Bradley K Weiner
Affiliation: Texas Medical Center
- Outcomes of decompression for lumbar spinal canal stenosis based upon preoperative radiographic severityBradley K Weiner
Division of Spinal Surgery, Department of Orthopaedics, The Methodist Hospital Texas Medical Center, Houston, Texas, USA
J Orthop Surg Res 2:3. 2007..We determined pre-operative radiographic severity on MRI scans using strict methodological controls and correlated such severity with post-operative outcomes using prospectively collected data...
- Microdecompression for lumbar synovial cysts: an independent assessment of long term outcomesBradley K Weiner
Division of Spinal Surgery The Methodist Hospital 6550 Fannin, Suite 2500 Houston, Texas 77030, USA
J Orthop Surg Res 2:5. 2007..This study aims to fill that void...
- Matching patient-specific expectations with physician-specific outcomes: towards transparency in treatment decision-making and consentBradley K Weiner
Division of Spine Surgery, Texas Medical Center The Methodist Hospital, 6550 Fannin, Suite 2500, Houston, TX 77030, USA
Med Hypotheses 68:1287-91. 2007..A 'next-step', aimed at matching such expectations with outcomes is suggested and a method for implementation is presented...
- Bacterial shedding in common spine surgical procedures: headlamp/loupes and the operative microscopeBradley K Weiner
Department of Orthopaedic Surgery, The Methodist Hospital Texas Medical Center, Houston, TX 77030, USA
Spine (Phila Pa 1976) 32:918-20. 2007..Simulated discectomy was performed using 1) headlamp/loupes, 2) the operative microscope, or 3) neither; and bacterial shedding was assessed using air sampler/settle plate techniques...
- Patient preferences regarding spine surgical decision makingBradley K Weiner
Division of Spine Surgery, The Methodist Hospital Texas Medical Center, Houston, TX 77030, USA
Spine (Phila Pa 1976) 31:2857-60; discussion 2861-2. 2006..Patient surveys to determine preferences in surgical decision making...
- Towards the reduction of medication errors in orthopedics and spinal surgery: outcomes using a pharmacist-led approachBradley K Weiner
Division of Spinal Surgery, Department of Orthopaedic Surgery, The Methodist Hospital, Houston, TX 77030, USA
Spine (Phila Pa 1976) 33:104-7. 2008..OBJECTIVE.: In this study the authors aimed to assess the frequency of medication ordering errors and to examine the impact of local measures set forth to reduce their occurrence...
- Spine update: the biopsychosocial model and spine careBradley K Weiner
Weill Cornell Medical College, Department of Orthopaedics, The Methodist Hospital, Houston, TX, USA
Spine (Phila Pa 1976) 33:219-23. 2008..Spine Update on the biopsychosocial model...
- Historical perspective: the development and use of spinal disease categoriesBradley K Weiner
Department of Orthopaedic Surgery, The Methodist Hospital, Houston, Texas 77030, USA
Spine (Phila Pa 1976) 33:925-30. 2008..The positive and negative implications of the use of spinal disease categories are discussed...
- Tissue Engineering: Biomimetic Concealing of PLGA Microspheres in a 3D Scaffold to Prevent Macrophage Uptake (Small 11/2016)Silvia Minardi
Department of Regenerative Medicine, Houston Methodist Research Institute HMRI, 6670 Bertner Ave, Houston, TX, 77030, USA
Small 12:1394. 2016..Tasciotti and co-workers, through a "concealing" strategy: cloaking PLGA microspheres with the type I collagen matrix of a biomimetic scaffold, which enables the control of the production of inflammatory mediators. ..
- Chondroitin Sulfate Immobilized on a Biomimetic Scaffold Modulates Inflammation While Driving ChondrogenesisBruna Corradetti
Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas, USA Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy
Stem Cells Transl Med 5:670-82. 2016..In support of its effective use in tissue-engineering applications of cartilage repair, the potential of the proposed platform to drive chondrogenic and osteogenic differentiation of MSC was also proven...
- IL-4 Release from a Biomimetic Scaffold for the Temporally Controlled Modulation of Macrophage ResponseSilvia Minardi
Department of Regenerative Medicine, Houston Methodist Research Institute HMRI, 6670 Bertner Avenue, Houston, TX, 77030, USA
Ann Biomed Eng 44:2008-19. 2016....
- Biomimetic Concealing of PLGA Microspheres in a 3D Scaffold to Prevent Macrophage UptakeSilvia Minardi
Department of Regenerative Medicine, Houston Methodist Research Institute HMRI, 6670 Bertner Ave, Houston, TX, 77030, USA
Small 12:1479-88. 2016..The data provide detailed strategies for fabricating three dimensional (3D) biomimetic scaffolds able to conceal delivery systems and preserve the therapeutic molecules for release. ..
- Evaluation of the osteoinductive potential of a bio-inspired scaffold mimicking the osteogenic niche for bone augmentationSilvia Minardi
Institute of Science and Technology for Ceramics CNR, Via Granarolo 64, 48018, Faenza, RA, Italy Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA
Biomaterials 62:128-37. 2015....
- Cross-Linking of Porcine Acellular Dermal Matrices Negatively Affects Induced Neovessel Formation Using Platelet-Rich Plasma in a Rat Model of Hernia RepairJoseph S Fernandez-Moure
Department of Surgery, Houston Methodist Hospital, 6565 Fannin St, Houston, Texas, 77030
Wound Repair Regen . 2017..PRP use could be advantageous in patients undergoing VHR where poor incorporation is anticipated and early-enhanced neovascularization is desired. This article is protected by copyright. All rights reserved...
- Biomimetic collagenous scaffold to tune inflammation by targeting macrophagesFrancesca Taraballi
Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA
J Tissue Eng 7:2041731415624667. 2016..The present work provides indications regarding the immunomodulatory potential of molecules used for the development of biomimetic materials and suggests their use to direct macrophage immune modulation for tissue repair. ..
- Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healingJoseph S Fernandez-Moure
Department of Surgery, Houston Methodist Hospital, Houston, Texas Surgical Advanced Technologies Laboratory, Department of Biomimetic and Regenerative Medicine, Houston Methodist Research Institute, Houston, Texas Electronic address
J Surg Res 207:33-44. 2017..In this review, we will discuss the wound healing properties of platelet-rich plasma and various surgical applications...
- Increased use of surgical energy promotes methicillin-resistant Staphylococcus aureus colonization in rabbits following open ventral hernia mesh repairJoseph S Fernandez-Moure
Department of Surgery, Houston Methodist Hospital, 6565 Fannin St, Suite 1660, Houston, TX, 77030, USA
Surg Endosc . 2016..We hypothesized that increasing amounts of surgical energy will result in higher infectious burden after oVHR with composite multifilament polyester mesh (Parietex™ PCO)...
- Platelet rich plasma enhances tissue incorporation of biologic meshJoseph S Fernandez-Moure
Department of Surgery, Houston Methodist Hospital, Houston, Texas Surgical Advanced Technologies Laboratory, Department of Regenerative Medicine, Houston Methodist Research Institute, Houston, Texas
J Surg Res 199:412-9. 2015..We sought to study the effect of PRP on a porcine noncross-linked ADM in an in vivo model of VHR. We hypothesized that PRP would enhance ADM-tissue incorporation in a rat model of VHR...
- Transforaminal lumbar interbody fusion: an independent assessment of outcomes in a difficult patient populationBradley K Weiner
Spine Unit, Department of Orthopaedics, Penn State University College of Medicine, Hershey, PA 17033 0850, USA
Med Sci Monit 12:CR99-102. 2006..Transforaminal lumbar interbody fusion is becoming increasingly popular for the surgical treatment of lumbar degenerative conditions. However, the outcomes following the procedure have only begun to be evaluated...
- Osteoprogenitor cells from bone marrow and cortical bone: understanding how the environment affects their fateBruna Corradetti
1 Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas
Stem Cells Dev 24:1112-23. 2015..Our data suggest that the effect of the tissue's microenvironment makes the CBF-MSC a superior candidate in the development of new strategies for bone repair. ..
- Commentary: Exploring the space betweenBradley K Weiner
Department of Orthopedics, The Methodist Hospital, 6550 Fannin St, Ste 2500, Houston, TX 77030, USA
Spine J 13:373-4. 2013..Commentary on: Kang KK, Shen MS, Zhao W, et al. Retrolisthesis and lumbar disc herniation: a postoperative assessment of patient function. Spine J 2013;13:367-72 (in this issue)...
- Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesisEugene J Carragee
Department of Orthopaedic Surgery, Stanford University School of Medicine, 450 Broadway Street, Pavilion C, 4th Floor, Redwood City, CA 94063, USA
J Bone Joint Surg Am 95:1537-45. 2013..The effect of rhBMP-2 on the risk of cancer has been a concern. We sought to evaluate the risk of new cancers in patients receiving high-dose rhBMP-2...
- Randomized trials and registries: a computer simulation to study the impact of surgeon/patient factors on outcomesBradley K Weiner
Department of Orthopaedics, The Methodist Hospital, 6550 Fannin Street, Suite 2500, Houston, TX 77030, USA
Spine J 8:959-67. 2008..Computer simulation offers a viable and useful alternative...
- Toward the establishment of optimal computed tomographic parameters for the assessment of lumbar spinal fusionJessica M Ho
Department of Orthopaedic Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Spine J 11:636-40. 2011..Thin-cut computed tomography (CT) has emerged as the study of choice for this purpose...
- Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: a comparative analysisJoseph S Fernandez-Moure
Houston Methodist Hospital Department of Surgery, Houston, USA
Stem Cell Res Ther 6:203. 2015..Although MSCs from bone marrow (BM-MSCs) and adipose tissue (AD-MSCs) have been extensively characterized, there is still debate as to the ideal source of MSCs for tissue-engineering applications in bone repair...
- Lateral lumbar disc herniations treated with a paraspinal approach: an independent assessment of longer-term outcomesBradley K Weiner
Department of Orthopaedics, Penn State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
J Spinal Disord Tech 18:519-21. 2005..Based on our review of the literature, results using the paraspinal window appear similar, but not superior, to other available techniques, and the choice of approach should be based on the comfort of the surgeon...
- Multiscale patterning of a biomimetic scaffold integrated with composite microspheresSilvia Minardi
Bioceramics and Bio hybrid composites, Institute of Science and Technology for Ceramics, National Research Council of Italy ISTEC CNR, Via Granarolo 64, 48018, Faenza, RA, Italy Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA
Small 10:3943-53. 2014..The versatile manufacturing of each component of the scaffold results in the ability to customize it to better mimic the architecture and composition of the tissues and biological systems. ..
- A novel method for the reproducible production of thoracolumbar burst fractures in human cadaveric specimensHugh L Jones
Department of Orthopaedics, The Methodist Hospital, Spine Surgery, 6550 Fannin Street, Houston, TX 77030, USA
Spine J 11:447-51. 2011..Currently, there is no reproducible method that produces thoracolumbar burst fractures in human cadavers wherein the fracture configuration mirrors that seen naturally, and soft tissues are maintained...
- Does the combination of erythropoietin and tapered oral corticosteroids improve recovery following iatrogenic nerve injury?Derek T Bernstein
Houston Methodist Hospital, Department of Orthopaedic Surgery, 6550 Fannin Street, Smith Tower, Suite 2500, Houston, TX, 77030, United States Electronic address
Injury 47:1819-23. 2016..The purpose of this study was to evaluate the effect of systemically-administered Erythropoietin and tapered oral corticosteroids on the recovery of postoperative nerve palsies in the setting of total hip and knee arthroplasty...
- The case of James A. Garfield: a historical perspectiveBradley K Weiner
Department of Orthopaedic Surgery, Penn State University, Hershey, Pennsylvania, USA
Spine (Phila Pa 1976) 28:E183-6. 2003..What did the autopsy show? Even this was controversial, with different observers claiming different results. This historical perspective reviews the case as well the controversies that surrounded it...
- Aortic dissection presenting as an acute cauda equina syndrome : a case reportNilesh M Patel
Department of Orthopaedics, Summa Health Systems and Northeastern Ohio Universities College of Medicine, Akron, OH 44310, USA
J Bone Joint Surg Am 84:1430-2. 2002
- Characterization of controlled bone defects using 2D and 3D ultrasound imaging techniquesBiren J Parmar
Department of Electrical and Computer Engineering, Dwight Look College of Engineering, Texas A and M University, College Station, TX, USA
Phys Med Biol 55:4839-59. 2010..In the future, ultrasound imaging techniques might provide a cost-effective, real-time, safe and portable diagnostic tool for bone imaging applications...
- The accuracy of MRI in the detection of lumbar disc containmentBradley K Weiner
Weill Cornell Medical College, USA
J Orthop Surg Res 3:46. 2008..Determination of such containment is important to determine candidacy for intradiscal techniques and has prognostic significance. The accuracy of MRI in detecting containment has been insufficiently documented...
- Multi-composite bioactive osteogenic sponges featuring mesenchymal stem cells, platelet-rich plasma, nanoporous silicon enclosures, and Peptide amphiphiles for rapid bone regenerationMatthew B Murphy
Department of Nanomedicine and BioMedical Engineering, The Methodist Hospital Research Institute, Houston, TX 77053, USA
J Funct Biomater 2:39-66. 2011..This study indicates that CB MSC should be considered as an alternative to marrow as a source of stem cells, while the PRP-PA cell and microparticle delivery system may be utilized for diverse tissue engineering applications. ..
- Endplate changes following discectomy: natural history and associations between imaging and clinical dataBradley K Weiner
Department of Orthopaedic Surgery, The Methodist Hospital, Houston, TX, USA
Eur Spine J 24:2449-57. 2015..One potential source is the vertebral endplates. The goal of this study was to document the changes that occur in lumbar endplates following discectomies, and to assess associations between endplate changes and clinical outcomes...
- Access to spine care for the poor and near poorBradley K Weiner
Division of Spinal Surgery, Department of Orthopaedic Surgery, The Methodist Hospital, 6550 Fannin Street, Suite 2500, Houston, TX 77030, USA
Spine J 9:221-4. 2009..Access to care for poor/near poor patients is a concerning and growing problem within the American system of medical care...
- Spine journals: is reviewer agreement on publication recommendations greater than would be expected by chance?Bradley K Weiner
Weill Cornell Medical College, New York, NY, USA
Spine J 10:209-11. 2010....
- Microsurgery in the lumbar intertransverse intervalJohn A McCulloch
Northeastern Ohio Universities, College of Medicine, Rootstown, Ohio, USA
Instr Course Lect 51:233-41. 2002..By avoiding the previous scarred-in canal and nerve root, it has been possible to remove the ruptured disk. Visualization, however, is not good with this approach...
- Re: Walsh TL, Hanscom B, Lurie JD, et al. Is a condition-specific instrument for patients with low back pain/leg symptoms really necessary? The responsiveness of the Oswestry Disability Index, MODEMS, and the SF-36. Spine 2003;28:607-15Bradley K Weiner
Spine (Phila Pa 1976) 28:2304-5; author reply 2305. 2003
- Interspinous process decompression system (X STOP) device affords superior outcomes and equal safety to nonoperative therapyBradley K Weiner
Spine (Phila Pa 1976) 30:2846-7. 2005
- Difficult medical problems: on explanatory models and a pragmatic alternativeBradley K Weiner
Med Hypotheses 68:474-9. 2007..In this paper, we expand and detail the strengths and weaknesses of using these explanatory models and conclude by presenting a 'pragmatic alternative' hypothesis...
- The lateral buttress: an anatomic feature of the lumbar pars interarticularisBradley K Weiner
Northeastern Ohio Universities College of Medicine, Summa Health Systems, Akron, Ohio, USA
Spine (Phila Pa 1976) 27:E385-7. 2002..A morphometric study of the lateral buttress region of the lumbar pars interarticularis from L1-L5 on 10 dried lumbar spines was performed...
- The profit motive and spine surgeryBradley K Weiner
Department of Spine Surgery and Orthopaedics, Penn State University, Penn State College of Medicine, Hershey, Pennsylvania 17033 0850, USA
Spine (Phila Pa 1976) 29:2588-91. 2004..The profit motive and market medicine have had a significant impact on clinical practice and research in the field of spine surgery. An overview of current concerns is presented...