Gang Wu

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Binding kinetics of calmodulin with target peptides of three nitric oxide synthase isozymes
    Gang Wu
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Inorg Biochem 105:1226-37. 2011
  2. pmc Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation
    Gang Wu
    Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA
    Biochemistry 46:534-42. 2007
  3. pmc Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2
    Ah Lim Tsai
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Inorg Biochem 105:366-74. 2011
  4. pmc Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects
    Gang Wu
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Inorg Biochem 105:382-90. 2011
  5. pmc Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping
    Jian ming Lu
    Department of Internal Medicine, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Inorg Biochem 105:356-65. 2011
  6. pmc Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2
    Gang Wu
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Biochemistry 48:11902-11. 2009
  7. pmc The selectivity of Vibrio cholerae H-NOX for gaseous ligands follows the "sliding scale rule" hypothesis. Ligand interactions with both ferrous and ferric Vc H-NOX
    Gang Wu
    Division of Hematology, Department of Internal Medicine, The University of Texas Medical School at Houston, 6431 Fannin Street, Houston, Texas 77030, United States
    Biochemistry 52:9432-46. 2013
  8. ncbi request reprint Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin
    Vladimir Berka
    Division of Hematology, Department of Internal Medicine, University of Texas Health Science Center at Houston, 77030, USA
    J Biol Chem 279:32243-51. 2004
  9. ncbi request reprint Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2
    Corina E Rogge
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Biochemistry 43:1560-8. 2004
  10. pmc High-yield production, purification and characterization of functional human duodenal cytochrome b in an Escherichia coli system
    Wen Liu
    Department of Internal Medicine, University of Texas Health Science Center, Houston, TX 77030, United States
    Protein Expr Purif 79:115-21. 2011

Collaborators

Detail Information

Publications16

  1. pmc Binding kinetics of calmodulin with target peptides of three nitric oxide synthase isozymes
    Gang Wu
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Inorg Biochem 105:1226-37. 2011
    ..Only iNOS(507-531) was able to bind apo Alexa-CaM, but in a very different conformation from its binding to holo Alexa-CaM...
  2. pmc Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation
    Gang Wu
    Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA
    Biochemistry 46:534-42. 2007
    ..Computer modeling to a minimal mechanism was consistent with oxyferryl heme being the source of peroxidase inactivation...
  3. pmc Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2
    Ah Lim Tsai
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Inorg Biochem 105:366-74. 2011
    ..The improved understanding of the dynamics of AA and tyrosyl radicals in PGHS-1 and -2 will be useful for elucidating details of the cyclooxygenase mechanism, particularly the H-transfer between tyrosyl radical and AA...
  4. pmc Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects
    Gang Wu
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Inorg Biochem 105:382-90. 2011
    ..The large difference of the observed KIE from that of lipoxygenase indicates very different mechanism of hydrogen transfer...
  5. pmc Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping
    Jian ming Lu
    Department of Internal Medicine, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Inorg Biochem 105:356-65. 2011
    ..To reconcile the results from EPR and NO-trapping studies, we propose that the NS1c is in equilibrium with an AA pentadienyl radical, and that the latter reacts preferentially with NO...
  6. pmc Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2
    Gang Wu
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Biochemistry 48:11902-11. 2009
    ..This dramatic modulation of tyrosyl radical stability by cyclooxygenase site ligands suggests a mechanism for regulating the reactivity of PGHS tyrosyl radicals with cellular antioxidants...
  7. pmc The selectivity of Vibrio cholerae H-NOX for gaseous ligands follows the "sliding scale rule" hypothesis. Ligand interactions with both ferrous and ferric Vc H-NOX
    Gang Wu
    Division of Hematology, Department of Internal Medicine, The University of Texas Medical School at Houston, 6431 Fannin Street, Houston, Texas 77030, United States
    Biochemistry 52:9432-46. 2013
    ..Characterization of both ferric and ferrous Vc H-NOX and their complexes with various ligands lays the foundation for understanding the possible dual roles in gas and redox sensing of Vc H-NOX...
  8. ncbi request reprint Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin
    Vladimir Berka
    Division of Hematology, Department of Internal Medicine, University of Texas Health Science Center at Houston, 77030, USA
    J Biol Chem 279:32243-51. 2004
    ..BH(4) prevented superoxide formation by chemical conversions of the Fe(II)O(2) intermediate, and l-arginine delayed superoxide formation by electronic interaction with the heme-bound oxygen...
  9. ncbi request reprint Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2
    Corina E Rogge
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Biochemistry 43:1560-8. 2004
    ....
  10. pmc High-yield production, purification and characterization of functional human duodenal cytochrome b in an Escherichia coli system
    Wen Liu
    Department of Internal Medicine, University of Texas Health Science Center, Houston, TX 77030, United States
    Protein Expr Purif 79:115-21. 2011
    ....
  11. pmc Functional and structural roles of residues in the third extramembrane segment of adrenal cytochrome b561
    Wen Liu
    Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas 77030, United States
    Biochemistry 50:3149-60. 2011
    ..These results also support our topological model of the adrenal cytochrome, which positions b(H) near the cytoplasmic side of the membrane...
  12. ncbi request reprint Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2
    Ah Lim Tsai
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biol Chem 277:38311-21. 2002
    ....
  13. doi request reprint H-NOX from Clostridium botulinum, like H-NOX from Thermoanaerobacter tengcongensis, Binds Oxygen but with a Less Stable Oxyferrous Heme Intermediate
    Gang Wu
    Division of Hematology, Department of Internal Medicine, The University of Texas Medical School at Houston, 6431 Fannin Street, Houston, Texas 77030, United States
    Biochemistry 54:7098-109. 2015
    ..L. et al. Antioxid. Redox Signal. 2012, 17, 1246-1263), and the presence of hydrogen bond donor Tyr139 in Cb H-NOX selectively enhanced its affinity for oxygen...
  14. pmc Comparison of oxygen-induced radical intermediates in iNOS oxygenase domain with those from nNOS and eNOS
    Vladimir Berka
    Division of Hematology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, United States Electronic address
    J Inorg Biochem 139:93-105. 2014
    ..Tsai, Biochemistry 47 (2008) 405-420]. Overall, our data suggests different regulatory roles of l-arginine and BH4 in the production of oxygen-induced radical intermediates in NOS isoforms which nicely serve individual functional role. ..
  15. ncbi request reprint Cyclooxygenase inactivation kinetics during reaction of prostaglandin H synthase-1 with peroxide
    Gang Wu
    Division of Hematology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Biochemistry 42:13772-7. 2003
    ....
  16. pmc The most informative spacing test effectively discovers biologically relevant outliers or multiple modes in expression
    Iwona Pawlikowska
    Departments of Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA, Institue of Mathematics, University of Silesia, Katowice, Poland, Department of Computational Biology and Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Bioinformatics 30:1400-8. 2014
    ..MIST was also effective at identifying features related to gender or molecular subtype in an example application involving 157 adult cases of acute myeloid leukemia...