Genomes and Genes
Affiliation: Texas Medical Center
- The bovine lactation genome: insights into the evolution of mammalian milkDanielle G Lemay
Department of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
Genome Biol 10:R43. 2009..The newly assembled Bos taurus genome sequence enables the linkage of bovine milk and lactation data with other mammalian genomes...
- Multispecies comparison of the casein gene loci and evolution of casein gene familyMonique Rijnkels
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
J Mammary Gland Biol Neoplasia 7:327-45. 2002..These observations suggest a possible common ancestry for the genes in this region...
- Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteinsMonique Rijnkels
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Genomics 82:417-32. 2003..The conserved regions might have biological importance for the regulation of genes in this genomic "neighborhood."..
- Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elementsElena B Kabotyanski
Departments of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Mail Box BCM 130, Houston, TX 77030, USA
J Biol Chem 284:22815-24. 2009..Collectively, these data suggest that the communication between these regulatory regions with intervening DNA looping is a crucial step required to both create and maintain active chromatin domains and regulate transcription...
- Short-term administration of rhGH increases markers of cellular proliferation but not milk protein gene expression in normal lactating womenPatricia D Maningat
Department of Pediatrics Nutrition, Baylor College of Medicine, Children s Nutrition Research Center, Houston, Texas, USA
Physiol Genomics 43:381-91. 2011....
- The epigenetic landscape of mammary gland development and functional differentiationMonique Rijnkels
USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
J Mammary Gland Biol Neoplasia 15:85-100. 2010..With the new tools for epigenomics developed in recent years, we now can begin to establish a framework for the role of epigenetics in mammary gland development and disease...
- Epigenetic modifications unlock the milk protein gene loci during mouse mammary gland development and differentiationMonique Rijnkels
United States Department of Agriculture Agriculture Research Service Children s Nutrition Research Center, Department of Pediatrics Nutrition, Baylor College of Medicine, Houston, Texas, United States of America
PLoS ONE 8:e53270. 2013..Here, we have studied the changes in chromatin organization at the milk protein gene loci (casein, whey acidic protein, and others) in the mouse mammary gland before and after functional differentiation...
- Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiersElena B Kabotyanski
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 20:2355-68. 2006..Collectively, these data suggest a model for the assembly of a multiprotein complex that helps to define how the signaling pathways controlled by these lactogenic hormones are integrated to regulate beta-casein gene expression...
- Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptomePatricia D Maningat
Department of Pediatrics Nutrition, Baylor College of Medicine, Children s Nutrition Research Center, Houston, Texas 77030, USA
Physiol Genomics 37:12-22. 2009..This paper is the first to describe the MFG transcriptome in sequential human samples over a 24 h period, providing valuable insights into gene expression in the human MEC...
- In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk lociDarryl L Hadsell
Department of Pediatrics, USDA ARS Children s Nutrition Research Center, Baylor College of Medicine, 1100 Bates St Suite 10072, Mail Stop BCM 320, Houston, TX, 77030 2600, USA
Mamm Genome 26:57-79. 2015..These results support the conclusion that mammary tumorigenesis and normal ductal development are influenced by common genetic factors and that further studies of genetically diverse mice can improve our understanding of BrCa in humans...
- A noncoding RNA is a potential marker of cell fate during mammary gland developmentMelanie R Ginger
Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:5781-6. 2006..This is one of the first reports describing the functional properties of a large, developmentally regulated, mammalian, noncoding RNA...