Hsien Yu Wang

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Wnt-frizzled signaling to G-protein-coupled effectors
    H Y Wang
    Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Cell Mol Life Sci 61:69-75. 2004
  2. ncbi request reprint WNT-frizzled signaling via cyclic GMP
    Hsien Yu Wang
    Department of Physiology and Biophysics, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Front Biosci 9:1043-7. 2004
  3. ncbi request reprint Expression of Galpha 13 (Q226L) induces P19 stem cells to primitive endoderm via MEKK1, 2, or 4
    Hsien Yu Wang
    Department of Physiology and Biophysics, University Medical Center, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 277:3530-6. 2002
  4. ncbi request reprint PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development
    H Wang
    Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    Biochem Soc Trans 32:792-6. 2004
  5. pmc pp60Src mediates insulin-stimulated sequestration of the beta(2)-adrenergic receptor: insulin stimulates pp60Src phosphorylation and activation
    Elena Shumay
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794 8651, USA
    Mol Biol Cell 13:3943-54. 2002
  6. ncbi request reprint Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP
    Adriana Ahumada
    Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Center, University Medical Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    Science 298:2006-10. 2002
  7. pmc Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor
    Jiangchuan Tao
    Departments of Pharmacology and Physiology and Biophysics, Heath Sciences Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    EMBO J 22:6419-29. 2003
  8. ncbi request reprint Successful expression of a functional yeast G-protein-coupled receptor (Ste2) in mammalian cells
    Dezhong Yin
    Department of Molecular Pharmacology, University Medical Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    Biochem Biophys Res Commun 329:281-7. 2005
  9. ncbi request reprint Trafficking of beta2-adrenergic receptors: insulin and beta-agonists regulate internalization by distinct cytoskeletal pathways
    Elena Shumay
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center HSC, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 117:593-600. 2004
  10. ncbi request reprint Activation of the beta-catenin/Lef-Tcf pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid
    Tong Liu
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, State University of New York SUNY at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Biol Chem 277:30887-91. 2002

Research Grants

  1. Cyclic GMP Phosphodiesterase in Signaling
    Hsien Yu Wang; Fiscal Year: 2007

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Wnt-frizzled signaling to G-protein-coupled effectors
    H Y Wang
    Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Cell Mol Life Sci 61:69-75. 2004
    ..Prominent among these additional pathways is a Wnt-Fz pathway regulating intracellular [Ca(++)] and cyclic GMP levels. The essential role of heterotrimeric G proteins in Wnt-Fz signaling is highlighted...
  2. ncbi request reprint WNT-frizzled signaling via cyclic GMP
    Hsien Yu Wang
    Department of Physiology and Biophysics, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Front Biosci 9:1043-7. 2004
    ..The molecular features of how changes in intracellular cyclic GMP concentrations control development remain to be elucidated...
  3. ncbi request reprint Expression of Galpha 13 (Q226L) induces P19 stem cells to primitive endoderm via MEKK1, 2, or 4
    Hsien Yu Wang
    Department of Physiology and Biophysics, University Medical Center, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 277:3530-6. 2002
    ....
  4. ncbi request reprint PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development
    H Wang
    Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    Biochem Soc Trans 32:792-6. 2004
    ..On the basis of results from these three analyses, the cGMP-specific phosphodiesterase, PDE6, is demonstrated to be an effector for the Wnt/Ca(2+)/cGMP signalling pathway of development, which is mediated by Frizzled-2...
  5. pmc pp60Src mediates insulin-stimulated sequestration of the beta(2)-adrenergic receptor: insulin stimulates pp60Src phosphorylation and activation
    Elena Shumay
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794 8651, USA
    Mol Biol Cell 13:3943-54. 2002
    ..We report a novel positioning of Src, mediating signals from insulin to phosphatidylinositol 3-kinase and to beta(2)-adrenergic receptor trafficking...
  6. ncbi request reprint Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP
    Adriana Ahumada
    Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Center, University Medical Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    Science 298:2006-10. 2002
    ..Moreover, PDE inhibitors blocked Rfz2-induced calcium transients in zebrafish embryos. Thus, Frizzled-2 appears to couple to PDEs and calcium transients through G proteins...
  7. pmc Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor
    Jiangchuan Tao
    Departments of Pharmacology and Physiology and Biophysics, Heath Sciences Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    EMBO J 22:6419-29. 2003
    ....
  8. ncbi request reprint Successful expression of a functional yeast G-protein-coupled receptor (Ste2) in mammalian cells
    Dezhong Yin
    Department of Molecular Pharmacology, University Medical Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    Biochem Biophys Res Commun 329:281-7. 2005
    ..This is the first successful demonstration of the ability to express a functional yeast GPCR in mammalian cells...
  9. ncbi request reprint Trafficking of beta2-adrenergic receptors: insulin and beta-agonists regulate internalization by distinct cytoskeletal pathways
    Elena Shumay
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center HSC, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 117:593-600. 2004
    ....
  10. ncbi request reprint Activation of the beta-catenin/Lef-Tcf pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid
    Tong Liu
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, State University of New York SUNY at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Biol Chem 277:30887-91. 2002
    ..These data reveal the obligate role of the beta-catenin/Lef-Tcf transcriptional pathway in the action of the morphogen retinoic acid...
  11. ncbi request reprint The 15-amino acid motif of the C terminus of the beta2-adrenergic receptor is sufficient to confer insulin-stimulated counterregulation to the beta1-adrenergic receptor
    Shai Gavi
    Department of Pharmacology, University Medical Center, State University of New York Stony Brook, Stony Brook, New York 11794 8651, USA
    Endocrinology 146:450-7. 2005
    ....
  12. ncbi request reprint G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation
    Yi Nan Lee
    Department of Physiology and Biophysics, Diabetes and Metabolic Diseases Research Center, State University of New York Stony Brook, New York 11794 8661, USA
    J Biol Chem 279:54896-904. 2004
    ..In a concerted effort, RhoA in tandem with Cdc42 and Rac1 activates the MEKK1/4, MEK1/MKK4, and JNK cascade, thereby stimulating formation of primitive endoderm...
  13. ncbi request reprint Akt mediates sequestration of the beta(2)-adrenergic receptor in response to insulin
    Sergey Doronin
    Department of Molecular Pharmacology, University Medical Center, State University of New York Stony Brook, Stony Brook, New York 11794 8651, USA
    J Biol Chem 277:15124-31. 2002
    ..The action of the serine-threonine protein kinase Akt in insulin counterregulation mirrors the central role of protein kinase A in beta-agonist-induced desensitization...
  14. ncbi request reprint Ku80 is required but not sufficient for Galpha13-mediated endodermal differentiation in P19 embryonic carcinoma cells
    Jyotshnabala Kanungo
    Department of Molecular Pharmacology, University Medical Center, SUNY Stony Brook, NY 11794, USA
    Biochem Biophys Res Commun 323:293-8. 2004
    ..These results suggest that Ku80 is required for Galpha13-mediated endodermal differentiation in P19 cells...
  15. ncbi request reprint Regulation of AKAP-membrane interactions by calcium
    Jiangchuan Tao
    Department of Pharmacology, School of Medicine, Heath Sciences Center, State University of New York, Stony Brook, New York 11794 8651, USA
    J Biol Chem 281:23932-44. 2006
    ..Mutation of any two PCDs eliminates membrane association of the non-myristoylated gravin, the sensitivity to Ca2+/calmodulin, and the ability of this scaffold to catalyze receptor resensitization and recycling...
  16. ncbi request reprint Inducible, tissue-specific suppression of heterotrimeric G protein alpha subunits in vivo
    Xi Ping Huang
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, University Medical Center, State University of New York, Stony Brook, New York 11794, USA
    Methods Enzymol 344:318-27. 2002
  17. ncbi request reprint Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling
    Yuan Gao
    Department of Physiology and Biophysics, Diabetes and Metabolic Disease Research Center, School of Medicine, State University of New York at Stony Brook, New York 11794 8661, USA
    J Biol Chem 281:18394-400. 2006
    ..Thus, casein kinase 2 is shown to be regulated by Wnt3a and essential to stimulation of the Frizzled-1/beta-catenin/Lef-Tcf pathway...
  18. ncbi request reprint Wnt signaling, Ca2+, and cyclic GMP: visualizing Frizzled functions
    Hsien Yu Wang
    Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    Science 300:1529-30. 2003
    ..Wnt regulation of intracellular Ca2+ and cGMP levels requires the G protein transducin and a cGMP-specific phosphodiesterase, which are major elements in signaling of the visual pathway...
  19. ncbi request reprint Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer
    Hsien Yu Wang
    Department of Physiology and Biophysics, University Medical Center, SUNY Stony Brook, Stony Brook, NY 11794 8661, USA
    Cancer Lett 191:229-37. 2003
    ..Suppression of MKP activity therapeutically may enable the expression of the pro-apoptotic signals from JNK in malignant cells...
  20. ncbi request reprint G-Protein-coupled receptor-associated A-kinase anchoring proteins: AKAP79 and AKAP250 (gravin)
    Hsien Yu Wang
    Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    Eur J Cell Biol 85:643-50. 2006
    ..Each AKAP provides a template that enables space-time continuum features to G-protein-coupled signaling pathways as well as a paradigm for explaining apparent compartmentalization of cell signaling...
  21. ncbi request reprint Targeted, regulatable expression of activated heterotrimeric G protein alpha subunits in transgenic mice
    Xiaosong Song
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, University Medical Center, State University of New York, Stony Brook, New York 11794, USA
    Methods Enzymol 344:309-18. 2002
  22. ncbi request reprint The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor
    Anthony J DeCostanzo
    Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Center, University Medical Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    Naunyn Schmiedebergs Arch Pharmacol 365:341-8. 2002
    ....
  23. pmc Dvl3 translocates IPMK to the cell membrane in response to Wnt
    Ying Wang
    Department of Physiology and Biophysics, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8661 USA
    Cell Signal 24:2389-95. 2012
    ..Targeting the IPMKΔN back to the cell membrane by addition of an isoprenylated CAAX box rescues its function in Wnt3a downstream signaling...
  24. ncbi request reprint Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway
    Li Ma
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 281:30990-1001. 2006
    ..Protein kinase G is shown to be a critical downstream effector of the noncanonical Wnt-Frizzled-2/cGMP/Ca2+ pathway...
  25. ncbi request reprint Gene profiling of transgenic mice with targeted expression of activated heterotrimeric G protein alpha subunits using DNA microarray
    Hsien Yu Wang
    Department of Physiology and Biophysics, Diabetes and Metabolic Diseases Research Center, University Medical Center, State University of New York, Stony Brook, New York 11794, USA
    Methods Enzymol 345:529-39. 2002
  26. ncbi request reprint Targeted expression of activated Q227L G(alpha)(s) in vivo
    Xi Ping Huang
    Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Program, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Am J Physiol Cell Physiol 283:C386-95. 2002
    ....
  27. ncbi request reprint Probing receptor structure/function with chimeric G-protein-coupled receptors
    Dezhong Yin
    Department of Molecular Pharmacology, University Medical Center, Stony Brook University, Stony Brook, New York, USA
    Mol Pharmacol 65:1323-32. 2004
    ....
  28. ncbi request reprint Gene profiling of Frizzled-1 and Frizzled-2 signaling: expression of G-protein-coupled receptor chimeras in mouse F9 teratocarcinoma embryonal cells
    Hong Li
    Department of Pharmacology, Health Science Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    Mol Pharmacol 65:45-55. 2004
    ..We demonstrate the utility of beta2-adrenergic receptor-Frizzled chimeras to provide the tools with which to activate and to probe Frizzled-specific downstream signaling to gene activation...
  29. pmc Wnt-dependent assembly of supermolecular Dishevelled-3-based complexes
    Noriko Yokoyama
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 123:3693-702. 2010
    ..We establish for the first time the physical and functional nature of very large, supermolecular Dvl3-based complexes...
  30. ncbi request reprint Dishevelled: a mobile scaffold catalyzing development
    Craig C Malbon
    Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Curr Top Dev Biol 72:153-66. 2006
    ..Much excitement awaits the elucidation of the complete set of tools in the toolbox and of the dynamic regulation of Dishevelled proteins and their interacting proteins...
  31. ncbi request reprint Src docks to A-kinase anchoring protein gravin, regulating beta2-adrenergic receptor resensitization and recycling
    Jiangchuan Tao
    Department of Pharmacology, State University of New York, Stony Brook, New York 11794 8651, USA
    J Biol Chem 282:6597-608. 2007
    ..The tyrosine kinase Src plays an essential role in the AKAP gravin-mediated receptor resensitization and recycling, an essential aspect of receptor biology...
  32. ncbi request reprint Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway
    Li Ma
    Department of Physiology, Diabetes and Metabolic Diseases Research Center, School of Medicine, State University of New York Stony Brook, Stony Brook, New York 11794 8661, USA
    J Biol Chem 282:28980-90. 2007
    ..These novel results are the first to detail a Dishevelled-independent Wnt response, demonstrating a critical role of the mitogen-activated protein kinase p38 in regulating the Wnt non-canonical pathway...
  33. ncbi request reprint Inositol pentakisphosphate mediates Wnt/beta-catenin signaling
    Yuan Gao
    Department of Physiology and Biophysics, Diabetes and Metabolic Disease Research Center, School of Medicine, Health Sciences Center, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 282:26490-502. 2007
    ..Phosphatidylinositol signaling mediates Wnt3a action in the canonical pathway, acting to generate inositol pentakisphosphate, a key second messenger of Wnt3a...
  34. ncbi request reprint G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation
    Shai Gavi
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Trends Endocrinol Metab 17:48-54. 2006
    ..A broader understanding of how G-protein-coupled receptors and tyrosine kinases cross-talk reveals new insights into signaling modalities in both health and disease...
  35. pmc AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes
    Craig C Malbon
    Department of Molecular Pharmacology, University Medical Center, Stony Brook University, Stony Brook, NY 11794 8651, USA
    Biochem J 379:1-9. 2004
    ..Dynamic regulation of the AKAP-receptor complex is mediated by ordered protein phosphorylation...
  36. ncbi request reprint Wnt signaling and heterotrimeric G-proteins: strange bedfellows or a classic romance?
    C C Malbon
    Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794 8651, USA
    Biochem Biophys Res Commun 287:589-93. 2001
    ..The new data, consistent with the properties known for virtually all members of the G-protein-coupled receptors, reveal a more classic romance of signaling elements controlling aspects of early development...
  37. ncbi request reprint Separation of heart rate variability components of the autonomic nervous system by utilizing principal dynamic modes
    K H Chon
    State University of New York, Stony Brook, HSC T18, Rm 030, State University of New York at Stony Brook, Stony Brook, NY, 11794 8181, USA
    Nonlinear Dynamics Psychol Life Sci 10:163-85. 2006
    ..The PDM methodology is expected to have an added benefit that diagnosis and prognostication of a patient's health can be determined simply via a non-invasive electrocardiogram...
  38. pmc Local osmosis and isotonic transport
    R T Mathias
    Department of Physiology and Biophysics, SUNY at Stony Brook, NY 11794 8661, USA
    J Membr Biol 208:39-53. 2005
    ..These findings provide a plausible hypothesis on how the proximal tubule or other epithelia appear to transport an isotonic solution...
  39. pmc Yeast Ste2 receptors as tools for study of mammalian protein kinases and adaptors involved in receptor trafficking
    Dezhong Yin
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    J Mol Signal 1:2. 2006
    ....
  40. ncbi request reprint Lysophosphatidic acid regulates trafficking of beta2-adrenergic receptors: the Galpha13/p115RhoGEF/JNK pathway stimulates receptor internalization
    Elena Shumay
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Program, School of Medicine, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 282:21529-41. 2007
    ....
  41. ncbi request reprint Insulin-like growth factor-I provokes functional antagonism and internalization of beta1-adrenergic receptors
    Shai Gavi
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine HSC, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Endocrinology 148:2653-62. 2007
    ..IGF-I attenuates the ability of beta(1)-adrenergic receptors to accumulate intracellular cAMP in response to Iso and promotes internalization of beta(1)-adrenergic receptors in these cardiac myocytes...
  42. pmc Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation
    Alexander C Bertalovitz
    Department of Physiology and Biophysics, Health Sciences Center, School of Medicine, Stony Brook University, Stony Brook, NY 11794 8661, USA
    J Mol Signal 11:1. 2016
    ....
  43. pmc Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin
    Noriko Yokoyama
    Departments of Pharmacology, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY, 11794 8651, USA
    J Mol Signal 7:8. 2012
    ..In the canonical Wnt/β-catenin pathway specifically, Dvl3 polymerizes to form dynamic protein aggregates, so-called "signalsomes", which propagate signals from the Wnt receptor Frizzled to downstream elements...
  44. pmc AKAR2-AKAP12 fusion protein "biosenses" dynamic phosphorylation and localization of a GPCR-based scaffold
    Jiangchuan Tao
    Department of Pharmacology, School of Medicine, Heath Sciences Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    J Mol Signal 5:3. 2010
    ..In the current work, the AKAR2 biosensor was fused to the N-terminus of AKAP12 to evaluate its ability to function and report on dynamic phosphorylation of the AKAP12 scaffold...
  45. pmc Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling
    Li Ma
    Departments of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794
    J Mol Signal 5:19. 2010
    ....
  46. pmc Probing the stoichiometry of β2-adrenergic receptor phosphorylation by targeted mass spectrometry
    Shujuan Gao
    Department of Pharmacology, Health Sciences Center, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Mol Signal 9:3. 2014
    ....
  47. ncbi request reprint Structure-function analysis of Frizzleds
    Hsien Yu Wang
    Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, United States
    Cell Signal 18:934-41. 2006
    ....
  48. pmc "Shaping" of cell signaling via AKAP-tethered PDE4D: Probing with AKAR2-AKAP5 biosensor
    Salih S Kocer
    Department of Pharmacological Sciences, Health Sciences Center, BST 7, SUNY at Stony Brook, School of Medicine, Stony Brook, New York 11794 8651, USA
    J Mol Signal 7:4. 2012
    ....
  49. pmc Wnt and Frizzled RNA expression in human mesenchymal and embryonic (H7) stem cells
    Ujunwa C Okoye
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    J Mol Signal 3:16. 2008
    ..Wnt signals are important for embryonic stem cells renewal, growth and differentiation. Although 19 Wnt, 10 Frizzled genes have been identified in mammals, their expression patterns in stem cells were largely unknown...
  50. pmc AKAP12 and AKAP5 form higher-order hetero-oligomers
    Shujuan Gao
    Department of Pharmacology, Health Sciences Center, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8651 USA
    J Mol Signal 6:8. 2011
    ..AKAP5 (MW ~47 kDa) and AKAP12 (MW ~191 kDa) homo-oligomerize, but whether or not such AKAPs can hetero-oligomerize into supermolecular scaffolds of increased complexity is unknown...
  51. pmc Probing the physical nature and composition of signalsomes
    Hsien Yu Wang
    Departments of Physiology and Biophysics, Health Sciences Center, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8661 USA
    J Mol Signal 6:1. 2011
    ..signalsomes" when applied to protein assemblies involved in cell signaling provokes the question, what is the physical nature of these structures made visible in live cells through the expression of fluorescently-tagged fusion molecules?..
  52. ncbi request reprint Galpha i2 enhances in vivo activation of and insulin signaling to GLUT4
    X Song
    Department of Molecular Pharmacology, University Medical Center, State University of New York, Stony Brook, New York 11794-8651, USA
    J Biol Chem 276:34651-8. 2001
    ..These data provide an explanation for the marked glucose tolerance of the Q205L Galpha(i2) mice and demonstrate a linkage between Galpha(i2) and GLUT4 translocation...
  53. ncbi request reprint The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization
    G Fan
    Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Program, University Medical Center, SUNY Stony Brook, Stony Brook, New York 11794 8651, USA
    J Biol Chem 276:24005-14. 2001
    ..This is the first report of an AKAP scaffold protein translocating with its receptor, in this case a G-protein-coupled receptor...

Research Grants1

  1. Cyclic GMP Phosphodiesterase in Signaling
    Hsien Yu Wang; Fiscal Year: 2007
    ..These studies are highly relevant to signaling as well as to elucidation of basis for human diseases in which alterations in signaling pathways translate into aberrant biology. ..