Mingyao Liu

Summary

Affiliation: Texas A and M Health Science Center
Country: USA

Publications

  1. ncbi request reprint TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1
    Yuequn Wang
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, People s Republic of China
    Biochem Biophys Res Commun 323:9-16. 2004
  2. ncbi request reprint TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK
    Bing Han
    Thoracic Surgery Research Laboratory, University Health Network Toronto General Research Institute, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Immunol 175:8303-11. 2005
  3. ncbi request reprint G-protein coupled receptor 124 (GPR124) in endothelial cells regulates vascular endothelial growth factor (VEGF)-induced tumor angiogenesis
    Y Wang
    Institute of BioScience and Technology, Texas A and M University Health Science Center, 2121 West Holcombe Blvd, Houston, Texas 77030, USA
    Curr Mol Med 14:543-54. 2014
  4. pmc Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway
    Chenghai Li
    The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
    Mol Cancer 9:73. 2010
  5. ncbi request reprint A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1
    Fang Liu
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, People s Republic of China
    Biochem Biophys Res Commun 333:5-13. 2005
  6. ncbi request reprint A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates SRE and AP-1 mediated MAPK signaling pathway
    Jianping Ai
    The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, Peoples Republic of China
    Mol Biol Rep 35:179-87. 2008
  7. ncbi request reprint ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway
    Jing Li
    The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, People s Republic of China
    Biochem Biophys Res Commun 363:895-900. 2007
  8. ncbi request reprint ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway
    Xinqiong Huang
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Biochem Biophys Res Commun 346:621-8. 2006
  9. pmc Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation
    Sung Gook Cho
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology and Department of Molecular and Cellular Medicine, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    Cancer Res 69:7062-70. 2009
  10. ncbi request reprint ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways
    Yongqing Li
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, Peoples Republic of China
    Biochem Biophys Res Commun 325:1383-92. 2004

Research Grants

Collaborators

Detail Information

Publications87

  1. ncbi request reprint TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1
    Yuequn Wang
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, People s Republic of China
    Biochem Biophys Res Commun 323:9-16. 2004
    ..Overexpression of TRIM45 in COS-7 cells inhibits the transcriptional activities of ElK-1 and AP-1. These results suggest that TRIM45 may act as a new transcriptional repressor in mitogen-activated protein kinase signaling pathway...
  2. ncbi request reprint TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK
    Bing Han
    Thoracic Surgery Research Laboratory, University Health Network Toronto General Research Institute, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Immunol 175:8303-11. 2005
    ..The importance of the JNK pathway for the regulated PTX3 expression may be a potential target for its regulation in the lung...
  3. ncbi request reprint G-protein coupled receptor 124 (GPR124) in endothelial cells regulates vascular endothelial growth factor (VEGF)-induced tumor angiogenesis
    Y Wang
    Institute of BioScience and Technology, Texas A and M University Health Science Center, 2121 West Holcombe Blvd, Houston, Texas 77030, USA
    Curr Mol Med 14:543-54. 2014
    ..GPR124 regulated VEGF-induced tumor angiogenic processes in vitro including cell-cell interaction, permeability, migration, invasion, and tube formation. Therefore, GPR124 plays a key role in VEGF-induced tumor angiogenesis...
  4. pmc Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway
    Chenghai Li
    The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
    Mol Cancer 9:73. 2010
    ..The aim of this study was to determine whether MA potentiates the anti-tumor activity of TNFalpha though the regulation of NF-kappaB activation...
  5. ncbi request reprint A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1
    Fang Liu
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, People s Republic of China
    Biochem Biophys Res Commun 333:5-13. 2005
    ....
  6. ncbi request reprint A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates SRE and AP-1 mediated MAPK signaling pathway
    Jianping Ai
    The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, Peoples Republic of China
    Mol Biol Rep 35:179-87. 2008
    ..These results suggest that hLBH proteins may act as a transcriptional activator in mitogen-activated protein kinase signaling pathway to mediate cellular functions...
  7. ncbi request reprint ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway
    Jing Li
    The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, People s Republic of China
    Biochem Biophys Res Commun 363:895-900. 2007
    ..ZNF307 might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing p53 degradation...
  8. ncbi request reprint ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway
    Xinqiong Huang
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Biochem Biophys Res Commun 346:621-8. 2006
    ..The results suggest that ZNF569 protein may act as a transcriptional repressor that suppresses MAPK signaling pathway to mediate cellular functions...
  9. pmc Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation
    Sung Gook Cho
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology and Department of Molecular and Cellular Medicine, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    Cancer Res 69:7062-70. 2009
    ....
  10. ncbi request reprint ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways
    Yongqing Li
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, Peoples Republic of China
    Biochem Biophys Res Commun 325:1383-92. 2004
    ..Together, these results suggest that ZNF322 is a member of the zinc-finger transcription factor family and may act as a positive regulator in gene transcription mediated by the MAPK signaling pathways...
  11. ncbi request reprint Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394
    Chunxia Huang
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, PR China
    Biochem Biophys Res Commun 320:1298-305. 2004
    ....
  12. ncbi request reprint WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway
    Ying Zhu
    College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, China
    J Cell Biochem 93:579-87. 2004
    ..These results suggest that WDR26 may act as a negative regulator in MAPK signaling pathway and play an important role in cell signal transduction...
  13. ncbi request reprint PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer
    Jinsheng Weng
    Center for Cancer Biology and Nutrition, Alkek Institute of Biosciences and Technology, Department of Medical Biochemistryand Genetics, Texas A and M University System Health Science Center, Houston, TX, USA
    Int J Cancer 118:1471-80. 2006
    ..Together, our results suggest that PSGR2 is a novel prostate specific G-protein coupled receptor and may be useful as a tissue marker and molecular target for the early detection and treatment of human prostate cancers...
  14. ncbi request reprint ZNF325, a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity
    Yulian Zhao
    The Center for Heart Development, Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, People s Republic of China
    Biochem Biophys Res Commun 346:1191-9. 2006
    ..These results indicate that the ZNF325 protein may act as a novel transcription repressor in MAPK signaling pathway to mediate cellular functions...
  15. ncbi request reprint ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway
    Lei Cao
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, People s Republic of China
    Biochem Biophys Res Commun 333:1050-9. 2005
    ..Overexpression of ZNF383 in cells inhibits the transcriptional activities of AP-1 and SRE, suggesting that ZNF383 may act as a negative regulator in MAPK-mediated signaling pathways...
  16. pmc Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
    Tingfang Yi
    Center for Cancer and Stem Cell Biology, Institute for Bioscience and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 7:1789-96. 2008
    ..Overall, our results indicate that thymoquinone inhibits tumor angiogenesis and tumor growth and could be used as a potential drug candidate for cancer therapy...
  17. pmc KiSS1 suppresses TNFalpha-induced breast cancer cell invasion via an inhibition of RhoA-mediated NF-kappaB activation
    Sung Gook Cho
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    J Cell Biochem 107:1139-49. 2009
    ..Therefore, our data demonstrate that KiSS1 inhibits TNFalpha-induced NF-kappaB activation via downregulation of RhoA activation and suppression of breast cancer cell migration and invasion...
  18. ncbi request reprint IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor
    Yuequn Wang
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Biochem Biophys Res Commun 325:1330-8. 2004
    ....
  19. ncbi request reprint ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1
    Ying Ou
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, People s Republic of China
    Biochem Biophys Res Commun 333:1034-44. 2005
    ..These results suggest that ZNF328 protein may act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions...
  20. ncbi request reprint Expression of a novel Krüpple-like zinc-finger gene, ZNF382, in human heart
    Kaimei Luo
    Laboratory of Molecular Developmental Genetics, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, PR China
    Biochem Biophys Res Commun 299:606-12. 2002
    ..At the adult stage, ZNF382 expression is restricted largely to heart tissue suggesting a potential role in heart development and function...
  21. ncbi request reprint Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase
    Heidi Y Shi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Cell Motil Cytoskeleton 64:338-46. 2007
    ..In addition, the AP-1 transcription activity downstream of JNK kinase pathway was also reduced. Together, we have identified Rac1 and Cdc42 as the downstream targets that mediate the inhibition of mammary tumor cell migration by maspin...
  22. ncbi request reprint GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis
    Wenbin Ma
    Institute of Biosciences and Technology, and Department of Molecular and Cellular Medicine, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    J Cell Biochem 100:1376-86. 2007
    ..Finally, we demonstrate that GCIP specifically interacts with one of the class III HDAC proteins, SirT6, which is important for maintaining genome stability. Together, our data suggest a possible function of GCIP in tumor suppression...
  23. ncbi request reprint A novel KRAB zinc-finger protein, ZNF480, expresses in human heart and activates transcriptional activities of AP-1 and SRE
    Zhengfang Yi
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, PR China
    Biochem Biophys Res Commun 320:409-15. 2004
    ..Therefore, our data suggest that ZNF480 may act as a positive regulator in MAPK-mediated signaling pathways that lead to the activation of AP-1 and SRE...
  24. ncbi request reprint A novel six-transmembrane protein hhole functions as a suppressor in MAPK signaling pathways
    Junmei Zhou
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, People s Republic of China
    Biochem Biophys Res Commun 333:344-52. 2005
    ..These results suggest that the hhole protein may interact with SH3-domain proteins or ERKs to mediate signaling pathways/networks that lead to the suppression of AP-1 and SRE...
  25. ncbi request reprint ZNF411, a novel KRAB-containing zinc-finger protein, suppresses MAP kinase signaling pathway
    Hui Liu
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, People s Republic of China
    Biochem Biophys Res Commun 320:45-53. 2004
    ..These results indicate that ZNF411 is a member of the zinc-finger transcription factor family and may be involved in the heart development, and it probably works as a negative regulator in MAPK signaling pathway...
  26. ncbi request reprint hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor
    Zhenyu Cai
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, PR China
    Biochem Biophys Res Commun 343:973-81. 2006
    ....
  27. ncbi request reprint ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor
    Hong Yang
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, People s Republic of China
    Biochem Biophys Res Commun 333:206-15. 2005
    ..These results suggest that ZNF649 protein may act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway to mediate cellular functions...
  28. pmc Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression
    Tingfang Yi
    Department of Molecular and Cellular Medicine, Texas A and M University Health Science Center, Institute of BioScience and Technology, Center for Cancer and Stem Cell Biology, Houston, Texas 77030, USA
    J Biol Chem 285:17811-20. 2010
    ..Together, these data suggest that Gpr54 regulates Bmp7 expression through NFAT2 and Sp1 and plays an important role in embryonic kidney branching morphogenesis and glomerular development...
  29. ncbi request reprint A novel human SCAN/(Cys)2(His)2 zinc-finger transcription factor ZNF323 in early human embryonic development
    Hualiang Pi
    College of Life Science, Hunan Normal University, Changsha, 410081, Hunan, People s Republic of China
    Biochem Biophys Res Commun 296:206-13. 2002
    ..Taken together, these results indicate that ZNF323 is a member of the zinc-finger transcription factor family and may be involved in the development of multiple embryonic organs...
  30. ncbi request reprint Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors
    Jinsheng Weng
    Alkek Institute of Biosciences and Technology, Department of Medical Biochemistry and Genetics, Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, Texas 77030, USA
    J Cell Biochem 96:1034-48. 2005
    ..These data suggest that two functional promoters regulate the transcriptional expression of PSGR in human prostate tissues and PSGR is a new target for IL-6 transcriptional regulation...
  31. ncbi request reprint A novel human gene ZNF415 with five isoforms inhibits AP-1- and p53-mediated transcriptional activity
    Yingduan Cheng
    The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, PR China
    Biochem Biophys Res Commun 351:33-9. 2006
    ....
  32. ncbi request reprint Cloning and expression of a novel human gene, Isl-2, encoded a LIM-homeodomain protein
    Yongqing Li
    Center for Heart Development, Key Laboratory of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, People s Republic of China
    Mol Biol Rep 34:19-26. 2007
    ..The broad expression of Isl-2 gene in tissues during embryogenesis and adult development suggests that it may be involved in both differentiation and maintenance of these tissues and might play an important role...
  33. ncbi request reprint Estrogen regulates KiSS1 gene expression through estrogen receptor alpha and SP protein complexes
    Dali Li
    Institute of Biosciences and Technology, Texas A and M Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Endocrinology 148:4821-8. 2007
    ....
  34. ncbi request reprint Activation of transcriptional activities of AP-1 and SRE by a new zinc-finger protein ZNF641
    Xingzhu Qi
    The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, PR China
    Biochem Biophys Res Commun 339:1155-64. 2006
    ..These results suggest that ZNF641 may be a positive regulator in MAPK-mediated signaling pathways that lead to the activation of AP-1 and SRE...
  35. pmc Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2
    Jinsheng Weng
    Institute of Biosciences and Technology and Department of Molecular and Cellular Medicine, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:6081-6. 2008
    ....
  36. ncbi request reprint A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway
    Zhiming Xiang
    The Center for Heart Development, Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, Hunan, People s Republic of China
    Biochem Biophys Res Commun 347:288-96. 2006
    ..Taken together, these results suggest that ZNF540 may act as a transcriptional repressor in MAPK signaling pathway to mediate cellular functions...
  37. pmc Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway
    Huiping Song
    Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 283:36687-97. 2008
    ....
  38. pmc Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the i
    Bokyung Sung
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, USA
    Blood 111:4880-91. 2008
    ..Overall, our results demonstrate a novel role for anacardic acid in potentially preventing or treating cancer through modulation of NF-kappaB signaling pathway...
  39. ncbi request reprint The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth
    Brad A Bryan
    Alkek Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    J Neurosci Res 83:1151-9. 2006
    ..Together, our data provide new evidence suggesting that GEFT is an important regulator of multiple processes involved in axon and dendrite formation...
  40. pmc GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression
    Yi Cai
    Department of Pathology, Baylor College of Medicine, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Cancer Res 69:819-27. 2009
    ..Thus, increased GGAP2 expression, which is present in three quarters of human prostate cancers, can activate two critical pathways that have been linked to prostate cancer initiation and progression...
  41. doi request reprint Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells
    Bokyung Sung
    Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 68:8938-44. 2008
    ..Overall, our results show that zerumbone is a novel inhibitor of CXCR4 expression and thus has a potential in the suppression of cancer metastasis...
  42. ncbi request reprint A novel mutation of TGF beta1 in a Chinese family with Camurati-Engelmann disease
    Songlin Wu
    The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, People s Republic of China
    Bone 40:1630-4. 2007
    ..This mutation has not been previously reported in other countries in the world...
  43. ncbi request reprint A novel mutation of p63 in a Chinese family with inherited syndactyly and adactylism
    Tongxiu Luo
    The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Science, Hunan Normal University, Changsha 410081, Hunan, PR China
    Mutat Res 637:182-9. 2008
    ..SSCP analysis of the segregation pattern of the mutation strongly suggests a causal relationship to the SHFM phenotype in p63. This mutation has not been observed in other countries in the world...
  44. ncbi request reprint Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development
    Weiqi Zeng
    College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, People s Republic of China
    Biochem Biophys Res Commun 299:542-8. 2002
    ..Strong liver expression of SNX-L is maintained from 12 to 25 weeks during human fetus development, suggesting that SNX-L may be a regulatory gene involved in receptor protein degradation during embryonic liver development...
  45. pmc LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects
    Tingfang Yi
    From the Institute of Biosciences and Technology and Department of Molecular and Cellular Medicine, Texas A and M University Health Science Center, Houston, Texas 77030 and
    J Biol Chem 289:8767-80. 2014
    ....
  46. ncbi request reprint Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus
    Xiao yang Mo
    Center for Heart Development, Key Lab of National Education Ministry, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    J Med Virol 79:1783-91. 2007
    ..Except for ZNF175, gene annotation indicated four of these genes encoded interferon or interferon-induced genes. These results suggest that genes relevant to interferon-regulated pathways may be involved in the pathogenesis of rubella...
  47. pmc GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins
    Chunzhi Xia
    Center for Cancer Biology and Nutrition, Alkek Institute of Biosciences and Technology, and Department of Medical Biochemistry and Genetics, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Mol Cell Biol 23:2476-88. 2003
    ..Overexpression of GGAPs leads to changes in cell morphology and activation of gene transcription...
  48. pmc Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor
    Vivek R Yadav
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA
    J Mol Med (Berl) 88:1243-53. 2010
    ..Overall, these results show that celastrol has potential in suppressing invasion and metastasis of cancer cells by down-modulation of CXCR4 expression...
  49. pmc Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression
    Byoungduck Park
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 129:23-33. 2011
    ..Overall, our results show that AKBA is a novel inhibitor of CXCR4 expression and, thus, has the potential to suppress the invasion and metastasis of cancer cells...
  50. ncbi request reprint G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6
    Yi Cai
    Department of Medical Biochemistry and Genetics, Alkek Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Oncogene 24:4293-300. 2005
    ....
  51. pmc Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling
    Tingfang Yi
    Center for Cancer and Stem Cell Biology, Institute for Bioscience and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Cancer Res 68:1843-50. 2008
    ..Together, these data suggest that GA inhibits angiogenesis and may be a viable drug candidate in antiangiogenesis and anticancer therapies...
  52. pmc Haploinsufficiency in the prometastasis Kiss1 receptor Gpr54 delays breast tumor initiation, progression, and lung metastasis
    Sung Gook Cho
    Center for Cancer and Stem Cell Biology, Institute of BioScience and Technology, Texas A and M System Health Science Center, Houston, Texas 77030, USA
    Cancer Res 71:6535-46. 2011
    ..In summary, we concluded that Kiss1r attenuation was sufficient to delay breast tumor initiation, progression, and metastasis through inhibitory effects on the downstream Gαq-p63RhoGEF-RhoA signaling pathway...
  53. ncbi request reprint A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration
    Xiangrong Guo
    Center for Cancer Biology and Nutrition, Alkek Institute of Biosciences and Technology, and Department of Medical Biochemistry and Genetics, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 278:13207-15. 2003
    ..Together, our data suggest that GEFT is a Rac/Cdc42-specific GEF protein that regulates cell morphology, cell proliferation, and transformation...
  54. pmc Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth
    Zhenyu Cai
    Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas, USA
    Cancer Res 71:2466-75. 2011
    ....
  55. pmc Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signaling
    Bokyung Sung
    Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 129:2062-72. 2011
    ..Collectively, our results indicate that butein suppresses the osteoclastogenesis induced by tumor cells and by RANKL, by suppression of the NF-κB activation pathway...
  56. pmc Developmental expression of three small GTPases in the mouse eye
    Dianne C Mitchell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX, USA
    Mol Vis 13:1144-53. 2007
    ..To explore this possibility, we examined the expression patterns of three major Rho-GTPases: RhoA, Rac1, and Cdc42 in embryonic, postnatal (one day after birth), and adult (two-month old) mouse eye...
  57. ncbi request reprint GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation
    Brad Bryan
    Alkek Institute of Biosciences and Technology, and Department of Medical Biochemistry and Genetics, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    J Biol Chem 279:45824-32. 2004
    ..Together, our data suggest that GEFT enhances dendritic spine formation and neurite outgrowth in primary neurons and neuroblastoma cells, respectively, through the activation of Rac/Cdc42-PAK signaling pathways...
  58. pmc Transcriptional regulation of Tlr11 gene expression in epithelial cells
    Zhenyu Cai
    Center for Infectious and Inflammatory Disease, Institute of BioScience and Technology, Texas A and M University Health Science Center, USA
    J Biol Chem 284:33088-96. 2009
    ..Our results imply that the distinctive transcription regulatory machinery for TLRs on epithelium may represent a promising new avenue for the development of epithelia-specific therapeutic interventions...
  59. pmc Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis
    Ajaikumar B Kunnumakkara
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 109:5112-21. 2007
    ..Overall, our results demonstrate that gossypin inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation, carcinogenesis, and angiogenesis...
  60. ncbi request reprint Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development
    Liang Zhou
    College of Life Sciences, Hunan Normal University, Changsha, Hunan, People s Republic of China
    Biochem Biophys Res Commun 295:862-8. 2002
    ..A further analysis using human embryonic tissues (18-23 weeks) showed a development-specific expression pattern in heart, skeletal muscle, liver, lung, kidney, and brain, suggesting a role for these genes in embryonic development...
  61. ncbi request reprint Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase
    Ya Chieh Hsu
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 445:785-8. 2007
    ..Our studies identify TCTP as a direct regulator of Rheb and a potential therapeutic target for TSC disease...
  62. pmc Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2
    Ying Wang
    Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas, USA
    Stem Cells 31:1921-31. 2013
    ..Importantly, Sox2 overexpression restored the in vivo mammary regeneration potential of Lgr4(-/-) mammary stem cells. Therefore, Lgr4 activates Sox2 to regulate mammary development and stem cell functions via Wnt/β-catenin/Lef1...
  63. pmc Lgr4 is a key regulator of prostate development and prostate stem cell differentiation
    Weijia Luo
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, TexasA and M University Health Science Center, Houston, Texas, USA
    Stem Cells 31:2492-505. 2013
    ..Taken together, our data revealed the roles of Lgr4 in early prostate development and in stem cell differentiation through regulation of the Wnt, Notch, and Sonic Hedgehog signaling pathways...
  64. doi request reprint GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway
    Xiaolong Tang
    Authors Affiliations East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China and Center for Cancer and Stem Cell Biology, Alkek Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas
    Cancer Res 73:6206-18. 2013
    ..These findings show that GPR116 is crucial for the metastasis of breast cancer and support GPR116 as a potential prognostic marker and drug target against metastatic human breast cancer...
  65. ncbi request reprint Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:6517-24. 2007
    ..Our study suggests a novel role for SUMO modification in the regulation of myogenic differentiation...
  66. doi request reprint Caffeic acid 3,4-dihydroxy-phenethyl ester induces cancer cell senescence by suppressing twist expression
    Anliang Dong
    Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
    J Pharmacol Exp Ther 339:238-47. 2011
    ..Therefore, our studies provide evidence for a novel role of CADPE in cancer cell senescence by targeting the Twist1-dependent senescence signaling pathway...
  67. pmc (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis
    Xiufeng Pang
    Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China
    Mol Cancer Ther 10:795-805. 2011
    ..Taken together, the present study shows that (-)-gossypol potently inhibits human prostate tumor growth through modulating VEGF signaling pathway, which further validates its great potential in clinical practice...
  68. doi request reprint Regulation of KiSS1 gene expression
    Dali Li
    Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China
    Peptides 30:130-8. 2009
    ....
  69. pmc SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin
    Dali Li
    The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241
    Nucleic Acids Res 37:7059-71. 2009
    ..Taken together, these studies demonstrated that SMYD1 is a key regulator of myogenic differentiation and acts as a downstream target of muscle regulatory factors, SRF and myogenin...
  70. doi request reprint Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1
    Lei Wang
    The Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, China
    Int J Cancer 127:1220-9. 2010
    ..These results are the first to reveal the function of IAX in tumor metastasis and its underlying molecular mechanism, thus suggest IAX to be a promising antimetastatic agent...
  71. ncbi request reprint XB130, a novel adaptor protein for signal transduction
    Jing Xu
    Division of Cellular and Molecular Biology, University Health Network Toronto General Research Institute, and Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    J Biol Chem 282:16401-12. 2007
    ..These data suggest that XB130 as an adaptor may play an important role in the regulation of signal transduction and cellular functions...
  72. ncbi request reprint Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway
    Hua Xiang
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey, NJ 08084, USA
    Oncogene 21:3784-91. 2002
    ..Taken together, our results suggest that hTERT, when overexpressed in human lens epithelial cells, accelerates cell growth rate through regulation of RB/E2F pathway and possibly other genes...
  73. ncbi request reprint Conversion of mechanical force into biochemical signaling
    Bing Han
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Biol Chem 279:54793-801. 2004
    ..Cytoskeleton deformation-induced protein-protein interaction via specific binding sites may represent a novel intracellular mechanism for cells to sense mechanical stimulation...
  74. ncbi request reprint Regulation of c-fos expression by static stretch in rat myometrial smooth muscle cells
    Oksana P Shynlova
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Obstet Gynecol 186:1358-65. 2002
    ..We investigated whether mechanical stretch stimulates expression of the immediate early gene c-fos messenger RNA in rat myometrial smooth muscle cells...
  75. ncbi request reprint The Blimp-1 gene regulatory region directs EGFP expression in multiple hematopoietic lineages and testis in mice
    Dingyan Wang
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, 620 University Avenue, Room 8 205, Toronto, ON, Canada, M5G 2C1
    Transgenic Res 17:193-203. 2008
    ..Our studies collectively suggest that Blimp-1 may play a general role in the development of hematopoietic lineages and a stage-specific role in spermatogenesis...
  76. ncbi request reprint Targeted cell replacement with bone marrow cells for airway epithelial regeneration
    Amy P Wong
    Latner Thoracic Surgery Research Laboratories, McEwen Centre for Regenerative Medicine, Toronto Lung Transplant Program, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada
    Am J Physiol Lung Cell Mol Physiol 293:L740-52. 2007
    ..Some BMC cultured in vitro over time also expressed GFP transgene, suggesting epithelial transdifferentiation of the BMC. The results indicate that targeted delivery of BMC can promote airway regeneration...
  77. ncbi request reprint Molecular cloning of actin filament-associated protein: a putative adaptor in stretch-induced Src activation
    Monika Lodyga
    Thoracic Surgery Research Laboratory, Division of Cellular and Molecular Biology, University Health Network Toronto General Research Institute and Department of Surgery, University of Toronto, Toronto, Ontario, Canada M5G 2C4
    Am J Physiol Lung Cell Mol Physiol 283:L265-74. 2002
    ..On the basis of the molecular structure of AFAP protein, we speculate that it is an adaptor in mechanical stretch-induced activation of c-Src. A novel model of mechanoreception is proposed...
  78. ncbi request reprint Long pentraxin 3 in pulmonary infection and acute lung injury
    Xiaolin He
    Thoracic Surgery Research Laboratory, University Health Network Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 292:L1039-49. 2007
    ..These studies will provide insight into the pathological processes of pulmonary infection and acute lung injury and provide potential novel therapeutic strategies to control pulmonary infections without severe lung injury...
  79. ncbi request reprint Toll-like receptor and cytokine gene expression in the early phase of human lung transplantation
    Cristiano Feijó Andrade
    Thoracic Surgery Research Laboratory, Toronto General Hospital, University Health Network, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 25:1317-23. 2006
    ..We hypothesized that gene expression of TLRs during lung transplantation may be affected by the donor condition and the ischemia-reperfusion process, which may subsequently influence graft function...
  80. ncbi request reprint Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor
    Lewis Joe Stafford
    Center for Cancer Biology and Nutrition, Alkek Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Cancer Res 62:5399-404. 2002
    ..Furthermore, activation of the KiSS1 receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis...
  81. ncbi request reprint Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells
    Alexandra D Oldenhof
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario
    Am J Physiol Cell Physiol 283:C1530-9. 2002
    ..Collectively, this data indicate that mechanical stretch modulates MAPK activity in the myometrium leading to c-fos expression...
  82. ncbi request reprint Regulation of hematopoietic-specific G-protein Galpha15 and Galpha16 by protein kinase C
    Jennifer L Gu
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Cell Biochem 88:1101-11. 2003
    ....
  83. ncbi request reprint Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42
    Zhong Li
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cell 114:215-27. 2003
    ..Although ligand-induced production of PIP(3) is not required for activation of this pathway, PIP(3) appears to localize the activation of Cdc42 by the pathway...
  84. ncbi request reprint Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury
    Tamas Dolinay
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 170:613-20. 2004
    ..Our data lead to a tempting speculation that inhaled CO might be useful in minimizing VILI...
  85. ncbi request reprint Reperfusion-induced gene expression profiles in rat lung transplantation
    Masaomi Yamane
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Transplant 5:2160-9. 2005
    ..Reperfusion-induced genes related to inflammatory response may contribute to graft dysfunction in LTx...
  86. ncbi request reprint PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP
    Liang Chen
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario
    FEBS J 272:2746-59. 2005
    ..Taken together, our observations suggest that Cdx-2 expression is regulated by the second messenger cAMP, cell-type specifically, via the Epac pathway...

Research Grants3

  1. PLC-Ca+ Signaling in the Vascular Smooth Muscle
    Mingyao Liu; Fiscal Year: 2004
    ..Together, we will understand the molecular basis for the modulation of G-protein mediated PLC-Ca2+ signaling in the vascular smooth muscle cells and the regulation of Ca2+ homeostasis in general. ..
  2. PSGR as a Molecular Target in Human Prostate Cancer
    Mingyao Liu; Fiscal Year: 2005
    ..abstract_text> ..
  3. KiSS1 and Its G-Protein Coupled Receptor in Metastasis
    Mingyao Liu; Fiscal Year: 2009
    ..The long-term benefit of this research is the great potential of KiSSl and its GPCR as an important drug candidate and molecular target for anti-cancer drug discovery and tumor metastasis treatment. ..