Kausik Si

Summary

Affiliation: Stowers Institute for Medical Research
Country: USA

Publications

  1. doi Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation
    Kausik Si
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Cell 140:421-35. 2010
  2. doi Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory
    Amitabha Majumdar
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Cell 148:515-29. 2012
  3. pmc Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover
    Tomoko Mastushita-Sakai
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 107:11987-92. 2010
  4. pmc Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator
    Mohammed Repon Khan
    Stowers Institute for Medical Research, 1000 East 50 th Street, Kansas City, MO 64110, USA Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Cell 163:1468-83. 2015
  5. pmc A Putative Biochemical Engram of Long-Term Memory
    Liying Li
    Stowers Institute for Medical Research, 1000 East 50 th Street, Kansas City, MO 64110, USA Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Curr Biol 26:3143-3156. 2016
  6. pmc Contribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2
    Erica White-Grindley
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS Biol 12:e1001786. 2014
  7. pmc The Role of Functional Prion-Like Proteins in the Persistence of Memory
    Kausik Si
    Stowers Institute for Medical Research, Kansas City, Missouri 64113 Department of Physiology, School of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160
    Cold Spring Harb Perspect Biol 8:a021774. 2016
  8. pmc Immediate perception of a reward is distinct from the reward's long-term salience
    John P McGinnis
    Stowers Institute for Medical Research, Kansas City, United States
    elife 5:. 2016
  9. ncbi RISC-y Memories
    Erica White-Grindley
    The Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Cell 124:23-6. 2006

Collaborators

  • Amitabha Majumdar
  • Liying Li
  • Erica White-Grindley
  • Mohammed Repon Khan
  • John P McGinnis
  • Brian D Slaughter
  • Jay R Unruh
  • Anita Saraf
  • Laurence Florens
  • Tomoko Mastushita-Sakai
  • Frédéric Marion-Poll
  • ZuLin Yu
  • Consuelo Perez Sanchez
  • Jeffrey J Lange
  • Huoqing Jiang
  • Boris Rubinstein
  • Yubai Zhao
  • Moutaz Ali Agha
  • Consuelo Pérez Sánchez
  • Consuelo Pérez-Sánchez
  • Fengzhen Ren
  • Repon Mohammad Khan
  • Jessica Samuelson
  • Chris Seidel

Detail Information

Publications9

  1. doi Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation
    Kausik Si
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Cell 140:421-35. 2010
    ..These results are consistent with the idea that ApCPEB can act as a self-sustaining prion-like protein in the nervous system and thereby might allow the activity-dependent change in synaptic efficacy to persist for long periods of time...
  2. doi Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory
    Amitabha Majumdar
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Cell 148:515-29. 2012
    ..However the mutant flies failed to stabilize memory beyond 48 hr. These results support the idea that amyloid-like oligomers of neuronal CPEB are critical for the persistence of long-term memory...
  3. pmc Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover
    Tomoko Mastushita-Sakai
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 107:11987-92. 2010
    ..These targets suggest that the persistent form of the memory trace might be comprised of molecules that maintain a sustained, permissive environment for synaptic growth in an activated synapse...
  4. pmc Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator
    Mohammed Repon Khan
    Stowers Institute for Medical Research, 1000 East 50 th Street, Kansas City, MO 64110, USA Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Cell 163:1468-83. 2015
    ....
  5. pmc A Putative Biochemical Engram of Long-Term Memory
    Liying Li
    Stowers Institute for Medical Research, 1000 East 50 th Street, Kansas City, MO 64110, USA Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Curr Biol 26:3143-3156. 2016
    ..Our data indicate that self-sustaining aggregates of Orb2 may serve as a physical substrate of memory and provide a molecular basis for the perduring yet malleable nature of memory...
  6. pmc Contribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2
    Erica White-Grindley
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS Biol 12:e1001786. 2014
    ..These observations suggest that the interplay between PP2A and Tob-LimK activity may dynamically regulate Orb2 amyloid-like oligomer formation and the stabilization of memories. ..
  7. pmc The Role of Functional Prion-Like Proteins in the Persistence of Memory
    Kausik Si
    Stowers Institute for Medical Research, Kansas City, Missouri 64113 Department of Physiology, School of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160
    Cold Spring Harb Perspect Biol 8:a021774. 2016
    ..Here, we review recent experimental evidence of prion-like properties of neuronal CPEB in various organisms and propose a model of how the prion-like state may stabilize memory. ..
  8. pmc Immediate perception of a reward is distinct from the reward's long-term salience
    John P McGinnis
    Stowers Institute for Medical Research, Kansas City, United States
    elife 5:. 2016
    ..However, how sensory neurons communicate information about L-arabinose quality and concentration-features relevant for long-term memory-remains unknown...
  9. ncbi RISC-y Memories
    Erica White-Grindley
    The Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Cell 124:23-6. 2006
    ..2006) observe persistent local protein synthesis in the antennal lobe synapses of the fruit fly following olfactory-avoidance learning. This protein synthesis is regulated by the RNA-induced silencing complex (RISC)...