Genomes and Genes
Affiliation: Texas Medical Center
- Genetics of coronary artery calcification among African Americans, a meta-analysisMary K Wojczynski
Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
BMC Med Genet 14:75. 2013..African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants...
- Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology studyKira C Taylor
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
BMC Genet 14:33. 2013..Here, we investigated whether GWAS-identified SNPs for lipid traits exhibited heterogeneity by sex in the Population Architecture using Genomics and Epidemiology (PAGE) study...
- Ranking analysis of F-statistics for microarray dataYuan De Tan
College of Life Sciences, Hunan Normal University, Changsha, 410081, China
BMC Bioinformatics 9:142. 2008..Methods for large-scale statistical analyses have been developed but most of them are applicable to two-sample or two-condition data...
- Genetics of strokeMyriam Fornage
Brown Foundation Institute of Molecular Medicine, 1825 Pressler Street, Houston, TX 77030, USA
Curr Atheroscler Rep 11:167-74. 2009..This review provides an overview of the current progress and future prospects of the application of genomic sciences to stroke research...
- Inverse effects of the PPAR(gamma)2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites. The CARDIA studyMyriam Fornage
Institute of Molecular Science, University of Texas Health Science Center at Houston, Houston TX 77030, USA
Metabolism 54:910-7. 2005..01) in African Americans but not in whites. Important roles of BMI and ethnic background in influencing the complex relationships among PPAR gamma gene variation, adiposity, and insulin resistance are suggested...
- Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle ageMyriam Fornage
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, TX, USA
Metabolism 59:1084-91. 2010..A similar trend was observed in blacks who consistently maintained a body mass index less than 25 kg/m(2) over the study period. These data support a role of INSIG2 sequence variation in the regulation of cholesterol metabolism...
- Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortiumMyriam Fornage
Brown Foundation Institute of Molecular Medicine, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA
Ann Neurol 69:928-39. 2011..WMHs are associated with an increased risk of cognitive and motor dysfunction, dementia, depression, and stroke. Despite a significant heritability, few genetic loci influencing WMH burden have been identified...
- Parental history of stroke and myocardial infarction predicts coronary artery calcification: The Coronary Artery Risk Development in Young Adults (CARDIA) studyMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Science Center Houston, Houston, TX 77030, USA
Eur J Cardiovasc Prev Rehabil 11:421-6. 2004..This study investigates the association between coronary artery calcification (CAC) and parental history of stroke and MI in African-Americans and Caucasians from the CARDIA study...
- Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injuryMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, Room 530 G, Houston, TX 77030, USA
Hum Genet 120:671-80. 2007..They provide the basis for further investigation of the role of these genes in susceptibility and/or progression to clinical disease...
- Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) studyMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Science Center, Houston, 2121 W Holcombe Blvd, Houston, TX 77030, USA
Circulation 109:335-9. 2004..We examined the relationship between a common, functional polymorphism of the human sEH gene and coronary artery calcification (CAC) in young, largely asymptomatic African-American and non-Hispanic white subjects...
- Gene expression profiling and functional proteomic analysis reveal perturbed kinase-mediated signaling in genetic stroke susceptibilityMyriam Fornage
Houston Institute of Molecular Medicine, University of Texas, Houston, USA
Physiol Genomics 15:75-83. 2003..Altered gene and protein expression patterns in SHRSP are consistent with increased vulnerability of this strain to cerebrovascular injury...
- Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health StudyMyriam Fornage
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Stroke 39:1952-9. 2008....
- Genomics and epigenomics of hypertensionMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 WHolcombe Boulevard, Houston, TX 77030, USA
Curr Opin Mol Ther 8:206-14. 2006..This review provides an overview of the current progress of and future prospects for the application of genomic and epigenomic sciences to hypertension research...
- Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA StudyQi Wei
Institute of Molecular Medicine, The University of Texas Health Science Center Houston, 1825 Pressler St, Houston, TX 77030, USA
J Mol Med (Berl) 84:955-65. 2006..It underscores the role of genetic and environmental contexts in shaping the patterns of associations of PPARgamma sequence variants with metabolic traits in human populations...
- Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smokingQi Wei
Institute of Molecular Medicine, University of Texas Health Science Center Houston, Houston, TX 77030, United States
Atherosclerosis 190:26-34. 2007..This detailed investigation of the association of EPHX2 genetic variation with CAC supports EPHX2's emerging role as a risk factor for atherosclerosis, whose effects are influenced by smoking...
- The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohortsJan Bressler
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
BMC Med Genet 10:56. 2009..The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants...
- The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic strokeMyriam Fornage
Institute of Molecular Medicne for the prevention of Human Diseases, University of Texas Health Science Center, Houston, TX 77030, USA
Hum Mol Genet 14:2829-37. 2005..These findings suggest that multiple variants exist within or near the EPHX2 gene, with greatly contrasting relationships to ischemic stroke incidence; some associated with a higher incidence and others with a lower incidence...
- Genome-wide identification of allelic expression in hypertensive ratsRenata I Dmitrieva
Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center, 2121 Holcombe Blvd, Houston, TX 77030, USA
Circ Cardiovasc Genet 2:106-15. 2009..Inbred animal models can facilitate genetic studies of disease traits. The spontaneously hypertensive rat (SHR) is an inbred model of hypertension that exists in several closely related but genetically distinct lines...
- Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive ratMandi J Corenblum
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, 530 G, Houston, TX 77030, USA
Hypertension 51:567-73. 2008..These data support a role for Ephx2 polymorphism on sEH gene expression and function and risk of end-organ injury in the stroke-prone SHR...
- Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genesCruz A Hinojos
Institute for Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
Hypertension 45:698-704. 2005..The present approach identifies a number of genes that may influence blood pressure in SHR by virtue of allelic effects on gene expression...
- Hepatocyte nuclear factor 1 and hypertensive nephropathyRenata I Dmitrieva
Institute of Molecular Medicine, University of Texas HSC at Houston, TX 77030, USA
Hypertension 51:1583-9. 2008..The present experiments uncover a major change in transcriptional control by HNF1 that affects redox and other genes and precedes emergence of hypertensive renal injury...
- Best practices and joint calling of the HumanExome BeadChip: the CHARGE ConsortiumMegan L Grove
School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, USA
PLoS ONE 8:e68095. 2013..The cluster file from this experiment is available at www.chargeconsortium.com/main/exomechip. ..
- Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities StudyJan Bressler
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, USA
Neurology 80:92-9. 2013....
- The uncoupling protein 2 Ala55Val polymorphism is associated with diabetes mellitus: the CARDIA studyXinhua Yu
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
Clin Chem 51:1451-6. 2005..Uncoupling proteins (UCPs) reduce ATP generation with concomitant increased release of heat. The activities of UCPs have been related to obesity and energy metabolism...
- Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participantsKathy L E Klos
University of Texas Health Science Center at Houston, School of Public Health, Human Genetics Center, P O Box 20186, Houston, Texas 77225, USA
Arterioscler Thromb Vasc Biol 26:1828-36. 2006..To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels...
- Ala54Thr polymorphism of the fatty acid binding protein 2 gene and saturated fat intake in relation to lipid levels and insulin resistance: the Coronary Artery Risk Development in Young Adults (CARDIA) studyAlanna M Chamberlain
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
Metabolism 58:1222-8. 2009..Lipid levels and log(HOMA-IR) did not vary by genotype with saturated fat intake less than 53.2 g/d. Limiting dietary saturated fat intake may be particularly important among carriers of the A allele of FABP2...
- Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive ratsMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, Tex 77030, USA
Hypertension 40:485-90. 2002..These data indicate that sequence variation determining functional alterations in EPHX2 is not likely to contribute to blood pressure levels in SHR...
- The transcribed genome and the heritable basis of essential hypertensionPeter A Doris
Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
Cardiovasc Toxicol 5:95-108. 2005..This review explores the potential to uncover hypertension genes by exploiting quantitative variation in the heritable control of gene expression...
- Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated lociEllen W Demerath
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
Hum Mol Genet 24:4464-79. 2015..Adiposity traits are associated with DNA methylation at numerous CpG sites that replicate across studies despite variation in tissue type, ethnicity and analytic approaches. ..
- Cardiovascular biomarkers and subclinical brain disease in the atherosclerosis risk in communities studyRazvan T Dadu
Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Stroke 44:1803-8. 2013....
- Single-nucleotide polymorphism genotyping for disease association studiesMyriam Fornage
The University of Texas, Institute of Molecular Medicine, Research Center for Human Genetics, Houston, USA
Methods Mol Med 108:159-72. 2005..This chapter focuses on two of them: the 5'-nuclease assay and mass spectrometry genotyping...
- Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) StudyMaitreyee Bose
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
BMC Bioinformatics 15:312. 2014..Over 480,000 cytosine-guanine (CpG) dinucleotide sites were surveyed on the HM450 BeadChip. To evaluate the impact of technical variation, 265 technical replicates from 130 participants were included in the study...
- L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesionYasunori Abe
Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, 6565 Fannin, A679B, Houston, TX 77030, United States
Atherosclerosis 192:56-66. 2007....
- Characterization of a human 12/15-lipoxygenase promoter variant associated with atherosclerosis identifies vimentin as a promoter binding proteinSusmita Samanta
Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
PLoS ONE 7:e42417. 2012..Sequence variation in the human 12/15 lipoxygenase (ALOX15) has been associated with atherosclerotic disease. We functionally characterized an ALOX15 promoter polymorphism, rs2255888, previously associated with carotid plaque burden...
- Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA StudyJennifer A Smith
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
BMC Med Genomics 2:16. 2009....
- Parent-child pair design for detecting gene-environment interactions in complex diseasesYuan De Tan
Institute of Molecular Medicine, University of Texas Houston, Houston, TX, USA
Hum Genet 121:745-57. 2007....
- Ranking analysis of microarray data: a powerful method for identifying differentially expressed genesYuan De Tan
Institute of Molecular Medicine, School of Public Health, University of Texas at Houston, Houston, TX 77030, USA
Genomics 88:846-54. 2006....
- Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumferenceStella Aslibekyan
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 23:1493-501. 2015..To conduct an epigenome-wide analysis of DNA methylation and obesity traits...
- Genome-wide Meta-analysis on the Sense of Smell Among US Older AdultsJing Dong
From the Epidemiology Branch JD, ZX, SL, HC and Biostatistics Branch LN, National Institute of Environmental Health Sciences, Research Triangle Park, NC Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL JY, RSW, ly, DAB California Pacific Medical Center Research Institute, San Francisco, CA GT, NP, SC Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC NF Department of Human Genetics, University of Chicago, Chicago, IL GA A Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN AA Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX MF Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA XH Sticht Center on Aging SK and Division of Public Health Sciences YL, Wake Forest School of Medicine, Winston Salem, NC Program in Translational Neuro Psychiatric Genomics, Departments of Neurology and Psychiatry, Institute for the Neurosciences, Brigham and Women s Hospital Harvard Medical School Program in Medical and Population Genetics, Broad Institute, Boston, Hamburg
Medicine (Baltimore) 94:e1892. 2015....
- Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genesRanjan Dutta
Research Center for Human Genetics, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 W Holcombe Blvd, Houston, TX 77030, USA
Atherosclerosis 169:51-62. 2003..The results of the study provide new insights into the significance of calcification in atherogenesis...
- D-dimer, inflammatory markers, and lower extremity functioning in patients with and without peripheral arterial diseaseMary Mcgrae McDermott
Department of Medicine, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
Circulation 107:3191-8. 2003..We determined whether higher levels of D-dimer, C-reactive protein (CRP), fibrinogen, and serum amyloid A are associated independently with functional impairment in patients with and without peripheral arterial disease (PAD)...
- Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levelsChristopher S Carlson
Department of Genome Sciences, University of Washington, Seattle, WA, USA
Am J Hum Genet 77:64-77. 2005..We also demonstrate the functional importance of these SNPs in vitro...
- Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) studyCraig R Lee
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health Research, Triangle Park, NC 27709, USA
Hum Mol Genet 15:1640-9. 2006..315). Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene...
- Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA studyBrent C Taylor
Center for Chronic Disease Outcomes Research, VA Medical Center 152 2E, One Veterans Drive, Minneapolis, MN 55417, USA
Hum Genet 116:525-8. 2005..Given the significant role of both MGP and SPP1 in arteriosclerosis, further research in higher risk, older populations are needed to determine fully the way in which MGP and SPP1 polymorphisms are associated with disease...
- Genomic susceptibility loci for brain atrophy in hypertensive sibships from the GENOA studyStephen T Turner
Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
Hypertension 45:793-8. 2005....
- A whole-genome scan for stroke or myocardial infarction in family blood pressure program familiesRichard Sherva
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
Stroke 39:1115-20. 2008..Using data from the Family Blood Pressure Program, we tested for chromosomal regions linked to the composite phenotype of stroke or myocardial infarction in a large set of hypertensive families...
- Heritability of leukoaraiosis in hypertensive sibshipsStephen T Turner
Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
Hypertension 43:483-7. 2004..671+/-0.110 (P<0.0001). This evidence of strong genetic influence on the susceptibility to leukoaraiosis justifies efforts to localize the responsible genes and characterize the predisposing genetic polymorphisms...
- Genome-wide linkage analysis for loci affecting pulse pressure: the Family Blood Pressure ProgramSuzette J Bielinski
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
Hypertension 46:1286-93. 2005..The identification of these loci for pulse pressure and the apparent congruence with other blood pressure phenotypes provide increased support that these regions contain genes influencing blood pressure phenotypes...
- Unraveling hypertension: epigenomics comes of ageMyriam Fornage
Pharmacogenomics 8:125-8. 2007
- Family history of stroke among Mexican-American and non-Hispanic white patients with stroke and TIA: implications for the feasibility and design of stroke genetics researchLynda D Lisabeth
Stroke Program, University of Michigan Health System, Ann Arbor, MI 48109, USA
Neuroepidemiology 24:96-102. 2005..9%; 95% CI: 0.1-3.8). Since MAs are more likely to have living siblings with stroke compared with NHWs, MAs may be a more feasible population for family stroke studies than predominantly white populations...
- Changes over 14 years in androgenicity and body mass index in a biracial cohort of reproductive-age womenBarbara Sternfeld
Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
J Clin Endocrinol Metab 93:2158-65. 2008..Body mass index (BMI) is directly related to testosterone (total T and free T) and inversely to SHBG cross-sectionally, but little is known about how changes in body fat and androgen markers affect each other over time...
- Mapping functionsYuan De Tan
College of Life Science, Hunan Normal University, Changsha, Hunan 410081, China
Genetica 133:235-46. 2008..Therefore, they can provide much more precise estimates of map distances than the two conventional mapping functions. Furthermore, our mapping functions produced almost linear (additive) map distances...
- FUNCTIONAL GENOMICS OF ARTERIAL THROMBOSISMyriam Fornage; Fiscal Year: 2004..This collaborative effort is novel for its ability to translate unique animal model research findings to the human condition. ..
- Gene-Environment Interactions and Stroke SusceptibilityMyriam Fornage; Fiscal Year: 2004..We will also identify and characterize DNA variation in a panel of selected stroke-candidate human genes and test whether variation in these genes is associated with risk of developing a stroke in the ARIC sample. ..
- Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical AtherosclerosisMyriam Fornage; Fiscal Year: 2010....
- A Genome-Wide Association Study of Ischemic Brain Vascular InjuryMyriam Fornage; Fiscal Year: 2010....