J Grotta

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Lubeluzole treatment of acute ischemic stroke. The US and Canadian Lubeluzole Ischemic Stroke Study Group
    J Grotta
    Department of Neurology, University of Texas Health Science Center at Houston 77030, USA
    Stroke 28:2338-46. 1997
  2. ncbi request reprint tPA-associated reperfusion after acute stroke demonstrated by SPECT
    J C Grotta
    Department of Neurology, University of Texas Health Science Center, Houston 77030, USA
    Stroke 29:429-32. 1998
  3. ncbi request reprint Agreement and variability in the interpretation of early CT changes in stroke patients qualifying for intravenous rtPA therapy
    J C Grotta
    Department of Neurology, University of Texas Houston Medical School, Houston, Texas, USA
    Stroke 30:1528-33. 1999
  4. ncbi request reprint Neuroprotective therapy
    J C Grotta
    Rev Neurol (Paris) 155:644-6. 1999
  5. ncbi request reprint Combination Therapy Stroke Trial: recombinant tissue-type plasminogen activator with/without lubeluzole
    J Grotta
    University of Texas Houston Medical School, Houston, TX 77030, USA
    Cerebrovasc Dis 12:258-63. 2001
  6. pmc Phase IIB/III trial of tenecteplase in acute ischemic stroke: results of a prematurely terminated randomized clinical trial
    E Clarke Haley
    Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 41:707-11. 2010
  7. doi request reprint Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 358:2127-37. 2008
  8. pmc Intraventricular hemorrhage: Anatomic relationships and clinical implications
    H Hallevi
    Department of Neurology, 6431 Fannin Street, MSB 7 044, Houston, TX 77030, USA
    Neurology 70:848-52. 2008
  9. ncbi request reprint Hypothermia after cardiac arrest: feasibility and safety of an external cooling protocol
    R A Felberg
    Department of Neurology, Stroke Treatment Team, University of Texas-Houston Medical School, Houston, Texas, USA
    Circulation 104:1799-804. 2001
  10. ncbi request reprint Acute stroke care in non-urban emergency departments
    W S Burgin
    Stroke Program, Department of Neurology, University of Texas Medical School-Houston, TX 77030, USA
    Neurology 57:2006-12. 2001

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Lubeluzole treatment of acute ischemic stroke. The US and Canadian Lubeluzole Ischemic Stroke Study Group
    J Grotta
    Department of Neurology, University of Texas Health Science Center at Houston 77030, USA
    Stroke 28:2338-46. 1997
    ..The present multicenter, double-blind, placebo-controlled study was conducted to assess the efficacy and safety of lubeluzole in the treatment of ischemic stroke...
  2. ncbi request reprint tPA-associated reperfusion after acute stroke demonstrated by SPECT
    J C Grotta
    Department of Neurology, University of Texas Health Science Center, Houston 77030, USA
    Stroke 29:429-32. 1998
    ....
  3. ncbi request reprint Agreement and variability in the interpretation of early CT changes in stroke patients qualifying for intravenous rtPA therapy
    J C Grotta
    Department of Neurology, University of Texas Houston Medical School, Houston, Texas, USA
    Stroke 30:1528-33. 1999
    ..We performed a detailed review of selected baseline CT scans from the NINDS rt-PA Stroke Trial to test agreement among experienced stroke specialists and other physicians on the presence of early CT ischemic changes...
  4. ncbi request reprint Neuroprotective therapy
    J C Grotta
    Rev Neurol (Paris) 155:644-6. 1999
    ..Progress depends on designing our clinical trials to better simulate the experimental conditions under which these drugs have been found to be effective...
  5. ncbi request reprint Combination Therapy Stroke Trial: recombinant tissue-type plasminogen activator with/without lubeluzole
    J Grotta
    University of Texas Houston Medical School, Houston, TX 77030, USA
    Cerebrovasc Dis 12:258-63. 2001
    ..A neuroprotective drug may be safe and effective if given very early and in combination with recombinant tissue-type plasminogen activator (rt-PA) to acute stroke patients. No clinical trial has yet tested this hypothesis...
  6. pmc Phase IIB/III trial of tenecteplase in acute ischemic stroke: results of a prematurely terminated randomized clinical trial
    E Clarke Haley
    Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 41:707-11. 2010
    ..If promise was established, then the trial would continue as a Phase III efficacy trial comparing the selected tenecteplase dose to standard rtPA...
  7. doi request reprint Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 358:2127-37. 2008
    ..We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes...
  8. pmc Intraventricular hemorrhage: Anatomic relationships and clinical implications
    H Hallevi
    Department of Neurology, 6431 Fannin Street, MSB 7 044, Houston, TX 77030, USA
    Neurology 70:848-52. 2008
    ..The purpose of this study was to examine the relationship between ICH volume and anatomic location to IVH, and to determine if ICH decompression into the ventricle is truly beneficial...
  9. ncbi request reprint Hypothermia after cardiac arrest: feasibility and safety of an external cooling protocol
    R A Felberg
    Department of Neurology, Stroke Treatment Team, University of Texas-Houston Medical School, Houston, Texas, USA
    Circulation 104:1799-804. 2001
    ..CONCLUSIONS: Mild-to-moderate induced hypothermia after cardiac arrest is feasible and safe. However, external cooling is slow and imprecise. Efforts to speed the start of cooling and to improve the cooling process are needed...
  10. ncbi request reprint Acute stroke care in non-urban emergency departments
    W S Burgin
    Stroke Program, Department of Neurology, University of Texas Medical School-Houston, TX 77030, USA
    Neurology 57:2006-12. 2001
    ..The use of heparin is common, more so than aspirin treatment. These facts argue for educational interventions aimed at non-urban physicians to improve evidence-based medical practice...
  11. ncbi request reprint Myocardial injury in patients with intracerebral hemorrhage treated with recombinant factor VIIa
    R M Sugg
    Department of Neurology, The University of Houston Medical School, Houston, TX 77030, USA
    Neurology 67:1053-5. 2006
    ..Elevated troponin occurred in 20% treated vs 3% nontreated (p = 0.02). Myocardial infarction occurred in 10% vs 1% (p = 0.01). We found a significant increase in myocardial injury in rFVIIa treated patients...