Sandra M Hayes

Summary

Affiliation: SUNY Upstate Medical University
Country: USA

Publications

  1. pmc Activation-induced modification in the CD3 complex of the gammadelta T cell receptor
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 196:1355-61. 2002
  2. pmc Genetic requirements for the development and differentiation of interleukin-17-producing γδ T cells
    Sandra M Hayes
    Department of Microbiology and Immunology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Crit Rev Immunol 32:81-95. 2012
  3. pmc Beyond alphabeta/gammadelta lineage commitment: TCR signal strength regulates gammadelta T cell maturation and effector fate
    Sandra M Hayes
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Semin Immunol 22:247-51. 2010
  4. pmc Stoichiometry of the murine gammadelta T cell receptor
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:47-52. 2006
  5. pmc γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation
    Renee M Laird
    Department of Microbiology and Immunology, State University of New York, Upstate Medical University, Syracuse, New York, USA
    PLoS ONE 8:e63178. 2013
  6. ncbi Premature expression of chemokine receptor CCR9 impairs T cell development
    Shoji Uehara
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    J Immunol 176:75-84. 2006
  7. pmc Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cells
    Renee M Laird
    Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    J Immunol 185:6518-27. 2010
  8. doi Dynamics of CD3gammaepsilon and CD3deltaepsilon dimer expression during murine T cell development
    Renee M Laird
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, United States
    Mol Immunol 47:582-9. 2009
  9. pmc Roles of the Src tyrosine kinases Lck and Fyn in regulating gammadeltaTCR signal strength
    Renee M Laird
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York, United States of America
    PLoS ONE 5:e8899. 2010
  10. ncbi TCR signal strength influences alphabeta/gammadelta lineage fate
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    Immunity 22:583-93. 2005

Collaborators

Detail Information

Publications20

  1. pmc Activation-induced modification in the CD3 complex of the gammadelta T cell receptor
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 196:1355-61. 2002
    ....
  2. pmc Genetic requirements for the development and differentiation of interleukin-17-producing γδ T cells
    Sandra M Hayes
    Department of Microbiology and Immunology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Crit Rev Immunol 32:81-95. 2012
    ..Based on this comparison, we propose a model for murine γδ-17 development and differentiation...
  3. pmc Beyond alphabeta/gammadelta lineage commitment: TCR signal strength regulates gammadelta T cell maturation and effector fate
    Sandra M Hayes
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Semin Immunol 22:247-51. 2010
    ..In this review, we discuss how a strong TCR signal is a recurring theme in gammadelta T cell development and activation...
  4. pmc Stoichiometry of the murine gammadelta T cell receptor
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:47-52. 2006
    ..Our results support a model of murine gammadeltaTCR stoichiometry in which there are two CD3gammaepsilon dimers for every TCRgammadelta heterodimer...
  5. pmc γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation
    Renee M Laird
    Department of Microbiology and Immunology, State University of New York, Upstate Medical University, Syracuse, New York, USA
    PLoS ONE 8:e63178. 2013
    ..Together, these data not only demonstrate an enhanced glucose metabolism in γδ T cells but also provide an explanation for why γδ T cells are less dependent on CD28 costimulation than αβ T cells...
  6. ncbi Premature expression of chemokine receptor CCR9 impairs T cell development
    Shoji Uehara
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    J Immunol 176:75-84. 2006
    ..Together, these results suggest that regulated expression of CCR9 is critical for normal development of immature thymocytes, but that down-regulation of CCR9 is not a prerequisite for thymocyte emigration...
  7. pmc Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cells
    Renee M Laird
    Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    J Immunol 185:6518-27. 2010
    ..Furthermore, Blk is expressed in lymphoid precursors and, in this capacity, plays a role in regulating thymus cellularity during ontogeny...
  8. doi Dynamics of CD3gammaepsilon and CD3deltaepsilon dimer expression during murine T cell development
    Renee M Laird
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, United States
    Mol Immunol 47:582-9. 2009
    ....
  9. pmc Roles of the Src tyrosine kinases Lck and Fyn in regulating gammadeltaTCR signal strength
    Renee M Laird
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York, United States of America
    PLoS ONE 5:e8899. 2010
    ..These results indicate that the cellular levels of Lck and Fyn play a role in regulating the strength of the gammadeltaTCR signaling response at different stages in the life of the gammadelta T cell...
  10. ncbi TCR signal strength influences alphabeta/gammadelta lineage fate
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    Immunity 22:583-93. 2005
    ..These results support a model in which the strength of the TCR signal is a critical determinant in the lineage fate decision...
  11. ncbi Strength of signal: a fundamental mechanism for cell fate specification
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    Immunol Rev 209:170-5. 2006
    ..In this review, we compare the alphabeta/gammadelta fate decision with other cell fate decisions that occur outside of the lymphoid system to attain a better picture of the quantitative signaling mechanism for cell fate specification...
  12. pmc Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice
    Elizabeth M Samuelson
    Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, New York, United States of America
    PLoS ONE 9:e92054. 2014
    ..Together, these findings suggest that BLK risk alleles confer susceptibility to SLE through the dysregulation of a proinflammatory cytokine network. ..
  13. doi Profiling of the early transcriptional response of murine gammadelta T cells following TCR stimulation
    Renee M Laird
    Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 E Adams Street, 2220 Weiskotten Hall, Syracuse, NY 13210, USA
    Mol Immunol 46:2429-38. 2009
    ....
  14. ncbi A retrospective on the requirements for gammadelta T-cell development
    Sandra M Hayes
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY, USA
    Immunol Rev 215:8-14. 2007
    ..In addition, we compare the genetic requirements for alphabeta and gammadelta T-cell development with the hope of gaining a better picture of the signaling pathways that govern the development of gammadelta lineage cells...
  15. pmc Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells
    Liqi Li
    Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:129-36. 2011
    ..Our results identify a central role for Ldb1 in regulating the transcriptional program responsible for the maintenance of HSCs...
  16. pmc Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells
    Elizabeth M Samuelson
    Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Immunol Cell Biol 90:620-9. 2012
    ..Thus, this study has revealed a previously unappreciated role for Blk in the development and activation of MZ B cells...
  17. ncbi Distinct structure and signaling potential of the gamma delta TCR complex
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:827-38. 2002
    ..These results reveal fundamental differences in the primary structure and signaling potential of the alpha beta- and gamma delta TCR complexes...
  18. pmc ITAM-mediated signaling by the T-cell antigen receptor
    Paul E Love
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Cold Spring Harb Perspect Biol 2:a002485. 2010
    ..Here, we summarize data generated during the past two decades and discuss how these findings have in some cases resolved, and in others complicated, outstanding questions relating to the function of TCR ITAMs...
  19. ncbi An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 191:28-37. 2003
    ....
  20. ncbi T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7
    Sherri W Christianson
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Autoimmun 18:119-30. 2002
    ..We conclude that abnormal T cell development in me(v)/ me(v) mice may in part be due to defects in the ability of bone marrow-derived accessory cells to provide bioavailable IL-7 to developing thymocytes...