ann Handel
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Mol Cell Endocrinol 250:201-5. 2006
  9. ncbi Analysis of hair follicles in mutant laboratory mice
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Investig Dermatol Symp Proc 10:264-70. 2005
  10. ncbi Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis
    Chul Ho Lee
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Diabetes 54:2525-32. 2005

Research Grants

  1. PATHOGENESIS OF AUTOIMMUNE DIABETES IN MICE
    Edward Leiter; Fiscal Year: 1993
  2. GENETICS AND PATHOLOGY OF NON-OBESE DIABETES
    Edward Leiter; Fiscal Year: 1990
  3. NEW MOUSE MODELS OF DIABESITY
    Edward Leiter; Fiscal Year: 2002
  4. GENETICS AND PATHOLOGY OF NON-OBESE DIABETIC (NOD) MICE
    Edward Leiter; Fiscal Year: 1993
  5. GENETICS AND PATHOLOGY OF NONOBESE DIABETIC (NOD) MICE
    Edward Leiter; Fiscal Year: 2002
  6. GENETICS AND PATHOLOGY OF NON-OBESE DIABETIC (NOD) MICE
    Edward Leiter; Fiscal Year: 2005
  7. New Insights into Animals Models of Diabetes
    Edward Leiter; Fiscal Year: 2003
  8. PATHOGENESIS OF AUTOIMMUNE DIABETES IN MICE
    Edward Leiter; Fiscal Year: 2004
  9. FACSVantage SE Sorting Flow Cytometer
    Jane Barker; Fiscal Year: 2002
  10. HEMOLYTIC ANEMIAS--MODELS
    Jane Barker; Fiscal Year: 2002

Scientific Experts

Detail Information

Publications62

  1. pmc MeCP2 is required for normal development of GABAergic circuits in the thalamus
    Zhong Wei Zhang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Neurophysiol 103:2470-81. 2010
    ..Our findings suggest that MeCP2 differentially regulates the development of GABAergic synapses in excitatory and inhibitory neurons in the thalamus...
  2. ncbi From information to understanding: the role of model organism databases in comparative and functional genomics
    C J Bult
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Anim Genet 37:28-40. 2006
    ....
  3. ncbi The long and short of it: somite formation in mice
    Thomas Gridley
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Dev Dyn 235:2330-6. 2006
    ....
  4. ncbi FIMRe: Federation of International Mouse Resources: global networking of resource centers
    Muriel Davisson
    The Jackson Laboratory, 600 Main St, Bar Harbor, Maine 04609, USA
    Mamm Genome 17:363-4. 2006
  5. ncbi Beyond the data deluge: data integration and bio-ontologies
    Judith A Blake
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Biomed Inform 39:314-20. 2006
    ....
  6. ncbi Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration
    Bonnie L Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Invest Ophthalmol Vis Sci 47:1201-9. 2006
    ..These mice exhibit immune dysfunction, hyperproliferation of myeloid cells, and regenerative anemia. This study focused on the role of SHP-1 in retinal homeostasis...
  7. ncbi Mouse oocytes control metabolic co-operativity between oocytes and cumulus cells
    John Eppig
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Reprod Fertil Dev 17:1-2. 2005
  8. ncbi Mutagenesis as an unbiased approach to identify novel contraceptive targets
    Mary Ann Handel
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Mol Cell Endocrinol 250:201-5. 2006
    ..The ReproGenomics Program at The Jackson Laboratory is a United States National Institutes of Health resource for production, identification and distribution ..
  9. ncbi Analysis of hair follicles in mutant laboratory mice
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Investig Dermatol Symp Proc 10:264-70. 2005
    ..A variety of systematic approaches to analysis of the pilosebacous unit are provided here...
  10. ncbi Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis
    Chul Ho Lee
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Diabetes 54:2525-32. 2005
    ....
  11. ncbi Mechanistic insights into glaucoma provided by experimental genetics the cogan lecture
    Simon W M John
    Howard Hughes Medical Institute and The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Invest Ophthalmol Vis Sci 46:2649-61. 2005
  12. ncbi Kick it up a Notch: NOTCH1 activation in T-ALL
    Thomas Gridley
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Cancer Cell 6:431-2. 2004
    ..A recent paper by Weng et al. (2004) demonstrates that novel types of activating mutations in the NOTCH1 gene occur in more than half of all T-ALL cases, implicating NOTCH1 as a major player in the etiology of T-ALL...
  13. ncbi Antibodies that label paraffin-embedded mouse tissues: a collaborative endeavor
    Igor Mikaelian
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Toxicol Pathol 32:181-91. 2004
    ..Regularly updated information on immunohistochemistry of normal and neoplastic mouse tissues is accessible online at (http://tumor.informatics.jax.org); links to antibody suppliers' web sites are provided...
  14. ncbi A collaborative database of inbred mouse strain characteristics
    Stephen C Grubb
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Bioinformatics 20:2857-9. 2004
    ..The current focus is on a set of 40 inbred strains. The MPD as of February 2004 contains approximately 500 phenotypic parameters relevant to human health, voluntarily contributed by several dozen investigators and laboratories...
  15. ncbi Impact of trisomy on fertility and meiosis in male mice
    M Davisson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hum Reprod 22:468-76. 2007
    ..Thus, impairment of spermatogenesis in trisomic males could be due to the presence of extra genomic material (i.e. triplicated genes) or due to the chromosomal abnormality and presence of an unpaired chromosome in meiosis...
  16. ncbi fjoin: simple and efficient computation of feature overlaps
    Joel E Richardson
    The Jackson Laboratory, Mouse Genome Informatics, Bar Harbor, Maine 04609, USA
    J Comput Biol 13:1457-64. 2006
    ..The reference implementation is a stand-alone Python program; it implements the basic algorithm and a number of useful extensions, which are also discussed in this paper...
  17. pmc Mouse Tumor Biology Database (MTB): status update and future directions
    Dale A Begley
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
    Nucleic Acids Res 35:D638-42. 2007
    ..A new pathology data submission tool allows users to submit, edit and release data to the MTB system...
  18. pmc MouseCyc: a curated biochemical pathways database for the laboratory mouse
    Alexei V Evsikov
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Genome Biol 10:R84. 2009
    ..jax.org. MouseCyc has been integrated with genetic and genomic data for the laboratory mouse available from the Mouse Genome Informatics database and with pathway data from other organisms, including human...
  19. pmc A mouse by any other name
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Invest Dermatol 129:1599-601. 2009
    ..This is both an educational and a regulatory task, one in which it is vital to succeed if we are to efficiently and accurately share and use the huge volume of data emerging in the biosciences...
  20. pmc Recombinant human hepatitis B vaccine initiating alopecia areata: testing the hypothesis using the C3H/HeJ mouse model
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Vet Dermatol 20:99-104. 2009
    ....
  21. pmc Pooling and PCR as a method to combat low frequency gene targeting in mouse embryonic stem cells
    A C Brown
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA
    Cytotechnology 51:81-8. 2006
    ..This technically streamlined approach bypasses the need to troubleshoot and re-engineer an existing targeting construct that is functionally suitable despite its low targeting frequency...
  22. pmc A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice
    Kenneth R Johnson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Genomics 92:219-25. 2008
    ..We conclude that ahl8 is a major contributor to the hearing loss of DBA/2J mice and that its effects are dependent on the predisposing Cdh23 ahl genotype of this strain...
  23. pmc Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice
    V E DeMambro
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Endocrinology 149:2051-61. 2008
    ..In summary, there are gender- and compartment-specific changes in Igfbp2(-/-) mice. IGFBP-2 may regulate bone turnover in both an IGF-I-dependent and -independent manner...
  24. doi Stem cell and kinase activity-independent pathway in resistance of leukaemia to BCR-ABL kinase inhibitors
    Shaoguang Li
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Cell Mol Med 11:1251-62. 2007
    ..Apart from BCR-ABL and SRC kinases, stem cell pathways must also be targeted for curative therapy of Ph+ leukaemia...
  25. pmc Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia
    Shaoguang Li
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Leuk Lymphoma 49:19-26. 2008
    ....
  26. pmc Virtues and limitations of the preimplantation mouse embryo as a model system
    Robert A Taft
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Theriogenology 69:10-6. 2008
    ....
  27. ncbi Adipokine and insulin profiles distinguish diabetogenic and non-diabetogenic obesities in mice
    Edward H Leiter
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Obesity (Silver Spring) 15:1961-8. 2007
    ..To use longitudinal profiling of plasma adipokines to distinguish diabetogenic vs. non-diabetogenic obesity syndrome in two new mouse models of polygenic obesity...
  28. ncbi Recombinant inbred strain panels: a tool for systems genetics
    Gary A Churchill
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Physiol Genomics 31:174-5. 2007
  29. ncbi Notch signaling in vascular development and physiology
    Thomas Gridley
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Development 134:2709-18. 2007
    ..Defects in Notch signaling also cause inherited vascular and cardiovascular diseases. In this review, I summarize recent findings and discuss the growing relevance of Notch pathway modulation for therapeutic applications in disease...
  30. pmc Src kinase signaling in leukaemia
    Shaoguang Li
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Int J Biochem Cell Biol 39:1483-8. 2007
    ..Leukaemic stem cells exist in acute lymphoblastic leukaemia, and complete eradication of this group of cells would provide a curative therapy for this disease...
  31. ncbi The XY body: a specialized meiotic chromatin domain
    Mary Ann Handel
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Cell Res 296:57-63. 2004
    ..The special features of the XY body might reflect absence of homology between the sex chromosomes, rather than any form of dosage compensation, and may also serve to mark parental origin of the paternal X chromosome...
  32. ncbi Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice
    Keith DiPetrillo
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 17:215-20. 2004
    ..3-cM region where the high allele strains shared a common haplotype. Bpq8 is concordant with known QTL in both rat and human, suggesting that the causal gene underlying Bpq8 may be conserved as a disease gene in human hypertension...
  33. ncbi Algorithms for mutant sorting: the need for phenotype vocabularies
    J T Eppig
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mamm Genome 11:584-9. 2000
    ..The rationale for developing vocabularies and examples of several vocabularies being developed are described. Finally, the critical nature of community participation in both building and applying phenotype vocabularies is discussed...
  34. pmc A novel mechanism of resistance to mouse mammary tumor virus infection
    T V Golovkina
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Virol 74:2752-9. 2000
    ..JK)F(1) females. Based on the susceptible-resistant phenotype distribution in N(2) females, both MMTV mammary gland infection and mammary gland tumor development in I/LnJ mice are controlled by a single locus...
  35. ncbi NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells
    L D Shultz
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 164:2496-507. 2000
    ..These data demonstrate the advantages of NOD/LtSz-Rag1null mice as a radiation and lymphoma-resistant model for long-term analyses of engrafted human hematolymphoid cells or diabetogenic NOD lymphoid cells...
  36. ncbi Apoptotic and effector pathways in autoimmunity
    A V Chervonsky
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Curr Opin Immunol 11:684-8. 1999
    ..However, in autoimmune diseases, activation of programmed cell death by effector mechanisms that are similar to the normal immune response leads to augmented destruction of the targeted tissues...
  37. ncbi Motor dysfunction in a mouse model for Down syndrome
    A C Costa
    The Jackson Laboratory, Bar Harbor, ME 04609 USA
    Physiol Behav 68:211-20. 1999
    ....
  38. ncbi Characterization of equine natural killer and IL-2 stimulated lymphokine activated killer cell populations
    M M Viveiros
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Dev Comp Immunol 23:521-32. 1999
    ..Hence, equine NK cells can be identified by the NK-5C6 mAb and distinguished from IL-2 stimulated LAK cells by their cytotoxic response to specific target cell lines...
  39. ncbi Identification of a missense mutation in the alphaA-crystallin gene of the lop18 mouse
    B Chang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mol Vis 5:21. 1999
    ..Here we report the identification of a missense mutation in the alphaA-crystallin gene of lop18/lop18 mutant mice...
  40. ncbi It's a knockout!
    A V Anagnostopoulos
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Trends Genet 15:379-80. 1999
    ..Where possible, interesting knockouts will be grouped according to gene families, application or phenotypic similarities...
  41. pmc Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice
    L L Peters
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA Department of Biomedical Research, St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Clin Invest 103:1527-37. 1999
    ..The increased passive Na+ permeability of 4.2(-/-) RBCs is also dependent on cell shrinkage. We conclude that protein 4.2 is important in the maintenance of normal surface area in RBCs and for normal RBC cation transport...
  42. ncbi Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans
    P M Nishina
    Axys Pharmaceuticals, Inc, La Jolla, California, 92037, USA
    Genomics 54:215-20. 1998
    ..We also report that TULP3 maps to human chromosome 12p13. The murine homolog, Tulp3, maps to the telomere of mouse chromosome 6...
  43. ncbi Rhino-9J (hr(rh9J)): a new allele at the hairless locus
    J P Sundberg
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Vet Pathol 35:297-9. 1998
    ..Crosses with RHJ/Le +/hr(rhJ) (rhino-J) mutant mice yielded affected offspring with the same phenotype, verifying the presence of a new allele of rhino, a mutation at the hairless (hr) locus on mouse chromosome 14...
  44. ncbi Development and progression of psoriasiform dermatitis and systemic lesions in the flaky skin (fsn) mouse mutant
    J P Sundberg
    Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Pathobiology 65:271-86. 1997
    ..This spontaneous mouse mutation provides a useful model for modulating neovascularization and keratinocyte hyperproliferation, especially since the cutaneous changes resemble some forms of psoriasis in humans...
  45. ncbi Experimental strategies for the genetic dissection of complex traits in animal models
    A Darvasi
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Nat Genet 18:19-24. 1998
    ..In this study, novel and existing experimental strategies for QTL analysis are presented and evaluated...
  46. ncbi Metaphase I arrest and spontaneous parthenogenetic activation of strain LTXBO oocytes: chimeric reaggregated ovaries establish primary lesion in oocytes
    J J Eppig
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Dev Biol 224:60-8. 2000
    ..Nevertheless, the oocyte's companion somatic cells play crucial roles in the expression of these lesions...
  47. pmc Interdigitated deletion complexes on mouse chromosome 5 induced by irradiation of embryonic stem cells
    J C Schimenti
    The Jackson Laboratory, Bar Harbor, Maine 04609 USA
    Genome Res 10:1043-50. 2000
    ..Overlapping deletion complexes generated in the fashion described in this report will be useful as multipurpose genetic tools and in systematic functional mapping of the mouse genome...
  48. ncbi Development of mouse and rat oocytes in chimeric reaggregated ovaries after interspecific exchange of somatic and germ cell components
    J J Eppig
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Biol Reprod 63:1014-23. 2000
    ..Moreover, although granulosa cells play important roles in oocyte development, the development of species-specific characteristics of oocytes occurs without apparent modification by a xenogeneic follicular environment...
  49. ncbi Transplanted ER-MP12hi20-58med/hi myeloid progenitors produce resident macrophages from marrow that are therapeutic for lysosomal storage disease
    Brian W Soper
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood Cells Mol Dis 32:199-213. 2004
    ..The ability of cells derived from these primitive precursors to seed deep within tissues make them excellent candidates for both cellular therapy and gene transfer techniques to cure a wide range of metabolic diseases...
  50. pmc Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice
    Robert W Burgess
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mol Cell Biol 24:1096-105. 2004
    ..elegans, we propose that Phr1 plays a conserved role in synaptic development and is a candidate gene for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing...
  51. pmc Moving forward with chemical mutagenesis in the mouse
    TIMOTHY P O'BRIEN
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Physiol 554:13-21. 2004
    ..The unique advantages offered using chemical mutagenesis compare favourably to and complement the spectrum of approaches available for functional annotation of the mammalian genome...
  52. ncbi Normoblastosis, a murine model for ankyrin-deficient hemolytic anemia, is caused by a hypomorphic mutation in the erythroid ankyrin gene Ank1
    Connie S Birkenmeier
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hematol J 4:445-9. 2003
    ..A spontaneous mutation, normoblastosis (Ank1nb), discovered in 1969 in a mouse stock maintained at the Jackson Laboratory, provides an important animal model for these human ankyrin-deficient anemias...
  53. ncbi Donor cell replacement in mice transplanted in utero is limited by immune-independent mechanisms
    J E Barker
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Blood Cells Mol Dis 31:291-7. 2003
    ..The mechanism limiting initial expansion may differ from that supporting long-term cell retention...
  54. pmc Ahl2, a second locus affecting age-related hearing loss in mice
    Kenneth R Johnson
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609, USA
    Genomics 80:461-4. 2002
    ..The statistically significant effect of Ahl2 observed in crosses with NOD/LtJ was not seen in crosses involving three other strains with early onset AHL: A/J, BUB/BnJ, and SKH2/J...
  55. ncbi A goniolens for clinical monitoring of the mouse iridocorneal angle and optic nerve
    Richard S Smith
    The Howard Hughes Medical Institute and The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mol Vis 8:26-31. 2002
    ..Due to the increasing importance of mouse models and mouse genetics in ophthalmic research, we have developed a goniolens for mice...
  56. ncbi Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene
    S A Cook
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Cytogenet Cell Genet 93:77-82. 2001
    ..Clinical, histopathological, and Northern analyses indicate that our radiation-induced mutation, uox(In), is a putative null...
  57. ncbi Morphology of hair in normal and mutant laboratory mice
    J P Sundberg
    Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Eur J Dermatol 11:357-61. 2001
    ..Examples of characterized mutant mice with abnormal pilosebaceous unit phenotypes are presented to illustrate the value of these animals as models to help understand human diseases of the skin and hair...
  58. ncbi Mapping of microsatellite loci and association of aorta atherosclerosis with LG VI markers in the rabbit
    R Korstanje
    Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands
    Physiol Genomics 6:11-8. 2001
    ..A significant cosegregation was found between the degree of aorta atherosclerosis and the allelic variation of the biochemical marker Est-2 on LG VI in male rabbits. This association was not found in female rabbits...
  59. ncbi Diverse repertoire of the MHC class II-peptide complexes is required for presentation of viral superantigens
    T Golovkina
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 166:2244-50. 2001
    ..Thus, MHC class II peptide repertoire is critical for recognition of v-Sag by the T cells and affects the outcome of infection with a retrovirus...
  60. ncbi Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation
    D V Serreze
    The Jackson Laboratory, Bar Harbor, ME 04609 Department of Medicine, University of Alberta, Edmonton, Canada
    J Immunol 166:1352-9. 2001
    ....
  61. ncbi Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice
    B Paigen
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 4:59-65. 2000
    ..L-Lith2(s). Other suggestive, but not statistically significant, loci mapped to chromosomes 6, 7, 8, 10, and X. The identification of these Lith genes will elucidate the pathophysiology of cholesterol gallstone formation...
  62. ncbi Comparative maps: adding pieces to the mammalian jigsaw puzzle
    J T Eppig
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Curr Opin Genet Dev 6:723-30. 1996
    ..The availability of these data in electronically accessible formats is critical to the growth and analysis of comparative maps...

Research Grants62

  1. PATHOGENESIS OF AUTOIMMUNE DIABETES IN MICE
    Edward Leiter; Fiscal Year: 1993
    ....
  2. GENETICS AND PATHOLOGY OF NON-OBESE DIABETES
    Edward Leiter; Fiscal Year: 1990
    ..The proposed studies employing manipulation of the immune system should allow an understanding of how defects in immunoregulation in a diabetes-susceptible genotype can trigger pathogenetic sequelae leading to overt diabetes...
  3. NEW MOUSE MODELS OF DIABESITY
    Edward Leiter; Fiscal Year: 2002
    ..Collectively, these studies will permit genetic and metabolic characterization of key events in the transition from simple obesity to diabesity in thee novel mouse models. ..
  4. GENETICS AND PATHOLOGY OF NON-OBESE DIABETIC (NOD) MICE
    Edward Leiter; Fiscal Year: 1993
    ..Results from these proposed studies will guide geneticists in their search for non-MHC linked diabetogenic susceptibility genes in humans and enhance understanding of their interactions with diabetogenic MHC genes...
  5. GENETICS AND PATHOLOGY OF NONOBESE DIABETIC (NOD) MICE
    Edward Leiter; Fiscal Year: 2002
    ..The combination of approaches proposed should permit not only molecular identification of major non-MHC associated IDDM susceptibility genes, but also establishment of their pathogenic contributions at a cellular level. ..
  6. GENETICS AND PATHOLOGY OF NON-OBESE DIABETIC (NOD) MICE
    Edward Leiter; Fiscal Year: 2005
    ..These latter investigations are of particular importance in view of an ongoing NIDDK trial to prevent T1D in humans deemed at high risk by oral insulin treatment. ..
  7. New Insights into Animals Models of Diabetes
    Edward Leiter; Fiscal Year: 2003
    ..meeting will convene over a period of 3-4 days, June 17-20, 2003 in Bar Harbor, Maine under the aegis of The Jackson Laboratory's Courses and Conferences department. The meeting is planned for 200 participants...
  8. PATHOGENESIS OF AUTOIMMUNE DIABETES IN MICE
    Edward Leiter; Fiscal Year: 2004
    ..Understanding the contributions of diabetes modifying genes in the extended mouse MIHC may identify human HLA orthologs whose presence has recently been established. ..
  9. FACSVantage SE Sorting Flow Cytometer
    Jane Barker; Fiscal Year: 2002
    ..genetically predetermined pathobiological syndromes is critical to biomedical research and researchers at the Jackson Laboratory (TJL) are at the forefront of this endeavor...
  10. HEMOLYTIC ANEMIAS--MODELS
    Jane Barker; Fiscal Year: 2002
    ..abstract_text> ..
  11. Hemolytic Anemia: Models
    Jane Barker; Fiscal Year: 2004
    ..5 isoform in the structure and assembly of the sarcoplasmic reticulum by an in vivo developmental study. ..
  12. Q
    Jane Barker; Fiscal Year: 1993
    ..W41/W39 blastocysts will be used because their cells will not compete with cells from the alpha thalassemic teratocarcinomas or from the "cured" W41/W39 teratocarcinomas to populate the erythrypoietic organs...
  13. HEMOLYTIC ANEMIAS MODELS
    Jane Barker; Fiscal Year: 1990
    ....