Martin Matzuk

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline
    Lang Ma
    Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 5:e1000635. 2009
  2. pmc Revisiting oocyte-somatic cell interactions: in search of novel intrafollicular predictors and regulators of oocyte developmental competence
    Qinglei Li
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Hum Reprod 14:673-8. 2008
  3. pmc Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction
    Roopa L Nalam
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e11797. 2010
  4. pmc Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans
    Caterina Clementi
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America Departments of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 9:e1003863. 2013
  5. pmc Identification and characterization of RBM44 as a novel intercellular bridge protein
    Tokuko Iwamori
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e17066. 2011
  6. ncbi request reprint Ovarian function in superoxide dismutase 1 and 2 knockout mice
    M M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Endocrinology 139:4008-11. 1998
  7. pmc Germ-line immortality
    Martin M Matzuk
    Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:16395-6. 2004
  8. ncbi request reprint Genetic dissection of mammalian fertility pathways
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Cell Biol 4:s41-9. 2002
  9. ncbi request reprint Intercellular communication in the mammalian ovary: oocytes carry the conversation
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 296:2178-80. 2002
  10. ncbi request reprint Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
    H Chang
    Departments of Pathology, Cell Biology and Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA
    Development 126:1631-42. 1999

Research Grants

  1. Defining the Mammalian Intercellular Bridge Interactome
    Martin M Matzuk; Fiscal Year: 2010
  2. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin M Matzuk; Fiscal Year: 2010
  3. Regulation of Key Processes in Oocyte Biology
    Martin Matzuk; Fiscal Year: 2007

Detail Information

Publications87

  1. pmc GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline
    Lang Ma
    Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 5:e1000635. 2009
    ..These studies provide the first evidence for an essential structural role for GASZ in male fertility and epigenetic and post-transcriptional silencing of retrotransposons by stabilizing MILI in nuage...
  2. pmc Revisiting oocyte-somatic cell interactions: in search of novel intrafollicular predictors and regulators of oocyte developmental competence
    Qinglei Li
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Hum Reprod 14:673-8. 2008
    ....
  3. pmc Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction
    Roopa L Nalam
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e11797. 2010
    ..These results demonstrate that RB is not essential for Sertoli cell tumorigenesis in Inha KO mice but that loss of Inha accelerates the infertility phenotype of Rb cKO mice...
  4. pmc Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans
    Caterina Clementi
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America Departments of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 9:e1003863. 2013
    ....
  5. pmc Identification and characterization of RBM44 as a novel intercellular bridge protein
    Tokuko Iwamori
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e17066. 2011
    ..Rbm44 null male mice produce somewhat increased sperm, and show enhanced fertility of unknown etiology. Thus, although RBM44 localizes to intercellular bridges during meiosis, RBM44 is not required for fertility in contrast to TEX14...
  6. ncbi request reprint Ovarian function in superoxide dismutase 1 and 2 knockout mice
    M M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Endocrinology 139:4008-11. 1998
    ..These studies support an important role of SOD1 in female reproductive function and suggest that SOD2 is not essential for ovarian function...
  7. pmc Germ-line immortality
    Martin M Matzuk
    Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:16395-6. 2004
  8. ncbi request reprint Genetic dissection of mammalian fertility pathways
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Cell Biol 4:s41-9. 2002
    ....
  9. ncbi request reprint Intercellular communication in the mammalian ovary: oocytes carry the conversation
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 296:2178-80. 2002
    ..The challenge for the future is to identify the factors that participate in this communication and their mechanisms of action...
  10. ncbi request reprint Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
    H Chang
    Departments of Pathology, Cell Biology and Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA
    Development 126:1631-42. 1999
    ..Despite the expression of Smad5 from gastrulation onwards, and in contrast to knockouts of Smad2 and Smad4, Smad5 only becomes essential later in extraembryonic and embryonic development...
  11. ncbi request reprint Revelations of ovarian follicle biology from gene knockout mice
    M M Matzuk
    Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Endocrinol 163:61-6. 2000
    ..Thus, GDF-9 functions as an oocyte-secreted growth and differentiation factor during early and late folliculogenesis and at ovulation to regulate several key somatic cell functions essential for female reproduction...
  12. ncbi request reprint Interrelationship of growth differentiation factor 9 and inhibin in early folliculogenesis and ovarian tumorigenesis in mice
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 18:1509-19. 2004
    ..Thus, GDF9 appears to function indirectly to regulate early granulosa cell proliferation and theca recruitment in vivo...
  13. pmc Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility
    Michael P Greenbaum
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 80:449-57. 2009
    ..Thus, while TEX14 and intercellular bridges have an essential role in postnatal spermatogenesis, they are not required in the embryo...
  14. ncbi request reprint Expression profiling analyses of gonadotropin responses and tumor development in the absence of inhibins
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 144:4492-507. 2003
    ..These 10 genes have expression patterns and postulated functions suggesting that they mediate important processes in the physiology and pathology of ovarian and adrenal tissue...
  15. pmc Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis
    Michelle Myers
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 334:458-67. 2009
    ..Together, these data provide key evidence to suggest that regulation of the inhibin/activin system is essential for early folliculogenesis in the prepubertal mouse ovary...
  16. ncbi request reprint Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 17:2053-69. 2003
    ....
  17. ncbi request reprint Mining the oocyte transcriptome
    Claudia Andreu-Vieyra
    Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Endocrinol Metab 17:136-43. 2006
    ..These technological improvements will help to expand our understanding of folliculogenesis and oocyte physiology and improve human reproductive health...
  18. pmc Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:8090-5. 2006
    ..In addition, we show that Lhx8 is downstream of Sohlh1 and critical in fertility. Thus, Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis...
  19. ncbi request reprint Intraovarian activins are required for female fertility
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 21:2458-71. 2007
    ..Thus, in contrast to the known tumor suppressor role of activins in some tissues, our data indicate that activin betaA and betaB function redundantly in a growth stimulatory pathway in the mammalian ovary...
  20. ncbi request reprint Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein
    Qinglei Li
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Hum Reprod 13:675-83. 2007
    ..The current findings have potential implications in the design of new drugs or strategies for the treatment of ovarian and testicular tumors and other conditions where ligands signal through ActRII...
  21. ncbi request reprint Effects of granulosa cell-specific deletion of Rb in Inha-alpha null female mice
    Claudia Andreu-Vieyra
    Baylor College of Medicine, Department of Pathology, One Baylor Plaza, Smith Building S217, Houston, Texas 77030, USA
    Endocrinology 148:3837-49. 2007
    ..These findings confirm the importance of P27 as a cell cycle regulator in granulosa cells and suggest functional compensation between RB-like proteins in ovarian tumorigenesis...
  22. ncbi request reprint Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Genet 33:187-91. 2003
    ..Thus, Zar1 is the first identified oocyte-specific maternal-effect gene that functions at the oocyte-to-embryo transition and, as such, offers new insights into the initiation of embryonic development and fertility control in mammals...
  23. pmc Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice
    Ankur K Nagaraja
    Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocrinology 151:4994-5006. 2010
    ..These data indicate the gonadotropins initiate an improper program of cell differentiation prior to tumor formation in the absence of inhibins...
  24. pmc Conditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure
    Claudia Andreu-Vieyra
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 22:2141-61. 2008
    ..Taken together, our results suggest that RB is required for the temporal-specific pattern of expression of key genes involved in follicular development...
  25. pmc TEX14 is essential for intercellular bridges and fertility in male mice
    Michael P Greenbaum
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:4982-7. 2006
    ..Thus, TEX14 is required for intercellular bridges in vertebrate germ cells, and these studies provide evidence that the intercellular bridge is essential for spermatogenesis and fertility...
  26. ncbi request reprint Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:32281-6. 2004
    ..We propose that gremlin modulates the cross-talk between GDF9 and BMP signaling that is necessary during follicle development because both ligands use components of the same signaling pathway...
  27. ncbi request reprint NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression
    Aleksandar Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 305:1157-9. 2004
    ..Therefore, Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development...
  28. ncbi request reprint The art and artifact of GDF9 activity: cumulus expansion and the cumulus expansion-enabling factor
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 73:582-5. 2005
    ..Standardization in preparation for recombinant GDF9, as well as a more biochemical analysis of the oocyte-secreted forms of GDF9, may help to resolve the conflicts currently seen in the literature...
  29. ncbi request reprint Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice
    T Rajendra Kumar
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Endocrinol 212:19-27. 2003
    ..Our studies confirm the importance of using in vivo genetic models for studying regulation of the hypothalamic-pituitary-gonadal axis...
  30. ncbi request reprint Activins are critical modulators of growth and survival
    Chester W Brown
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 17:2404-17. 2003
    ....
  31. pmc Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice
    Mark A Edson
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocrinology 151:358-68. 2010
    ..Thus, Gpr149 null mice are one of the few models with enhanced fertility, and GPR149 could be a target for small molecules to enhance fertility in the assisted reproductive technology clinic...
  32. ncbi request reprint Genetic engineering to study testicular tumorigenesis
    Wei Yan
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    APMIS 111:174-81; discussion 182-3. 2003
    ..Genetic engineering in mouse models provides a powerful tool to study the mechanisms of testicular tumorigenesis and define the important genetic modifiers in vivo...
  33. ncbi request reprint Regulation of growth differentiation factor 9 expression in oocytes in vivo: a key role of the E-box
    Changning Yan
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 74:999-1006. 2006
    ..3MUT-mGdf9-Luc) abolished expression in the ovary but not in the testis. These observations indicate that the E-box is a key regulatory sequence for Gdf9 expression in the ovary...
  34. ncbi request reprint Characterization of integrin expression in the mouse ovary
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 67:743-51. 2002
    ..Specific integrins are associated with ovarian cellular phenotypes in mice, which raises intriguing possibilities as to integrin functions in oocyte competence, follicular development, luteinization, and granulosa cell proliferation...
  35. ncbi request reprint Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Science 300:633-6. 2003
    ..Thus, Npm2 is a maternal effect gene critical for nuclear and nucleolar organization and embryonic development...
  36. ncbi request reprint Inhibin alpha-iCre mice: Cre deleter lines for the gonads, pituitary, and adrenal
    Carolina J Jorgez
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genesis 44:183-8. 2006
    ..These lines could be useful to understand reproduction and other processes by establishing conditional knockout mouse models...
  37. ncbi request reprint Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:1406-22. 2006
    ....
  38. ncbi request reprint Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein
    Wei Yan
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mech Dev 118:233-9. 2002
    ..We hypothesize that ZFP393 functions as a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development...
  39. ncbi request reprint Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility
    Simona Varani
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 16:1154-67. 2002
    ..These studies demonstrate that PTX3 plays important roles in cumulus cell-oocyte interaction in the periovulatory period as a downstream protein in the GDF-9 signal transduction cascade...
  40. ncbi request reprint Society for Reproductive Biology Founders' Lecture 2007. Insights into germ cell biology: from the bench to the clinic
    Angshumoy Roy
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA
    Reprod Fertil Dev 19:783-91. 2007
    ..These models have helped us identify novel and unexplored areas of germ cell biology and translate this work into the fertility clinic...
  41. ncbi request reprint SMAD3 regulates gonadal tumorigenesis
    Qinglei Li
    Department of Pathology, One Baylor Plaza, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 21:2472-86. 2007
    ..Moreover, the activin-induced cachexia syndrome is potentially mediated through both SMAD2 and SMAD3 or only through SMAD2 in the liver and stomach. These studies identify sexually dimorphic functions of SMAD3 in gonadal tumorigenesis...
  42. pmc Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo
    Qinglei Li
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 28:7001-11. 2008
    ....
  43. pmc Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 28:248-57. 2008
    ..These data strongly implicate the BR-SMADs as part of a critical developmental pathway in ovaries and testis that, when disrupted, leads to malignant transformation...
  44. ncbi request reprint Obox, a family of homeobox genes preferentially expressed in germ cells
    Aleksandar Rajkovic
    Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genomics 79:711-7. 2002
    ..The Obox1 and Obox2 genomic structures revealed the presence of six exons each. The Obox genes represent a new family of tissue-specific homeobox genes preferentially expressed in gonads...
  45. pmc Testicular cell adhesion molecule 1 (TCAM1) is not essential for fertility
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Endocrinol 315:246-53. 2010
    ..However, Tcam1 knockout mice that we generated are fertile, and testis weights and sperm counts were not significantly altered. Therefore, we conclude that TCAM1 is not essential for male fertility or germ cell function in Mus musculus...
  46. ncbi request reprint Genetic analysis of the mammalian transforming growth factor-beta superfamily
    Hua Chang
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocr Rev 23:787-823. 2002
    ..This review attempts to collate and integrate the extensive body of in vivo mammalian studies produced over the last decade...
  47. pmc Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice
    Saneal Rajanahally
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Reprod Biol Endocrinol 8:69. 2010
    ....
  48. ncbi request reprint Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 69:338-46. 2003
    ....
  49. ncbi request reprint Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 17:2039-52. 2003
    ....
  50. pmc Local signalling environments and human male infertility: what we can learn from mouse models
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Expert Rev Mol Med 12:e15. 2010
    ..Analysis of these signalling processes in spermatogenesis using mouse models has provided investigators with an invaluable tool to effectively translate basic science research to the research of human disease and infertility...
  51. pmc Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15
    Qinglei Li
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Hum Reprod 15:779-88. 2009
    ..The purified rhBMP15 is also biologically active and very stable, and can induce the expression of a variety of mouse granulosa cell genes...
  52. ncbi request reprint Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes
    Nobuhiro Suzumori
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mech Dev 111:137-41. 2002
    ..In situ hybridization analysis demonstrates that Nobox mRNA is present in primordial and growing oocytes. Nobox is one of the first homeobox-encoding genes preferentially expressed during mammalian folliculogenesis...
  53. pmc Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero
    Subrahmanyam S Chirala
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:6358-63. 2003
    ..These observations are very important in considering teratogenic consequences of drugs aimed at inhibiting FAS activity, to reduce either obesity or the growth of cancerous tissues...
  54. ncbi request reprint Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Gene Expr Patterns 5:257-63. 2004
    ..The mouse Nohma gene is comprised of 15 exons and maps to chromosome 3. A human ortholog was also identified. The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis...
  55. ncbi request reprint GDF-9 and BMP-15: oocyte organizers
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Rev Endocr Metab Disord 3:27-32. 2002
  56. ncbi request reprint Genetic models for transforming growth factor beta superfamily signaling in ovarian follicle development
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Endocrinol 225:83-91. 2004
    ..These new models may reveal the in vivo genetic interactions of TGFbeta superfamily ligands, receptors, binding proteins, and downstream signaling pathways...
  57. ncbi request reprint Identification and characterization of evolutionarily conserved pufferfish, zebrafish, and frog orthologs of GASZ
    Wei Yan
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 70:1619-25. 2004
    ..The data presented here are important for future studies of the physiological roles of GASZ using fish and amphibians as animal models...
  58. ncbi request reprint Granulosa cell-specific inactivation of follistatin causes female fertility defects
    Carolina J Jorgez
    Program in Developmental Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Endocrinol 18:953-67. 2004
    ..These studies are the first report of a granulosa cell-specific deletion of a gene in the postnatal ovary and have important implications for future endeavors to generate ovary-specific knockout mouse models...
  59. ncbi request reprint Genetic manipulations to study reproduction
    Carolina J Jorgez
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Endocrinol 234:127-35. 2005
    ....
  60. pmc Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development
    Mark A Edson
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 24:1251-66. 2010
    ..These studies support a role for a functional BMP signaling axis as a tumor suppressor pathway in the ovary, with BMPR1A and BMPR1B acting downstream of BMP ligands and upstream of BMP receptor SMADs...
  61. pmc RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway
    Nobuhiro Suzumori
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:550-5. 2003
    ..The specificity of its expression and these interactions suggest that RFPL4 targets cyclin B1 for proteasomal degradation, a key aspect of oocyte cell cycle control during meiosis and the crucial oocyte-to-embryo transition to mitosis...
  62. ncbi request reprint Deconstructing mammalian reproduction: using knockouts to define fertility pathways
    Angshumoy Roy
    Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Reproduction 131:207-19. 2006
    ..This review focuses on the merits, utility, and the variations of the knockout technology in studies of reproduction in mammals...
  63. ncbi request reprint Impaired male sexual behavior in activin receptor type II knockout mice
    Xiaoping Ma
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 73:1182-90. 2005
    ..Our studies identify a previously unrecognized role of activin signaling in male sexual behavior and suggest that activins and/or related family members are upstream regulators of NOS activity within the mPOA of the forebrain...
  64. pmc Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility
    Wei Yan
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:4615-24. 2005
    ..We propose that OAS1D suppresses the interferon/OAS/RNase L-mediated cellular destruction by interacting with OAS1A during oogenesis and early embryonic development...
  65. pmc Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis
    Yi Nan Lin
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:6794-805. 2007
    ..Whereas ZPBP1 was discovered for an in vitro role in sperm-egg interactions, we have shown that both ZPBP proteins play an earlier structural role during spermiogenesis...
  66. pmc The mammalian ovary from genesis to revelation
    Mark A Edson
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocr Rev 30:624-712. 2009
    ..Clearly, we have learned much about the mammalian ovary and manipulating its most important cargo, the oocyte, since the birth of Louise Brown over 30 yr ago...
  67. ncbi request reprint Absence of tektin 4 causes asthenozoospermia and subfertility in male mice
    Angshumoy Roy
    Department of Pathology, One Baylor Plaza, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 21:1013-25. 2007
    ..5 h. Our studies demonstrate that TEKT4 is necessary for the proper coordinated beating of the sperm flagellum and male reproductive physiology...
  68. pmc The menstrual cycle: basic biology
    Shannon M Hawkins
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA
    Ann N Y Acad Sci 1135:10-8. 2008
    ..Although not perfect, mouse models have helped to identify and confirm additional components and pathways in menstrual cycle function and dysfunction in humans...
  69. pmc The power of mouse genetics to study spermatogenesis
    A N Yatsenko
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    J Androl 31:34-44. 2010
    ..Ultimately, basic advances in mammalian nonhuman reproduction will translate to clinical advances in human reproduction and testing for infertile humans, thereby helping to improve diagnostics and health care for infertile patients...
  70. ncbi request reprint Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells
    You Qiang Su
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 135:111-21. 2008
    ..Therefore, oocyte-derived paracrine factors, particularly, BMP15 and GDF9, promote cholesterol biosynthesis in cumulus cells, probably as compensation for oocyte deficiencies in cholesterol production...
  71. ncbi request reprint Minireview: genetic models for the study of gonadotropin actions
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Endocrinology 143:2823-35. 2002
    ....
  72. ncbi request reprint Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin
    Motonobu Nakamura
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    FASEB J 17:497-9. 2003
    ..These observations suggest that follistatin and activin interaction plays an important role in both HF development and cycling, possibly in part by regulating expression of BMP-2 and its antagonist...
  73. ncbi request reprint Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 231:98-108. 2004
    ..We propose that finely tuned antagonistic effects between follistatin and TGF beta superfamily signals are critical for enamel knot formation and function, as well as for patterning of tooth cusps...
  74. ncbi request reprint Follicle-stimulating hormone increases testicular Anti-Mullerian hormone (AMH) production through sertoli cell proliferation and a nonclassical cyclic adenosine 5'-monophosphate-mediated activation of the AMH Gene
    CĂ©line Lukas-Croisier
    Centro de Investigaciones Endocrinologicas, Hospital de Ninos, Gallo 1330, C1425EFD Buenos Aires, Argentina
    Mol Endocrinol 17:550-61. 2003
    ..We conclude that prepubertal testicular AMH production is increased by FSH stimulation through Sertoli cell proliferation and an enhancement of AMH gene transcription...
  75. ncbi request reprint FSH and TGF-beta superfamily members regulate granulosa cell connective tissue growth factor gene expression in vitro and in vivo
    Christopher R Harlow
    Department of Reproductive and Developmental Sciences, University of Edinburgh, Center for Reproductive Biology, Edinburgh, United Kingdom EH3 9ET
    Endocrinology 143:3316-25. 2002
    ....
  76. ncbi request reprint The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo
    Canhe Chen
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Development 133:319-29. 2006
    ..Our findings indicate that Gdf3 acts in a Nodal-like signaling pathway in pre-gastrulation development, and provide evidence for the functional conservation of Vg1 activity in mice...
  77. pmc Normal reproductive function in InhBP/p120-deficient mice
    Daniel J Bernard
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60201, USA
    Mol Cell Biol 23:4882-91. 2003
    ..Moreover, they showed no alterations in FSH synthesis or secretion or in ovarian or testicular function. These data contribute to a growing body of evidence indicating that InhBP/p120 does not play an essential role in inhibin biology...
  78. pmc Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility
    Juxiang Yang
    Center for Research on Reproduction and Women s Health and Department of Biology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:5755-60. 2005
    ..Thus, Msy2 represents one of a small number of germ-cell-specific genes whose deletion leads to the disruption of both spermatogenesis and oogenesis...
  79. pmc MRG15 regulates embryonic development and cell proliferation
    Kaoru Tominaga
    Department of Cellular and Structural Biology, Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Mol Cell Biol 25:2924-37. 2005
    ..These findings demonstrate that MRG15 has an essential role in embryonic development via chromatin remodeling and transcriptional regulation...
  80. ncbi request reprint GDF11 controls the timing of progenitor cell competence in developing retina
    Joon Kim
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Science 308:1927-30. 2005
    ..Thus, GDF11 governs the temporal windows during which multipotent progenitors retain competence to produce distinct neural progeny...
  81. pmc Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms
    Shyr Yeu Lin
    Monash Institute of Medical Research, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Mol Endocrinol 22:415-29. 2008
    ....
  82. pmc Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis
    Humphrey H C Yao
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Dev Dyn 230:210-5. 2004
    ..Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary...
  83. ncbi request reprint Hormonal control of somatic cell oocyte interactions during ovarian follicle development
    Catherine M H Combelles
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Mol Reprod Dev 69:347-55. 2004
    ....
  84. pmc MrgX is not essential for cell growth and development in the mouse
    Kaoru Tominaga
    Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Mol Cell Biol 25:4873-80. 2005
    ....
  85. ncbi request reprint Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Dev Cell 7:719-30. 2004
    ....
  86. ncbi request reprint Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells
    Koji Sugiura
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 134:2593-603. 2007
    ..Therefore, oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells...
  87. ncbi request reprint Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte-granulosa cell regulatory loop
    You Qiang Su
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Dev Biol 276:64-73. 2004
    ..Therefore, this study provides further evidence for the existence and functioning of an oocyte-granulosa cell regulatory loop...

Research Grants3

  1. Defining the Mammalian Intercellular Bridge Interactome
    Martin M Matzuk; Fiscal Year: 2010
    ..Our proposed Specific Aims will also help us to develop additional high throughput screening assays for the identification of small molecule disruptors of the intercellular bridge. ..
  2. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin M Matzuk; Fiscal Year: 2010
    ..Characterization of these mice will lead to important insights into the development of gonadal cancers in men and women and the roles of several proteins in reproductive physiology. ..
  3. Regulation of Key Processes in Oocyte Biology
    Martin Matzuk; Fiscal Year: 2007
    ..Compromised fertility in knockout models lacking these oocyte-specific genes would demonstrate that these proteins are potential contraceptive targets and possibly mutated in infertile women. ..