Genomes and Genes
Prasun K Datta
Affiliation: Temple University
- Nitric oxide induces metallothionein-I gene expression in mesangial cellsPrasun K Datta
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA 19122, USA
Transl Res 148:180-7. 2006..These observations identify MT-I as a putative antioxidant system in NO-mediated mesangial cell injury...
- HIV and complement: hijacking an immune defenseP K Datta
Department of Neuroscience, Temple University School of Medicine, 1900 N 12th Street, Philadelphia, PA 19122, USA
Biomed Pharmacother 60:561-8. 2006....
- Regulatory effects of inducible nitric oxide synthase on cyclooxygenase-2 and heme oxygenase-1 expression in experimental glomerulonephritisPrasun K Datta
Division of Nephrology, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Nephrol Dial Transplant 21:51-7. 2006....
- Differential nephron HO-1 expression following glomerular epithelial cell injuryPrasun K Datta
Laboratory of AIDS Pathogenesis and Molecular Therapeutics, Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA 19122, USA
Nephron Exp Nephrol 103:e131-8. 2006..In this model, we assessed nephron distribution of the expression of the inducible HO isoform, HO-1, and the role of free radicals in modulating HO-1 expression...
- Effect of nitric oxide synthase inhibition on proteinuria in glomerular immune injuryPrasun K Datta
Center for Neurovirology Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
Exp Biol Med (Maywood) 231:576-84. 2006..We conclude that NOS-catalyzed NO production is an important mechanism in regulating glomerular permeability to protein. This mechanism involves control of the bioavailability of superoxide...
- Long-term effect of heme oxygenase (HO)-1 induction in glomerular immune injuryPrasun K Datta
Temple University Center for Neurovirology and Cancer Biology, Philadelphia, Pennsylvania, USA
J Lab Clin Med 147:150-5. 2006..This effect could be mechanistically linked to blunting of the ability of infiltrating macrophages to cause injury or to changes in tubular handling of filtered protein...
- Superoxide dismutase mimetic preserves the glomerular capillary permeability barrier to proteinPu Duann
Department of Medicine Division of Nephrology, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medicine School, New Brunswick, NJ 08903 0019, USA
J Pharmacol Exp Ther 316:1249-54. 2006..These observations indicate that SOD mimetics can preserve the glomerular permeability barrier to protein under conditions of oxidative stress from O2* production...
- Interactions between inducible nitric oxide synthase and heme oxygenase-1 in glomerulonephritisPrasun K Datta
Division of Nephrology, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, P O Box 19, MEB 412, New Brunswick, NJ, USA
Kidney Int 61:847-50. 2002..These observations prompted us to explore regulatory interactions between iNOS and HO-1 in anti-GBM nephritis...
- Glutamate metabolism in HIV-1 infected macrophages: Role of HIV-1 VprPrasun K Datta
a Department of Neuroscience and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA
Cell Cycle 15:2288-98. 2016..Our studies demonstrate that dysregulation of mitochondrial glutamate metabolism induced by Vpr in HIV-1 infected macrophages commonly seen, may contribute to neurodegeneration via excitotoxic mechanisms in the context of NeuroAIDS. ..
- HIV-1 Tat and Cocaine Impair Survival of Cultured Primary Neuronal Cells via a Mitochondrial PathwayFrancesca Isabella De Simone
Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, 3500 N Broad Street, Philadelphia, PA, 19140, USA
J Neuroimmune Pharmacol 11:358-68. 2016..The importance of mitochondrial damage is also indicated by reductions in mitochondrial membrane potential and ATP content induced by HIV-1 Tat and cocaine. ..
- Non-Metabolic Role of PKM2 in Regulation of the HIV-1 LTRSatarupa Sen
Department of Neuroscience, Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania
J Cell Physiol 232:517-525. 2017..These observations demonstrate for the first time that PKM2 is a transcriptional co-activator of HIV-1 LTR. J. Cell. Physiol. 232: 517-525, 2017. © 2016 Wiley Periodicals, Inc...
- Differential regulation of the rat heme oxygenase-1 expression by Ets oncoproteins in glomerular mesangial cellsPrasad D K Dhulipala
Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903 0019, USA
J Lab Clin Med 146:326-32. 2005..Furthermore, mutation of EBS-2 and 4 completely abolished Erg-2-mediated promoter activation. Our results support a role for Ets transcription factors in the regulation of rat hmox-1 gene expression in mesangial cells...
- Induction of metallothionein-I protects glomeruli from superoxide-mediated increase in albumin permeabilityRam Sharma
Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Exp Biol Med (Maywood) 227:26-31. 2002..We conclude that MT-I gene products may play an important role in protecting the glomerular filtration barrier from the injury induced by reactive oxygen species in immune and/or nonimmune renal diseases...
- HIV-1 Latency and Eradication: Past, Present and FuturePrasun K Datta
Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, 3500 N Broad Street, 7th Floor, Philadelphia, PA 19140, USA
Curr HIV Res 14:431-441. 2016..Studies have demonstrated that modification of chromatin structure plays a role in establishing persistence, in part suggesting that latency is, controlled epigenetically...
- Interplay of Rad51 with NF-κB pathway stimulates expression of HIV-1Rafal Kaminski
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 9:e98304. 2014....
- HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysisCarlos A Barrero
Department of Biochemistry, Temple University School of Medicine, Fels Institute, Philadelphia, Pennsylvania, USA
PLoS ONE 8:e68376. 2013..Furthermore, dysregulation of mitochondrial glutamate metabolism in macrophages can contribute to neurodegeneration via neuroexcitotoxic mechanisms in the context of NeuroAIDS. ..
- Epigenetics of µ-opioid receptors: intersection with HIV-1 infection of the central nervous systemPatrick M Regan
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA
J Cell Physiol 227:2832-41. 2012..Additionally, we suggest that differential regulation of newly identified MOR isoforms by opioids and HIV-1 has functional consequence in enhancing HIV-1 neurocognitive dysfunction...
- Role of C/EBP-β, p38 MAPK, and MKK6 in IL-1β-mediated C3 gene regulation in astrocytesJeffrey Maranto
Department of Neuroscience, Temple University School of Medicine, 3500, N Broad Street, Philadelphia, Pennsylvania 19140, USA
J Cell Biochem 112:1168-75. 2011..These results suggest that the p38α, MAPK, and MKK6 play prominent roles in IL-1β and C/EBP-β-mediated C3 gene expression in astrocytes...
- Expression profile of genes associated with antimetastatic gene: nm23-mediated metastasis inhibition in breast carcinoma cellsHui Zhao
Department of Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
Int J Cancer 109:65-70. 2004....