The Children's Hospital of Philadelphia

Summary

Organization: The Children's Hospital of Philadelphia
Country: USA

Top Publications

  1. doi Outpatient management of pediatric heart failure
    Matthew J O'Connor
    Division of Cardiology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    Heart Fail Clin 6:515-29, ix. 2010
  2. ncbi Long-term noninvasive arrhythmia assessment after total anomalous pulmonary venous connection repair
    Ronn E Tanel
    Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am Heart J 153:267-74. 2007
  3. ncbi Timeline to operative intervention for solid organ injuries in children
    Michael L Nance
    Department of Surgery, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Trauma 61:1389-92. 2006
  4. ncbi Sequential liver and bone marrow transplantation for treatment of erythropoietic protoporphyria
    Elizabeth B Rand
    Department of Pediatrics, University of Pennsylvania, Children s Hospital of Philadelphia, 324 S 34th St, Philadelphia, PA 19104, USA
    Pediatrics 118:e1896-9. 2006
  5. ncbi A multidisciplinary approach to vascular access in children
    Theresa R Schultz
    Radiology, Sedation, Vascular Access Service, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Spec Pediatr Nurs 11:254-6. 2006
  6. ncbi Successful revision of portoenterostomy in an infant with biliary atresia
    Barbara A Haber
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 41:e1-3. 2006
  7. ncbi Artefactual atrial flutter
    Jonathan R Kaltman
    Division of Cardiology, University of Pennsylvania School of Medicine and The Cardiac Center, The Children s Hospital of Philadelphia, 19104, USA
    Cardiol Young 16:195-6. 2006
  8. ncbi Endocrine problems in critically ill children: an overview
    Tara Trimarchi
    Children s Hospital of Philadelphia and the School of Nursing, The University of Pennsylvania, 19104, USA
    AACN Clin Issues 17:66-78. 2006
  9. ncbi Pediatric body packing: drug smuggling reaches a new low
    Suzanne Beno
    Division of Emergency Medicine, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Emerg Care 21:744-6. 2005
  10. ncbi Protracted pain following partial splenic embolization in an adolescent female with hypersplenism
    Arjunan Ganesh
    Department of Anesthesiology and Critical Care, The Children s Hospital of Philadelphia, Philadelphia, PA 19010, USA
    Paediatr Anaesth 15:1013-5. 2005

Detail Information

Publications62

  1. doi Outpatient management of pediatric heart failure
    Matthew J O'Connor
    Division of Cardiology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    Heart Fail Clin 6:515-29, ix. 2010
    ..This review focuses on the current state-of-the-art with respect to the outpatient management of heart failure in children...
  2. ncbi Long-term noninvasive arrhythmia assessment after total anomalous pulmonary venous connection repair
    Ronn E Tanel
    Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am Heart J 153:267-74. 2007
    ..However, there has been no comprehensive, long-term, electrophysiologic study of patients who have undergone repair of total anomalous pulmonary venous connection...
  3. ncbi Timeline to operative intervention for solid organ injuries in children
    Michael L Nance
    Department of Surgery, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Trauma 61:1389-92. 2006
    ..Little is know regarding the time to failure for those children requiring operative intervention. We sought to delineate this timeline to operative intervention for the subset of single solid organ injured patients requiring laparotomy...
  4. ncbi Sequential liver and bone marrow transplantation for treatment of erythropoietic protoporphyria
    Elizabeth B Rand
    Department of Pediatrics, University of Pennsylvania, Children s Hospital of Philadelphia, 324 S 34th St, Philadelphia, PA 19104, USA
    Pediatrics 118:e1896-9. 2006
    ..This combination corrected the severe phenotype, resolving the severe photosensitivity and halting erythropoietic protoporphyria associated liver graft injury. Splenectomy seemed to facilitate the successful bone marrow transplant...
  5. ncbi A multidisciplinary approach to vascular access in children
    Theresa R Schultz
    Radiology, Sedation, Vascular Access Service, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Spec Pediatr Nurs 11:254-6. 2006
  6. ncbi Successful revision of portoenterostomy in an infant with biliary atresia
    Barbara A Haber
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 41:e1-3. 2006
    ..At 14 months of age, the child is anicteric and growing well. In this case, successful revision of hepatoportoenterostomy averted the need for liver transplantation...
  7. ncbi Artefactual atrial flutter
    Jonathan R Kaltman
    Division of Cardiology, University of Pennsylvania School of Medicine and The Cardiac Center, The Children s Hospital of Philadelphia, 19104, USA
    Cardiol Young 16:195-6. 2006
  8. ncbi Endocrine problems in critically ill children: an overview
    Tara Trimarchi
    Children s Hospital of Philadelphia and the School of Nursing, The University of Pennsylvania, 19104, USA
    AACN Clin Issues 17:66-78. 2006
    ....
  9. ncbi Pediatric body packing: drug smuggling reaches a new low
    Suzanne Beno
    Division of Emergency Medicine, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Emerg Care 21:744-6. 2005
    ..This article is the first to report on the phenomenon of body packing in young children. It also highlights the use of prescription opioids as cargo, which has not previously been addressed in the literature...
  10. ncbi Protracted pain following partial splenic embolization in an adolescent female with hypersplenism
    Arjunan Ganesh
    Department of Anesthesiology and Critical Care, The Children s Hospital of Philadelphia, Philadelphia, PA 19010, USA
    Paediatr Anaesth 15:1013-5. 2005
    ..Massive splenomegaly treated with PSE may require an extended hospital stay to achieve pain control. Such patients may subsequently require transition to enteral opioids and weaning...
  11. ncbi Adolescent use of the monthly contraceptive injection
    Lisa Kessler Tuchman
    Pediatric Residency Training Program, Cincinnati Children s Hospital Medical Center, Ohio, USA
    J Pediatr Adolesc Gynecol 18:255-60. 2005
    ..To compare weight and continuation among adolescents using monthly medroxyprogesterone acetate (MPA)/ethinyl estradiol cypionate (E2C), tri-monthly depot MPA (DMPA), and daily oral contraceptive pills (OCP)...
  12. ncbi A national study of neighborhood safety, outdoor play, television viewing, and obesity in preschool children
    Hillary L Burdette
    Division of Gastroenterology and Nutrition, Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 116:657-62. 2005
    ..To test the hypothesis that preschool children have a higher prevalence of obesity, spend less time playing outdoors, and spend more time watching television (TV) when they live in neighborhoods that their mothers perceive as unsafe...
  13. ncbi Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States)
    Greta R Bunin
    Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cancer Causes Control 16:877-91. 2005
    ..French fries (OR = 2.4, 95% CI: 1.2, 4.9) and chili peppers (OR = 1.8, 95% CI: 1.0, 3.0) were associated with medulloblastoma/PNET. The results suggest that some aspects of diet are worthy of further research...
  14. pmc Pneumococcal HtrA protease mediates inhibition of competence by the CiaRH two-component signaling system
    M E Sebert
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Bacteriol 187:3969-79. 2005
    ..These findings suggest a novel regulatory role for pneumococcal HtrA in modulating the activity of a two-component signaling system that controls the development of genetic competence...
  15. ncbi Food and Drug Administration public hearing on the conduct of emergency clinical research: testimony of Dr. Nelson
    Robert M Nelson
    Department of Anesthesiology, Critical Care, The Children s Hospital of Philadelphia, Philadelphia, PA
    Acad Emerg Med 14:e43-4. 2007
  16. ncbi Secular trends in response rates for controls selected by random digit dialing in childhood cancer studies: a report from the Children's Oncology Group
    Greta R Bunin
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Epidemiol 166:109-16. 2007
    ..4% per year (95% CI: -2.7, -2.0; p < 0.001). The current low response rates for RDD indicate a substantial potential for selection bias and a need to seek alternative sources of controls...
  17. ncbi Interlobular bile duct loss in pediatric cholestatic disease is associated with aberrant cytokeratin 7 expression by hepatocytes
    Linda M Ernst
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Dev Pathol 10:383-90. 2007
    ..Aberrant CK7 expression may reflect a metaplastic change to a "stem cell" phenotype induced by loss of contact with the more distal biliary tree...
  18. pmc The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages
    Margarita de la Llera-Moya
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 30:796-801. 2010
    ..Thus, we wanted to elucidate why efflux capacity could be independent of total HDL-C or apolipoprotein A-I (apoA-I)...
  19. pmc The role of outpatient facilities in explaining variations in risk-adjusted readmission rates between hospitals
    Scott A Lorch
    Department of Pediatrics, Center for Outcomes Research, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Health Serv Res 45:24-41. 2010
    ..Validate risk-adjusted readmission rates as a measure of inpatient quality of care after accounting for outpatient facilities, using premature infants as a test case...
  20. pmc Interictal EEG spikes identify the region of electrographic seizure onset in some, but not all, pediatric epilepsy patients
    Eric D Marsh
    Division of Child Neurology, Department of Neurology and Pediatrics, Children s Hospital of Philadelphia, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Epilepsia 51:592-601. 2010
    ..Indeed, past studies suggest an inconsistent relationship between IED and seizure-onset location, although these studies were based upon relatively short EEG epochs...
  21. pmc Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children
    Charles A Stanley
    The Children s Hospital of Philadelphia, PA 19104, USA
    Am J Clin Nutr 90:862S-866S. 2009
    ....
  22. ncbi Enteropeptidase, a type II transmembrane serine protease
    X Long Zheng
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Front Biosci (Elite Ed) 1:242-9. 2009
    ..Conversely, duodenopancreatic reflux of proteolytically active enteropeptidase may cause acute and chronic pancreatitis...
  23. doi A prospective, multicenter study of caspofungin for the treatment of documented Candida or Aspergillus infections in pediatric patients
    Theoklis E Zaoutis
    Children s Hospital of Philadelphia, Division of Infectious Diseases, 34th Street and Civic Center Boulevard, CHOP North, Suite 1527, Philadelphia, PA 19104, USA
    Pediatrics 123:877-84. 2009
    ..We evaluated the safety, tolerability, and efficacy of caspofungin in pediatric patients with invasive aspergillosis, invasive candidiasis, or esophageal candidiasis...
  24. doi Esophageal obstruction and intracardiac "mass" in association with omphalocele closure
    Teresa Victoria
    Radiology Department, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 44:448-50. 2009
    ..Knowledge of these less well-recognized anatomical variations is important to avoid unnecessary interventions...
  25. pmc Vaccines and autism: a tale of shifting hypotheses
    Jeffrey S Gerber
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Clin Infect Dis 48:456-61. 2009
    ..We will discuss the genesis of each of these theories and review the relevant epidemiological evidence...
  26. doi Robotic ureterocalicostomy in the pediatric population
    Pasquale Casale
    Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Urol 180:2643-8. 2008
    ....
  27. doi Primary early thoracoscopy and reduction in length of hospital stay and additional procedures among children with complicated pneumonia: results of a multicenter retrospective cohort study
    Samir S Shah
    Division of Infectious Diseases, The Childrens Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 162:675-81. 2008
    ....
  28. doi The impact of aortic arch geometry on flow dynamics using a simplified approach with magnetic resonance velocity mapping
    Mark A Fogel
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Congenit Heart Dis 1:300-8. 2006
    ..We sought to determine, in vivo, the impact of aortic arch geometry on flow dynamics, which affects overall cardiovascular energetics and has implications for organ perfusion and Doppler flow calculations...
  29. ncbi Pediatric musculoskeletal MRI: basic principles to optimize success
    Diego Jaramillo
    Department of Radiology, Children s Hospital of Philadelphia, 34th Street and Civic Center Blvd, Philadelphia, PA, 19104, USA
    Pediatr Radiol 38:379-91. 2008
    ..Finally, special considerations for imaging at 3 T are also reviewed...
  30. ncbi Intermediate levels of neuronal palmitoyl-protein Delta-9 desaturase in heterozygotes for murine Batten disease
    Srinivas B Narayan
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Mol Genet Metab 93:89-91. 2008
    ..This is the first report of a heterozygous abnormality in Batten disease and provides important confirmation that this is the function of the CLN3 protein in neuronal tissues...
  31. ncbi A sampling bias in identifying children in foster care using Medicaid data
    David M Rubin
    Pediatric Generalist Research Group, Safe Place The Center for Child Protection and Health of the Division of General Pediatrics, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Ambul Pediatr 5:185-90. 2005
    ..Prior research identified foster care children using Medicaid eligibility codes specific to foster care, but it is unknown whether these codes capture all foster care children...
  32. ncbi School performance of children with gestational cocaine exposure
    Hallam Hurt
    Neonatology, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, United States
    Neurotoxicol Teratol 27:203-11. 2005
    ..To document school performance (pass/fail, grade point average, reading level, standardized test scores, absences) of cocaine-exposed and control children...
  33. ncbi Activated polyurethane modified with latent thiol groups
    Ivan S Alferiev
    Division of Cardiology, Abramson Research Center, Children s Hospital of Philadelphia, Suite 702, 3516 Civic Center Blvd, Philadelphia, PA 19104 4318, USA
    Biomaterials 23:4753-8. 2002
    ..The acetylthio-modified polyurethane is sufficiently stable to withstand conditions typical for the high-temperature processing (molding, extrusion) of polyurethanes...
  34. ncbi Laryngeal electromyography in the management of vocal cord mobility problems in children
    Ian N Jacobs
    Divisions of Pediatric Otolaryngology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, U S A
    Laryngoscope 112:1243-8. 2002
    ....
  35. ncbi Psychotropic medication use in a population of children who have attention-deficit/hyperactivity disorder
    James Guevara
    Division of General Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 109:733-9. 2002
    ..The objectives of this study were to examine differences in nonstimulant psychotropic medication fills between children with and without identified ADHD and to assess associations with non-ADHD neurobehavioral disorders...
  36. ncbi Analysis of genomic imprinting at 1p35-36 in neuroblastoma
    M D Hogarty
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 36:52-5. 2001
    ..2-36.3. Indirect evidence suggests the presence of an imprinted neuroblastoma suppressor gene within this region, as well as an additional nonimprinted, proximal suppressor gene, inactivation of which correlates with MYCN amplification...
  37. ncbi Constipation as a cause of scrotal pain in children
    J A Fein
    Division of Emergency Medicine, The Children s Hospital of Philadelphia, PA 19104, USA
    Am J Emerg Med 19:290-2. 2001
    ..Recognition of the association between constipation and subacute or chronic scrotal pain can guide the clinician towards appropriate therapy for these patients...
  38. ncbi gamma-Aminobutyric acid(A) receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development
    A R Brooks-Kayal
    Pediatric Regional Epilepsy Program and Joseph Stokes Research Institute of The Children s Hospital of Philadelphia, PA 19104, USA
    J Neurochem 77:1266-78. 2001
    ..These findings suggest that developmental differences in subunit expression contribute to alterations in GABA(A) receptor function during postnatal development...
  39. ncbi BIN1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN amplification
    M D Hogarty
    Department of Pediatrics, University of Pennsylvania School of Medicine and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 35:559-62. 2000
    ..We hypothesized that BIN1, a MYC interacting protein capable of inducing apoptosis, may be an important regulator of MYCN in neuroblastoma...
  40. ncbi Utility of laboratory testing for infants with seizures
    R J Scarfone
    MCP Hahnemann School of Medicine, Philadelphia, PA, USA
    Pediatr Emerg Care 16:309-12. 2000
    ....
  41. ncbi Outpatient pediatric blood cultures: time to positivity
    K L McGowan
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 106:251-5. 2000
    ..Using a continuously monitoring blood culture system, we determined the time to positivity of blood cultures performed on immunocompetent infants and children who were not receiving antibiotics at the time of culture...
  42. ncbi The Xenopus eomesodermin promoter and its concentration-dependent response to activin
    K Ryan
    Wellcome CRC Institute, Cambridge, UK
    Mech Dev 94:133-46. 2000
    ..A repressor element extinguishes Eomes expression in the endoderm. We relate our results to mesoderm patterning in early Xenopus development and to a mechanism of morphogen gradient response...
  43. ncbi Treatment of acquired epileptic aphasia with the ketogenic diet
    A G Bergqvist
    Pediatric Regional Epilepsy Program, Division of Neurology, The Children s Hospital of Philadelphia, PA 19104, USA
    J Child Neurol 14:696-701. 1999
    ..This is the first reported series of patients with acquired epileptic aphasia successfully treated with the ketogenic diet, and suggests a new therapeutic alternative for patients with this often difficult-to-treat disorder...
  44. ncbi Treatment of pyogenic granuloma by shave excision and laser photocoagulation
    R E Kirschner
    Division of Plastic and Reconstructive Surgery, Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, 19104 4399, USA
    Plast Reconstr Surg 104:1346-9. 1999
    ....
  45. ncbi Maturation-dependent apoptotic cell death of oligodendrocytes in myelin-deficient rats
    J B Grinspan
    Department of Research Neurology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Neurosci Res 54:623-34. 1998
    ..Mature oligodendrocytes fail to accumulate in md brain because they die before they fully mature...
  46. ncbi Gene therapy for bleeding disorders
    Catherine S Manno
    University of Pennsylvania School of Medicine, Philadelphia, USA
    Curr Opin Hematol 9:511-5. 2002
    ..Multiple approaches to gene transfer in the hemophilias are currently under investigation...
  47. ncbi Upper airway size analysis by magnetic resonance imaging of children with obstructive sleep apnea syndrome
    Raanan Arens
    Division of Pulmonary Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Am J Respir Crit Care Med 167:65-70. 2003
    ....
  48. ncbi Tissue oxygen tension during regional low-flow perfusion in neonates
    William M DeCampli
    Divisions of Pediatric Cardiothoracic Surgery and Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 125:472-80. 2003
    ..We examined cerebral cortical and peripheral organ tissue Po(2) values in a neonatal piglet model of regional low-flow perfusion...
  49. ncbi Efficacy of botulinum toxin A, serial casting, and combined treatment for spastic equinus: a retrospective analysis
    Allan M Glanzman
    Department of Physical Therapy, Children s Seashore House of The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Dev Med Child Neurol 46:807-11. 2004
    ..37). There was no significant difference between casting with or without BTX-A, and both improved ROM to a greater degree than BTX-A alone. Casting demonstrated a significantly more robust impact on range of motion than BTX-A alone...
  50. ncbi Pediatric interventional catheterization: reasonable expectations and outcomes
    Jonathan J Rome
    Department of Pediatrics, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatr Clin North Am 51:1589-610, viii. 2004
    ..This article considers the role transcatheter therapy plays in the treatment of each major type of congenital heart lesion. The focus is on the clinical ramifications of the interventions rather than their technical aspects...
  51. ncbi Somatostatin and cancer: applying endocrinology to oncology
    Adda Grimberg
    Division od Pediatric Endocrinology, The Children s Hospital of Philadelphia, Philadephia, PA 19104 4318, USA
    Cancer Biol Ther 3:731-3. 2004
    ..Potential mechanisms by which somatostatin analogs may be useful in oncology include its endocrine actions, autocrine/paracrine effects, SSTR-mediated cell signaling and SSTR-mediated cell labeling...
  52. ncbi Placement stability and mental health costs for children in foster care
    David M Rubin
    Pediatric Generalist Research Group, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 113:1336-41. 2004
    ..The secondary aim is to test the hypothesis that foster care children are also more likely to generate high costs for mental health services if they generate higher costs for non-mental health claims...
  53. ncbi Parental report of outdoor playtime as a measure of physical activity in preschool-aged children
    Hillary L Burdette
    Divisions of General and Community Pediatrics and Cardiology, Cincinnati Children s Hospital Medical Center, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 158:353-7. 2004
    ..Time spent playing outdoors is a potential surrogate measure of physical activity in preschoolers, but parental-report measures of outdoor playtime have not been evaluated...
  54. ncbi New insights into erythropoietin and epoetin alfa: mechanisms of action, target tissues, and clinical applications
    Mitchell J Weiss
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Oncologist 8:18-29. 2003
    ..Further investigation into the nonerythropoietic effects of epoetin alfa could broaden its clinical utility for patients with cancer and also provide new therapies for various neurologic disorders...
  55. ncbi Conservation of Sox4 gene structure and expression during chicken embryogenesis
    Kathryn L Maschhoff
    Department of Pediatrics, Children s Hospital of Philadelphia and University of Pennsylvania Medical Center, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Gene 320:23-30. 2003
    ....
  56. ncbi 14th EORTC-NCI-AACR symposium on "Molecular Targets and Cancer Therapeutics," November 19-22, 2002, Frankfurt, Germany
    Audrey E Evans
    University of Pennsylvania School of Medicine, Department of Pediatrics, Children s Hospital of Philadelphia, Suite 902 Abramson Research Building, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 41:541-4. 2003
  57. ncbi Booster seats for children: closing the gap between science and public policy in the United States
    Dennis R Durbin
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Traffic Inj Prev 4:5-8. 2003
  58. ncbi Atypicality, intelligence, and age: a conceptual model of autistic spectrum disorder
    James Coplan
    Children s Seashore House, Room 210A, 3405 Civic Center Boulevard, Philadelphia, PA 19104 4388, USA
    Dev Med Child Neurol 45:712-6. 2003
  59. ncbi Dysplasia: a common finding in intractable pediatric temporal lobe epilepsy
    B E Porter
    Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, and Department of Pediatrics and Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurology 61:365-8. 2003
    ..Pre-existing cortical dysplasia (CD) may also predispose to refractory TLE, independent of other risk factors for epilepsy...
  60. ncbi The requirement for evasion of programmed cell death in neuroblastomas with MYCN amplification
    Michael D Hogarty
    Division of Oncology, The Children s Hospital of Philadelphia and the Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Cancer Lett 197:173-9. 2003
    ....
  61. ncbi Fetoscopic surgery
    Timothy M Crombleholme
    Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    Clin Obstet Gynecol 46:76-91. 2003
  62. pmc Oral inoculation with herpes simplex virus type 1 infects enteric neuron and mucosal nerve fibers within the gastrointestinal tract in mice
    R M Gesser
    Division of Allergy, Immunology, and Infectious Diseases, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Virol 70:4097-102. 1996
    ..These intramucosal nerve fibers may be a conduit by which intraluminal virus is able to gain access to the enteric nervous system from the gastrointestinal lumen...

Research Grants62

  1. Risk Factors and Outcomes of Candidemia in Children
    Theoklis Zaoutis; Fiscal Year: 2007
    ....
  2. Comparative Effectiveness and Safety of Hospital-Based Pediatric Palliative Care
    JOHN CHRIS FEUDTNER; Fiscal Year: 2010
    ....
  3. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2007
    ..We propose to evaluate this cohort at 4 years of age to test the hypothesis that APOE genotype predicts cognitive impairment, impaired attention and executive function, as well as impairment of fine motor and visual-motor skills. ..
  4. Decisionmaking in Pediatric Palliative Care
    JOHN FEUDTNER; Fiscal Year: 2007
    ....
  5. Decisionmaking in Pediatric Advanced Care
    JOHN CHRIS FEUDTNER; Fiscal Year: 2010
    ....
  6. Pimecrolius on T cell Responses in Atopic March
    Jonathan Spergel; Fiscal Year: 2007
    ..In third aim of the trial, we explore the effects of pimecrolimus as a disease-modifying agent in the prevention of asthma. Asthma phenotype will be examined by spirometry per and post-beta-2-agonist and exhaled nitric oxide. ..
  7. Cerebral Blood Flow in Single Ventricle and Normal Children Utilizing MRI
    MARK ALAN FOGEL; Fiscal Year: 2010
    ..Changing the way the blood flows in these patients by surgery may alter the way we ultimately manage these patients medically and surgically. ..
  8. Patient Oriented Research in Vitamin D and Physical Functioning in CKD
    Mary Leonard; Fiscal Year: 2007
    ..Delineation of the relations between vitamin D levels and physical functioning outcomes is necessary in order to develop anticipated randomized trials of vitamin D supplementation in CKD. ..
  9. Structural Bone Disease in Chronic Renal Insufficiency
    Mary Leonard; Fiscal Year: 2007
    ..Accurate characterization of bone structure in CRI is necessary to identify risk factors for fragility, and to evaluate potential therapies. ..
  10. CHANGES IN SKELETAL MICROARCHITECTURE FOLLOWING RENAL TRANSPLANTATION
    Mary Leonard; Fiscal Year: 2007
    ..The determination of changes in bone density and structure after transplantation is necessary in order to identify appropriate interventions for this high-risk population. ..
  11. CHANGES IN SKELETAL MICROARCHITECTURE FOLLOWING RENAL TRANSPLANTATION
    MARY BETH LEONARD; Fiscal Year: 2010
    ..The determination of changes in bone density and structure after transplantation is necessary in order to identify appropriate interventions for this high-risk population. ..
  12. Bone Health in Pediatric Crohn Disease: A Low Magnitude Mechanical Stimulus Trial
    MARY BETH LEONARD; Fiscal Year: 2010
    ..The NIH Osteoporosis Consensus Statement called for studies to identify interventions that promote bone health in children at risk. LMMS may provide a safe and effective treatment for myriad chronic pediatric diseases. ..
  13. Vitamin D Deficiency, Physical Performance and Cardiovascular Outcomes in CRIC
    Mary Leonard; Fiscal Year: 2009
    ..Delineation of the relations between 25(OH)D and 1,25(OH)2D and clinical outcomes is necessary in order to develop anticipated randomized trials of vitamin D supplementation in CRI. ..
  14. CHANGES IN SKELETAL MICROARCHITECTURE FOLLOWING RENAL TRANSPLANTATION
    Mary Leonard; Fiscal Year: 2009
    ..The determination of changes in bone density and structure after transplantation is necessary in order to identify appropriate interventions for this high-risk population. ..
  15. Bone Health in Pediatric Crohn Disease: A Low Magnitude Mechanical Stimulus Trial
    Mary Leonard; Fiscal Year: 2009
    ..The NIH Osteoporosis Consensus Statement called for studies to identify interventions that promote bone health in children at risk. LMMS may provide a safe and effective treatment for myriad chronic pediatric diseases. ..
  16. Vitamin D Deficiency, Physical Performance and Cardiovascular Outcomes in CRIC
    Mary Leonard; Fiscal Year: 2007
    ..Delineation of the relations between 25(OH)D and 1,25(OH)2D and clinical outcomes is necessary in order to develop anticipated randomized trials of vitamin D supplementation in CRI. ..
  17. Low Magnitude Mechanical Stimuli Effects on Bone Structu
    Mary Leonard; Fiscal Year: 2006
    ..Consistent with the Program Announcement, it is anticipated that this innovative study will lead to a full-scale clinical trial of LMMS as an anabolic bone therapy for ROD in dialysis patients. ..
  18. PROTECTION FROM VIRAL GASTROENTERITIS BY INTESTINAL CTLS
    Paul Offit; Fiscal Year: 1993
    ..Adaptation of murine rotaviruses to growth in tissue culture allows for an accurate determination of the virus dose used for in vitro and in vivo studies...
  19. ENHANCEMENT OF IMMUNOGENICITY BY MICROENCAPSULATION
    Paul Offit; Fiscal Year: 1999
    ..alter the fine antigenic specificities of virus-specific neutralizing antibodies or CTLs? 4) Does oral inoculation of mice with microencapsulated virus or viral proteins enhance the capacity of immunization to protect against challenge? ..
  20. STRUCTURAL EFFECTS OF RENAL OSTEODYSTROPHY DURING GROWTH
    Mary Leonard; Fiscal Year: 2006
    ....
  21. GLUCOCORTICOID-INDUCED OSTEOPENIA IN CHILDREN
    Mary Leonard; Fiscal Year: 2005
    ..The accurate characterization of GC and disease effects on skeletal development is necessary to identify and evaluate targeted therapies to optimize skeletal architecture and peak bone mass in childhood. ..
  22. ENHANCING MUCOSAL IMMUNE RESPONSES BY MICROENCAPSULATION
    Paul Offit; Fiscal Year: 2005
    ..The availability of microencapsulated virus provides a unique opportunity to understand the relationship between APC and protective mucosal immune responses. ..