NANCY WEIGEL

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Steroid receptor phosphorylation: a key modulator of multiple receptor functions
    Nancy L Weigel
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 21:2311-9. 2007
  2. ncbi request reprint Interactions between vitamin D and androgen receptor signaling in prostate cancer cells
    Nancy L Weigel
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nutr Rev 65:S116-7. 2007
  3. ncbi request reprint Androgen receptor signaling and vitamin D receptor action in prostate cancer cells
    Shalini Murthy
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030, USA
    Prostate 64:362-72. 2005
  4. ncbi request reprint Vitamin D and prostate cancer
    Lamonica V Stewart
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Exp Biol Med (Maywood) 229:277-84. 2004
  5. pmc Coactivator selective regulation of androgen receptor activity
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, M130, One Baylor Plaza, Houston, TX 77030, United States
    Steroids 74:669-74. 2009
  6. ncbi request reprint Stable expression of full length human androgen receptor in PC-3 prostate cancer cells enhances sensitivity to retinoic acid but not to 1alpha,25-dihydroxyvitamin D3
    Shalini Murthy
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Prostate 56:293-304. 2003
  7. pmc Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator
    Ramesh Narayanan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:264-77. 2005
  8. ncbi request reprint Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 65:7959-67. 2005
  9. pmc Steroid receptor phosphorylation: Assigning function to site-specific phosphorylation
    Robert D Ward
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Biofactors 35:528-36. 2009
  10. pmc 1{alpha},25-Dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene fusion
    Michele N Washington
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza BCM130, Houston, Texas 77030, USA
    Endocrinology 151:1409-17. 2010

Research Grants

Collaborators

  • Carolyn Smith
  • G E Ayala
  • Ming Fong Lin
  • Michael Mancini
  • Michael M Ittmann
  • DOLORES JEAN LAMB
  • Grant Buchanan
  • Michael B Cohen
  • M Falzon
  • D P Edwards
  • Robert Schwartz
  • W Li
  • Efisio Puxeddu
  • Irina U Agoulnik
  • Ramesh Narayanan
  • Lamonica V Stewart
  • Shalini Murthy
  • Michele N Washington
  • Harish Srinivas
  • William E Bingman
  • Marco Marcelli
  • Tara C Polek
  • Suzanne E Wardell
  • Francesca De Amicis
  • JoyAnn N Phillips Rohan
  • Robert D Ward
  • Manjula Nakka
  • David A Proia
  • Ajula Vaid
  • Anna Frolov
  • Jonathan M Kurie
  • Kevin M Coleman
  • Dinakar Iyer
  • Brian G Rowan
  • Alaina J James
  • Jung Sun Kim
  • Suzanne A W Fuqua
  • Michael T Lewis
  • Susan G Hilsenbeck
  • Jennifer Selever
  • Sebastiano Ando
  • Matthew H Herynk
  • Janagi Thirugnansampanthan
  • Amanda Beyer
  • Yukun Cui
  • Irma Parra
  • Anna Tsimelzon
  • Gary C Chamness
  • Qianben Wang
  • Myles Brown
  • X Shirley Liu
  • Silvia Simeoni
  • Ivan P Uray
  • Nicole L Moore
  • Long Ma
  • Jeffrey H Price
  • Tim Moran
  • Halime Erdem
  • Adam T Szafran
  • Dianren Xia
  • Bonnie W Nannenga
  • Misty Alvarado
  • Heetae Kim
  • David L Stenoien
  • Powel H Brown
  • Ivana Mikic
  • Lawrence A Donehower
  • Shailaja Kalyankrishna
  • Denise M Juroske
  • Besstina Lyles
  • Dianna D Cody
  • Xiao Chun Xu
  • Abayomi A Adigun
  • Roger E Price
  • Halime Erdeme
  • Denis R Headon
  • Neely E Atkinson
  • Klaus Körner
  • Dirk G Kieback
  • Dagmar C Fischer
  • Veronica A Tovar Sepulveda
  • Xiao Wen Tong
  • Elizabeth A Allegretto
  • Abeer El-Gharbawy
  • Hassan T Rahman
  • Henry F Epstein
  • Frank W Booth
  • Lei Wei
  • Martin Dutertre
  • William C Krause

Detail Information

Publications36

  1. ncbi request reprint Steroid receptor phosphorylation: a key modulator of multiple receptor functions
    Nancy L Weigel
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 21:2311-9. 2007
    ..As functional assays become more sophisticated, it is likely that additional roles for phosphorylation in receptor function will be identified...
  2. ncbi request reprint Interactions between vitamin D and androgen receptor signaling in prostate cancer cells
    Nancy L Weigel
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nutr Rev 65:S116-7. 2007
  3. ncbi request reprint Androgen receptor signaling and vitamin D receptor action in prostate cancer cells
    Shalini Murthy
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030, USA
    Prostate 64:362-72. 2005
    ..Because androgen ablation therapy is used for metastatic prostate cancer, we sought to better characterize this androgen dependence...
  4. ncbi request reprint Vitamin D and prostate cancer
    Lamonica V Stewart
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Exp Biol Med (Maywood) 229:277-84. 2004
    ..Additional studies are required in order to determine whether these 1,25D analogs will be useful therapeutic agents for the treatment of prostate cancer...
  5. pmc Coactivator selective regulation of androgen receptor activity
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, M130, One Baylor Plaza, Houston, TX 77030, United States
    Steroids 74:669-74. 2009
    ..These data indicate that different groups of AR target genes have distinct requirements for coactivators and response to AR ligands...
  6. ncbi request reprint Stable expression of full length human androgen receptor in PC-3 prostate cancer cells enhances sensitivity to retinoic acid but not to 1alpha,25-dihydroxyvitamin D3
    Shalini Murthy
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Prostate 56:293-304. 2003
    ..PC-3 cells do not express AR. We therefore asked whether re-expression of AR would enhance the response of PC-3 cells to 1,25 D and retinoids...
  7. pmc Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator
    Ramesh Narayanan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:264-77. 2005
    ....
  8. ncbi request reprint Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 65:7959-67. 2005
    ....
  9. pmc Steroid receptor phosphorylation: Assigning function to site-specific phosphorylation
    Robert D Ward
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Biofactors 35:528-36. 2009
    ..As functional assays become more sophisticated, it is likely that additional roles for phosphorylation in receptor function will be identified...
  10. pmc 1{alpha},25-Dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene fusion
    Michele N Washington
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza BCM130, Houston, Texas 77030, USA
    Endocrinology 151:1409-17. 2010
    ..Thus, the beneficial effects of VDR agonist treatment override some of the negative effects of ERG induction, although others remain to be tested...
  11. ncbi request reprint A novel androgen receptor mutant, A748T, exhibits hormone concentration-dependent defects in nuclear accumulation and activity despite normal hormone-binding affinity
    Alaina J James
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Endocrinol 16:2692-705. 2002
    ..Consistent with this conclusion, our structural model predicts that A748T disrupts crucial contact points with ligand, thereby altering the conformation of the ligand-binding domain...
  12. doi request reprint Androgen receptor coactivators and prostate cancer
    Irina U Agoulnik
    Dept of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Adv Exp Med Biol 617:245-55. 2008
  13. ncbi request reprint Vitamin D receptor agonists induce prostatic acid phosphatase to reduce cell growth and HER-2 signaling in LNCaP-derived human prostate cancer cells
    Lamonica V Stewart
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    J Steroid Biochem Mol Biol 97:37-46. 2005
    ..These data therefore suggest that 1,25D-mediated decreases in LNCaP and C81 LN cell growth are in part due to decreases in tyrosine kinase signaling that result from up-regulation of PAcP...
  14. ncbi request reprint The functional consequences of cross-talk between the vitamin D receptor and ERK signaling pathways are cell-specific
    Ramesh Narayanan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:47298-310. 2004
    ..In cells in which RXRalpha is the VDR partner, the transcriptional activation of VDR by 1,25-D is attenuated by the concomitant activation of ERK. In cells utilizing RXRgamma, ERK activation enhances VDR transcriptional activity...
  15. ncbi request reprint Quantifying effects of ligands on androgen receptor nuclear translocation, intranuclear dynamics, and solubility
    Marco Marcelli
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biochem 98:770-88. 2006
    ..These results further support the notion that ligand specific interactions rapidly affect receptor and co-factor organization, solubility, and molecular dynamics, and each can be aberrantly affected by mutation and overexpression...
  16. ncbi request reprint Androgen receptor action in hormone-dependent and recurrent prostate cancer
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biochem 99:362-72. 2006
    ..These pathways are, therefore, potential therapeutic targets...
  17. ncbi request reprint Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 66:10594-602. 2006
    ..The elevated expression of TIF2 at low hormone levels likely aids in inducing AR activity under these conditions; treatment with Casodex has the potential to counteract this induction...
  18. pmc Target gene-specific regulation of androgen receptor activity by p42/p44 mitogen-activated protein kinase
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 22:2420-32. 2008
    ..Thus, treatments that reduce p42/p44 MAPK activity in prostate cancer have the potential to reduce AR activity through a reduction in expression levels as well as by target gene-selective inhibition of AR function...
  19. ncbi request reprint Dual roles for the phosphatase PPM1D in regulating progesterone receptor function
    David A Proia
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 281:7089-101. 2006
    ..Thus, we speculate that PPM1D promotes breast tumor growth both by inhibiting p53 activity and by enhancing steroid hormone receptor action...
  20. ncbi request reprint Vitamin D and prostate cancer
    Tara C Polek
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Androl 23:9-17. 2002
    ....
  21. ncbi request reprint p53 Is required for 1,25-dihydroxyvitamin D3-induced G0 arrest but is not required for G1 accumulation or apoptosis of LNCaP prostate cancer cells
    Tara C Polek
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 144:50-60. 2003
    ....
  22. ncbi request reprint Mechanistic differences in the activation of estrogen receptor-alpha (ER alpha)- and ER beta-dependent gene expression by cAMP signaling pathway(s)
    Kevin M Coleman
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Biol Chem 278:12834-45. 2003
    ....
  23. ncbi request reprint Molecular analysis of the androgen receptor in ten prostate cancer specimens obtained before and after androgen ablation
    Dolores J Lamb
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA
    J Androl 24:215-25. 2003
    ..Further experiments are needed to conclusively determine whether the Q26 clone was responsible for sustaining survival of prostate cancer cells in the androgen-depleted milieu of this patient...
  24. ncbi request reprint Repressors of androgen and progesterone receptor action
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:31136-48. 2003
    ..We found that although DAX-1 is expressed in normal human prostate, its expression is strongly reduced in benign prostatic hyperplasia suggesting that DAX-1 plays a role in limiting AR activity in prostate...
  25. ncbi request reprint Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcription
    Dinakar Iyer
    Department of Medicine, Division of Endocrinology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochemistry 42:7477-86. 2003
    ..Phosphorylation of the MADS box may constitute a novel mechanism for regulation of SRF-dependent actin gene transcription...
  26. ncbi request reprint 1alpha,25-dihydroxyvitamin D3 induced growth inhibition of PC-3 prostate cancer cells requires an active transforming growth factor beta signaling pathway
    Shalini Murthy
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Prostate 59:282-91. 2004
    ..Finally, we assessed the role of TGFbeta signaling in the induction of the growth inhibitory protein, insulin like growth factor binding protein 3 (IGFBP-3), by 1,25(OH)2D3...
  27. pmc Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity
    Ramesh Narayanan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:2885-98. 2005
    ....
  28. pmc c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha
    Harish Srinivas
    Department of Thoracic Head and Neck Oncology Unit 432, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Biol 25:1054-69. 2005
    ..These findings point to JNK as a key mediator of aberrant retinoid signaling in lung cancer cells...
  29. ncbi request reprint A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer risk
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 89:6340-7. 2004
    ..This is of special interest, because only a few genetic markers are available for the majority of women diagnosed with sporadic ovarian cancer...
  30. pmc Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha
    Harish Srinivas
    Department of Thoracic Head and Neck Medical Oncology, Unit 432, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Biochem J 395:653-62. 2006
    ..The findings presented here show that Akt inhibits RAR transactivation and contributes to retinoid resistance in a subset of NSCLC cells...
  31. pmc Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400
    Suzanne E Wardell
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, Texas 77030, USA
    Mol Endocrinol 24:335-45. 2010
    ..These data underscore the structural flexibility of the NTD of PR, and the ability of steroid ligands together with interacting proteins to affect the conformation and activity of the NTD...
  32. pmc Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells
    Francesca De Amicis
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Cancer Res Treat 121:1-11. 2010
    ..Our data suggest a role for AR overexpression as a novel mechanism of hormone resistance, so that AR may offer a new clinical therapeutic target in human breast cancers...
  33. pmc 1Alpha,25-dihydroxyvitamin D3 reduces c-Myc expression, inhibiting proliferation and causing G1 accumulation in C4-2 prostate cancer cells
    JoyAnn N Phillips Rohan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 150:2046-54. 2009
    ..Thus, 1,25(OH)(2)D(3) reduces both c-Myc mRNA levels and c-Myc protein stability to inhibit growth of prostate cancer cells...
  34. ncbi request reprint Role of insulin-like growth factor binding proteins in 1alpha,25-dihydroxyvitamin D(3)-induced growth inhibition of human prostate cancer cells
    Lamonica V Stewart
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Prostate 64:9-19. 2005
    ....
  35. pmc Kinases and protein phosphorylation as regulators of steroid hormone action
    Nancy L Weigel
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Nucl Recept Signal 5:e005. 2007
    ..Thus, the specific combinations of phosphorylations of the steroid receptor combined with the expression levels and phosphorylation status of coregulators will determine the genes regulated and the biological response...
  36. pmc 1α,25-dihydroxyvitamin D3 inhibits C4-2 prostate cancer cell growth via a retinoblastoma protein (Rb)-independent G1 arrest
    Michele N Washington
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 USA
    Prostate 71:98-110. 2011
    ..Since up to 60% of prostate cancers demonstrate a loss of heterozygosity for Rb, we sought to determine whether Rb is required for the growth inhibitory effects of 1,25D...

Research Grants5

  1. Conference on Hormonal Regulation of Tumorigenesis
    NANCY WEIGEL; Fiscal Year: 2005
    ....
  2. INHIBITION OF PROSTATE CANCER CELL GROWTH BY VITAMIN D
    NANCY WEIGEL; Fiscal Year: 2004
    ..We have also shown that 1,25-dihydroxyvitamin D/3 induces apoptosis and concomitant down-regulation of Bcl-2 and Bcl/X/L. We will assess the roles of p53, TNFalpha, ceramide generation, and regulation of Bcl-2 in this response. ..
  3. Coactivators and Androgen Receptors in Prostate Cancer
    NANCY WEIGEL; Fiscal Year: 2006
    ..abstract_text> ..
  4. Targets of Vitamin D Receptor Action in Prostate
    NANCY WEIGEL; Fiscal Year: 2008
    ..abstract_text> ..
  5. REGULATION OF HUMAN STEROID RECEPTORS BY PHOSPHORYLATION
    NANCY LYNN WEIGEL; Fiscal Year: 2010
    ..Our studies will provide a better understanding of how PR function is regulated: this information can be used to develop means to selectively regulate PR function for medical applications. ..