Slava Rom

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania Electronic address
    Am J Pathol 183:1548-58. 2013
  2. pmc Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, 3401 N Broad St, Philadelphia, PA 19140, USA
    J Neuroimmune Pharmacol 8:608-20. 2013
  3. pmc Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 181:1414-25. 2012
  4. pmc Inhibition of glycogen synthase kinase 3β promotes tight junction stability in brain endothelial cells by half-life extension of occludin and claudin-5
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e55972. 2013
  5. pmc HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction
    Slava Rom
    Temple University School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Biochim Biophys Acta 1813:1836-44. 2011
  6. pmc Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Leukoc Biol 93:801-10. 2013
  7. pmc Dysfunction of brain pericytes in chronic neuroinflammation
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, USA Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA
    J Cereb Blood Flow Metab 36:794-807. 2016
  8. pmc Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, 19140, USA
    J Neuroimmune Pharmacol 10:302-8. 2015
  9. pmc Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 35:28-36. 2015
  10. pmc CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells
    Slava Rom
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    FASEB J 24:2292-300. 2010

Collaborators

  • Ming Zhang
  • Yu Zhou
  • Xu Wang
  • Pal Pacher
  • Wen Zhe Ho
  • Francesca Peruzzi
  • Yuri Persidsky
  • Servio H Ramirez
  • Nancy L Reichenbach
  • Holly Dykstra
  • Jeremy Hill
  • Shongshan Fan
  • Raghava Potula
  • Viviana Zuluaga-Ramirez
  • Andrea K Watters
  • Steven F Merkel
  • Giovanni Passiatore
  • Malika Winfield
  • Abir Mukherjee
  • Jonathan Cena
  • Jeremy D Hill
  • Young Jin Son
  • Allison M Andrews
  • Marie K Dematatis
  • Andrew Skuba
  • Larisa Gofman
  • Aaron Mercer
  • Davide Eletto

Detail Information

Publications15

  1. pmc Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania Electronic address
    Am J Pathol 183:1548-58. 2013
    ..These results indicate that selective CB2 activation in leukocytes decreases key steps in monocyte-BBB engagement, thus suppressing inflammatory leukocyte responses and preventing neuroinflammation...
  2. pmc Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, 3401 N Broad St, Philadelphia, PA 19140, USA
    J Neuroimmune Pharmacol 8:608-20. 2013
    ..This review attempts to summarize recent advances in studies of CB(2) activation in the setting of neuroinflammation, immunomodulation and HIV-1 infection...
  3. pmc Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 181:1414-25. 2012
    ..These results indicate that GSK3β inhibition in monocytes affects active integrin expression, cytoskeleton rearrangement, and adhesion via suppression of Rac1-diminishing inflammatory leukocyte responses...
  4. pmc Inhibition of glycogen synthase kinase 3β promotes tight junction stability in brain endothelial cells by half-life extension of occludin and claudin-5
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e55972. 2013
    ..Collectively, our findings suggest the possibility of using GSK3β inhibitors as a means to extend the half-life of key tight junction proteins to promote re-sealing of the BBB during neuroinflammation...
  5. pmc HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction
    Slava Rom
    Temple University School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Biochim Biophys Acta 1813:1836-44. 2011
    ..The Tat/Grb2 interaction affects also viral function by inhibiting the Tat-mediated transactivation of HIV-1 LTR and viral replication in infected primary microglia...
  6. pmc Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Leukoc Biol 93:801-10. 2013
    ..Together, these results indicate that CB₂ may offer a means to limit HIV-1 infection in macrophages...
  7. pmc Dysfunction of brain pericytes in chronic neuroinflammation
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, USA Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA
    J Cereb Blood Flow Metab 36:794-807. 2016
    ..These data suggest an important role of pericytes in BBB regulation in neuroinflammation. ..
  8. pmc Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium
    Yuri Persidsky
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, 19140, USA
    J Neuroimmune Pharmacol 10:302-8. 2015
    ..Such changes in gene expression paralleled diminished secretion of proinflammatory factors. These results indicate the potential utility of CB2 agonists for the treatment of neuroinflammation...
  9. pmc Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 35:28-36. 2015
    ..These results point to PARP suppression as a novel approach to BBB protection in the setting of endothelial dysfunction caused by inflammation. ..
  10. pmc CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells
    Slava Rom
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    FASEB J 24:2292-300. 2010
    ....
  11. pmc miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions
    Slava Rom
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 35:1957-65. 2015
    ..For the first time, we showed that miRNAs could be used as a therapeutic tool to prevent the BBB dysfunction in neuroinflammation. ..
  12. pmc Craniula: A cranial window technique for prolonged imaging of brain surface vasculature with simultaneous adjacent intracerebral injection
    Viviana Zuluaga-Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, 3500 N Broad St, MERB 880A, Philadelphia, PA, 19140, USA
    Fluids Barriers CNS 12:24. 2015
    ..Development of the cranial window technique provided a major advance in the acquisition of live images of the brain vasculature and its response to different insults and treatments...
  13. pmc Emerging roles of pericytes in the regulation of the neurovascular unit in health and disease
    Jeremy Hill
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    J Neuroimmune Pharmacol 9:591-605. 2014
    ..The uncovering of the regulatory role of pericytes on the BBB will provide key insight into how barrier integrity can be re-established during neuroinflammation. ..
  14. pmc Identification and dynamic regulation of tight junction protein expression in human neural stem cells
    Andrea K Watters
    1Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania
    Stem Cells Dev 24:1377-89. 2015
    ..Taken together, our results indicate that TJPs possibly aid in maintaining the intercellular configuration of NSCs and that reduction in TJP expression consequently affects the stemness status. ..
  15. pmc HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity
    Giovanni Passiatore
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, USA
    Biochim Biophys Acta 1793:378-87. 2009
    ..Moreover, cleavage of Tat101 by calpain 1 increased neurotoxic effect of this viral protein and presence of the calpain inhibitor protected neuronal cells from Tat-mediated toxicity...