Genomes and Genes
Affiliation: Texas Medical Center
- The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic strokeMyriam Fornage
Institute of Molecular Medicne for the prevention of Human Diseases, University of Texas Health Science Center, Houston, TX 77030, USA
Hum Mol Genet 14:2829-37. 2005..These findings suggest that multiple variants exist within or near the EPHX2 gene, with greatly contrasting relationships to ischemic stroke incidence; some associated with a higher incidence and others with a lower incidence...
- Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smokingQi Wei
Institute of Molecular Medicine, University of Texas Health Science Center Houston, Houston, TX 77030, United States
Atherosclerosis 190:26-34. 2007..This detailed investigation of the association of EPHX2 genetic variation with CAC supports EPHX2's emerging role as a risk factor for atherosclerosis, whose effects are influenced by smoking...
- Genome-wide identification of allelic expression in hypertensive ratsRenata I Dmitrieva
Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center, 2121 Holcombe Blvd, Houston, TX 77030, USA
Circ Cardiovasc Genet 2:106-15. 2009..Inbred animal models can facilitate genetic studies of disease traits. The spontaneously hypertensive rat (SHR) is an inbred model of hypertension that exists in several closely related but genetically distinct lines...
- Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA StudyQi Wei
Institute of Molecular Medicine, The University of Texas Health Science Center Houston, 1825 Pressler St, Houston, TX 77030, USA
J Mol Med (Berl) 84:955-65. 2006..It underscores the role of genetic and environmental contexts in shaping the patterns of associations of PPARgamma sequence variants with metabolic traits in human populations...
- Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive ratMandi J Corenblum
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, 530 G, Houston, TX 77030, USA
Hypertension 51:567-73. 2008..These data support a role for Ephx2 polymorphism on sEH gene expression and function and risk of end-organ injury in the stroke-prone SHR...
- Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injuryMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, Room 530 G, Houston, TX 77030, USA
Hum Genet 120:671-80. 2007..They provide the basis for further investigation of the role of these genes in susceptibility and/or progression to clinical disease...
- Hepatocyte nuclear factor 1 and hypertensive nephropathyRenata I Dmitrieva
Institute of Molecular Medicine, University of Texas HSC at Houston, TX 77030, USA
Hypertension 51:1583-9. 2008..The present experiments uncover a major change in transcriptional control by HNF1 that affects redox and other genes and precedes emergence of hypertensive renal injury...
- Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genesCruz A Hinojos
Institute for Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
Hypertension 45:698-704. 2005..The present approach identifies a number of genes that may influence blood pressure in SHR by virtue of allelic effects on gene expression...
- Best practices and joint calling of the HumanExome BeadChip: the CHARGE ConsortiumMegan L Grove
School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, USA
PLoS ONE 8:e68095. 2013..The cluster file from this experiment is available at www.chargeconsortium.com/main/exomechip. ..
- The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohortsJan Bressler
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
BMC Med Genet 10:56. 2009..The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants...
- Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) studyMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Science Center, Houston, 2121 W Holcombe Blvd, Houston, TX 77030, USA
Circulation 109:335-9. 2004..We examined the relationship between a common, functional polymorphism of the human sEH gene and coronary artery calcification (CAC) in young, largely asymptomatic African-American and non-Hispanic white subjects...
- Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participantsKathy L E Klos
University of Texas Health Science Center at Houston, School of Public Health, Human Genetics Center, P O Box 20186, Houston, Texas 77225, USA
Arterioscler Thromb Vasc Biol 26:1828-36. 2006..To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels...
- Parental history of stroke and myocardial infarction predicts coronary artery calcification: The Coronary Artery Risk Development in Young Adults (CARDIA) studyMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Science Center Houston, Houston, TX 77030, USA
Eur J Cardiovasc Prev Rehabil 11:421-6. 2004..This study investigates the association between coronary artery calcification (CAC) and parental history of stroke and MI in African-Americans and Caucasians from the CARDIA study...
- Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health StudyMyriam Fornage
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Stroke 39:1952-9. 2008....
- Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortiumMyriam Fornage
Brown Foundation Institute of Molecular Medicine, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA
Ann Neurol 69:928-39. 2011..WMHs are associated with an increased risk of cognitive and motor dysfunction, dementia, depression, and stroke. Despite a significant heritability, few genetic loci influencing WMH burden have been identified...
- The transcribed genome and the heritable basis of essential hypertensionPeter A Doris
Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
Cardiovasc Toxicol 5:95-108. 2005..This review explores the potential to uncover hypertension genes by exploiting quantitative variation in the heritable control of gene expression...
- Cardiovascular biomarkers and subclinical brain disease in the atherosclerosis risk in communities studyRazvan T Dadu
Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Stroke 44:1803-8. 2013....
- Gene expression profiling and functional proteomic analysis reveal perturbed kinase-mediated signaling in genetic stroke susceptibilityMyriam Fornage
Houston Institute of Molecular Medicine, University of Texas, Houston, USA
Physiol Genomics 15:75-83. 2003..Altered gene and protein expression patterns in SHRSP are consistent with increased vulnerability of this strain to cerebrovascular injury...
- Single-nucleotide polymorphism genotyping for disease association studiesMyriam Fornage
The University of Texas, Institute of Molecular Medicine, Research Center for Human Genetics, Houston, USA
Methods Mol Med 108:159-72. 2005..This chapter focuses on two of them: the 5'-nuclease assay and mass spectrometry genotyping...
- Inverse effects of the PPAR(gamma)2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites. The CARDIA studyMyriam Fornage
Institute of Molecular Science, University of Texas Health Science Center at Houston, Houston TX 77030, USA
Metabolism 54:910-7. 2005..01) in African Americans but not in whites. Important roles of BMI and ethnic background in influencing the complex relationships among PPAR gamma gene variation, adiposity, and insulin resistance are suggested...
- Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle ageMyriam Fornage
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, TX, USA
Metabolism 59:1084-91. 2010..A similar trend was observed in blacks who consistently maintained a body mass index less than 25 kg/m(2) over the study period. These data support a role of INSIG2 sequence variation in the regulation of cholesterol metabolism...
- Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive ratsMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, Tex 77030, USA
Hypertension 40:485-90. 2002..These data indicate that sequence variation determining functional alterations in EPHX2 is not likely to contribute to blood pressure levels in SHR...
- Ranking analysis of microarray data: a powerful method for identifying differentially expressed genesYuan De Tan
Institute of Molecular Medicine, School of Public Health, University of Texas at Houston, Houston, TX 77030, USA
Genomics 88:846-54. 2006....
- Parent-child pair design for detecting gene-environment interactions in complex diseasesYuan De Tan
Institute of Molecular Medicine, University of Texas Houston, Houston, TX, USA
Hum Genet 121:745-57. 2007....
- Genetics of strokeMyriam Fornage
Brown Foundation Institute of Molecular Medicine, 1825 Pressler Street, Houston, TX 77030, USA
Curr Atheroscler Rep 11:167-74. 2009..This review provides an overview of the current progress and future prospects of the application of genomic sciences to stroke research...
- Genomics and epigenomics of hypertensionMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 WHolcombe Boulevard, Houston, TX 77030, USA
Curr Opin Mol Ther 8:206-14. 2006..This review provides an overview of the current progress of and future prospects for the application of genomic and epigenomic sciences to hypertension research...
- L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesionYasunori Abe
Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, 6565 Fannin, A679B, Houston, TX 77030, United States
Atherosclerosis 192:56-66. 2007....
- Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genesRanjan Dutta
Research Center for Human Genetics, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 W Holcombe Blvd, Houston, TX 77030, USA
Atherosclerosis 169:51-62. 2003..The results of the study provide new insights into the significance of calcification in atherogenesis...
- Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) studyCraig R Lee
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health Research, Triangle Park, NC 27709, USA
Hum Mol Genet 15:1640-9. 2006..315). Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene...
- A whole-genome scan for stroke or myocardial infarction in family blood pressure program familiesRichard Sherva
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
Stroke 39:1115-20. 2008..Using data from the Family Blood Pressure Program, we tested for chromosomal regions linked to the composite phenotype of stroke or myocardial infarction in a large set of hypertensive families...
- Genome-wide linkage analysis for loci affecting pulse pressure: the Family Blood Pressure ProgramSuzette J Bielinski
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
Hypertension 46:1286-93. 2005..The identification of these loci for pulse pressure and the apparent congruence with other blood pressure phenotypes provide increased support that these regions contain genes influencing blood pressure phenotypes...
- The uncoupling protein 2 Ala55Val polymorphism is associated with diabetes mellitus: the CARDIA studyXinhua Yu
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
Clin Chem 51:1451-6. 2005..Uncoupling proteins (UCPs) reduce ATP generation with concomitant increased release of heat. The activities of UCPs have been related to obesity and energy metabolism...
- Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levelsChristopher S Carlson
Department of Genome Sciences, University of Washington, Seattle, WA, USA
Am J Hum Genet 77:64-77. 2005..We also demonstrate the functional importance of these SNPs in vitro...
- Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA studyBrent C Taylor
Center for Chronic Disease Outcomes Research, VA Medical Center 152 2E, One Veterans Drive, Minneapolis, MN 55417, USA
Hum Genet 116:525-8. 2005..Given the significant role of both MGP and SPP1 in arteriosclerosis, further research in higher risk, older populations are needed to determine fully the way in which MGP and SPP1 polymorphisms are associated with disease...
- Genomic susceptibility loci for brain atrophy in hypertensive sibships from the GENOA studyStephen T Turner
Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
Hypertension 45:793-8. 2005....
- Heritability of leukoaraiosis in hypertensive sibshipsStephen T Turner
Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
Hypertension 43:483-7. 2004..671+/-0.110 (P<0.0001). This evidence of strong genetic influence on the susceptibility to leukoaraiosis justifies efforts to localize the responsible genes and characterize the predisposing genetic polymorphisms...
- D-dimer, inflammatory markers, and lower extremity functioning in patients with and without peripheral arterial diseaseMary Mcgrae McDermott
Department of Medicine, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
Circulation 107:3191-8. 2003..We determined whether higher levels of D-dimer, C-reactive protein (CRP), fibrinogen, and serum amyloid A are associated independently with functional impairment in patients with and without peripheral arterial disease (PAD)...
- Unraveling hypertension: epigenomics comes of ageMyriam Fornage
Pharmacogenomics 8:125-8. 2007
- Mapping functionsYuan De Tan
College of Life Science, Hunan Normal University, Changsha, Hunan 410081, China
Genetica 133:235-46. 2008..Therefore, they can provide much more precise estimates of map distances than the two conventional mapping functions. Furthermore, our mapping functions produced almost linear (additive) map distances...
- Ranking analysis of F-statistics for microarray dataYuan De Tan
College of Life Sciences, Hunan Normal University, Changsha, 410081, China
BMC Bioinformatics 9:142. 2008..Methods for large-scale statistical analyses have been developed but most of them are applicable to two-sample or two-condition data...
- Changes over 14 years in androgenicity and body mass index in a biracial cohort of reproductive-age womenBarbara Sternfeld
Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
J Clin Endocrinol Metab 93:2158-65. 2008..Body mass index (BMI) is directly related to testosterone (total T and free T) and inversely to SHBG cross-sectionally, but little is known about how changes in body fat and androgen markers affect each other over time...
- Family history of stroke among Mexican-American and non-Hispanic white patients with stroke and TIA: implications for the feasibility and design of stroke genetics researchLynda D Lisabeth
Stroke Program, University of Michigan Health System, Ann Arbor, MI 48109, USA
Neuroepidemiology 24:96-102. 2005..9%; 95% CI: 0.1-3.8). Since MAs are more likely to have living siblings with stroke compared with NHWs, MAs may be a more feasible population for family stroke studies than predominantly white populations...