Mauro Ferrari

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Frontiers in cancer nanomedicine: directing mass transport through biological barriers
    Mauro Ferrari
    University of Texas Health Science Center at Houston UTHSC H, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Trends Biotechnol 28:181-8. 2010
  2. doi request reprint The mathematical engines of nanomedicine
    Mauro Ferrari
    The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, 1825 Pressler, Suite 537D, Houston, TX 77031, USA
    Small 4:20-5. 2008
  3. ncbi request reprint Nanoncology
    Mauro Ferrari
    MD Anderson Cancer Center, Houston TX, USA
    Tumori 94:197-9. 2008
  4. pmc Mitotic trafficking of silicon microparticles
    Rita E Serda
    University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Nanoscale 1:250-9. 2009
  5. pmc Shrinkage of pegylated and non-pegylated liposomes in serum
    Joy Wolfram
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA Electronic address
    Colloids Surf B Biointerfaces 114:294-300. 2014
  6. pmc Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells
    Mingzhen Zhang
    Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA College of Life Information Science and Instrumental Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang 310018, China
    Biomaterials 35:423-31. 2014
  7. doi request reprint Multistage delivery of chemotherapeutic nanoparticles for breast cancer treatment
    Elvin Blanco
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, United States
    Cancer Lett 334:245-52. 2013
  8. pmc Tailoring of the nanotexture of mesoporous silica films and their functionalized derivatives for selectively harvesting low molecular weight protein
    Ye Hu
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, Texas 77030, USA
    ACS Nano 4:439-51. 2010
  9. pmc Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biomed Mater Res A 94:1236-43. 2010
  10. doi request reprint Nanochannel technology for constant delivery of chemotherapeutics: beyond metronomic administration
    Alessandro Grattoni
    Department of NanoMedicine and Biomedical Engineering nBME, The University of Texas Medical School at Houston, Houston, Texas, USA
    Pharm Res 28:292-300. 2011

Research Grants

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. pmc Frontiers in cancer nanomedicine: directing mass transport through biological barriers
    Mauro Ferrari
    University of Texas Health Science Center at Houston UTHSC H, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Trends Biotechnol 28:181-8. 2010
    ....
  2. doi request reprint The mathematical engines of nanomedicine
    Mauro Ferrari
    The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, 1825 Pressler, Suite 537D, Houston, TX 77031, USA
    Small 4:20-5. 2008
  3. ncbi request reprint Nanoncology
    Mauro Ferrari
    MD Anderson Cancer Center, Houston TX, USA
    Tumori 94:197-9. 2008
  4. pmc Mitotic trafficking of silicon microparticles
    Rita E Serda
    University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Nanoscale 1:250-9. 2009
    ..The finding that mitotic sorting of endosomes is unencumbered by the presence of nanoporous silicon microparticles advocates the use of silicon microparticles for biomedical applications...
  5. pmc Shrinkage of pegylated and non-pegylated liposomes in serum
    Joy Wolfram
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA Electronic address
    Colloids Surf B Biointerfaces 114:294-300. 2014
    ..The liposomes with polyethylene glycol expressed different characteristics than their non-polymeric counterparts, suggesting the potential formation of a denser protein corona around the non-pegylated liposomes. ..
  6. pmc Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells
    Mingzhen Zhang
    Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA College of Life Information Science and Instrumental Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang 310018, China
    Biomaterials 35:423-31. 2014
    ..As a consequence, PEI-modified porous silicon particles may have substantial potential as safe and effective siRNA delivery systems...
  7. doi request reprint Multistage delivery of chemotherapeutic nanoparticles for breast cancer treatment
    Elvin Blanco
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, United States
    Cancer Lett 334:245-52. 2013
    ..Results highlight effective chemotherapeutic shuttling and site-specific controlled release afforded by MSVs, potentially translating towards improvements in patient outcomes and morbidity...
  8. pmc Tailoring of the nanotexture of mesoporous silica films and their functionalized derivatives for selectively harvesting low molecular weight protein
    Ye Hu
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, Texas 77030, USA
    ACS Nano 4:439-51. 2010
    ....
  9. pmc Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biomed Mater Res A 94:1236-43. 2010
    ....
  10. doi request reprint Nanochannel technology for constant delivery of chemotherapeutics: beyond metronomic administration
    Alessandro Grattoni
    Department of NanoMedicine and Biomedical Engineering nBME, The University of Texas Medical School at Houston, Houston, Texas, USA
    Pharm Res 28:292-300. 2011
    ....
  11. pmc Engineering multi-stage nanovectors for controlled degradation and tunable release kinetics
    Jonathan O Martinez
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Biomaterials 34:8469-77. 2013
    ..Empirical loading and release studies of nanoparticles along with diffusion modeling revealed that this prolonged release was modulated by the penetration within the porous core of the vectors regulated by their pore size. ..
  12. pmc Thioaptamer conjugated liposomes for tumor vasculature targeting
    Aman P Mann
    Department of Nanomedicine, University of Texas Health Science Center at Houston, 1825 Hermann Pressler, Houston, Texas 77030, USA
    Oncotarget 2:298-304. 2011
    ....
  13. pmc Near-infrared imaging method for the in vivo assessment of the biodistribution of nanoporous silicon particles
    Ennio Tasciotti
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mol Imaging 10:56-68. 2011
    ....
  14. doi request reprint Characterization of a nanogland for the autotransplantation of human pancreatic islets
    Omaima M Sabek
    Department of Surgery, The Methodist Hospital, 6565 Fannin Street, Houston, TX 77030, USA
    Lab Chip 13:3675-88. 2013
    ..In this context, mouse endothelial cell infiltration suggesting neovascularization from the host were identified in the retrieved grafts. The NanoGland represents a novel, promising approach for the autotransplantation of human islets. ..
  15. ncbi request reprint Validated RP-HPLC method for the simultaneous analysis of gemcitabine and LY-364947 in liposomal formulations
    Shyam S Bansal
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Curr Drug Targets 14:1061-9. 2013
    ..The method specificity was evaluated in presence of liposomal components in fetal bovine serum (FBS). Finally, the method was demonstrated by quantifying Gem/LY liposomal encapsulation efficiency and concentration liposomes-spiked FBS. ..
  16. pmc Short and long term, in vitro and in vivo correlations of cellular and tissue responses to mesoporous silicon nanovectors
    Jonathan O Martinez
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave MS R7 414 Houston, TX 77030, USA
    Small 9:1722-33. 2013
    ..It is proposed that future endeavors aimed at understanding the toxicology of naked drug carriers should be designed to address their impact using in vitro and in vivo short- and long-term evaluations of systemic response...
  17. pmc Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery
    Haifa Shen
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Clin Cancer Res 19:1806-15. 2013
    ....
  18. pmc Multistage vectored siRNA targeting ataxia-telangiectasia mutated for breast cancer therapy
    Rong Xu
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, Texas 77030, USA
    Small 9:1799-808. 2013
    ..These results indicate that MSV/ATM is biocompatible and efficacious in inhibiting tumor growth, and that further preclinical evaluation is warranted for the development of MSV/ATM as a potential therapeutic agent...
  19. pmc Silicon micro- and nanofabrication for medicine
    Daniel Fine
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Adv Healthc Mater 2:632-66. 2013
    ....
  20. ncbi request reprint Nanotechnologies and regenerative medical approaches for space and terrestrial medicine
    Alessandro Grattoni
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Aviat Space Environ Med 83:1025-36. 2012
    ..These studies target significant areas of human disease such as osteoporosis, diabetes, radiation injury, and many others...
  21. pmc Live-cell single-molecule imaging reveals clathrin and caveolin-1 dependent docking of SMAD4 at the cell membrane
    Yong Yang
    Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA Electronic address
    FEBS Lett 587:3912-20. 2013
    ..The notion that membrane-docking behaviors of downstream molecules could predict the cellular response to growth factors may revolutionize the way we view cell signaling...
  22. pmc Porous silicon nanocarriers for dual targeting tumor associated endothelial cells and macrophages in stroma of orthotopic human pancreatic cancers
    Kenji Yokoi
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner St, Houston, TX 77030, USA
    Cancer Lett 334:319-27. 2013
    ..5±1.8% with non-targeted nanocarriers. These results suggest that Ly6C (or CD59) can serve as a novel dual target to deliver therapeutic agents to the stroma of pancreatic tumors...
  23. pmc Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells
    Yong Yang
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX, USA
    Cell Biochem Funct 31:374-9. 2013
    ..Hesperetin also decreased cellular proliferation, which is likely due to the inhibition of glucose uptake. Cancer cells are highly dependent on glucose and hesperetin may, therefore, have potential application as an anticancer agent...
  24. pmc Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution
    Anne L van de Ven
    Department of Translational Imaging and Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    J Control Release 158:148-55. 2012
    ..Plateloid particles appeared well-suited for taking advantage of hydrodynamic forces and interfacial interactions required for efficient tumoritropic accumulation, even without using specific targeting ligands...
  25. pmc Enabling individualized therapy through nanotechnology
    Jason H Sakamoto
    The University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, Houston, TX 77030, USA
    Pharmacol Res 62:57-89. 2010
    ....
  26. ncbi request reprint Drug delivery: Logic-Embedded Vectors for Intracellular Partitioning, Endosomal Escape, and Exocytosis of Nanoparticles (Small 23/2010)
    Rita E Serda
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center, 1825 Pressler Street, Suite 537, Houston, TX 77030, USA
    Small 6:2690. 2010
    ..Thus, LEVs provide a mechanism for shielded transport of nanoparticles to the lesion, cellular manipulation at multiple levels, and a means for targeting both within and between cells...
  27. doi request reprint Device for rapid and agile measurement of diffusivity in micro- and nanochannels
    Alessandro Grattoni
    The University of Texas Health Science Center at Houston, 1825 Pressler Street Suite 537A, Houston, Texas, 77030, USA
    Anal Chem 83:3096-103. 2011
    ..Our design thus is ready for rapid translation into a standard analytical tool--useful for multiple applications...
  28. pmc An integrated approach for the rational design of nanovectors for biomedical imaging and therapy
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, Texas, USA
    Adv Genet 69:31-64. 2010
    ....
  29. ncbi request reprint Hesperetin Liposomes for Cancer Therapy
    Joy Wolfram
    Department of Nanomedicine, Houston Methodist Research Institute, R8460 9, 6670 Bertner Ave, Houston, TX 77030, USA
    Curr Drug Deliv 13:711-9. 2016
    ....
  30. doi request reprint Characterization of nanochannel delivery membrane systems for the sustained release of resveratrol and atorvastatin: new perspectives on promoting heart health
    Juliana Sih
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Anal Bioanal Chem 405:1547-57. 2013
    ....
  31. pmc Preparation, characterization, and cellular associations of silicon logic-embedded vectors
    Anne L van de Ven
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, Texas, USA
    Methods Enzymol 508:1-16. 2012
    ..A specific example of LEV fabrication from start to finish, along with optimization and troubleshooting information, is presented to serve as a template for future designs...
  32. doi request reprint Molecular-targeted nanotherapies in cancer: enabling treatment specificity
    Elvin Blanco
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mol Oncol 5:492-503. 2011
    ..We will also summarize work regarding the development of a multistage drug delivery strategy, a robust carrier platform designed to overcome several biological barriers while en route to tumors...
  33. pmc Multistage nanovectors: from concept to novel imaging contrast agents and therapeutics
    Biana Godin
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Acc Chem Res 44:979-89. 2011
    ..We envision that the versatility of the MSV platform and its emerging properties will enable the creation of personalized solutions with broad clinical implications within and beyond the realm of cancer theranostics...
  34. pmc Cellular association and assembly of a multistage delivery system
    Rita E Serda
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center UTHSC, Houston, TX 77030, USA
    Small 6:1329-40. 2010
    ..This study demonstrates the assembly and cellular association of a multiparticle delivery system that is biomolecularly targeted and has potential for applications in biological imaging...
  35. doi request reprint Agarose surface coating influences intracellular accumulation and enhances payload stability of a nano-delivery system
    Enrica De Rosa
    The Methodist Hospital Research Institute TMHRI, 6670 Bertner Av Suite R7 114, Houston, Texas 77030, USA
    Pharm Res 28:1520-30. 2011
    ..We describe a surface modification of nanoporous silicon particles (NSP) with an agarose hydrogel matrix that enhances their ability to load and release proteins, influencing intracellular delivery and preserving molecular stability...
  36. pmc Intracellular trafficking of silicon particles and logic-embedded vectors
    Silvia Ferrati
    University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler Street, Suite 537, Houston, TX 77030, USA
    Nanoscale 2:1512-20. 2010
    ..These results reinforce the concept of multi-functional nanocarriers, in which different particles are able to perform specific tasks, in order to deliver single- or multi-component payloads to specific sub-cellular compartments...
  37. doi request reprint Nanomedicine in cancer therapy: innovative trends and prospects
    Elvin Blanco
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, Texas, USA
    Cancer Sci 102:1247-52. 2011
    ....
  38. pmc Multi-stage delivery nano-particle systems for therapeutic applications
    Rita E Serda
    University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Biochim Biophys Acta 1810:317-29. 2011
    ..The progressive evolution of nanovectors has led to the development of multi-stage delivery systems aimed at overcoming the numerous obstacles encountered by nanovectors on their journey to the target site...
  39. pmc Surface engineering on mesoporous silica chips for enriching low molecular weight phosphorylated proteins
    Ye Hu
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, Houston, TX, USA
    Nanoscale 3:421-8. 2011
    ..The novel technology reported provides a platform capable of efficiently profiling the serum proteome for biomarker discovery, forensic sampling, and routine diagnostic applications...
  40. pmc A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
    Bronwyn Scott
    Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA
    Pharmacol Res 111:413-21. 2016
    ..The results demonstrate that the enzyme therapy decreases cancer cell viability through production of acetaldehyde and reduction of lactic acid fermentation. ..
  41. pmc Multi-composite bioactive osteogenic sponges featuring mesenchymal stem cells, platelet-rich plasma, nanoporous silicon enclosures, and Peptide amphiphiles for rapid bone regeneration
    Matthew B Murphy
    Department of Nanomedicine and BioMedical Engineering, The Methodist Hospital Research Institute, Houston, TX 77053, USA
    J Funct Biomater 2:39-66. 2011
    ..This study indicates that CB MSC should be considered as an alternative to marrow as a source of stem cells, while the PRP-PA cell and microparticle delivery system may be utilized for diverse tissue engineering applications. ..
  42. pmc Porous silicon advances in drug delivery and immunotherapy
    David J Savage
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA MD Anderson Cancer Center, Department of Surgical Oncology, 1515 Holcombe Blvd 444, Houston, TX, USA The University of Texas Medical School at Houston, 6431 Fannin, Houston, TX, USA
    Curr Opin Pharmacol 13:834-41. 2013
    ....
  43. pmc Serum biomarkers for personalization of nanotherapeutics-based therapy in different tumor and organ microenvironments
    Kenji Yokoi
    Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Street, Houston, TX 77030, USA Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA Electronic address
    Cancer Lett 345:48-55. 2014
    ....
  44. pmc Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay
    Jia Fan
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Cancer Lett 334:202-10. 2013
    ..We strongly believe our findings can assist to discover stage-specific peptide signatures and lead to more specific and personalized treatments for patients suffering from pulmonary metastatic melanoma...
  45. pmc Enhanced MRI relaxivity of Gd(3+) -based contrast agents geometrically confined within porous nanoconstructs
    Richa Sethi
    Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, Center for Biological and Environmental Nanotechnology, Rice University, Houston, TX 77251 1892, USA
    Contrast Media Mol Imaging 7:501-8. 2012
    ....
  46. pmc The physiology of cardiovascular disease and innovative liposomal platforms for therapy
    Guillermo U Ruiz-Esparza
    Methodist Hospital Research Institute, Houston, TX, USA
    Int J Nanomedicine 8:629-40. 2013
    ..Potential pathological targets for therapy are introduced, and promising advances in nanotherapeutic cardiovascular applications involving liposomal platforms are presented...
  47. pmc Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions
    Alessandro Parodi
    Department of Nanomedicine, The Methodist Hospital System Research Institute, Houston, Texas 77030, USA
    Nat Nanotechnol 8:61-8. 2013
    ..Moreover, leukolike vectors retained their functions when injected in vivo, showing enhanced circulation time and improved accumulation in a tumour...
  48. doi request reprint Mesoporous silicon: short and long term, in vitro and in vivo correlations of cellular and tissue responses to mesoporous silicon nanovectors (small 9-10/2013)
    Jonathan O Martinez
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave MS R7 414 Houston, TX 77030, USA Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX USA
    Small 9:1721. 2013
    ..Alternative methods are proposed on page 1722 to effectively study the influences of nanovectors on biological systems...
  49. doi request reprint A low-voltage electrokinetic nanochannel drug delivery system
    Daniel Fine
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Lab Chip 11:2526-34. 2011
    ..The membrane's clinically relevant electrophoretic release rate at 2 VDC exceeds the passive release by nearly one order of magnitude, demonstrating the potential to realize the therapeutic paradigm goal...
  50. pmc Logic-embedded vectors for intracellular partitioning, endosomal escape, and exocytosis of nanoparticles
    Rita E Serda
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center, 1825 Pressler Street, Suite 537, Houston, TX 77030, USA
    Small 6:2691-700. 2010
    ..Thus, LEVs provide a mechanism for shielded transport of nanoparticles to the lesion, cellular manipulation at multiple levels, and a means for targeting both within and between cells...
  51. pmc A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis
    Yu Mi
    Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA
    Adv Healthc Mater 5:936-46. 2016
    ..The results indicate that the MNC can be used as an effective delivery vehicle for simultaneous enrichment of multiple therapeutic agents in the lungs. ..
  52. pmc An injectable nanoparticle generator enhances delivery of cancer therapeutics
    Rong Xu
    Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas, USA
    Nat Biotechnol 34:414-8. 2016
    ..Compared to its individual components or current therapeutic formulations, iNPG-pDox shows enhanced efficacy in MDA-MB-231 and 4T1 mouse models of metastatic breast cancer, including functional cures in 40-50% of treated mice. ..
  53. pmc Enzyme-responsive multistage vector for drug delivery to tumor tissue
    Yu Mi
    Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Pharmacol Res 113:92-99. 2016
    ....
  54. pmc Mild hyperthermia enhances transport of liposomal gemcitabine and improves in vivo therapeutic response
    Dickson K Kirui
    Department of Nanomedicine, Houston Methodist Research Institute, 6670, Bertner Avenue, Houston, TX, 77030, USA
    Adv Healthc Mater 4:1092-103. 2015
    ..In conclusion, improvements in vivo efficacy are demonstrated resulting from MHT treatment that overcome transport barriers, promote delivery, improve efficacy of nanomedicines. ..
  55. pmc Cell source determines the immunological impact of biomimetic nanoparticles
    Michael Evangelopoulos
    Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA
    Biomaterials 82:168-77. 2016
    ..As biomimicry continues to develop, this work demonstrates the necessity to consider the source of biological material in the development of future drug delivery carriers. ..
  56. pmc Evaluation of cell function upon nanovector internalization
    Jonathan O Martinez
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave MS R7 414 Houston, TX 77030, USA
    Small 9:1696-702. 2013
    ..Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function...
  57. doi request reprint Inter-endothelial transport of microvectors using cellular shuttles and tunneling nanotubes
    Silvia Ferrati
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Small 8:3151-60. 2012
    ..The opportunity to use microparticles to study cellular transfer events and biological triggers that induce these events may aid in the discovery of therapeutics that limit the spread of disease...
  58. pmc Cooperative, nanoparticle-enabled thermal therapy of breast cancer
    Haifa Shen
    The Methodist Hospital Research Institute, Department of Nanomedicine, 6670 Bertner Ave, Houston, Texas 77030, USA
    Adv Healthc Mater 1:84-9. 2012
    ..Collective electromagnetic coupling of nanoconfined hollow gold nanoshells leads to dramatic enhancement of thermal ablation...
  59. pmc Probing the mechanical properties of TNF-α stimulated endothelial cell with atomic force microscopy
    Sei Young Lee
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Medical School at Houston, Houston, TX, USA
    Int J Nanomedicine 6:179-95. 2011
    ....
  60. pmc Proteomic analysis of serum opsonins impacting biodistribution and cellular association of porous silicon microparticles
    Rita E Serda
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center, Houston, TX 77030, USA
    Mol Imaging 10:43-55. 2011
    ..In summary, particle surface chemistry drives selective binding of serum components impacting cellular interactions and biodistribution...
  61. pmc Mass partitioning effects in diffusion transport
    Milos Kojic
    Houston Methodist Research Institute, 6670 Bertner Ave, R7 116, Houston, TX 77030, USA
    Phys Chem Chem Phys 17:20630-5. 2015
    ....
  62. pmc Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane
    Giacomo Bruno
    Nanomedicine Department, Houston Methodist Research Institute HMRI, Houston, TX, USA
    Nanoscale 7:5240-8. 2015
    ....
  63. pmc Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier
    Kenji Yokoi
    The Houston Methodist Research Institute, Houston, TX 77030, United States
    J Control Release 217:293-9. 2015
    ..These results show that drug transport and partitioning characteristics can be phenotype- and microenvironment-dependent and are highly important in drug delivery and therapeutic efficacy. ..
  64. pmc Multistage Nanovectors Enhance the Delivery of Free and Encapsulated Drugs
    Jonathan O Martinez
    Houston Methodist Research Institute, 6670 Bertner Avenue MS R7 414, Houston, TX 77030 2602, USA
    Curr Drug Targets 16:1582-90. 2015
    ..Taken together, these results demonstrate increased loading of a payload in oxidized, large pore MSV, and effective delivery of free and nano-encapsulated drugs to endothelial and cancer cells. ..
  65. pmc A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics
    Guillermo U Ruiz-Esparza
    Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Street, MS R7 360 5, Houston, TX 77030, USA
    Eur J Heart Fail 18:169-78. 2016
    ....
  66. doi request reprint Delivering enhanced testosterone replacement therapy through nanochannels
    Silvia Ferrati
    The Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX, 77030, USA
    Adv Healthc Mater 4:446-51. 2015
    ..In conclusion, it is demonstrated that by providing long-term steady release 1:2 TES:HPCD nanochannel implants may represent a major breakthrough for the treatment of male hypogonadism. ..
  67. pmc Degradation and biocompatibility of multistage nanovectors in physiological systems
    Jonathan O Martinez
    Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, Texas, 77030 Graduate School of Biomedical Sciences, University of Texas Health Science Center, 6767 Bertner Ave, Houston, Texas, 77030
    J Biomed Mater Res A 102:3540-9. 2014
    ..In this study, we propose methods that lay the foundation for future investigations toward understanding the impact of the degradation of drug delivery platforms...
  68. pmc The nano-plasma interface: Implications of the protein corona
    Joy Wolfram
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA
    Colloids Surf B Biointerfaces 124:17-24. 2014
    ..Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions. ..
  69. pmc The effect of multistage nanovector targeting of VEGFR2 positive tumor endothelia on cell adhesion and local payload accumulation
    Jonathan O Martinez
    Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA Graduate School of Biomedical Sciences, University of Texas Health Science Center, 6767 Bertner Ave, Houston, TX 77030, USA
    Biomaterials 35:9824-32. 2014
    ..Surface functionalization with an anti-VEGFR2 antibody provided enhanced affinity towards the tumor vascular endothelium, which promoted enhanced adhesion and tumoritropic accumulation of a reporter molecule released by the MSV. ..
  70. pmc Antibody-free detection of Mycobacterium tuberculosis antigen using customized nanotraps
    Hung Jen Wu
    Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Avenue R8 213, Houston, TX 77030, United States
    Anal Chem 86:1988-96. 2014
    ..This assay can reach a detection limit of 10 fmol and an isolation rate of 90% for the antigen CFP-10. Our strategy has significant potential to fill the conceptual and technical gaps in rapid diagnosis of active TB disease. ..
  71. pmc In silico vascular modeling for personalized nanoparticle delivery
    Shaolie S Hossain
    Department of Translational Imaging, The Methodist Hospital Research Institute, 6670 Bertner Avenue, Room R8 218, Houston, TX 77030, USA
    Nanomedicine (Lond) 8:343-57. 2013
    ..To predict the deposition of nanoparticles in a patient-specific arterial tree as a function of the vascular architecture, flow conditions, receptor surface density and nanoparticle properties...
  72. pmc Monitoring the progression of metastatic breast cancer on nanoporous silica chips
    Jia Fan
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Philos Trans A Math Phys Eng Sci 370:2433-47. 2012
    ..The approach and results reported in this study possess a significant potential for the discovery of proteomic biomarkers that may significantly enhance personalized medicine targeted at metastatic breast cancer...
  73. pmc Mesoporous silica chips for selective enrichment and stabilization of low molecular weight proteome
    Ali Bouamrani
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Proteomics 10:496-505. 2010
    ..The introduction of this mesoporous material with fine controlled properties will provide a powerful platform for proteomics application offering a rapid and efficient methodology for low molecular weight biomarker discovery...
  74. doi request reprint Shaping the micromechanical behavior of multi-phase composites for bone tissue engineering
    Shivakumar I Ranganathan
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, TX, USA
    Acta Biomater 6:3448-56. 2010
    ....
  75. doi request reprint A robust nanofluidic membrane with tunable zero-order release for implantable dose specific drug delivery
    Daniel Fine
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Lab Chip 10:3074-83. 2010
    ..Finally, an optimal ratio of the molecular hydrodynamic diameter to the nanochannel dimension is determined to assure zero-order release for each tested molecule...
  76. doi request reprint Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows
    Sei Young Lee
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center at Houston, Houston, TX, USA
    Nanotechnology 20:495101. 2009
    ....
  77. pmc Polyarginine induces an antitumor immune response through binding to toll-like receptor 4
    Yong Yang
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA
    Small 10:1250-4. 2014
    ..Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy. ..
  78. pmc Hesperetin: an inhibitor of the transforming growth factor-β (TGF-β) signaling pathway
    Yong Yang
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Eur J Med Chem 58:390-5. 2012
    ..In addition we demonstrated that this compound hinders TGF-β1-induced cancer cell migration and invasion. These results suggest a potential future application for hesperetin as a TGF-β inhibitor in cancer therapy...
  79. pmc The preferential targeting of the diseased microvasculature by disk-like particles
    Giulia Adriani
    Department of Mechanical and Management Engineering, Politecnico di Bari, Bari, Italy
    Biomaterials 33:5504-13. 2012
    ..In view of the growing evidence on vascular molecular heterogeneity, the present data suggests that thin disk-like particles could more effectively target the diseased microvasculature as compared to spheres and slender rods...
  80. doi request reprint Intravascular delivery of particulate systems: does geometry really matter?
    Paolo Decuzzi
    School of Health Information Sciences, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Pharm Res 26:235-43. 2009
    ..The integration of mathematical modeling with in-vitro and in-vivo testing provides the tools for establishing a rational design of nanoparticles...
  81. doi request reprint Modulating cellular adhesion through nanotopography
    Paolo Decuzzi
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center Houston, Houston, TX, USA
    Biomaterials 31:173-9. 2010
    ..The model proposed supports the notion for rationally designing substrates where topography and physico-chemical properties are tailored to favour cellular proliferation whilst repelling bacterial adhesion...
  82. ncbi request reprint Molecular modeling of glucose diffusivity in silica nanochannels
    Arturas Ziemys
    School of Health Information Sciences, The University of Texas Health Science Center at Houston, 7000 Fannin, Suite 600, Houston, Texas 77030, USA
    J Nanosci Nanotechnol 9:6349-59. 2009
    ..It is also observed that the dynamics on the interface is characterized by adsorption-desorption processes. These results clearly suggest that glucose transport is affected by the interface in 10 nm nano-confinement...
  83. pmc Sustained small interfering RNA delivery by mesoporous silicon particles
    Takemi Tanaka
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center at Houston, Texas, USA
    Cancer Res 70:3687-96. 2010
    ..In summary, we have provided the first in vivo therapeutic validation of a novel, multistage siRNA delivery system for sustained gene silencing with broad applicability to pathologies beyond ovarian neoplasms...
  84. pmc Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Trends Pharmacol Sci 31:199-205. 2010
    ..Specifically, we discuss the use of nanoparticles for molecular imaging and advanced therapeutics, specially designed drug eluting stents and in vivo/ex vivo early detection techniques...
  85. pmc Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast
    Jeyarama S Ananta
    Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, Center for Biological and Environmental Nanotechnology, Rice University, Houston, Texas 77251 1892, USA
    Nat Nanotechnol 5:815-21. 2010
    ..Thus, nanoscale confinement offers a new and general strategy for enhancing the contrast of gadolinium-based contrast agents...
  86. pmc The margination propensity of spherical particles for vascular targeting in the microcirculation
    Francesco Gentile
    Center of Bio Nanotechnology and Engineering for Medicine University of Magna Graecia at Catanzaro, Viale Europa Loc, Germaneto, 88100, Catanzaro, Italy
    J Nanobiotechnology 6:9. 2008
    ....
  87. pmc Size of the nanovectors determines the transplacental passage in pregnancy: study in rats
    Jerrie S Refuerzo
    Department of Obstetrics, Gynecology, and Reproductive Medicine, University of Texas Health Science Center at Houston, 77030, USA
    Am J Obstet Gynecol 204:546.e5-9. 2011
    ..The objective of the study was to examine whether the size of silicon nanovectors (SNVs) inhibits their entrance into the fetal circulation...
  88. ncbi request reprint Osmotic pressure beyond concentration restrictions
    Alessandro Grattoni
    Dipartimento di Meccanica, Politecnico di Torino, C so Duca degli Abruzzi, 24, 10129, Torino, Italy
    J Phys Chem B 111:11770-5. 2007
    ..In this work, we examine the validity of predictive theories of osmosis, by comparison with our new experimental results, and a meta-analysis of literature data...
  89. pmc Quantitative mechanics of endothelial phagocytosis of silicon microparticles
    Rita E Serda
    Division of NanoMedicine, Department of Biomedical Engineering, University of Texas Health Science Center, Houston, Texas 77030, USA
    Cytometry A 75:752-60. 2009
    ..The resulting half-time for microparticle internalization was 15.7 min, with confirmation provided by live confocal imaging as well as transmission electron microscopy...
  90. ncbi request reprint Conference Scene: Nanotechnology and medicine: the next big thing is really small
    Ennio Tasciotti
    Division of NanoMedicine, Department of Biomedical Engineering, The University of Texas Health Science Center at Houston, 1825 Pressler St, Suite 537B, 77030 Houston, TX, USA
    Nanomed 4:619-21. 2009
    ....
  91. doi request reprint Nanotechnology for breast cancer therapy
    Takemi Tanaka
    Brown Institute of Molecular Medicine, Department of Biomedical Engineering, University of Texas Houston Health Science Center, 1825 Herman Pressler Street, Suite 537D, Houston, TX, 77030, USA
    Biomed Microdevices 11:49-63. 2009
    ....
  92. pmc Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction
    Yong Yang
    Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Chembiochem 14:929-33. 2013
    ..This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy...
  93. doi request reprint Adult and umbilical cord blood-derived platelet-rich plasma for mesenchymal stem cell proliferation, chemotaxis, and cryo-preservation
    Matthew B Murphy
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77025, USA
    Biomaterials 33:5308-16. 2012
    ..Lastly, we successfully demonstrated that PRP and PPP represented a viable alternative to FBS containing media for the cryo-preservation of MSC from human and rat BM...
  94. doi request reprint The association of silicon microparticles with endothelial cells in drug delivery to the vasculature
    Rita E Serda
    Brown Institute of Molecular Medicine, University of Texas Health Science Center, Nanomedicine Division, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Biomaterials 30:2440-8. 2009
    ..These findings suggest that it may be possible to bioengineer silicon microparticles to favor opsonization with proteins that enhance uptake by endothelial cells, without a concurrent enhanced uptake by macrophages...
  95. ncbi request reprint Antibiological barrier nanovector technology for cancer applications
    Jason Sakamoto
    Alliance for NanoHealth, 1825 Herman Pressler Street, Suite 537A, Houston, Texas 77030, USA
    Expert Opin Drug Deliv 4:359-69. 2007
    ..This novel, multi-stage strategy enables efficient localised delivery of chemotoxic drugs that may lead to significant improvements in therapy efficacy, reduced systemic toxicity and decreased total amount of injected drugs...
  96. pmc Prediction of drug response in breast cancer using integrative experimental/computational modeling
    Hermann B Frieboes
    School of Health Information Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 69:4484-92. 2009
    ....
  97. ncbi request reprint Nanotechnology and tumor imaging: seizing an opportunity
    Daniel C Sullivan
    Division of Cancer Treatment and Diagnosis, National Cancer Institute, EPN Room 6052, 6130 Executive Boulevard, Rockville, MD 20892 7412, USA
    Mol Imaging 3:364-9. 2004
    ..Appropriately labeled and targeted nanoparticles could lead to a paradigm change in which cancer detection, diagnosis, and therapy are combined in a single molecular complex...
  98. ncbi request reprint Cancer nanotechnology: opportunities and challenges
    Mauro Ferrari
    Division of Haematology and Oncology, 110U Davis Heart and Lung Research Institute, The Ohio State University, 473 West 12th Avenue, Columbus OH 43210 1002, USA
    Nat Rev Cancer 5:161-71. 2005
    ..These and other nanodevices can provide essential breakthroughs in the fight against cancer...
  99. ncbi request reprint Tailoring width of microfabricated nanochannels to solute size can be used to control diffusion kinetics
    Frank Martin
    iMEDD Inc, Columbus, OH, USA
    J Control Release 102:123-33. 2005
    ..Such a nonmechanical device offers important advantages in drug delivery applications, including zero-order release and high loading capacity...
  100. ncbi request reprint Opportunities for nanotechnology-based innovation in tissue proteomics
    David H Geho
    FDA NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Biomed Microdevices 6:231-9. 2004
    ....
  101. ncbi request reprint Object-oriented design tools for supramolecular devices and biomedical nanotechnology
    Stephen C Lee
    Biomedical Engineering Center, The Ohio State University, Columbus, Ohio 43210, USA
    Ann N Y Acad Sci 1013:110-23. 2004
    ..The nested, hierarchical nature of object-oriented approaches allows treatment of devices as objects in higher-order structures, and so will facilitate concatenation of multiple devices into higher-order, higher-function nanosystems...

Research Grants2

  1. Nanomechanical Method for Molecular Analysis of Cancer
    Mauro Ferrari; Fiscal Year: 2004
    ..In the R33 phase, the objectives of the proposed program would be to optimize the system's performance and create an actual prototype for clinical testing in the context of breast malignancies. ..
  2. Nanoparticles for Harvesting and Targeting Angiogenic Proteins
    Mauro Ferrari; Fiscal Year: 2006
    ..These studies may also provide strategies to selectively target tumor vessels for destruction using nanotechnology approaches. ..