Hong Lu

Summary

Affiliation: SUNY Upstate Medical University
Country: USA

Publications

  1. pmc Moderate activation of IKK2-NF-kB in unstressed adult mouse liver induces cytoprotective genes and lipogenesis without apparent signs of inflammation or fibrosis
    Hong Lu
    Department of Pharmacology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY, 13210, USA
    BMC Gastroenterol 15:94. 2015
  2. pmc RNA-sequencing quantification of hepatic ontogeny and tissue distribution of mRNAs of phase II enzymes in mice
    Hong Lu
    Department of Pharmacology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Drug Metab Dispos 41:844-57. 2013
  3. pmc Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing
    Hong Lu
    Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA
    Epigenetics 7:914-29. 2012
  4. doi request reprint Epigenetic regulation of drug processing genes
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Mech Methods 21:312-24. 2011
  5. pmc Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR
    Hong Lu
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Toxicol Sci 103:35-45. 2008
  6. pmc Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice
    Iván L Csanaky
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Hepatology 53:272-81. 2011
  7. pmc RNA sequencing reveals dynamic changes of mRNA abundance of cytochromes P450 and their alternative transcripts during mouse liver development
    Lai Peng
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Drug Metab Dispos 40:1198-209. 2012
  8. ncbi request reprint Gender differences in mRNA expression of ATP-binding cassette efflux and bile acid transporters in kidney, liver, and intestine of 5/6 nephrectomized rats
    Hong Lu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 36:16-23. 2008
  9. pmc Expression of human CAR splicing variants in BAC-transgenic mice
    Yu Kun Jennifer Zhang
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, KS, USA
    Toxicol Sci 132:142-50. 2013
  10. pmc Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice
    Julia Yue Cui
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Am J Physiol Gastrointest Liver Physiol 302:G979-96. 2012

Collaborators

Detail Information

Publications16

  1. pmc Moderate activation of IKK2-NF-kB in unstressed adult mouse liver induces cytoprotective genes and lipogenesis without apparent signs of inflammation or fibrosis
    Hong Lu
    Department of Pharmacology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY, 13210, USA
    BMC Gastroenterol 15:94. 2015
    ..The purpose of this study was to understand how moderate activation of IKK2-NF-kB in adult mouse livers alters hepatic gene expression and pathophysiology...
  2. pmc RNA-sequencing quantification of hepatic ontogeny and tissue distribution of mRNAs of phase II enzymes in mice
    Hong Lu
    Department of Pharmacology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Drug Metab Dispos 41:844-57. 2013
    ..The age- and tissue-specific expression of Phase II enzymes indicate that the detoxification of xenobiotics is highly regulated by age and cell type...
  3. pmc Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing
    Hong Lu
    Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA
    Epigenetics 7:914-29. 2012
    ..These data suggest that ontogenic changes in mRNA expression of epigenetic modifiers may play important roles in determining the addition and/or removal of corresponding epigenetic signatures during liver development...
  4. doi request reprint Epigenetic regulation of drug processing genes
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Mech Methods 21:312-24. 2011
    ....
  5. pmc Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR
    Hong Lu
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Toxicol Sci 103:35-45. 2008
    ..Oatp1b2-null mice are useful in elucidating the role of Oatp1b2 and its human orthologs OATP1B1/1B3 in hepatic uptake and systemic disposition of toxic chemicals and therapeutic drugs...
  6. pmc Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice
    Iván L Csanaky
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Hepatology 53:272-81. 2011
    ..After intravenous administration of cholate to Oatp1b2-null mice, its clearance was 50% lower than in WT mice, but the clearance of taurocholate was similar in the two genotypes...
  7. pmc RNA sequencing reveals dynamic changes of mRNA abundance of cytochromes P450 and their alternative transcripts during mouse liver development
    Lai Peng
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Drug Metab Dispos 40:1198-209. 2012
    ..In conclusion, this study reveals the mRNA abundance of all the P450s in mouse liver during development and provides a foundation for mechanistic studies in the future...
  8. ncbi request reprint Gender differences in mRNA expression of ATP-binding cassette efflux and bile acid transporters in kidney, liver, and intestine of 5/6 nephrectomized rats
    Hong Lu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 36:16-23. 2008
    ..Down-regulation of steroid hormone receptors and increase of inflammatory cytokines may contribute to alteration of transporter gene expression in kidney during CKD...
  9. pmc Expression of human CAR splicing variants in BAC-transgenic mice
    Yu Kun Jennifer Zhang
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, KS, USA
    Toxicol Sci 132:142-50. 2013
    ..In summary, the hCAR-TG mice developed by this study represent a valid model for studying in vivo function and regulation of hCAR and its splicing variants...
  10. pmc Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice
    Julia Yue Cui
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Am J Physiol Gastrointest Liver Physiol 302:G979-96. 2012
    ..In conclusion, at birth, BAs from the classic pathway of synthesis trigger the induction of transporters involved in EHC of BAs in mice, through activation of the nuclear receptor FXR...
  11. pmc Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis
    Hong Lu
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Appl Pharmacol 256:122-35. 2011
    ..The aggravated hepatosteatosis in TCDD-treated Nrf2-null mice is due to increased lipogenesis in liver and impaired lipogenesis in white adipose tissue...
  12. pmc Alterations of epigenetic signatures in hepatocyte nuclear factor 4α deficient mouse liver determined by improved ChIP-qPCR and (h)MeDIP-qPCR assays
    Qinghao Zhang
    Department of Pharmacology, SUNY Upstate Medical University, Syracuse, New York, United States of America
    PLoS ONE 9:e84925. 2014
    ..The underlying mechanism may be the induction of epigenetic enzymes responsible for the addition/removal of the epigenetic signatures, and/or the loss of HNF4α per se as a key coordinator for epigenetic modifiers. ..
  13. pmc Hepatocyte nuclear factor 4 alpha and farnesoid X receptor co-regulates gene transcription in mouse livers on a genome-wide scale
    Ann M Thomas
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA
    Pharm Res 30:2188-98. 2013
    ..Thus, we compared the genome-wide binding of Fxr and Hnf4α in the liver of mice and characterized their cooperative activity on binding to and activating target gene transcription...
  14. ncbi request reprint Xenobiotic transporters: ascribing function from gene knockout and mutation studies
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Building, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 101:186-96. 2008
    ....
  15. pmc Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha
    Hong Lu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 118:380-90. 2010
    ....
  16. ncbi request reprint Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression
    Xingguo Cheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Mol Pharmacol 70:1291-7. 2006
    ..In conclusion, gender-divergent Oatp expression in liver is caused by male-pattern GH secretion pattern and androgens. In kidney, gender-divergent Oatp expression is exclusively caused by stimulation by androgens...